Article
Cardiac & Cardiovascular Systems
Daniel Soetkamp, Romain Gallet, Sarah J. Parker, Ronald Holewinski, Vidya Venkatraman, Kiel Peck, Joshua Goldhaber, Eduardo Marban, Jennifer E. Van Eyk
Summary: The study suggests that the phosphorylation of sarcomeric proteins is associated with heart failure with preserved ejection fraction, and treatment with cardiosphere-derived cells can partially reverse this process, with PKC beta identified as a potential therapeutic target in HFpEF.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Hyun-Jung Lee, Hyung-Kwan Kim, Tae-Min Rhee, You-J Ung Choi, In-Chang Hwang, Yeonyee E. Yoon, Jun-Bean Park, Seung-Pyo Lee, Yong-Jin Kim, Goo-Yeong Cho
Summary: LARS can be used to categorize LV diastolic function and predict HF events in patients with hypertrophic cardiomyopathy.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Genri Numata, Eiki Takimoto, Taro Kariya, Yusuke Adachi, Hiroyuki Tokiwa, Masayuki Toyoda, Ryo Mafune, Yoshihiro Saito, Shun Nakamura, Kazutaka Ueda, Yuichi Ikeda, Issei Komuro
Summary: HFpEF is a global health issue with a lack of stable methods for detecting diastolic dysfunction in mouse models. The authors developed a pacing-controlled protocol to evaluate diastolic function at different heart rates in mice and successfully detected diastolic dysfunction specific to an HFpEF model.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Pediatrics
Bo Pan, Di Hu, Huichao Sun, Tiewei Lv, Wangguo Xu, Jie Tian
Summary: This study summarized the differences between pediatric diastolic heart failure and systolic heart failure in terms of primary causes, clinical features, and short-term prognosis. B-type natriuretic peptide has limited diagnostic value in pediatric DHF. Diastolic function indicators significantly improved after treatment in DHF patients.
FRONTIERS IN PEDIATRICS
(2022)
Article
Multidisciplinary Sciences
Maria Francesca Evaristi, Bruno Poirier, Xavier Chenede, Anne-Marie Lefebvre, Alain Roccon, Florence Gillot, Sandra Beeske, Alain Corbier, Marie-Pierre Pruniaux-Harnist, Philip Janiak, Ashfaq A. Parkar
Summary: The study found that SAR247799 can improve LVH and diastolic function, two major components of HFpEF. The drug can slow down cardiac hypertrophy and improve endothelial function.
Article
Multidisciplinary Sciences
Kenichiro Suzuki, Yasunori Inoue, Kazuo Ogawa, Tomohisa Nagoshi, Kosuke Minai, Takayuki Ogawa, Makoto Kawai, Michihiro Yoshimura
Summary: This study investigated the effects of coronary risk factors on left ventricular size and cardiac function using structure equation modeling. It found that each risk factor directly affected the shape of the heart. Managing risk factors is crucial in reducing the heart failure pandemic, as vascular risk and heart failure risk are likely to evolve simultaneously.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Akito Eguchi, Ryan Coleman, Kenneth Gresham, Erhe Gao, Jessica Ibetti, J. Kurt Chuprun, Walter J. Koch
Summary: Pathological remodeling of the heart in chronic heart failure is linked to structural changes perpetuated by cardiac fibroblasts, with GRK5 playing a key role in regulating fibroblast activation and cardiac fibrosis. GRK5 inhibition shows potential beneficial effects in cardiac disease by preventing fibroblast activation and reducing fibrosis and hypertrophy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Pharmacology & Pharmacy
Prachi Umbarkar, Anand P. Singh, Sultan Tousif, Qinkun Zhang, Palaniappan Sethu, Hind Lal
Summary: Nintedanib (NTB) is an FDA-approved tyrosine kinase inhibitor for pulmonary fibrosis, and study shows its potential in reducing cardiac fibrosis and improving cardiac function in a murine heart failure model, suggesting its promising application in treating HF patients.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Andrey Lozhkin, Aleksandr E. Vendrov, R. Ramos-Mondragon, Chandrika Canugovi, Mark D. Stevenson, Todd J. Herron, Scott L. Hummel, C. Alberto Figueroa, Dawn E. Bowles, Lori L. Isom, Marschall S. Runge, Nageswara R. Madamanchi
Summary: This study suggests that mitochondrial oxidative stress contributes to diastolic dysfunction by causing mitochondrial dysfunction, impaired mitochondrial dynamics, increased synthesis of pro-inflammatory and pro-fibrotic cytokines, activation of fibroblasts, and the accumulation of extracellular matrix, resulting in interstitial fibrosis and passive stiffness of the myocardium.
Article
Medicine, General & Internal
Keiichi Hirono, Teruhiko Imamura, Kaori Tsuboi, Shinya Takarada, Mako Okabe, Hideyuki Nakaoka, Keijiro Ibuki, Sayaka Ozawa
Summary: In Fontan surgery patients, the overlap length in Doppler transmitral flow echocardiography is associated with ventricular dysfunction and can reflect the status of cardiac reverse remodeling. Hemodynamic preservation at lower heart rate may be critical for these patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Peripheral Vascular Disease
Javier Diez, Javed Butler
Summary: Hypertensive heart disease is a significant cause of heart failure and its prevalence has been increasing despite improvements in hypertension treatment. The prevention of heart failure in patients with hypertensive heart disease is an important unmet medical need. This article proposes a new perspective that focuses on the detection and reversal of histological changes in the hypertensive heart, particularly myocardial interstitial fibrosis.
Article
Cardiac & Cardiovascular Systems
Sebastian Rosch, Karl-Patrik Kresoja, Christian Besler, Karl Fengler, Anne Rebecca Schoeber, Maximilian von Roeder, Christian Luecke, Matthias Gutberlet, Karin Klingel, Holger Thiele, Karl-Philipp Rommel, Philipp Lurz
Summary: In this study, patients with heart failure with preserved ejection fraction (HFpEF) were stratified based on left ventricular ejection fraction (LVEF), resulting in distinct morphologic and pathophysiologic subphenotypes. Patients with LVEF ranging from 50% to 60% demonstrated reduced contractility, impaired ventriculo-arterial coupling, and higher extracellular volume fraction, while patients with LVEF >60% exhibited a hypercontractile state with excessive left ventricular afterload and diminished preload reserve.
Article
Cardiac & Cardiovascular Systems
Darwin F. Yeung, River Jiang, Delaram Behnami, John Jue, Rajat Sharma, Mansi Turaga, Christina L. Luong, Michael Y. C. Tsang, Kenneth G. Gin, Hany Girgis, Pui-Kee Lee, Parvathy Nair, Purang Abolmaesumi, Teresa S. M. Tsang
Summary: The study assessed the impact of the 2016 ASE/EACVI updated algorithm on the assessment of diastolic function in real-world clinical practice. Significant differences were found in the evaluation results based on different guidelines, especially in reclassifying mild diastolic dysfunction to normal diastolic function.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Youn-Hoa Jung, Xianfeng Ren, Giancarlo Suffredini, Jeffery M. Dodd-o, Wei Dong Gao
Summary: This manuscript reviews issues related to right ventricular diastolic dysfunction and failure, including diagnosis, mechanisms, clinical impact, and management, highlighting its importance as a sensitive marker of end-organ dysfunction.
HEART FAILURE REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Masataka Kamiya, Kuniya Asai, Yasuhiro Maejima, Akihiro Shirakabe, Koji Murai, Satsuki Noma, Hidenori Komiyama, Naoki Sato, Kyoichi Mizuno, Wataru Shimizu
Summary: Chronic infusion of a beta 3-adrenergic receptor agonist attenuates cardiac fibrosis and improves diastolic dysfunction independently of blood pressure in an angiotensin II-induced hypertensive mouse model. This drug might be an effective treatment of heart failure with preserved ejection fraction.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2021)
Letter
Endocrinology & Metabolism
Atsushi Tanaka, Takumi Imai, Makoto Suzuki, Shinya Hiramitsu, Naohiko Takahashi, Toshiaki Kadokami, Arihiro Kiyosue, Masami Nishino, Yasushi Sakata, Koichi Node
DIABETES OBESITY & METABOLISM
(2022)
Article
Peripheral Vascular Disease
Kazuomi Kario, Yoshiaki Yokoi, Keisuke Okamura, Masahiko Fujihara, Yukako Ogoyama, Eiichiro Yamamoto, Hidenori Urata, Jin-Man Cho, Chong-Jin Kim, Seung-Hyuk Choi, Keisuke Shinohara, Yasushi Mukai, Tomokazu Ikemoto, Masato Nakamura, Shuichi Seki, Satoaki Matoba, Yoshisato Shibata, Shigeo Sugawara, Kazuhiko Yumoto, Kouichi Tamura, Fumiki Yoshihara, Satoko Nakamura, Woong Chol Kang, Taro Shibasaki, Keigo Dote, Hiroyoshi Yokoi, Akiko Matsuo, Hiroshi Fujita, Toshiyuki Takahashi, Hyun-Jae Kang, Yasushi Sakata, Kazunori Horie, Naoto Inoue, Ken-ichiro Sasaki, Takafumi Ueno, Hirofumi Tomita, Yoshihiro Morino, Yuhei Nojima, Chan Joon Kim, Tomoaki Matsumoto, Hisashi Kai, Shinsuke Nanto
Summary: This study found no significant difference in ambulatory blood pressure reductions between renal denervation and a sham procedure in treated patients with resistant hypertension. Although the blood pressure reduction after renal denervation was similar to other sham-controlled studies, the unexpected greater reduction in the sham control group in this study highlights design issues that will be addressed in a new trial.
HYPERTENSION RESEARCH
(2022)
Article
Medicine, General & Internal
Tomoka Tabata, Yuki Kuramoto, Tomohito Ohtani, Hiroshi Miyawaki, Yohei Miyashita, Fusako Sera, Hidetaka Kioka, Shuichiro Higo, Yoshihiro Asano, Shungo Hikoso, Yasushi Sakata
Summary: Phospholamban p.Arg14del gene mutation can cause hereditary cardiomyopathy, leading to dilated cardiomyopathy and severe ventricular tachycardia in patients with advanced heart failure. Genetic screening for phospholamban p.Arg14 del is important for patients with dilated cardiomyopathy.
Article
Cardiac & Cardiovascular Systems
Hirota Kida, Yohei Sotomi, Shungo Hikoso, Daisaku Nakatani, Hiroya Mizuno, Shinichiro Suna, Katsuki Okada, Tetsuhisa Kitamura, Sho Komukai, Tomoharu Dohi, Takayuki Kojima, Bolrathanak Oeun, Akihiro Sunaga, Taiki Sato, Yasuhiko Sakata, Hiroshi Sato, Masatsugu Hori, Issei Komuro, Yasushi Sakata
Summary: This study investigated the prognostic significance of combining intra-aortic balloon pumping (IABP) with extracorporeal membrane oxygenation (ECMO) for acute myocardial infarction (AMI) patients. The results showed that the addition of IABP support to ECMO was associated with a reduced risk of short-term mortality, but an increased risk of major bleeding.
JOURNAL OF CARDIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Atsushi Kimura, Akiyoshi Hirayama, Tatsuaki Matsumoto, Yuiko Sato, Tami Kobayashi, Satsuki Ikeda, Midori Maruyama, Mari Kaneko, Mayo Shigeta, Eri Ito, Tomoya Soma, Kana Miyamoto, Tomoyoshi Soga, Masaru Tomita, Akihito Oya, Morio Matsumoto, Masaya Nakamura, Arihiko Kanaji, Takeshi Miyamoto
Summary: Ossification of the posterior longitudinal ligament (OPLL), a disease characterized by ectopic ossification of a spinal ligament, can lead to neurological disorders. This study investigated the role of hydroxyacid oxidase 1 (Hao1) in OPLL development and found that Hao1 expression decreased during osteoblast differentiation. Further experiments using Hao1-deficient mice showed that Hao1 loss did not promote ectopic ossification, but rather regulated the tricarboxylic acid (TCA) cycle metabolism.
Article
Cardiac & Cardiovascular Systems
Koshiro Kanaoka, Taku Nishida, Yuichi Nishioka, Tomoya Myojin, Shinichiro Kubo, Tsunenari Soeda, Katsuki Okada, Tatsuya Noda, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Yasushi Sakata, Tomoaki Imamura, Yoshihiko Saito
Summary: This study examined the association between hospital case volume for catheter ablation (CA) and periprocedural complications and atrial fibrillation (AF) recurrence in Japan. The results showed that the case-volume effect was observed in the radiofrequency ablation group but not in the cryoballoon ablation group.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Tatsuya Shiraki, Yasuhiro Ichibori, Tomohito Ohtani, Isamu Mizote, Hidetaka Kioka, Yasumasa Tsukamoto, Daisuke Nakamura, Kensuke Yokoi, Seiko Ide, Kei Nakamoto, Yasuharu Takeda, Jun-ichi Kotani, Shungo Hikoso, Yoshiki Sawa, Yasushi Sakata
Summary: This study investigates the morphological characteristics and association with serum cytokine levels of de novo and donor-transmitted plaques in patients with coronary allograft vasculopathy within one year after heart transplantation. The results indicate that fibrous proliferation contributes to the progression of these plaques, and baseline serum interleukin-31 levels may contribute to intimal fibrous proliferation.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Biochemistry & Molecular Biology
Adriaan A. Voors, Christiane E. Angermann, John R. Teerlink, Sean P. Collins, Mikhail Kosiborod, Jan Biegus, Joao Pedro Ferreira, Michael E. Nassif, Mitchell A. Psotka, Jasper Tromp, C. Jan Willem Borleffs, Changsheng Ma, Joseph Comin-Colet, Michael Fu, Stefan P. Janssens, Robert G. Kiss, Robert J. Mentz, Yasushi Sakata, Henrik Schirmer, Morten Schou, P. Christian Schulze, Lenka Spinarova, Maurizio Volterrani, Jerzy K. Wranicz, Uwe Zeymer, Shelley Zieroth, Martina Brueckmann, Jonathan P. Blatchford, Afshin Salsali, Piotr Ponikowski
Summary: The sodium-glucose cotransporter 2 inhibitor empagliflozin improves clinical outcomes in patients hospitalized for acute heart failure, regardless of ejection fraction or the presence of diabetes.
Article
Biochemistry & Molecular Biology
Yukako Suzuki, Ryosuke Hayasaka, Masako Hasebe, Satsuki Ikeda, Tomoyoshi Soga, Masaru Tomita, Akiyoshi Hirayama, Hiroki Kuroda
Summary: This study identified specific small molecules expressed in the dorsal or ventral marginal zones in vertebrate gastrula, investigating their impact on cell fate. By analyzing hydrophilic metabolites and lipids, the research found differences in metabolism-related molecules between the two regions, contributing to a better understanding of cellular physiology during early embryogenesis.
Article
Cardiac & Cardiovascular Systems
Koshiro Kanaoka, Yoshitaka Iwanaga, Michikazu Nakai, Yuichi Nishioka, Tomoya Myojin, Shinichiro Kubo, Katsuki Okada, Tatsuya Noda, Yasushi Sakata, Yoshihiro Miyamoto, Yoshihiko Saito, Tomoaki Imamura
Summary: This study investigated the effects of outpatient cardiac rehabilitation in patients with heart failure using a nationwide database. The results showed that outpatient cardiac rehabilitation was associated with a reduction in mortality and rehospitalization for heart failure without increasing medical costs.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Martin Arnold, Mark Richards, Antonio D'Onofrio, Brett Faulknier, Michele Gulizia, Ranjan Thakur, Yasushi Sakata, Wenjiao Lin, Annalisa Pollastrelli, Andrea Grammatico, Angelo Auricchio, Giuseppe Boriani
Summary: In bradycardia patients treated with dual-chamber pacing, pacing with AV delay management (AVH) reduces unnecessary ventricular pacing percentage (VPP) and is associated with better clinical outcomes.
Article
Cardiac & Cardiovascular Systems
Koshiro Kanaoka, Yoshitaka Iwanaga, Michikazu Nakai, Yuichi Nishioka, Tomoya Myojin, Shinichiro Kubo, Katsuki Okada, Tatsuya Noda, Yasushi Sakata, Yoshihiro Miyamoto, Yoshihiko Saito, Tomoaki Imamura
Summary: This retrospective cohort study examined the association of early use of SGLT2 inhibitors with outcomes in hospitalized patients with acute coronary syndrome. The results showed that SGLT2 inhibitors were associated with a lower risk of the primary outcome in patients with severe heart failure, but not in patients without severe heart failure.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Akiyoshi Hirayama, Takamasa Ishikawa, Haruka Takahashi, Sanae Yamanaka, Satsuki Ikeda, Aya Hirata, Sei Harada, Masahiro Sugimoto, Tomoyoshi Soga, Masaru Tomita, Toru Takebayashi
Summary: High-throughput metabolomics has facilitated large-scale cohort studies. Long-term studies require multiple batch-based measurements, which necessitates sophisticated quality control to eliminate bias. In this study, liquid chromatography-mass spectrometry was used to analyze 10,833 samples in 279 batch measurements. The quantified profile included 147 lipids. Normalization using QC samples reduced the coefficient of variation for the lipids. This study provides unbiased and quantified data for large-scale metabolomics.
Article
Biochemical Research Methods
Ryuhei Kudo, Kaori Igarashi, Tomoyoshi Soga, Takamasa Ishikawa, Yasuhiro Saito
Summary: Capillary electrophoresis mass spectrometry (CE-MS) and liquid chromatography mass spectrometry (LC-MS) are two commonly used methods for metabolite analysis, but require independent sample preparation. This article presents a sample preparation protocol for breast cancer cell lines.
