Article
Peripheral Vascular Disease
Brent M. Egan, Jianing Yang, Michael K. Rakotz, Susan E. Sutherland, Kenneth A. Jamerson, Jackson T. Wright, Keith C. Ferdinand, Gregory D. Wozniak
Summary: The study found that initial therapy with calcium channel blockers or thiazide-type diuretics had better antihypertensive effects in non-Hispanic Black adults than renin-angiotensin system blockers. Despite the recommendation to use this treatment approach, there is still a gap between the recommended and actual use. Evidence-based monotherapy appears insufficient to improve hypertension control in non-Hispanic Black adults.
Article
Immunology
Vignesh Chidambaram, Akshay Gupte, Jann-Yuan Wang, Jonathan E. Golub, Petros C. Karakousis
Summary: Patients with hypertension have increased all-cause mortality and infection-related mortality during the first 9 months following TB treatment initiation. The use of Dihydropyridine-CCB may lower all-cause mortality in TB patients with hypertension, but the presence of hypertension or the use of CCB does not significantly impact microbiological outcomes.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Peripheral Vascular Disease
Matthew C. Hyman, Michael G. Levin, Dipender Gill, Venexia M. Walker, Marios K. Georgakis, Neil M. Davies, Francis E. Marchlinski, Scott M. Damrauer
Summary: Genetic variants associated with higher blood pressure are linked to an increased risk of atrial fibrillation, suggesting a causal relationship between blood pressure and AF. Reduction of blood pressure with calcium channel blockers or beta-blockers may help lower the risk of AF.
Article
Peripheral Vascular Disease
Chien-Chang Lee, Meng-Tse Gabriel Lee, Wan-Ting Hsu, James Yeongjun Park, Lorenzo Porta, Michael A. Liu, Shyr-Chyr Chen, Shan-Chwen Chang
Summary: A nested case-control study using the National Health Insurance Research Database of Taiwan showed that the use of dihydropyridine CCBs is associated with a reduced risk of active tuberculosis. Subgroup analyses did not find significant differences in the risk of tuberculosis with CCB use among patients with heart failure or cerebrovascular diseases.
Review
Chemistry, Analytical
Ayyappa Bathinapatla, Suvardhan Kanchi, Rajasekhar Chokkareddy, Reddy Prasad Puthalapattu, Mulpuri Ravi Kumar
Summary: Stress, ingrained human behaviors, inactive lifestyle, and poor dietary decisions are primary causes of hypertension and coronary artery disease. High blood pressure treatment using fi-blockers and calcium channel blockers is effective. Electrochemical sensors provide multiple benefits for detecting fi-blockers and CCBs, including sensitivity, selectivity, rapidity, and cost-effectiveness.
MICROCHEMICAL JOURNAL
(2023)
Article
Oncology
Yuna Sadaka, Midori Soda, Akiyo Hori, Yuri Miyahara, Yasuhisa Oida, Yoichi Nishigaki, Eiichi Tomita, Takashi Mizui, Kiyoyuki Kitaichi
Summary: This study investigated the potential adverse reactions caused by the concomitant use of calcium channel blockers (CCBs) and the antiviral drug ritonavir, which is a substrate for cytochrome P450 3A4 (CYP3A4). The results showed that peripheral edema was common in patients, and the use of CCBs along with ritonavir increased the severity of edema. Close monitoring of peripheral edema is recommended for patients receiving this treatment.
ANTICANCER RESEARCH
(2022)
Article
Medicine, General & Internal
Eder H. Cativo, Persio D. Lopez, Diana P. Cativo, Steven A. Atlas, Clive Rosendorff
Summary: This study found that inhibitors of the renin-angiotensin system are more effective than calcium channel blockers in reducing albuminuria in patients with nephropathy due to hypertension and diabetes mellitus. However, there was no significant difference between the two drug classes in terms of markers of renal function.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Deniz Turkmen, Jane A. H. Masoli, Joao Delgado, Chia-Ling Kuo, Jack Bowden, David Melzer, Luke C. Pilling
Summary: This study aimed to investigate the association between reported pharmacogenetic variants and incident adverse events in patients prescribed dihydropyridine calcium-channel blockers (dCCBs). The results showed that carriers of the rs877087 T allele in RYR3 had an increased risk of heart failure. Additionally, genetic variants in NUMA1 and CYP3A5 were also associated with adverse clinical outcomes.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Review
Chemistry, Analytical
Suraj R. Chaudhari, Atul A. Shirkhedkar
Summary: This review article discusses crucial analytical methodologies for the pharmaceutical analysis of cilnidipine in various forms, including hyphenated techniques, high-performance thin-layer chromatography, high-performance liquid-chromatography, and other approaches. From the literature, it is concluded that high-performance liquid-chromatography and UV/Vis-spectrophotometry methods are the most commonly used for analyzing cilnidipine.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2021)
Review
Pediatrics
Nicola Bertazza Partigiani, Rachele Spagnol, Laura Di Michele, Micaela Santini, Benedetta Grotto, Alex Sartori, Elita Zamperetti, Margherita Nosadini, Davide Meneghesso
Summary: Hypertensive emergencies in pediatric patients are life-threatening conditions associated with severe hypertension and organ damage. Current guidelines for managing pediatric hypertensive emergencies are limited, with most of the evidence derived from adult studies. β-blockers appear to be safe and effective in hypertensive crises, while calcium-channel blockers, particularly clevidipine, show potential as effective and safe treatment options. However, further research is needed to establish a uniform approach to pediatric hypertensive emergencies.
FRONTIERS IN PEDIATRICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Gulbahar Ustaoglu, Emrah Erdal, Zeynep Karas
Summary: This study aimed to evaluate the occurrence rate of drug-induced gingival overgrowth in patients treated with ACE inhibitors, ARBs, and CCBs, with highest rate found in the amlodipine group. There was a significant relationship between drug dosage and DIGO, while no association was found with the duration of therapy.
Article
Pharmacology & Pharmacy
James P. Sheppard, Mark Lown, Jenni Burt, Gary A. Ford, F. D. Richard Hobbs, Paul Little, Jonathan Mant, Rupert A. Payne, Richard J. McManus
Summary: This study found that withdrawal of higher dose calcium channel blockers may lead to increased blood pressure and reduced blood pressure control, while stopping low dose beta-blockers has little impact on blood pressure. Larger studies are needed to confirm these associations.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Peripheral Vascular Disease
Sukainah Al Khalaf, Ali S. Khashan, Lucy C. Chappell, Eilis J. O'Reilly, Fergus P. McCarthy
Summary: This study investigated the adverse effects of chronic hypertension during pregnancy and the effectiveness of antihypertensive treatment. The results showed that women with chronic hypertension had a higher risk of developing preeclampsia, preterm birth, and fetal growth restriction. Women with chronic hypertension who were treated with antihypertensive medications still had a higher risk of these adverse outcomes compared to untreated women. Among women receiving treatment, methyldopa may have better pregnancy outcomes than beta-blockers.
Article
Biochemistry & Molecular Biology
Tingting Zhao, Wen Jiang, Xiaolan Zhen, Chengcheng Jin, Yifan Zhang, Hui Li
Summary: In this study, a QuEChERS pretreatment method combined with UPLC-MS/MS was used for rapid and reliable simultaneous detection of five calcium channel blockers (CCBs) in human plasma. The technique showed good linear response and accuracy, with a range of 1-800 ng.mL(-1), R-2 >= 0.9921, and accuracy of 87.54-113.05%. This time-saving method provided a promising basis for therapeutic drug monitoring in patients with hypertension.
Article
Pharmacology & Pharmacy
Liqiong Ding, Ping Jiang, Xinfeng Xu, Wanzhen Lu, Chan Yang, Lin Li, Pingzheng Zhou, Shuwen Liu
Summary: The study identified T-type calcium channel blockers as potential inhibitors of HSV-2 infection, while L-type calcium channel blockers showed no significant effect. Additionally, benidipine exerted antiviral effects by suppressing viral gene expression in the late stage of infection.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Rafael Harari, Sripal Bangalore, Ernest Chang, Binita Shah
Summary: A patient with COVID-19 developed acute myocardial infarction and eventually died from shock despite receiving percutaneous coronary intervention and mechanical circulatory support. Managing patients with COVID-19, AMI, and cardiogenic shock presents significant challenges.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Peripheral Vascular Disease
Philippe Gosse, Antoine Cremer, Ajay J. Kirtane, Melvin D. Lobo, Manish Saxena, Joost Daemen, Yale Wang, Johannes Stegbauer, Michael A. Weber, Josephine Abraham, Kazuomi Kario, Sripal Bangalore, Lisa Claude, Yuyin Liu, Michel Azizi
Summary: The study found that baseline nighttime systolic blood pressure and its variability can predict the blood pressure response to renal denervation in patients with hypertension, which is helpful in identifying potential responders.
Article
Cardiac & Cardiovascular Systems
Mario Gaudino, Irbaz Hameed, Antonino Di Franco, Ajita Naik, Michelle Demetres, Giuseppe Biondi-Zoccai, Sripal Bangalore
Summary: This study conducted a systematic review and meta-analysis to compare the efficacy of percutaneous coronary intervention and coronary artery bypass grafting stratified by SYNTAX score. The results showed no significant association between SYNTAX score and the comparative effectiveness of the two procedures.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Franz H. Messerli, Chirag Bavishi, Sripal Bangalore
Article
Cardiac & Cardiovascular Systems
Sripal Bangalore, John A. Spertus, Susanna R. Stevens, Philip G. Jones, G. B. John Mancini, Jonathon Leipsic, Harmony R. Reynolds, Matthew J. Budoff, Cameron J. Hague, James K. Min, William E. Boden, Sean M. O'Brien, Robert A. Harrington, Jeffrey S. Berger, Roxy Senior, Jesus Peteiro, Neeraj Pandit, Leonid Bershtein, Mark A. de Belder, Hanna Szwed, Rolf Doerr, Lorenzo Monti, Khaled Alfakih, Judith S. Hochman, David J. Maron
Summary: The study found that intermediate left main disease (LMD) was associated with cardiovascular events. An invasive strategy can reduce nonprocedural MI and improve angina-related quality of life.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Monil Majmundar, Gabriel Ibarra, Ashish Kumar, Rajkumar Doshi, Palak Shah, Roxana Mehran, Grant W. Reed, Rishi Puri, Samir R. Kapadia, Sripal Bangalore, Ankur Kalra
Summary: Invasive management is associated with lower mortality and major adverse cardiovascular events in NSTEMI-CKD patients compared to medical management, with minimal increase in in-hospital complications.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Sonal Pruthi, Sripal Bangalore
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Judith S. Hochman, Rebecca Anthopolos, Harmony. R. Reynolds, Sripal Bangalore, Yifan Xu, Sean M. O'Brien, Stavroula Mavromichalis, Michelle Chang, Aira Contreras, Yves Rosenberg, Ruth Kirby, Balram Bhargava, Roxy Senior, Ann Banfield, Shaun G. Goodman, Renato D. Lopes, Radoslaw Pracon, Jose Lopez-Sendon, Aldo Pietro Maggioni, Jonathan D. Newman, Jeffrey S. Berger, Mandeep S. Sidhu, Harvey D. White, Andrea B. Troxel, Robert A. Harrington, William E. Boden, Gregg W. Stone, Daniel B. Mark, John A. Spertus, David J. Maron
Summary: The ISCHEMIA trial compared the outcomes of initial invasive strategy versus initial conservative strategy in patients with chronic coronary disease and moderate or severe ischemia. The trial found no major difference in most outcomes, but there was lower risk of cardiovascular mortality and higher risk of noncardiovascular mortality with the invasive strategy.
Article
Cardiac & Cardiovascular Systems
Muhammad Haisum Maqsood, Samir Pancholy, Kristin A. A. Tuozzo, Nicole Moskowitz, Sunil V. V. Rao, Sripal Bangalore
Summary: For patients undergoing transradial access procedures, a hemostasis duration of 2 hours offers the best balance between preventing radial artery occlusion and reducing the risk of access site bleeding or hematoma.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2023)
Letter
Cardiac & Cardiovascular Systems
Monil Majmundar, Rajkumar Doshi, Rhythm Vasudeva, Kunal N. Patel, Ashish Kumar, Sripal Bangalore, Ankur Kalra
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2023)
Article
Cardiac & Cardiovascular Systems
Robert S. Zhang, Usman Alam, Muhammad H. Maqsood, Yuhe Xia, Rafael Harari, Norma Keller, Lindsay Elbaum, Sunil V. Rao, Carlos L. Alviar, Sripal Bangalore
Summary: In this study, percutaneous vegetation debulking was found to be a feasible, effective, and safe treatment option for patients with tricuspid valve infective endocarditis refractory to medical therapy.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2023)
Review
Cardiac & Cardiovascular Systems
Toshiki Kuno, Atsuyuki Watanabe, Satoshi Shoji, Tomohiro Fujisaki, Hiroki Ueyama, Hisato Takagi, Pierre Deharo, Thomas Cuisset, Sripal Bangalore, Roxana Mehran, Gregg W. Stone, Shun Kohsaka, Deepak L. Bhatt
Summary: In patients with acute coronary syndrome, unguided de-escalation is associated with the lowest risk of major adverse cardiovascular events and major or minor bleeding outcomes, while short DAPT followed by P2Y12 inhibitor is associated with the lowest risk of major bleeding and all-cause death.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2023)
Review
Peripheral Vascular Disease
Muhammad Haisum Maqsood, Franz H. Messerli, Adam H. Skolnick, Jonathan D. Newman, Jeffrey S. Berger, Sripal Bangalore
Summary: This study compared the efficacy of morning versus evening dosing of antihypertensive drugs and found that evening dosing significantly reduced ambulatory blood pressure parameters and cardiovascular events, but this effect was mainly driven by trials by the Hermida group. Therefore, the timing of antihypertensive drug administration should be chosen based on convenience and minimizing undesirable effects.
Article
Cardiac & Cardiovascular Systems
Zainali S. Chunawala, Melissa C. Caughey, Deepak L. Bhatt, Michael Hendrickson, Sameer Arora, Sripal Bangalore, John P. Erwin, Justin P. Levisay, Jonathan R. Rosenberg, Mark J. Ricciardi, Ron Blankstein, Kunihiro Matsushita, Sidney Smith, Arman Qamar
Summary: AMI is not rare among individuals without SMuRFs. The clinical characteristics and prognosis of SMuRFless individuals are not well described. Therefore, personalized prevention and treatment strategies need to be developed for this population.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Orly Leiva, Eugene Yuriditsky, Radu Postelnicu, Eric H. Yang, Vikramjit Mukherjee, Allison Greco, James Horowitz, Carlos Alviar, Sripal Bangalore
Summary: Among cancer patients with intermediate or high-risk PE, treatment with CBT was associated with a lower risk of in-hospital death or cardiac arrest but a higher risk of bleeding.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)