Article
Peripheral Vascular Disease
Enrique Rodilla, Maria Dolores Lopez-Carmona, Xavi Cortes, Lidia Cobos-Palacios, Sergio Canales, Maria Carmen Saez, Samara Campos Escudero, Manuel Rubio-Rivas, Jesus Diez Manglano, Santiago J. Freire Castro, Nuria Vazquez Piqueras, Elisabeth Mateo Sanchis, Paula Maria Pesqueira Fontan, Jeffrey Oskar Magallanes Gamboa, Andres Gonzalez Garcia, Victor Madrid Romero, Lara Tamargo Chamorro, Julio Gonzalez Moraleja, Javier Villanueva Martinez, Amara Gonzalez Noya, Ana Suarez-Lombrana, Anyuli Gracia Gutierrez, Manuel Lorenzo Lopez Reboiro, Jose Manuel Ramos Rincon, Ricardo Gomez Huelgas
Summary: This study analyzed the association between arterial stiffness (AS) and all-cause mortality in COVID-19 patients, finding that AS and systolic blood pressure <120 mm Hg independently predicted in-hospital all-cause mortality after adjusting for other factors.
Review
Cardiac & Cardiovascular Systems
Alicia Saz-Lara, Rosa Maria Bruno, Ivan Cavero-Redondo, Celia Alvarez-Bueno, Blanca Notario-Pacheco, Vicente Martinez-Vizcaino
Summary: This systematic review and meta-analysis found that arterial stiffness, systolic blood pressure, and diastolic blood pressure are associated with incident hypertension. These findings are clinically important for the prevention of arterial hypertension and reducing cardiovascular morbidity and mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Computer Science, Information Systems
Rebecca Mieloszyk, Hope Twede, Jonathan Lester, Jeremiah Wander, Sumit Basu, Gabe Cohn, Greg Smith, Dan Morris, Sidhant Gupta, Desney Tan, Nicolas Villar, Moni Wolf, Sailaja Malladi, Matt Mickelson, Lauren Ryan, Lindsey Kim, Jeffrey Kepple, Susanne Kirchner, Emma Wampler, Riena Terada, Joel Robinson, Ron Paulsen, T. Scott Saponas
Summary: This study demonstrated the results of blood pressure estimation in both lab and daily life using different feature groups, with superior performance shown by the radial tonometry-derived feature group. The study emphasizes the need for diverse populations and challenging evaluation settings in blood pressure estimation research.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2022)
Article
Multidisciplinary Sciences
Jacopo Belfiore, Etrusca Brogi, Niccolo Nicolini, Davide Deffenu, Francesco Forfori, Carlo Palombo
Summary: This study investigated the hemodynamic variations associated with the application of positive end-expiratory pressure (PEEP) in healthy subjects. The results showed that low levels of PEEP prolong diastolic phase and reduce systolic work of the heart.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Juraj Jug, Didi Delalic, Valerija Bralic Lang, Tomislav Bulum, Ingrid Prkacin
Summary: This study aimed to compare the pulse wave velocity (PWV) values in subjects with prediabetes, non-dipper profile, and arterial hypertension with their values in healthy subjects. The results showed that subjects with prediabetes and non-dipping profiles had significantly higher PWV values. Age, blood pressure, nocturnal indices, and fasting plasma glucose were identified as independent predictors of PWV values. These findings highlight the importance of prediabetes and non-dipping hypertension as factors contributing to increased PWV.
Article
Peripheral Vascular Disease
Ming-Xuan Li, Dong-Yan Zhang, Song-Tao Tang, Qi-Dong Zheng, Qi-Fang Huang, Chang-Sheng Sheng, Yan Li, Ji-Guang Wang
Summary: The control rate of ambulatory blood pressure is low in Chinese hypertensive patients, especially during the nighttime and morning time windows, and it may be associated with arterial stiffness.
HYPERTENSION RESEARCH
(2023)
Review
Urology & Nephrology
Christian Ott, Roland E. Schmieder
Summary: In the past 4 years, guidelines for the management of arterial hypertension have been published with mostly concordant recommendations but some discordant opinions. Accurate blood pressure measurement is crucial for diagnosis, and out-of-office measurements are also important. Simplified antihypertensive drug treatment and personalized goals are emphasized. Renal denervation is supported for uncontrolled and treatment-resistant hypertension.
KIDNEY INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Mengying Wang, Jie Huang, Tao Wu, Lu Qi
Summary: The study found that pulse wave arterial stiffness index (ASI) is positively associated with the risk of type 2 diabetes (T2D), while the association between pulse pressure (PP) and T2D shows a nonlinear J-shaped relationship. Additionally, the association between ASI and T2D is more pronounced among individuals with higher genetic susceptibility to T2D.
Article
Endocrinology & Metabolism
Mengying Wang, Jie Huang, Tao Wu, Lu Qi
Summary: Pulse wave arterial stiffness index (ASI) showed a dose-response association with type 2 diabetes (T2D), while pulse pressure (PP) displayed a nonlinear J-shaped association with T2D. Additionally, the association between ASI and T2D was partially strengthened by higher genetic susceptibility to T2D.
Article
Medicine, General & Internal
Francesca Coccina, Anna M. Pierdomenico, Chiara Cuccurullo, Jacopo Pizzicannella, Oriana Trubiani, Sante D. Pierdomenico
Summary: This study aimed to assess the prognostic impact of 24-hour pulse pressure (PP), elastic PP (elPP) and stiffening PP (stPP) in elderly treated hypertensive patients. The results showed that 24-hour elPP is a predictor of cardiovascular events in elderly treated hypertensive patients.
Review
Medicine, General & Internal
Sofie Brouwers, Isabella Sudano, Yoshihiro Kokubo, Elisabeth M. Sulaica
Summary: Arterial hypertension is a major contributor to the global burden of disease, but disease control remains poor. Diagnosis and treatment of hypertension should be based on a combination of various guidelines, with equal emphasis on pharmacological treatment and lifestyle adjustments. Device-based therapies such as renal denervation are rapidly evolving to expand therapeutic options.
Article
Engineering, Multidisciplinary
Lirui Xu, Pang Wu, Pan Xia, Fanglin Geng, Saihu Lu, Peng Wang, Xianxiang Chen, Zhenfeng Li, Lidong Du, Shuping Liu, Li Li, Hongbo Chang, Zhen Fang
Summary: This study presents an ultrasound system that can noninvasively measure local pulse pressure and blood pressure waveforms continuously. The system uses a low-computational method to evaluate pulse wave velocity and diameter waveforms, allowing the measurement of PP and blood pressure without calibration. The system has been validated in vitro and in vivo, demonstrating high accuracy and showing promise for diagnosing and preventing cardiovascular diseases.
Article
Peripheral Vascular Disease
Lucas S. Aparicio, Qi-Fang Huang, Jesus D. Melgarejo, Dong-Mei Wei, Lutgarde Thijs, Fang-Fei Wei, Natasza Gilis-Malinowska, Chang-Sheng Sheng, Jose Boggia, Teemu J. Niiranen, Augustine N. Odili, Katarzyna Stolarz-Skrzypek, Jessica Barochiner, Daniel Ackermann, Kalina Kawecka-Jaszcz, Valerie Tikhonoff, Zhen-Yu Zhang, Edoardo Casiglia, Krzysztof Narkiewicz, Jan Filipovsky, Aletta E. Schutte, Wen-Yi Yang, Antti M. Jula, Angela J. Woodiwiss, Murielle Bochud, Gavin R. Norton, Ji-Guang Wang, Yan Li, Jan A. Staessen
Summary: The IDCARS database includes 10,930 subjects from 13 studies across different regions, with prevalence rates of office hypertension and diabetes mellitus reported. The central and peripheral systolic/diastolic blood pressure, as well as aortic pulse wave velocity, were measured. Longitudinal studies showed a median follow-up of 4.2 years, with cardiovascular events and deaths reported during the follow-up period. The IDCARS database provides valuable information for investigating central hemodynamic measurements and may inform guidelines for managing hypertension.
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Article
Chemistry, Analytical
Yosuke Osawa, Tetsuji Dohi
Summary: In this paper, a new discriminant index is proposed to evaluate the wearing condition of a blood pressure pulse wave measurement device with small variability. The index is based on the ratio of the blood pressure pulse wave component to the noise component. The correlation coefficient between the index and the amplitude of the blood pressure pulse wave is 0.879, and the index reduces the coefficient of variation by 12.8%.
Article
Geriatrics & Gerontology
Maryam Farahmand, Maryam Mousavi, Amir Abbas Momenan, Fereidoun Azizi, Fahimeh Ramezani Tehrani
Summary: This study investigated the association between age at menarche and the incidence of arterial hypertension. The findings suggest that late menarche may be a risk factor for arterial hypertension and should be considered in cardiovascular risk assessment programs.
Article
Peripheral Vascular Disease
Simon Helleputte, Bart Spronck, James E. E. Sharman, Luc Van Bortel, Patrick Segers, Patrick Calders, Bruno Lapauw, Tine De Backer
Summary: The central blood pressure values estimated by radial artery tonometry in T1DM patients depend significantly on the method used for calibration of the radial waveforms. Using brachial MAP/DBP calibration resulted in higher central blood pressure compared to using brachial SBP/DBP calibration, indicating the importance of calibration approach for accurate estimation of central blood pressure using noninvasive methods.
JOURNAL OF HYPERTENSION
(2023)
Article
Engineering, Biomedical
Matthias Van Impe, Lisa Caboor, Violette Deleeuw, Margie Olbinado, Julie De Backer, Patrick Sips, Patrick Segers
Summary: This study successfully provides a biomechanical reference for the circulation in adult zebrafish by establishing 3D models of the cardiovascular system. By providing reference values for biomechanical stimuli in wild-type animals and a pipeline for image-based animal-specific computational biomechanical models, this study contributes to a more comprehensive understanding of the role of altered biomechanics and hemodynamics in heritable cardiovascular pathologies.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Annette Caenen, Stephanie Bezy, Aniela Petrescu, Annegret Werner, Jens-Uwe Voigt, Jan D'hooge, Patrick Segers
Summary: Shear wave elastography (SWE) is a promising technique for assessing myocardial stiffness non-invasively. The study found that the transmural wave speed gradient can distinguish between intrinsic myocardial stiffening and stiffening caused by increased pressure. This gradient may have potential as a new diagnostic parameter for future clinical studies.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Biophysics
Lise Gheysen, Lauranne Maes, Nele Famaey, Patrick Segers
Summary: This study investigates whether pulse wave velocity (PWV) can guide in determining appropriate parameter values for the Gasser-Ogden-Holzapfel (GOH) constitutive model. The results show that PWV80 and PWV110 are complementary measures that can reduce the parameter space in arterial models, particularly for media- and collagen-related parameters.
JOURNAL OF BIOMECHANICS
(2023)
Article
Cardiac & Cardiovascular Systems
Kristian Sorensen, Solveig Fadnes, Luc Mertens, Matthew Henry, Patrick Segers, Lasse Lovstakken, Siri Ann Nyrnes
Summary: This study developed and validated the calculation of intraventricular pressure difference (IVPD) using blood speckle-tracking (BST) in children and investigated its potential role in assessing diastolic function. The results showed that BST is highly feasible and provides information on diastolic suction and early filling in children with heart disease. The IVPD was significantly reduced in children with dilated cardiomyopathies (DCMs) and hypertrophic cardiomyopathies (HCMs) compared to controls.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Thierry C. Gillebert
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Physiology
Sandra Sjostrand, Alice Widerstrom, Ingrid Svensson, Patrick Segers, Tobias Erlov, Asa Ryden Ahlgren, Magnus Cinthio
Summary: Longitudinal motion of the carotid arterial wall, as measured with ultrasound, is a promising indicator of vascular health, but its underlying mechanisms are not fully understood. Blood pressure has a strong relation to the antegrade longitudinal displacement in early systole. Tapered geometry and intramural friction between two parts of a vessel wall also influence the longitudinal displacement.
PHYSIOLOGICAL REPORTS
(2023)
Review
Cardiac & Cardiovascular Systems
Jordi Alastruey, Peter H. Charlton, Vasiliki Bikia, Birute Paliakaite, Bernhard Hametner, Rosa Maria Bruno, Marijn P. Mulder, Samuel Vennin, Senol Piskin, Ashraf W. Khir, Andrea Guala, Christopher C. Mayer, Jonathan Mynard, Alun D. Hughes, Patrick Segers, Berend E. Westerhof
Summary: Arterial pulse waves (PWs), such as blood pressure and photoplethysmogram (PPG) signals, are rich sources of information for assessing vascular age and identifying individuals at elevated cardiovascular risk. This review explores the possibilities and limitations of reduced-order biophysical models and theoretical and empirical methods for analyzing PW signals and extracting clinically relevant information. Detailed mathematical derivations are provided, demonstrating the relationships between these models and methods. Suggestions for future research are also outlined to fully utilize the potential of modeling and analyzing PW signals for accurate vascular age assessment.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Edward Horton, Bryce Johnson, Mahesh Vidula, Soumya Kondaveety, Srinivas Denduluri, Patrick Segers, Howard C. Herrmann, Julio A. Chirinos
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Biophysics
Lise Gheysen, Lauranne Maes, Nele Famaey, Patrick Segers
Summary: This study developed a computational model to simulate the thickening process of dissected aorta wall, considering the effects of stress and inflammation on elastin and collagen. The results showed that the model with transient inflammation pattern was able to reproduce the clinically observed membrane thickening rates, diameter expansion rates, and adaptations in microstructure.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Marija Smoljkic, Jos Vander Sloten, Patrick Segers, Nele Famaey
Summary: This study provides an estimation method for material parameters in the study of continuous diseases using non-invasively measured human carotid artery data. Both different material models are able to simulate the behavior of the arteries, but the structural model provides more realistic results. Gender has a greater impact on mechanical properties, and there is a stiffening trend in arteries with age, body mass index, and blood pressure, although not strong. Meanwhile, there is a high intersubject variability.
CARDIOVASCULAR ENGINEERING AND TECHNOLOGY
(2023)
Article
Engineering, Biomedical
Federico Cane, Lucas Delcour, Alberto Cesare Luigi Redaelli, Patrick Segers, Joris Degroote
Summary: Cardiovascular diseases can lead to chronic pathological conditions, and early diagnosis is crucial for treatment. Image-based patient-specific Computational Fluid Dynamics (CFD) models provide detailed information about cardiac blood flow, supporting clinicians in diagnosis and treatment planning. This study developed a Chimera-based method to build a patient-specific 3D CFD model of the heart, considering the challenges of left ventricle and mitral valve motion. The results suggest that the mitral valve plays a crucial role in intraventricular flow development.
FRONTIERS IN MEDICAL TECHNOLOGY
(2022)
Meeting Abstract
Peripheral Vascular Disease
Simon Helleputte, Bart Spronck, James Sharman, Luc Van Bortel, Patrick Segers, Patrick Calders, Bruno Lapauw, Tine de Backer
JOURNAL OF HYPERTENSION
(2022)
Meeting Abstract
Peripheral Vascular Disease
Simon Helleputte, Bart Spronck, James Sharman, Luc Van Bortel, Patrick Segers, Patrick Calders, Bruno Lapauw, Tine de Backer
JOURNAL OF HYPERTENSION
(2022)
Meeting Abstract
Peripheral Vascular Disease
Hasan Obeid, Vasiliki Bikia, Catherine Fortier, Mathilde Pare, Patrick Segers, Nikos Stergiopulos, Mohsen Agharazii
JOURNAL OF HYPERTENSION
(2022)