☆ 4.8 Article

Gargantulide A, a Complex 52-Membered Macrolactone Showing Antibacterial Activity from Streptomyces sp.

ORGANIC LETTERS (2015)

Journal

ORGANIC LETTERS

Volume 17, Issue 6, Pages 1377-1380

Publisher

AMER CHEMICAL SOC

DOI: 10.1021/acs.orglett.5b00068

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Categories

Chemistry, Organic

Funding

NIH [NS053398, CA100851]

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Abstract

Gargantulide A (1), an extremely complex 52-membered macrolactone, was isolated from Streptomyces sp. A42983 and displayed moderate activity against MRSA. The planar structure of 1 was determined using 2D NMR, and its stereochemistry was partially established on the basis of NOESY correlations, J-based configuration analysis, and Kishis universal NMR database.

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