Article
Oncology
Yibin Pan, Jiena Zhou, Weidan Zhang, Lili Yan, Meifei Lu, Yongdong Dai, Hanjing Zhou, Songying Zhang, Jianhua Yang
Summary: The study found up-regulation of SHH and accumulation of SQSTM1/P62 in epithelial ovarian cancer. Cyp induced autophagy through the PI3K/AKT signaling pathway, and low-dose Cyp and chloroquine (CQ) significantly promoted the migratory ability of SKOV3 cells. The findings suggest that inhibition of the SHH pathway and autophagy may be a potential and effective therapy for the treatment of ovarian cancer.
Article
Cell Biology
Jangham Jung, Jaehun Kim, Tae-Lin Huh, Myungchull Rhee
Summary: TRIM46 is a RING finger E3 ligase that plays a role in neuronal polarity and axon specification. The zebrafish homologue trim46a is regulated by transcription factor Foxa2 and affects the development of the midbrain and MHB. Inhibition of SHH signaling pathway by cyclopamine leads to developmental defects in midbrain and MHB through trim46a regulation.
ANIMAL CELLS AND SYSTEMS
(2021)
Article
Medicine, Research & Experimental
Pingping Yu, Li Wang, Fanren Tang, Shuang Guo, Hongyan Liao, Cengceng Fan, Qin Yang
Summary: Resveratrol pretreatment promotes neurorestoration of ischemic cerebral injury through mediation of the Sonic Hedgehog signaling pathway, enhancing proliferation of neural stem cells.
Article
Cell Biology
Jianmin Liu, Jing Yin, Ping Chen, Daoquan Liu, Weixiang He, Yan Li, Mingzhou Li, Xun Fu, Guang Zeng, Yuming Guo, Xinghuan Wang, Michael E. DiSanto, Xinhua Zhang
Summary: The study revealed that the SMO cascade is upregulated in BPH tissues, and inhibiting SMO can induce cell apoptosis, cause cell cycle arrest, and reduce tissue fibrosis markers. The GLI gene family is positively correlated with clinical parameters, suggesting that the SMO cascade may play an important role in the development of BPH.
CELL DEATH DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Jun Wu, Rong Wang, Xuechun Kan, Jinghan Zhang, Wen Sun, David Goltzman, Dengshun Miao
Summary: This study reveals that the activation of the Shh-Gli-Bmi1 signaling pathway plays a critical role in the bone anabolic action induced by p27 deficiency. Bmi1 may be an important therapeutic target for treating osteoporosis caused by the activation of p27 signaling or inactivation of sonic hedgehog signaling.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Neurosciences
Haritha Kunhiraman, Leon McSwain, Shubin W. Shahab, Timothy R. Gershon, Tobey J. MacDonald, Anna Marie Kenney
Summary: This study found that the Sonic Hedgehog (SHH) subtype of medulloblastoma (MB) has a unique tumor microenvironment compared to other subtypes. The SHH MB cells were found to produce elevated levels of IGFBP2, which is required for SHH MB cell proliferation, colony formation, and cell migration. These findings suggest that targeting the IGFBP2-STAT3 axis could be a novel therapeutic approach for SHH medulloblastoma.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Review
Cell Biology
Issei S. Shimada, Yoichi Kato
Summary: The primary cilium is a sensory compartment that protrudes from the cellular surface and has various signaling molecules that regulate stem cells.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Clinical Neurology
Nail Benallegue, Hania Kebir, Richa Kapoor, Alexis Crockett, Cen Li, Lara Cheslow, Mohamed S. Abdel-Hakeem, James Gesualdi, Miles C. Miller, E. John Wherry, Molly E. Church, M. Andres Blanco, Jorge Alvarez
Summary: The study reveals the previously unrecognized role of the endogenous hedgehog signaling pathway in regulating pathogenic inflammation within the central nervous system. By targeting CD4 T cells and modulating the production of inflammatory cytokines, the hedgehog pathway shows potential as a therapeutic strategy to limit the progression of ongoing neuroinflammation. Systemic administration of a hedgehog agonist after disease onset effectively halts disease progression and reduces neuroinflammation and associated neuropathology.
Article
Plant Sciences
Yiqing Guan, Dongling Quan, Kai Chen, Liangqi Kang, Danni Yang, Huanxian Wu, Mengqiu Yan, Shaoyu Wu, Lin Lv, Guohua Zhang
Summary: The study investigates the effect of KAE therapy on extracellular matrix deposition and stimulation of EMT in vitro and in vivo. The results show that KAE can reduce blood pressure and decrease ECM components, TGF-01, and a-SMA in the kidneys of hypertension-induced rats with chronic kidney disease. In addition, KAE administration significantly suppresses proliferation, migration, and EMT in HK-2 cells treated with TGF-01.
Article
Pharmacology & Pharmacy
Fanping Wang, Xiaoyu Huang, Yanwei Sun, Zhixin Li, Ruili Sun, Tiesuo Zhao, Mingyong Wang, Chunxia Yan, Peijun Liu
Summary: This study investigated the effects of sulforaphane (SFN), the main ingredient in broccoli, on the proliferation of leukemia stem-like cells in acute myeloid leukemia cells. The results showed that SFN inhibited the proliferation of leukemia stem-like cells and regulated the stem characteristic of leukemia cells. Furthermore, SFN was found to negatively modulate proliferation of these cells by affecting the Sonic Hedgehog pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Sangwoo Shim, Raman Goyal, Alexios A. Panoutsopoulos, Olga A. Balashova, David Lee, Laura N. Borodinsky
Summary: The balance between neural stem cell proliferation and neuronal differentiation is crucial for the development of the nervous system. We found that Sonic hedgehog (Shh) enhances Ca2+ activity at the cilia of developing Xenopus laevis embryos, which promotes neuronal differentiation and inhibits proliferative signaling. These findings provide potential targets for the treatment of brain tumors and neurodevelopmental disorders.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Cell Biology
Jia Ding, Hui-Yan Li, Li Zhang, Yuan Zhou, Jian Wu
Summary: This review focuses on the role and potential mechanisms of Hh signaling in liver cancer, highlighting its impact on HCC initiation, progression, drug resistance, and metastasis. It emphasizes that exploring the deep mechanisms of Hh signaling can guide individualized HCC management.
Review
Oncology
Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Mohammad Taheri, Majid Samsami
Summary: The Sonic Hedgehog (Shh) signaling pathway plays a crucial role in tumor formation, resistance to conventional therapies, tissue regeneration, and neurodegenerative disorders. Numerous non-coding RNAs (ncRNAs) and miRNAs have been identified to interact with the Shh pathway in both malignant and non-malignant conditions. This review summarizes the interactions between ncRNAs and Shh in various contexts.
CANCER CELL INTERNATIONAL
(2022)
Article
Surgery
Ronan J. Kelly, Amir M. Ansari, Tomoharu Miyashita, Marianna Zahurak, Frank Lay, A. Karim Ahmed, Louis J. Born, Maryam K. Pezhouh, Kevan J. Salimian, Christopher Ng, Aerielle E. Matsangos, Anne-Heloise Stricker-Krongrad, Ken-ichi Mukaisho, Guy P. Marti, Christine H. Chung, Marcia I. Canto, Michelle A. Rudek, Stephen J. Meltzer, John W. Harmon
Summary: Itraconazole significantly reduces the development of esophageal adenocarcinoma and SHH expression in a preclinical animal model of Barrett's Metaplasia. In humans, BE tissue expresses higher levels of SHH, Indian Hedgehog, and bone morphogenic protein compared to normal squamous esophageal epithelium.
Article
Neurosciences
Wen Li, Lei Chen, Jonathan T. Fleming, Emily Brignola, Kirill Zavalin, Andre Lagrange, Tonia Rex, Shane A. Heiney, Gregory J. Wojaczynski, Javier F. Medina, Chin Chiang
Summary: Cerebellar inhibitory interneurons play an important role in regulating neural circuit activity for motor and nonmotor functions. GABAergic progenitors respond to Sonic hedgehog (Shh) signaling, influencing the generation and number of cerebellar inhibitory interneurons. Mutant mice studies reveal the essential role of Shh-dependent stellate cells in regulating inhibitory synapses and motor learning.
JOURNAL OF NEUROSCIENCE
(2022)