Article
Medicine, General & Internal
Saghir Ahmad, Hazir Rahman, Muhammad Qasim, Javed Nawab, Khalid J. Alzahrani, Khalaf F. Alsharif, Fuad M. Alzahrani
Summary: The study aimed to investigate the role of polysaccharide-dependent and polysaccharide-independent pathogenic determinants in biofilm formation of Staphylococcus epidermidis. The results showed that S. epidermidis isolates frequently produced biofilm and MSCRAMMs might actively play a role in biofilm formation.
MEDICINA-LITHUANIA
(2022)
Article
Immunology
Johanna Stamm, Samira Weisselberg, Anna Both, Antonio Virgilio Failla, Gerhard Nordholt, Henning Buettner, Stefan Linder, Martin Aepfelbacher, Holger Rohde
Summary: This study explores the effect of growth media on the biofilm formation of Staphylococcus epidermidis. By utilizing an artificial synovial fluid (ASF) medium that mimics the conditions encountered during host invasion, the researchers found that ASF induces the formation of biofilm and cluster in S. epidermidis. Gene expression analysis also revealed changes in the expression of genes related to adhesion and autolysis. These findings suggest the importance of using growth media that mimic host environments for future studies on the pathogenesis of S. epidermidis prosthetic joint infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Denis Swolana, Malgorzata Kepa, Celina Kruszniewska-Rajs, Robert D. Wojtyczka
Summary: Nanosilver has an impact on biofilm formation, gene expression, and viability of Staphylococcus epidermidis. Low concentrations of nanosilver may increase biofilm production, while high concentrations do not have this effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Bingjie Wang, Qing Zhan, Yanghua Xiao, Yanlei Xu, Huilin Zhao, Lulin Rao, Xinyi Wang, Jiao Zhang, Li Shen, Ying Zhou, Yinjuan Guo, Xiaocui Wu, Jingyi Yu, Fangyou Yu
Summary: Mupirocin stimulates the biofilm formation of Staphylococcus epidermidis by accelerating autolysis and eDNA release, depending on the specific gene atlE.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Review
Orthopedics
Konstantinos Tsikopoulos, Konstantinos Sidiropoulos, Dimitrios Kitridis, Elizabeth Moulder, Milad Ahmadi, Lorenzo Drago, David Lavalette
Summary: Animal evidence suggests that using active coating with organic antibacterial compounds and degradable passive finishing to reduce bacterial adhesion is effective against stainless steel-associated infections. Additionally, systemic vitamin D supplementation and systemic antibiotic therapy have shown positive outcomes against MSSA infections, while vaccination did not provide significant benefits. Further research is needed to explore the potential of bioresorbable surface modifications for improved infection outcomes in human subjects.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Andrej Minich, Zdenko Levarski, Maria Mikulasova, Marek Straka, Adriana Liptakova, Stanislav Stuchlik
Summary: The study showed that natural phenolic compounds vanillin and syringic acid have similar biofilm and extracellular polymer substance (EPS) inhibition effects on different genotypes of methicillin-resistant S. epidermidis strains. They effectively reduce biofilm formation and EPS content, making them potential inhibitors of biofilms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Tao Li, Yan Lu, Hua Zhang, Lei Wang, Ross C. Beier, Yajie Jin, Wenjing Wang, Huanrong Li, Xiaolin Hou
Summary: Aloe-emodin demonstrates promising antimicrobial activity against Gram-positive bacteria, particularly Staphylococcus epidermidis. Its mechanism of action involves disrupting cell morphology and selective membrane permeability, affecting protein synthesis and biofilm formation.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Yixin Jin, Qichen Wang, Haomin Zhang, Na Zhao, Ziyu Yang, Hua Wang, Min Li, Qian Liu
Summary: Staphylococcus epidermidis, a human commensal, can form biofilm and cause invasive infections. Our study found that S. epidermidis isolates from different infection sites exhibited different biofilm forming capacity. Isolates from sterile body fluid showed thicker biofilm and expressed higher levels of accumulation-associated protein. The increased expression of certain proteins may contribute to the dispersal of bacteria from biofilm and subsequent spread.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemical Research Methods
Chisato Takahashi, Mari Sato, Chikara Sato
Summary: Staphylococcus epidermidis, a gram-positive bacterium, plays an important role in biofilm formation and microvesicle secretion. This study successfully imaged the microvesicles secreted by Staphylococcus epidermidis and their integration into biofilms using atmospheric scanning electron microscopy (ASEM). The information obtained is expected to help elucidate the biological mechanism of biofilm formation and develop medicines against biofilms and associated infections.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Microbiology
Shihua Lan, Xiaofeng Chen, Chuanping Yin, Shengjun Xie, Shuaishuai Wang, Rongrong Deng, Zhibin Shen
Summary: Research found that Disaspidin BB obtained from plant extracts and purifications has inhibitory effect on drug-resistant Staphylococcus epidermidis biofilms, and its mechanism of anti-biofilm activity was preliminarily investigated.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Cell Biology
Kidon Sung, Miseon Park, Jungwhan Chon, Ohgew Kweon, Saeed A. Khan, Andrew Shen, Angel Paredes
Summary: This study investigates the effect of subinhibitory concentrations of tigecycline on biofilms formed by Staphylococcus epidermidis strain RP62A. The results show that different concentrations of tigecycline can cause changes in biofilm production and significantly affect protein expression. The study suggests that analyzing the global protein expression profile of biofilm cells under antibiotic pressure can improve our understanding of the mechanisms of antibiotic resistance.
Article
Microbiology
Yongqi Mu, Hong Zeng, Wei Chen
Summary: Quercetin exhibits anti-biofilm activity against Staphylococcus epidermidis by reducing cell surface hydrophobicity and inhibiting polysaccharide intercellular adhesin production, indicating its potential as an anti-biofilm agent for biofilm infections caused by S. epidermidis and potentially other bacteria.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Ranjith Konduri, Chinthala Reddy Saiabhilash, Sisinthy Shivaji
Summary: The study revealed that Staphylococcus aureus and Staphylococcus epidermidis isolated from patients with Endophthalmitis have the potential to form biofilms, with faster formation on corneas and dispersal phase occurring within 48 hours. Biofilm formation renders the bacteria several-fold more resistant to antibiotics compared to planktonic cells.
Article
Immunology
Lisanne de Vor, Coco R. R. Beudeker, Anne Flier, Lisette M. M. Scheepmaker, Piet C. C. Aerts, Daniel C. C. Vijlbrief, Mireille N. N. Bekker, Frank J. J. Beurskens, Kok P. M. van Kessel, Carla J. C. de Haas, Suzan H. M. Rooijakkers, Michiel van der Flier
Summary: Central line associated bloodstream infections (CLABSI) caused by Staphylococcus epidermidis are a significant morbidity factor in neonates. This study explores the use of monoclonal antibodies (mAbs) to induce phagocytic killing of S. epidermidis by human neutrophils. The researchers found that complement activation is crucial for efficient phagocytosis and that Fc mutations enhancing IgG1 hexamerization improve complement activation and phagocytic killing. In addition, the mAbs greatly enhanced phagocytosis of S. epidermidis in neonatal plasma conditions, indicating their potential as prophylactic agents for neonatal CLABSI.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
P. Kasparova, E. Vankova, L. Brazdova, K. Lokocova, O. Matatkova, J. Masak
Summary: Pterostilbene (PTE) is a natural compound with antioxidant and antimicrobial properties, which can enhance the effectiveness of erythromycin and tetracycline in inhibiting the growth and biofilm formation of Staphylococcus epidermidis. PTE was found to effectively inhibit S. epidermidis, reduce metabolic activity of biofilm cells, and enhance the action of antibiotics in overcoming biofilm cell tolerance.
MICROBIAL PATHOGENESIS
(2021)
