Bacterial DNA replication enzymes as targets for antibacterial drug discovery

Exploiting bacterial DNA gyrase as a drug target: current state and perspectives

(2011) Frédéric Collin et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

New antimicrobial agents on the horizon

(2011) Karen Bush et al.   BIOCHEMICAL PHARMACOLOGY

Discovery of bacterial NAD+-dependent DNA ligase inhibitors: Optimization of antibacterial activity

(2011) Suzanne S. Stokes et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Exploring Left-Hand-Side substitutions in the benzoxazinone series of 4-amino-piperidine bacterial type IIa topoisomerase inhibitors

(2011) Bolin Geng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases

(2011) Timothy J. Miles et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel cyclohexyl-amides as potent antibacterials targeting bacterial type IIA topoisomerases

(2011) Timothy J. Miles et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus and Escherichia coli by aminocoumarin antibiotics

(2011) S. Alt et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II: Broad-Spectrum Antibacterial Agents with Reduced hERG Activity

(2011) Folkert Reck et al.   JOURNAL OF MEDICINAL CHEMISTRY

A New DNA Gyrase Inhibitor Subclass of the Cyclothialidine Family Based on a Bicyclic Dilactam−Lactone Scaffold. Synthesis and Antibacterial Properties

(2011) Peter Angehrn et al.   JOURNAL OF MEDICINAL CHEMISTRY

Challenges of antibacterial discovery revisited

(2010) Michael N. Gwynn et al.   Annals of the New York Academy of Sciences

Novel Bacterial NAD+-Dependent DNA Ligase Inhibitors with Broad-Spectrum Activity and Antibacterial EfficacyIn Vivo

(2010) Scott D. Mills et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The role of ATP in the reactions of type II DNA topoisomerases

(2010) Andrew D. Bates et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

SnapShot: The Replisome

(2010) Nina Y. Yao et al.   CELL

Structural biology in fragment-based drug design

(2010) Christopher W Murray et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Contribution of reactive oxygen species to pathways of quinolone-mediated bacterial cell death

(2010) X. Wang et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Type IIA topoisomerase inhibition by a new class of antibacterial agents

(2010) Benjamin D. Bax et al.   NATURE

How antibiotics kill bacteria: from targets to networks

(2010) Michael A. Kohanski et al.   NATURE REVIEWS MICROBIOLOGY

Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance

(2010) Alexandre Wohlkonig et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases

(2010) Ivan Laponogov et al.   PLoS One

Structure of the adenylation domain of NAD+-dependent DNA ligase fromStaphylococcus aureus

(2009) Seungil Han et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Discovery, characterization and comparison of inhibitors of Bacillus anthracis and Staphylococcus aureus replicative DNA helicases

(2009) Daniel Aiello et al.   BIOORGANIC & MEDICINAL CHEMISTRY

DNA Ligases: Progress and Prospects

(2009) Stewart Shuman   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural insight into the quinolone–DNA cleavage complex of type IIA topoisomerases

(2009) Ivan Laponogov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Biological Activities of Novel Gyrase Inhibitors of the Aminocoumarin Class

(2008) C. Anderle et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discovery and Characterization of QPT-1, the Progenitor of a New Class of Bacterial Topoisomerase Inhibitors

(2008) A. A. Miller et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mechanism of Action of the Antibiotic NXL101, a Novel Nonfluoroquinolone Inhibitor of Bacterial Type II Topoisomerases

(2008) M. T. Black et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis and antibacterial activity of the C-7 side chain of 3-aminoquinazolinediones

(2008) Kim M. Hutchings et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New DNA Polymerase IIIC Inhibitors: 3-Subtituted Anilinouracils with Potent Antibacterial Activity in vitro and in vivo

(2008) Niels Svenstrup et al.   ChemMedChem

Recent advances in bacterial topoisomerase inhibitors

(2008) B BRADBURY et al.   CURRENT OPINION IN PHARMACOLOGY

DNA and RNA ligases: structural variations and shared mechanisms

(2008) John M Pascal   CURRENT OPINION IN STRUCTURAL BIOLOGY

Identification and characterization of an inhibitor specific to bacterial NAD+-dependent DNA ligases

(2008) Timothy I. Meier et al.   FEBS Journal

Novel Dual-Targeting Benzimidazole Urea Inhibitors of DNA Gyrase and Topoisomerase IV Possessing Potent Antibacterial Activity: Intelligent Design and Evolution through the Judicious Use of Structure-Guided Design and Stucture−Activity Relationships

(2008) Paul S. Charifson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Insights into the Replisome from the Structure of a Ternary Complex of the DNA Polymerase III α-Subunit

(2008) Richard A. Wing et al.   JOURNAL OF MOLECULAR BIOLOGY

Staphylococcus aureusprimase has higher initiation specificity, interacts with single-stranded DNA stronger, but is less stimulated by its helicase thanEscherichia coliprimase

(2008) Scott A. Koepsell et al.   MOLECULAR MICROBIOLOGY

Understanding how the replisome works

(2008) Kenneth J Marians   NATURE STRUCTURAL & MOLECULAR BIOLOGY