☆ 4.5 Letter

Stability of human metapneumovirus and human coronavirus NL63 on medical instruments and in the patient environment

JOURNAL OF HOSPITAL INFECTION (2008)

Journal

JOURNAL OF HOSPITAL INFECTION

Volume 69, Issue 4, Pages 406-408

Publisher

W B SAUNDERS CO LTD

DOI: 10.1016/j.jhin.2008.04.017

Keywords

-

Categories

Public, Environmental & Occupational Health Infectious Diseases

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Article Virology

Molecular mechanisms of human coronavirus NL63 infection and replication

Gino Castillo, Juan Carlos Mora-Diaz, Mary Breuer, Pallavi Singh, Rahul K. Nelli, Luis G. Gimenez-Lirola

Summary: Human coronavirus NL63 (HCoV-NL63) is a globally spread virus that mainly causes upper and lower respiratory tract infections in young children. It shares a host receptor (ACE2) with severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2, but is less severe and can be studied in lower biosafety level laboratories. HCoV-NL63 can be used as a safer surrogate for comparative studies on receptor dynamics, infectivity, virus replication, and potential therapeutic interventions against SARS-like CoVs.

VIRUS RESEARCH (2023)

Add to Collection

Article Multidisciplinary Sciences

Infection of primary nasal epithelial cells differentiates among lethal and seasonal human coronaviruses

Clayton J. Otter, Alejandra Fausto, Li Hui Tan, Alisha S. Khosla, Noam A. Cohen, Susan R. Weiss

Summary: This study compares the replication and cytotoxicity of several coronaviruses in human nasal epithelial cells. The results show that different viruses have different replication abilities and cytotoxic effects, and the status of nasal epithelial cells (such as asthma inflammation) also affects the availability of viral receptors and replication.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2023)

Add to Collection

Article Immunology

Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infection

Alexander C. Dowell, Megan S. Butler, Elizabeth Jinks, Gokhan Tut, Tara Lancaster, Panagiota Sylla, Jusnara Begum, Rachel Bruton, Hayden Pearce, Kriti Verma, Nicola Logan, Grace Tyson, Eliska Spalkova, Sandra Margielewska-Davies, Graham S. Taylor, Eleni Syrimi, Frances Baawuah, Joanne Beckmann, Ifeanyichukwu Okike, Shazaad Ahmad, Joanna Garstang, Andrew J. Brent, Bernadette Brent, Georgina Ireland, Felicity Aiano, Zahin Amin-Chowdhury, Samuel Jones, Ray Borrow, Ezra Linley, John Wright, Rafaq Azad, Dagmar Waiblinger, Chris Davis, Emma Thomson, Massimo Palmarini, Brian J. Willett, Wendy S. Barclay, John Poh, Gayatri Amirthalingam, Kevin E. Brown, Mary E. Ramsay, Jianmin Zuo, Paul Moss, Shamez Ladhani

Summary: Children exhibit stronger and more sustained immune responses to SARS-CoV-2 infection, with higher levels of antibodies and T cell responses compared to adults, and the ability to neutralize various viral variants. These findings suggest that children may have a more robust immune system against the virus, potentially providing insight into the milder clinical presentation of SARS-CoV-2 in most children.

NATURE IMMUNOLOGY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Antiviral Activities of Halogenated Emodin Derivatives against Human Coronavirus NL63

Monika Horvat, Martina Avbelj, Maria Beatriz Duran-Alonso, Mihailo Banjanac, Hrvoje Petkovic, Jernej Iskra

Summary: The study explores the impact of emodin derivatives on the activity against human coronavirus NL63, finding that halogenation of emodin can enhance its antiviral activity. The most active compound identified is the iodinated emodin analogue E_3I, which shows comparable activity to remdesivir but also exhibits some unwanted toxicity to Vero cells. Further research to modify the emodin structure may lead to analogues with improved anti-HCoV-NL63 activity and reduced toxicity.

MOLECULES (2021)

Add to Collection

Article Biology

Determinants of species-specific utilization of ACE2 by human and animal coronaviruses

Qingxing Wang, Sabrina Noettger, Qinya Xie, Chiara Pastorio, Alina Seidel, Janis A. Mueller, Christoph Jung, Timo Jacob, Konstantin M. J. Sparrer, Fabian Zech, Frank Kirchhoff

Summary: By analyzing the ability of Spike proteins from 26 human or animal coronaviruses to use ACE2 receptors, this study identifies determinants of ACE2 receptor usage for diverse coronaviruses and suggests that COVID-19 vaccination may protect against future zoonotic diseases caused by bat coronaviruses.

COMMUNICATIONS BIOLOGY (2023)

Add to Collection

Article Pharmacology & Pharmacy

Enteric Coronavirus Infection and Treatment Modeled With an Immunocompetent Human Intestine-On-A-Chip

Amir Bein, Seongmin Kim, Girija Goyal, Wuji Cao, Cicely Fadel, Arash Naziripour, Sanjay Sharma, Ben Swenor, Nina LoGrande, Atiq Nurani, Vincent N. Miao, Andrew W. Navia, Carly G. K. Ziegler, Jose Ordovas Montanes, Pranav Prabhala, Min Sun Kim, Rachelle Prantil-Baun, Melissa Rodas, Amanda Jiang, Lucy O'Sullivan, Gladness Tillya, Alex K. Shalek, Donald E. Ingber

Summary: The study using a human intestine-on-a-chip model demonstrated the inflammatory effects of NL63 coronavirus infection on intestinal epithelial and endothelial cells, and identified a potential antiviral drug.

FRONTIERS IN PHARMACOLOGY (2021)

Add to Collection

Article Infectious Diseases

A patient with human coronavirus NL63 falsely diagnosed with COVID-19; Lesson learned for the importance of definitive diagnosis

Yuki Otsuka, Hideharu Hagiya, Yasuhiro Nakano, Daisuke Omura, Kou Hasegawa, Haruto Yamada, Koji Iio, Tomoyuki Honda, Fumio Otsuka

Summary: The gold standard for COVID-19 diagnosis is nucleic acid detection, which may occasionally result in false positives or false negatives. Physicians should be aware of the potential issues caused by false positives and ensure accurate diagnosis to avoid unnecessary isolation.

JOURNAL OF INFECTION AND CHEMOTHERAPY (2021)

Add to Collection

Review Cell Biology

The Molecular Interplay between Human Coronaviruses and Autophagy

Ankit Shroff, Taras Y. Nazarko

Summary: This article discusses the interaction between human coronaviruses and autophagy, including recent SARS-CoV-2-related studies, focusing on understanding the molecular mechanisms for the development of effective therapies against coronaviral diseases.

CELLS (2021)

Add to Collection

Review Cardiac & Cardiovascular Systems

Kawasaki Disease Shock Syndrome vs Classical Kawasaki Disease: A Meta-analysis and Comparison With SARS-CoV-2 Multisystem Inflammatory Syndrome

Loubna Lamrani, Cedric Manlhiot, Matthew D. Elias, Nadine F. Choueiter, Audrey Dionne, Ashraf S. Harahsheh, Michael A. Portman, Brian W. McCrindle, Nagib Dahdah

Summary: This study found that compared to standard Kawasaki disease (KD), patients with Kawasaki disease shock syndrome (KDSS) tend to be older, have higher levels of C-reactive protein, lower levels of albumin and platelets, higher odds of intravenous immunoglobulin resistance, longer hospital stay, and higher odds of coronary artery abnormalities.

CANADIAN JOURNAL OF CARDIOLOGY (2021)

Add to Collection

Article Infectious Diseases

Clinical impact of human metapneumovirus infections before and during the COVID-19 pandemic

Mandy Jongbloed, Wouter T. Leijte, Catharina F. M. Linssen, Bernadette G. van den Hoogen, Eric C. M. van Gorp, Martijn D. de Kruif

Summary: The study found that during the COVID-19 pandemic, the incidence of HMPV infections remained stable, with similar clinical characteristics and outcomes in patients compared to the non-COVID-19 period, except for shorter hospital stays. HMPV infection and COVID-19 shared many clinical features, but HMPV was more common in females, elderly patients, and those with chronic conditions such as COPD and chronic heart failure.

INFECTIOUS DISEASES (2021)

Add to Collection

Article Public, Environmental & Occupational Health

Can a humid storage environment of surgical instruments before reprocessing increase patient safety and durability of instruments?

P. Rubak, J. Lorenzen, K. Ripadal, A-E Christensen, D. Aaen, H. L. Nielsen, K. Bundgaard

Summary: This study evaluated the association between storage environment, holding time, and number of treatment cycles with residual protein and corrosion on surgical instruments. The results showed no association between storage environment or holding time and protein residue or corrosion. However, a higher number of treatment cycles resulted in increased corrosion and decreased protein residue.

JOURNAL OF HOSPITAL INFECTION (2022)

Add to Collection

Article Microbiology

Atypical Antibody Dynamics During Human Coronavirus HKU1 Infections

Ferdyansyah Sechan, Marloes Grobben, Arthur W. D. Edridge, Maarten F. Jebbink, Katherine Loens, Margareta Ieven, Herman Goossens, Susan van Hemert-Glaubitz, Marit J. van Gils, Lia van der Hoek

Summary: This study investigated the antibody dynamics during PCR-confirmed HCoV-HKU1 infections and found that HCoV-HKU1-infected individuals displayed atypical antibody dynamics and milder symptoms compared to other endemic HCoVs.

FRONTIERS IN MICROBIOLOGY (2022)

Add to Collection

Article Medicine, General & Internal

Relative Ratios of Human Seasonal Coronavirus Antibodies Predict the Efficiency of Cross-Neutralization of SARS-CoV-2 Spike Binding to ACE2

Yannick Galipeau, Vinayakumar Siragam, Genevieve Laroche, Erika Marion, Matthew Greig, Michaeline McGuinty, Ronald A. Booth, Yves Durocher, Miroslava Cuperlovic-Culf, Steffany A. L. Bennett, Angela M. Crawley, Patrick M. Giguere, Curtis Cooper, Marc-Andre Langlois

Summary: Antibodies raised against human seasonal coronaviruses have cross-reactivity with SARS-CoV-2 antigens, potentially impacting the severity of COVID-19. While the abundance of sCoV antibodies does not directly correlate with neutralization, neutralizing activity is closely linked to the relative ratios of specific antibody types in serum.

EBIOMEDICINE (2021)

Add to Collection

Article Biology

Cytopathic Effect Assay and Plaque Assay to Evaluate in vitro Activity of Antiviral Compounds Against Human Coronaviruses 229E, OC43, and NL63

Yanmei Hu, Chunlong Ma, Jun Wang

Summary: This study provides detailed protocols for the cytopathic effect (CPE) assay and the plaque assay for human coronaviruses, which can be used to identify novel antivirals and evaluate the antiviral activity of existing drug candidates.

BIO-PROTOCOL (2022)

Add to Collection

Article Environmental Sciences

Human Coronavirus NL63 Among Other Respiratory Viruses in Clinical Specimens of Egyptian Children and Raw Sewage Samples

Waled Morsy El-Senousy, Mohamed Shouman

Summary: The study in Egypt from 2005-2006 found no presence of HCoV-NL63 in clinical specimens of children and raw sewage samples, while other respiratory viruses like parainfluenza virus, respiratory syncytial virus, and non-enteric adenoviruses were detected in some clinical specimens. Enteric adenoviruses showed a higher prevalence in raw sewage samples, possibly due to direct transmission.

FOOD AND ENVIRONMENTAL VIROLOGY (2021)

Add to Collection

Article Medicine, General & Internal

Differential cytology profiles in bronchoalveolar lavage (BAL) in COVID-19 patients A descriptive observation and comparison with other corona viruses, Influenza virus, Haemophilus influenzae, and Pneumocystis jirovecii

Vanessa Vedder, Verena Schildgen, Jessica Lusebrink, Ramona Liza Tillmann, Birgitta Domscheit, Wolfram Windisch, Christian Karagiannidis, Michael Brockmann, Oliver Schildgen

Summary: The study compared the cytological profiles of BALs from patients infected with various respiratory pathogens, finding that different pathogens caused distinct cell pattern changes but no general cell distribution pattern. Although the cytology pattern of BAL fluid is not specific enough to be used as the sole diagnostic criterion for COVID-19, it may support clinical decision-making.

MEDICINE (2021)

Add to Collection

Article Microbiology

Limits and Opportunities of SARS-CoV-2 Antigen Rapid Tests: An Experienced-Based Perspective

Verena Schildgen, Sabrina Demuth, Jessica Luesebrink, Oliver Schildgen

Summary: This study analyzed the performance of three different rapid antigen tests in a clinical setting, showing varying specificities and sensitivities which did not entirely meet all expectations. Therefore, careful evaluation is needed when considering their benefits for specific testing strategies and settings.

PATHOGENS (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Biosynthesis and Mechanism of Action of the Cell Wall Targeting Antibiotic Hypeptin

Daniel A. Wirtz, Kevin C. Ludwig, Melina Arts, Carina E. Marx, Sebastian Krannich, Paul Barac, Stefan Kehraus, Michaele Josten, Beate Henrichfreise, Anna Mueller, Gabriele M. Koenig, Aaron J. Peoples, Anthony Nitti, Amy L. Spoering, Losee L. Ling, Kim Lewis, Max Cruesemann, Tanja Schneider

Summary: Hypeptin is a cyclodepsipeptide antibiotic that blocks bacterial cell wall biosynthesis by binding to multiple biosynthesis intermediates, forming a 2:1 complex. It exhibits potent activity against gram-positive pathogens and resistance to it does not readily develop. Detailed analysis of the hypeptin biosynthetic gene cluster supports a model for the synthesis of the octapeptide.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Add to Collection

Correction Oncology

Human Bocavirus Infection of Permanent Cells Differentiated to Air-Liquid Interface Cultures Activates Transcription of Pathways Involved in Tumorigenesis (vol 10, 410, 2018)

Verena Schildgen, Monika Pieper, Soumaya Khalfaoui, Wolfgang H. Arnold, Oliver Schildgen

CANCERS (2021)

Add to Collection

Letter Anesthesiology

Perioperative risk evaluation in patients scheduled for elective surgery in close relation to their SARS-CoV-2 vaccination

Ulrich Limper, Jerome Defosse, Oliver Schildgen, Frank Wappler

BRITISH JOURNAL OF ANAESTHESIA (2021)

Add to Collection

Article Pathology

Comparison of Biocartis IDYLLATM cartridge assay with Qiagen GeneReader NGS for detection of targetable mutations in EGFR, KRAS/ NRAS, and BRAF genes

Tiffany Haiduk, Michael Brockmann, Ramona-Liza Tillmann, Monika Pieper, Jessica Lusebrink, Verena Schildgen, Oliver Schildgen

Summary: Lung and colorectal cancers have high mortality rates and were not affected by the COVID19 pandemic in terms of personalized diagnostics and therapy. Due to disruption of delivery chains, alternative testing methods, such as the Biocartis IdyllaTM platform, were implemented, showing acceptable sensitivity and specificity for therapy decision making.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2021)

Add to Collection

Editorial Material Pathology

SARS-CoV-2 and the community: time for sophisticated testing strategies beyond current approaches

Oliver Schildgen

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2021)

Add to Collection

Letter Infectious Diseases

False positive rapid antigen tests for SARS-CoV-2 in the real-world and their economic burden

Andreas Kretschmer, Annelene Kossow, Barbara Gruene, Oliver Schildgen, Tim Mathes, Verena Schildgen

JOURNAL OF INFECTION (2022)

Add to Collection

Expression of Concern Virology

SARS-CoV-2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro (vol 13, 2056, 2021) (Expression of Concern of Vol 13, art no 2056, 2021)

Eric O. Freed, Oliver Schildgen

VIRUSES-BASEL (2022)

Add to Collection

Letter Infectious Diseases

Compulsary SARS-CoV-2 (booster-) vaccination in healthcare facilities can not replace personal protection measures while dealing with vulnerable individuals

Verena Schildgen, Jessica Luesebrink, Oliver Schildgen

JOURNAL OF INFECTION (2022)

Add to Collection

Letter Infectious Diseases

Recommendation for broad use of Covid-19 mRNA vaccine boosters due to waning vaccine effectiveness is taking the easy way out

Verena Schildgen, Jessica Luesebrink, Oliver Schildgen

JOURNAL OF INFECTION (2023)

Add to Collection

Letter Infectious Diseases

The Takara SARS-CoV-2 direct PCR detection kit delivers reliable results with throat wash specimens

M. Nitsch, T. Stahlhut, O. Schildgen, V. Schildgen

NEW MICROBES AND NEW INFECTIONS (2022)

Add to Collection

Article Multidisciplinary Sciences

Dual targeting of the class V lanthipeptide antibiotic cacaoidin

Julia P. Deisinger, Melina Arts, Ioli Kotsogianni, Jan-Samuel Puls, Fabian Grein, Francisco Javier Ortiz-Lopez, Nathaniel I. Martin, Anna Mueller, Olga Genilloud, Tanja Schneider

Summary: Antibiotic resistance is a major concern, and new antibiotics with novel chemistry and mechanisms of action are needed. The recently discovered antibiotic cacaoidin is the first class V lanthipeptide, combining unique structural features and D-amino acid content. It shows antimicrobial activity against gram-positive pathogens and interferes with peptidoglycan biosynthesis. Further studies have demonstrated that cacaoidin exhibits a dual mode of action by binding to lipid IIPGN and inhibiting cell wall transglycosylases.

ISCIENCE (2023)

Add to Collection

Letter Infectious Diseases

Symptomatic SARS-CoV-2 breakthrough with delta variant after 3rd mRNA vaccine shot (booster)

Verena Schildgen, Jessica Luesebrink, Oliver Schildgen

NEW MICROBES AND NEW INFECTIONS (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Evidence for Association of Human Bocavirus Persistence with Morbus Crohn and Ulcerative Colitis

F. Boehm, O. Schildgen, M. Brockmann, V. Schildgen

Summary: This study found a significantly higher prevalence of HBoV in adult patients with Crohn and Ulcerative colitis, suggesting that HBoV may be a trigger of acute exacerbations of these diseases or one cause of the diseases.

MOLECULAR GENETICS MICROBIOLOGY AND VIROLOGY (2021)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.