Article
Engineering, Environmental
Hiluf T. Fissaha, Wook-Jin Chung, Gebremedhn T. Gebremichael, Anand Rajkamal, Hern Kim, Khino J. Parohinog, Grace M. Nisola
Summary: Alternative mining methods are important for sustainable and eco-friendly gold production. A multi-functional Au3+ adsorbent P(NIPAM-co-15TCE4)@SiO2 was successfully prepared with thermo-responsive properties, showing the ability to adsorb and release Au3+ at high temperatures and high selectivity for Au3+ recovery in a complex waste stream.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Yuki Sugiyama, Seikou Nakamura, Yuichi Tokuda, Masakazu Nakano, Yasunao Hattori, Hiroki Nishiguchi, Yuki Toda, Shigekuni Hosogi, Masayuki Yamashita, Kei Tashiro, Eishi Ashihara
Summary: Advances in pharmacy and medicine have led to the development of many anti-cancer and molecular targeted agents, but the development of agents capable of suppressing metastasis is still limited. A compound called 7,8-dihydroxy-3-(4'-hydroxyphenyl) coumarin (DHC) was found to inhibit invasion and migration of osteosarcoma cells by downregulating Rho small GTP-binding proteins. DHC treatment also showed potential in suppressing metastasis and prolonging overall survival in a spontaneous metastasis mouse model.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Ke Luan, Qiao-Fen Lin, Fang-Fang Xie, Yu Wang, Yun-Fei Li, Lu Wang, Su-Yuan Xie, Lan-Sun Zheng, Lin-Long Deng
Summary: A molecular tweezer DP-18C6 incorporating perylene subunits and a crown ether moiety can efficiently recognize and grasp fullerene molecules to form host-guest complexes, showing potential application for fullerene separation.
Article
Chemistry, Multidisciplinary
Nopawit Khamto, Lada Chaichuang, Puracheth Rithchumpon, Worrapong Phupong, Phuangthip Bhoopong, Suriya Tateing, Wilart Pompimon, Natthawat Semakul, Ni-orn Chomsri, Puttinan Meepowpan
Summary: This study synthesized thirty-three DMC derivatives and evaluated their cytotoxicity against six carcinoma cell lines in vitro, with most derivatives showing higher cytotoxicity than DMC. Derivatives with 4'-O-caproylation and 4'-O-methylation displayed the strongest cytotoxicity against specific cell lines. Structure-activity relationship analysis highlighted the importance of 2'-OH and the derivatization pattern of 4'-OH. Additionally, molecular docking simulation studies provided insights into the interactions of these bioactive compounds with cyclin-dependent kinase 2 (CDK2).
Article
Engineering, Chemical
Dong Yao, Tao Ge, Liang Xu, Gaojie Chen, Chao Yao, Cheng Yang, Yongpan Tian, Zhuo Zhao
Summary: In this study, KI was used to weaken the hydration of indium, hindering its recovery through solvent extraction. Crown ethers (CEs) of different sizes were synthesized and the effects of KI concentration, CE size, and CE/In mole ratio on the solvent extraction process of indium were investigated. The interactions between indium, water molecules, and CEs were analyzed through DFT calculations, and the complexation mechanism between CE and indium in the presence of KI was further clarified. B18C6 showed excellent extraction kinetics and selectivity, indicating its potential for efficient indium recovery in complex systems.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Anastasios Stergiou, Christina Stangel, Ruben Canton-Vitoria, Ryo Kitaura, Nikos Tagmatarchis
Summary: This study describes the functionalization of chemically exfoliated molybdenum disulfide nanosheets with a benzo-15-crown-5 ether for the fabrication of an ion-responsive electrode. Various characterization techniques revealed the structural characteristics and performance of the material, demonstrating the crucial role of basal plane functionalization in stabilizing the 1T phase.
Article
Chemistry, Physical
Dilawar Singh Sisodiya, Sk. Musharaf Ali, Anjan Chattopadhyay
Summary: Computational studies were conducted on the trans & RARR; cis and cis & RARR; trans isomerizations of photoresponsive azobis(benzo-15-crown-5). The photoexcited & pi; & pi;* state(S-2) of the trans isomer relaxes through the planar S-2 minimum and the planar S-2/S-1 conical intersection, both situated below the vertically excited S-2 state. The n & pi;* state (S-1) of this isomer has both planar and rotated minima, which may lead to a torsional conical intersection (S-0/S-1) geometry.
JOURNAL OF PHYSICAL CHEMISTRY A
(2023)
Article
Chemistry, Physical
Zuleyha Almaz, Aykut Oztekin, Ayse Tan, Hasan Ozdemir
Summary: Inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes has become a promising approach in treating dementia and alleviating symptoms of Alzheimer's disease. Investigation into the inhibitory effects of mono or di-substituted 4-aminobenzohydrazide derivatives against AChE and BChE showed compound 3a to have potent inhibition. Docking analysis revealed compound 3a had the best binding affinity against both enzymes.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Endocrinology & Metabolism
Priscilla Karla Fernandes Lopes, Daiane Fatima Engel, Natalia Oliveira Bertolini, Moises Silvestre de Azevedo Martins, Chrystian Araujo Pereira, Licio Augusto Velloso, Sergio Scherrer Thomasi, Rodrigo Ferreira de Moura
Summary: Physical activity can reduce anxiety symptoms, while DHMC may help lower fasting blood glucose levels. The study did not find differences in hypothalamic or hippocampal adult neurogenesis, but DHMC increased VEGF gene expression levels, showing potential in addressing neuropsychiatric disorders associated with metabolic conditions.
METABOLIC BRAIN DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Rasha Z. Batran, Ahmed Sabt, Mohammed A. Khedr, Abdou K. Allayeh, Christophe Pannecouque, Asmaa F. Kassem
Summary: A series of 4-phenylcoumarin derivatives were synthesized and evaluated for their antiviral activities against HIV-1 and HIV-2, as well as their inhibitory effects on HIV-1 reverse transcriptase. Compound 8b and derivative 4c showed the best inhibition activity against wild-type HIV-1, with compound 8b exhibiting comparable effect to the reference NNRTI Efavirenz. Structure-activity relationship study revealed the importance of 6-chloro and 4-phenyl substituents, as well as the 5-atoms linker at position 7 of the coumarin scaffold.
BIOORGANIC CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Gokhan Sadi, Hacer Bora, Mustafa Cicek, Kenan Koran, Ahmet Orhan Gorgulu, Ibrahim Yilmaz
Summary: This study investigated the antioxidant, antibacterial, cytotoxic, and antioxidant enzyme inhibitory properties of 7,8-dihydroxy-3-(4-methylphenyl) coumarin. It exhibited high free radical scavenging activity, total antioxidant capacity, and reducing power. The compound also demonstrated antibacterial effects and cytotoxic activity on breast cancer cells, while being non-toxic to liver cancer cells. Furthermore, it inhibited catalase enzyme and glutathione-S-transferase activities. These findings suggest the compound's potential in preventing oncogenesis and tumor progression in the liver and breast cancer.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2022)
Article
Chemistry, Physical
Ting Xiang, Ting Li, Miaosheng Wang, Wei Zhang, Mahshid Ahmadi, Xiaoyan Wu, Tianfei Xu, Meiqin Xiao, Long Xu, Ping Chen
Summary: In this study, the introduction of 1, 4, 7, 10-tetraoxacyclododecane ether successfully reduced the difficulty in controlling crystal growth in quasi-2D perovskite LEDs. Crown-ether assisted in-situ grown perovskite crystals with thick PbBr4 layers were obtained, resulting in a flat energy structure and improved stability. The new perovskite crystals showed enhanced carrier mobility, diffusion length, and photoluminescence quantum yield.
Article
Biochemistry & Molecular Biology
Xinnan Li, Yilin Jia, Junda Li, Pengfei Zhang, Tiantian Li, Li Lu, Hequan Yao, Jie Liu, Zheying Zhu, Jinyi Xu
Summary: Alzheimer's disease is a neurodegenerative disease that requires the development of novel anti-AD drugs. This study designed and synthesized a series of novel isochroman-4-one derivatives and evaluated their potential in treating AD. Compound 10a exhibited potent anti-acetylcholinesterase activity and antioxident activity, making it a promising candidate for the prevention and treatment of AD.
Article
Biochemistry & Molecular Biology
Yi-Fong Chen, Bashir Lawal, Li-Jiau Huang, Sheng-Chu Kuo, Maryam Rachmawati Sumitra, Ntlotlang Mokgautsi, Hung-Yun Lin, Hsu-Shan Huang
Summary: Our previous study found that 2-phenyl-4-quinolones (2-PQ) are antimitotic agents, and we designed 4-phenyl-2-quinolones (4-PQs) as a new class of anticancer drugs with simplified structures. We synthesized a series of 4-PQ derivatives and identified compound 22 as an excellent antiproliferative agent. Molecular docking studies revealed possible anticancer mechanisms. Pharmacokinetics indicated good drug-likeness, bioavailability, and minimal side effects, but also risks of drug-drug interactions and mutagenicity. Further studies are warranted to improve the PK properties and reduce side effects of these promising anticancer compounds.
Review
Chemistry, Inorganic & Nuclear
Guddekoppa S. Ananthnag
Summary: Crown ethers are cyclic polyethers that can bind to specific size and charge cations based on their ring size, donor atoms, and geometry. The introduction of other donor atoms can enhance their host-guest chemistry. Phosphorus donors can be added to the crown ethers to create hybrid ligands that selectively bind to different types of cations and transition metal centers. This review focuses on the synthesis and catalytic aspects of crown ethers, aza-crown ethers, and thia-crown ethers appended with phosphorus donors on the periphery.
COMMENTS ON INORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Ilhami Gulcin, Zeynebe Bingol, Parham Taslimi, Ahmet C. Goren, Saleh H. Alwasel, Ahmet Zafer Tel
Summary: This study is the first to evaluate the antioxidant and antidiabetic potentials of mountain mint. The extracts from mountain mint showed strong antioxidant effects and effective inhibition on various metabolic enzymes.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Entomology
Ayse Nalbantsoy, Nazli Boke Sarikahya, Cenk Serhan Ozverel, Ayse Bercin Barlas, Damla Kirci, Ismail Hakki Akgun, Tansel Yalcin, Gamze Duven, Duygu Kisla, Betul Demirci, Gulacti Topcu, Ahmet C. Goren
Summary: This study investigated propolis samples from seven different regions of Cyprus for their chemical content and biological activities. The composition of secondary metabolites was found to be diverse, with some samples exhibiting strong cytotoxic, anti-inflammatory, antioxidant, and antimicrobial properties.
JOURNAL OF APICULTURAL RESEARCH
(2022)
Editorial Material
Plant Sciences
Ahmet C. Goren
RECORDS OF NATURAL PRODUCTS
(2023)
Article
Chemistry, Applied
Kevser Taban Akca, Perihan Gurbuz, Sengul Dilem Dogan, Esra Emerce, Ahmet C. Goren, Ridvan Polat, Ipek Suntar
Summary: Two new sesquiterpene glucosides were isolated from Lecokia cretica, with their structures confirmed through NMR and HRMS analyses. However, these compounds exhibited no cytotoxic activity against human lung cancer cells and normal lung cells in vitro.
NATURAL PRODUCT RESEARCH
(2022)
Article
Plant Sciences
Mayssa Ben Mustapha, Houda Lazrag, Eya Khemis, Muammer Kaplan, Ahmet Ceyhan Goren, Abdel Halim Harrath, Hichem Ben Jannet
Summary: The phenolic profile of ethyl acetate and methanol extracts from the trunk bark of Pinus pinea growing in Tunisia was determined. The extracts exhibited anti-alpha-amylase potential and inhibition on alpha-amylase enzyme. Molecular docking analysis supported the activity of the extracts and suggested their potential use as alpha-amylase inhibitors for treating postprandial hyperglycemia in diabetic patients.
Article
Chemistry, Multidisciplinary
Steven Westwood, Katrice Lippa, Yoshitaka Shimuzu, Beatrice Lalerle, Takeshi Saito, David Duewer, Xinhua Dai, Stephen Davies, Marina Ricci, Annarita Baldan, Brian Lang, Stefan Sarge, Haifeng Wang, Ken Pratt, Ralf Josephs, Mikael Mariassy, Dietmar Pfeifer, John Warren, Wolfram Bremser, Stephen Ellison, Blaza Toman, Michael Nelson, Ting Huang, Ales Fajgelj, Ahmet Goren, Lindsey Mackay, Robert Wielgosz
Summary: This article discusses the definition of purity of an organic compound and the principal methods used to determine organic purity, including mass balance, quantitative NMR, thermal methods, and direct-assay techniques. The article also covers how to assign and report purity values and how to handle the associated uncertainty.
PURE AND APPLIED CHEMISTRY
(2023)
Article
Plant Sciences
Hatice Kiziltas, Zeynebe Bingol, Ahmet C. Goren, Saleh H. Alwasel, Ilhami Gulcin
Summary: Studies have shown that there is an inverse correlation between age-related diseases like coronary heart disease and cancer, and the consumption of fruits and vegetables. Due to the potential health benefits from natural antioxidants found in plants, research on them has increased. This particular study focuses on investigating the antioxidant properties of Verbascum speciosum Schrad., which is a plant grown in various regions of Turkey and used in traditional medicine.
RECORDS OF NATURAL PRODUCTS
(2023)
Article
Plant Sciences
Hatice Kiziltas, Zeynebe Bingol, Ahmet Ceyhan Goren, Sueuroleyman Mesut Pinare, Ahmet Bugra Ortaakarsu, Saleh H. Alwasel, Lhami Gulcin
Summary: The Acantholimon taxon, which includes thorny, perennial, and subshrub flowering plants, has been traditionally used for the treatment of liver disease and diabetes. This study investigated the radical scavenging activities and enzyme inhibitory effects of ethanol and water extracts of Acantholimon caryophyllaceum, as well as their phenolic compound composition. The extracts exhibited antioxidant activities comparable to the standards and showed potential as inhibitors of acetylcholinesterase, α-amylase, and α-glycosidase enzymes. The main phenolic compound identified was (-)-epigallocatechin.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Biology
Muzaffer Mutlu, Zeynebe Bingol, Eda Mehtap Uc, Ekrem Koksal, Ahmet C. Goren, Saleh H. Alwasel, Ilhami Gulcin
Summary: This study evaluated the antioxidant and antidiabetic properties of cinnamon leaf essential oil and determined its inhibitory effects on enzymes associated with metabolic diseases. Phenolic contents and essential oil profiles were analyzed. Cinnamon oil showed strong radical scavenging abilities and effectively inhibited carbonic anhydrase II, acetylcholinesterase, and alpha-amylase. This multidisciplinary study is valuable for further research on antioxidant properties and enzyme inhibition profiles of important plants and their oils.
Article
Chemistry, Analytical
Sema Carikci, Turgut Kilic, Tuncay Dirmenci, Ahmet C. Goren
Summary: This study investigated the quantities of phenolic compounds in extracts of Origanum species collected from Turkey, including chloroform, acetone, and methanol extracts. The most abundant compounds were found to be (E)-ferulic acid and caffeic acid, with O. syriacum identified as the richest species in terms of phenolic acids. Curcumin was used as an internal standard.
JOURNAL OF CHEMICAL METROLOGY
(2023)
Article
Chemistry, Analytical
Metin Demirel, Ayse Zehra Gul, Fatmanur Koktasoglu, Halime Agac, Ahmet C. Goren, Cumali Karatoprak, Sahabettin Selek
Summary: Iron deficiency anemia (IDA) is a global health issue caused by iron deficiency. This study used NMR spectroscopy to analyze the metabolite profiles of IDA patients and healthy participants, and identified significant differences in the levels of certain metabolites. These findings provide valuable insights into the metabolic pathways associated with IDA.
JOURNAL OF CHEMICAL METROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Abdurrahim Kocyigit, Eray Metin Guler, Ezgi Durmus, Vildan Betul Yenigun, Ebru Kanimdan, Zeynep Ozman, Oznur Yasar, Ahmet Ceyhan Goren, Emine Rumeysa Hekimoglu, Hasan Huseyin Oruc, Gokhan Aydogdu
Summary: The study investigated the combined treatment of Anatolian propolis extract (PE) and 5-fluorouracil (5-FU) on colorectal cancer (CRC) through in vitro and in vivo studies. The results showed that the combination therapy had selective anti-cancer effects and enhanced the effectiveness of 5-FU against CRC. PE was found to reduce side effects and increase the anti-tumor effects of 5-FU through intracellular reactive oxygen species (iROS) generation in a dose-dependent manner.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Biology
Eda Mehtap Ozden, Zeynebe Bingol, Muzaffer Mutlu, Hasan Karagecili, Ekrem Koksal, Ahmet C. Goren, Saleh H. Alwasel, Ilhami Gulcin
Summary: This research comprehensively examined and researched the kiwifruit oil using various bioanalytical methods, determining its antioxidant, antiglaucoma, antidiabetic, and anti-Alzheimer's capabilities. The inhibitory effects on several enzymes linked to metabolic illnesses were also established. The chemical composition and quantity of essential oils contained in kiwifruit oil were studied. The results demonstrated the potent radical scavenging properties and inhibition effects on enzymes of kiwifruit oil, suggesting its significant potential in pharmaceutical procedures.
Article
Chemistry, Analytical
T. Cagdas Akaslan, Sule Yalcin, Aysenur Gunaydin Akyildiz, Ahmet C. Goren
Summary: This study utilized an LC-HRMS method to identify minoxidil, finasteride, dutasteride, and clobetasol propionate in commercial hair serums. The compounds exhibited relative standard deviations (R.S.D.) below 1.5%. The correlation coefficient for each component fell within the range of 0.997-0.999 in the calibration range. The recoveries of the method were determined to be 97.5%, 105.5%, 104.2%, and 100.8% respectively. These active pharmaceutical ingredients were undisclosed by the manufacturers, yet pose potential risks to public health due to their toxicological properties. Manufacturers and government authorities should be aware and prioritize informing users to prevent potential risks.
JOURNAL OF CHEMICAL METROLOGY
(2023)
Letter
Oncology
Abdurrahim Kocyigit, Gokhan Aydogdu, Ezgi Balkan, Vildan Betul Yenigun, Eray Metin Guler, Huri Bulut, Fatmanur Koktasoglu, Ahmet Ceyhan Goren, Ali Timucin Atayoglu
INTEGRATIVE CANCER THERAPIES
(2022)
