Article
Environmental Sciences
Divjot Virk, Amit Kumar, Amteshwar Singh Jaggi, Nirmal Singh
Summary: Arsenic exposure can lead to serious health problems, but the PDE-4 inhibitor rolipram shows potential in treating vascular endothelial dysfunction and dementia induced by SA in rats. This treatment improved memory, reduced oxidative stress, and inflammation in the brain.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Muxuan Han, Hao Zhang, Minghui Hu, Wei Sun, Zifa Li, Guimao Cao, Xiwen Geng, Sheng Wei
Summary: The inhalation administration of agarwood can significantly improve the learning and memory impairment caused by scopolamine in mice, and the therapeutic effect varied between doses.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Kazuo Washida, Erika Kitajima, Tomotaka Tanaka, Shuhei Ikeda, Tetsuya Chiba, Kotaro Noda, Takeshi Yoshimoto, Kazuki Fukuma, Satoshi Saito, Masafumi Ihara
Summary: The study in Japan revealed a high number of stroke patients in hospitals, with executive dysfunction being the most common cognitive impairment. Many stroke survivors live alone at home, and cognitive rehabilitation treatments are more commonly and earlier applied than drug treatments.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Medicine, General & Internal
Gyeongsil Lee, Seulggie Choi, Jooyoung Chang, Daein Choi, Joung Sik Son, Kyuwoong Kim, Sung Min Kim, Seogsong Jeong, Sang Min Park
Summary: A study conducted in South Korea found that the use of alpha-GPC was associated with a higher 10-year stroke risk in a dose-response manner. Alpha-GPC users had a higher risk for both ischemic and hemorrhagic stroke compared to nonusers. Further research is needed to understand the mechanisms behind this potential cerebrovascular risk.
Article
Clinical Neurology
Ori J. Lieberman, Seonjoo Lee, Jeffrey Zabinski
Summary: The use of donepezil may improve outcomes and reduce delirium in patients with dementia during critical illness.
ALZHEIMERS & DEMENTIA
(2023)
Article
Behavioral Sciences
Balazs Knakker, Vilmos Olah, Attila Trunk, Balazs Lendvai, Gyorgy Levay, Istvan Hernadi
Summary: The study found that the acetylcholinesterase inhibitor donepezil partially rescued the scopolamine-induced impairments of visual working memory (VWM) performance, while scopolamine-induced impairments of VWM maintenance are delay-dependent, especially affecting the time range of 15 to 33 seconds.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Letter
Medicine, General & Internal
Juan P. Frias, Laura Fernandez Lando, Katelyn Brown
Summary: In the SURPASS-2 trial, treatment with Tirzepatide showed better glycemic control and greater weight loss compared to Semaglutide in patients with type 2 diabetes. Additionally, there were no significant differences in mean systolic blood pressure among the enrolled patients in different treatment groups.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Neurosciences
Karem H. Alzoubi, Omar F. Khabour, Mahmoud Alfaqih, Murad Tashtoush, Sayer Al-Azzam, Nizar M. Mhaidat, Nasr Alrabadi
Summary: The study suggests that pioglitazone can protect against memory loss caused by elevated levels of methionine by reducing oxidative stress in the hippocampus.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2022)
Article
Multidisciplinary Sciences
Toshiro Horigome, Kimihiro Hino, Hiroyoshi Toyoshiba, Norihisa Shindo, Kei Funaki, Yoko Eguchi, Momoko Kitazawa, Takanori Fujita, Masaru Mimura, Taishiro Kishimoto
Summary: Recent studies have explored using natural language processing (NLP) to identify dementia. This study aimed to develop a machine learning model that could discriminate between subjects with and without dementia based on unstructured free conversation data analyzed using NLP. The resulting model showed high accuracy in classifying dementia and non-dementia subjects.
SCIENTIFIC REPORTS
(2022)
Review
Biochemical Research Methods
Manikandan Selvaraj, Karthik Sadasivam, Muralidharan Jothimani, Karthikeyan Muthusamy
Summary: Alzheimer's Disease (AD), the most common and major disability issue in our society, has a substantial economic impact. Despite substantial advances in aetiology, diagnosis, and therapy, the fundamental causes of the disease remain unknown, accurate biomarkers are not well characterized, and current pharmaceutical medications are not cost-effective.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2023)
Article
Peripheral Vascular Disease
Brandon G. Shokoples, Olga Berillo, Kevin Comeau, Hao Yu Chen, Akinori Higaki, Antoine Caillon, Nathanne S. Ferreira, James C. Engert, George Thanassoulis, Pierre Paradis, Ernesto L. Schiffrin
Summary: Extracellular ATP, which is elevated in hypertensive mice and humans, may trigger immune activation through P2X7 receptor, leading to the production of interleukin-1 beta and the activation and development of T cells. P2RX7 activation is associated with hypertension. Therefore, we hypothesized that P2RX7 activation contributes to hypertension and cardiovascular injury by promoting immune activation.
JOURNAL OF HYPERTENSION
(2023)
Article
Biochemistry & Molecular Biology
Yunsi Zheng, Anqi Luo, Xiaoquan Liu
Summary: Prolonged exposure to high glucose leads to mitochondrial fragmentation, triggering cell apoptosis and vascular injury. AMPK is suppressed by high glucose, causing imbalanced mitochondrial fusion/fission, which can be reversed with AMPK stimulation, serving as a predictive factor for diabetic cardiovascular complications.
Article
Biotechnology & Applied Microbiology
Jingjing Wu, Dongmei Zhang, Linlin Hu, Xiaowei Zheng, Caihong Chen
Summary: This study found that paeoniflorin could improve the development of gestational hypertension by regulating SIRT1, reducing pathological damage and inflammatory response. This finding provides new insights into the prevention and treatment of gestational hypertension.
Review
Clinical Neurology
Paul F. Smith
Summary: Over the past five years, there has been a growing body of evidence linking hearing loss to cognitive dysfunction, including dementia. Similarly, studies have shown a connection between vestibular loss and cognitive dysfunction, especially in relation to spatial memory. Further research is needed to better understand and control for the role of hearing loss in vestibular-related cognitive dysfunction.
JOURNAL OF NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aamir Mushtaq, Fatima Habib, Rosana Manea, Rukhsana Anwar, Umar Farooq Gohar, Muhammad Zia-Ul-Haq, Mobasher Ahmad, Claudia Mihaela Gavris, Liana Chicea
Summary: This study reports the biomolecules of Pimpinella anisum L. for antioxidant and anti-amnesic activities. The oxadiazole compounds present in P. anisum were found to inhibit acetylcholinesterase and exhibit antioxidant properties. In vivo experiments showed that the oxadiazole compounds improved behavioral and biochemical indices in mice, indicating their potential therapeutic use. However, the LD50 of the active fraction suggests potential toxicity at higher doses.
Article
Neurosciences
Poonam Sharma, G. T. Kulkarni, Bhupesh Sharma
Article
Pharmacology & Pharmacy
Kanishk Luhach, Giriraj T. Kulkarni, Vijay P. Singh, Bhupesh Sharma
Summary: The study found that papaverine can improve behavioral deficits related to autism spectrum disorder in rats with hyperserotonemia, and has significant effects on neuronal function, brain inflammation, and brain oxidative stress.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2021)
Article
Clinical Neurology
Prabhat Singh, Bhupesh Sharma
Summary: Stroke is associated with cerebral ischemia/reperfusion injury. Ischemic postconditioning (IPoC) has been shown to reduce cerebral ischemic injury and offer neuroprotection in rats. The research demonstrated that IPoC may provide neuroprotection against cerebral I/R induced brain injury by modulating the histaminergic-H-1-receptor pathway.
CURRENT NEUROVASCULAR RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Kanishk Luhach, Giriraj T. Kulkarni, Vijay P. Singh, Bhupesh Sharma
Summary: This study investigated the effects of a PDE10A inhibitor, papaverine, on core phenotypes of ASD in a Pre-VPA model in rats. Papaverine administration improved social behavior, anxiety, locomotion, and nociception, while also impacting protein markers associated with neuronal function. The findings suggest that targeting PDE10A could be a potential strategy for further understanding ASD phenotypes.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Developmental Biology
Niti Sharma, Neerupma Dhiman, Lalit K. Golani, Bhupesh Sharma
Summary: ADHD is a neurodevelopmental disorder with complex etiology, and PDE10A has been implicated as a potential target for further understanding its phenotypes. Administration of the PDE10A inhibitor papaverine improved hyperactivity, inattention, and anxiety in an ADHD model, possibly by altering protein markers associated with neuronal function and brain inflammation.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2021)
Review
Chemistry, Multidisciplinary
Neerupma Dhiman, Rajendra Awasthi, Bhupesh Sharma, Harsha Kharkwal, Giriraj T. Kulkarni
Summary: Nanotechnology has significantly impacted industries like pharmaceuticals, biotechnology, food, and cosmetics, especially in improving the solubility and bioavailability of lipophilic drugs. Various nanotechnology-based drug delivery systems, such as solid lipid nanoparticulate drug delivery systems and emulsion-based nanodrug delivery systems, play crucial roles in the targeted delivery of poorly soluble drugs. This review provides a comprehensive overview of lipid nanoparticles as carriers of bioactive molecules, covering aspects like synthesis, characterization, advantages, disadvantages, toxicity, and applications in the medical field. Recent developments in patents and clinical trials related to solid lipid nanoparticles (SLNs) and nanostructure lipid carriers (NLCs) are also discussed.
FRONTIERS IN CHEMISTRY
(2021)
Article
Behavioral Sciences
Kanishk Luhach, Giriraj T. Kulkarni, Vijay P. Singh, Bhupesh Sharma
Summary: Vinpocetine, a PDE1 inhibitor, ameliorated ASD-associated symptoms in rats prenatally exposed to VPA, possibly by improving neuronal function, brain inflammation, and oxidative stress. This study suggests PDE1 as a potential new pharmacological target for ASD treatment.
Article
Pharmacology & Pharmacy
Kanishk Luhach, Giriraj T. Kulkarni, Vijay P. Singh, Bhupesh Sharma
Summary: The study showed that cilostazol could alleviate prenatal VPA exposure-related hyperlocomotion, social interaction deficits, repetitive behavior, and anxiety, while significantly increasing biochemical markers such as BDNF, pCREB, IL-10, and GSH in the assessed brain regions.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Neurosciences
Poonam Sharma, Prachi Kaushik, Swati Jain, Brij Mohan Sharma, Rajendra Awasthi, Giriraj Thirupathirao Kulkarni, Bhupesh Sharma
Summary: The study found that UTI and SUL, either alone or in combination, significantly alleviated impairments in behavioral, endothelial, and biochemical parameters induced by STZ-diabetes in rats modulating vascular dementia.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2021)
Article
Neurosciences
Hariom Kumar, G. T. Kulkarni, Vishal Diwan, Bhupesh Sharma
Summary: Propionic acid may lead to symptoms of autism, and the modulation of intracellular calcium regulation by propionic acid and its interaction with neurodevelopmental pathways are important mechanisms to be explored.
BASIC AND CLINICAL NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Poonam Sharma, Nikita Gaur, Shalini Jayant, B. M. Sharma, Bhagwat Singh, Harsha Kharkwal, Bhupesh Sharma
Summary: The study found that ulinastatin and quercetin alone or in combination can significantly attenuate the damage caused by hypertension-induced endothelial dysfunction and vascular dementia.
PHARMACOLOGICAL REPORTS
(2022)
Article
Substance Abuse
Niti Sharma, Kanishk Luhach, Lalit K. Golani, Bhagwat Singh, Bhupesh Sharma
Summary: The study found that administration of the PDE1 inhibitor vinpocetine to prenatal alcohol exposure (PAE) rat offspring resulted in improved behavioral profiles and increased levels of cerebral health markers, while reducing inflammation and oxidative stress. This suggests that the PDE1 enzyme may be an important pharmacological tool to study ADHD as a result of PAE.
Article
Food Science & Technology
Nouratan Singh, Poonam Rani, Neeraj Tandan, Dinesh Kumar Arya, Ansuman Mahato
Summary: An Ultra-High-Performance Liquid Chromatography (UHPLC) method was developed and validated for the analysis of 16 PAH compounds in soil samples from Manesar, India. The study found that PAH concentrations were highest in the winter season in industrial areas, while the lowest levels were observed during the monsoon season. The PAH levels in Manesar were relatively lower compared to Brazil, UK, Germany, and Korea.
JOURNAL OF MICROBIOLOGY BIOTECHNOLOGY AND FOOD SCIENCES
(2022)
Article
Neurosciences
Hariom Kumar, Vishal Diwan, Bhupesh Sharma
Summary: The study investigated the effects of nimodipine on behavior and biochemistry in prenatal valproic acid-induced autism in rats. The results showed that nimodipine attenuated the reduction in social behavior, inflammation, and blood brain barrier permeability induced by prenatal valproic acid administration, suggesting its potential in the treatment of autism.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2022)
Article
Mathematical & Computational Biology
Poonam Rani, Nouratan Singh, Monika Bhaskar, Neeraj Tandan
Summary: This study surveyed the microbial community and their antibiotic profiling in the domestic environment of rural and urban areas in Meerut city, India. The results revealed a higher bacterial load compared to fungal load, with kitchens being more contaminated than living rooms. The dominant bacteria were Pseudomonas sps, Citrobacter sps, Bacillus Subtilis, Brevundimonas diminuta, Bacillus megaterium, and Klebsiella pneumoniae. Antibiotic resistance was mainly derived from plasmids.