Article
Multidisciplinary Sciences
Rong-Rong Wu, Yi-Min Zhou, Xing-Yun Xie, Jin-Yang Chen, Ke-Run Quan, Yu-Ting Wei, Xiao-Yi Xia, Wen-Juan Chen
Summary: This study aimed to assess the feasibility of using MRI-based radiomics characteristics to identify intermediary- and high-risk factors in cervical cancer patients undergoing surgery after neoadjuvant chemoradiotherapy. The study developed three models and found that the combined clinical and radiomics model had the highest predictive efficacy.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Liliana Mereu, Basilio Pecorino, Martina Ferrara, Venera Tomaselli, Giuseppe Scibilia, Paolo Scollo
Summary: This retrospective observational study evaluated the use of NACT in LACC and identified tumor diameter, lymphovascular space invasion, and parametrium involvement as independent risk factors for response to NACT. Tumor initial diameter was found to be an independent prognostic predictor for overall and lymph node response. Tumors with diameter between 2 and 6 cm showed a better response to NACT compared to tumors larger than 6 cm, and LVSI absence was an independent prognostic factor for lymph node response to NACT.
Article
Ecology
Zizhuo Wang, Rourou Xiao, Jia Huang, Xu Qin, Dianxing Hu, Ensong Guo, Chen Liu, Funian Lu, Lixin You, Chaoyang Sun, Gang Chen
Summary: The study revealed a close relationship between the vaginal microbiota of cervical cancer patients and their responsiveness to platinum-based chemotherapy, with higher alpha diversity in nonresponders compared to responders and the enrichment of the Bacteroides genus in nonresponders.
Article
Oncology
Zhengjie Ou, Dan Zhao, Bin Li, Yating Wang, Shuanghuan Liu, Yanan Zhang
Summary: This study aimed to investigate factors associated with chemoresistance in patients with locally advanced cervical squamous carcinoma treated with neoadjuvant chemotherapy followed by radical hysterectomy. A nomogram was constructed to predict chemoresistance, with menopausal status, tumor size, serum SCC antigen level, and parametrial invasion identified as independent prognostic factors. The nomogram showed good discrimination ability and calibration, and its use was associated with progression free survival.
CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Weili Li, Ping Liu, Fangjie He, Lixin Sun, Hongwei Zhao, Li Wang, Jianxin Guo, Ying Yang, Xiaonong Bin, Jinghe Lang, Chunlin Chen
Summary: Comparing neoadjuvant chemotherapy before radical surgery (NCRS) with definitive chemoradiotherapy (DR), patients who had a clinical response to NCRS showed better oncological outcomes compared to those who underwent DR.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Surgery
Tingbo Liang, Qi Zhang, Guosheng Wu, Chaoxu Liu, Xueli Bai, Shunliang Gao, Tao Ma, Ke Sun, Senxiang Yan, Wenbo Xiao, Tian'an Jiang, Fangyan Lu, Yuntao Zhang, Yan Shen, Min Zhang, Xiaochen Zhang, Jianzhen Shan
Summary: This study aimed to evaluate the safety and benefits of intestinal autotransplantation in pancreatic surgery for locally advanced pancreatic ductal adenocarcinoma (PDAC) patients. The findings suggest that this surgical approach is safe and beneficial for highly selected PDAC patients.
Review
Medicine, General & Internal
Fani Kokka, Andrew Bryant, Elly Brockbank, Melanie Powell, David Oram, Adeola Olaitan
Summary: Cervical cancer is a leading cause of death from gynaecological cancers worldwide. While standard care for locally advanced cervical cancer in Europe and the US involves chemoradiotherapy, low-income countries often rely on chemotherapy and hysterectomy. However, it remains uncertain whether this combined treatment improves survival.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Review
Oncology
Chiara Borghi, Elena Biagioli, Jessica Mauro, Anna Roberto, Martina Borghese, Alessandro Buda
Summary: The objective of this systematic review was to evaluate the effect of different types of neoadjuvant chemotherapy regimens on optimal pathological response and oncological outcomes in patients with locally advanced cervical cancer. The study found that the three-drug combination of cisplatin, paclitaxel, and ifosfamide or anthracyclines showed a higher rate of complete or optimal partial response, with no difference in disease-free survival and higher overall survival. Neoadjuvant chemotherapy followed by radical surgery should not be considered a standard of care in locally advanced cervical cancer.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Oncology
Lu Li, Yue Yang, Wang Li, Xian Zhao, Jia He, Shuo Mei, Xuejun Guo, Xibin Zhang, Jianghua Ran
Summary: This study described the clinical outcome and physical condition of patients with locally advanced breast cancer who received neoadjuvant chemotherapy followed by mastectomy and latissimus dorsi myocutaneous flap repair. The results showed that neoadjuvant chemotherapy can shrink tumor size, and the use of a latissimus dorsi musculocutaneous flap for post-mastectomy reconstruction can improve the patients' physical condition.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Review
Oncology
Amy Body, Hans Prenen, Sarah Latham, Marissa Lam, Samuel Tipping-Smith, Ajay Raghunath, Eva Segelov
Summary: Neoadjuvant systemic therapy offers potential advantages in cancer treatment, but is not yet standard for colon cancer patients. Limitations include inaccurate staging, concerns about tumor progression during preoperative treatment, and a lack of randomized data demonstrating its benefits.
CANCER MANAGEMENT AND RESEARCH
(2021)
Review
Oncology
Huaqin Lin, Lei Wang, Xiaohong Zhong, Xueqing Zhang, Lingdong Shao, Junxin Wu
Summary: This meta-analysis comparing neoadjuvant chemotherapy (NAC) and neoadjuvant chemoradiotherapy (NACRT) for locally advanced rectal cancer (LARC) found that NAC was superior to NACRT in terms of sphincter preservation rate, but noninferior in terms of other outcomes. Further validation is needed for these conclusions.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Masahiro Shimomura, Takeshi Fukuda, Yuichiro Awazu, Shigenori Nanno, Yuta Inoue, Hiroaki Matsubara, Makoto Yamauchi, Tomoyo Yasui, Toshiyuki Sumi
Summary: PRMT1 expression is significantly associated with the efficacy of neoadjuvant chemotherapy (NAC) in locally advanced cervical cancer patients, with lower PRMT1 levels correlating with better response to NAC and increased sensitivity to cisplatin in cancer cells. These findings suggest PRMT1 as a potential predictive marker for NAC efficacy, which could improve the prognosis of patients with locally advanced cervical cancer.
Article
Radiology, Nuclear Medicine & Medical Imaging
Rosa Autorino, Benedetta Gui, Giulia Panza, Luca Boldrini, Davide Cusumano, Luca Russo, Alessia Nardangeli, Salvatore Persiani, Maura Campitelli, Gabriella Ferrandina, Gabriella Macchia, Vincenzo Valentini, Maria Antonietta Gambacorta, Riccardo Manfredi
Summary: This study aims to investigate whether radiomics features extracted from magnetic resonance images can predict long-term clinical outcomes in patients with locally advanced cervical cancer after neoadjuvant chemoradiotherapy. The results show that the proposed radiomics model has promising performance in predicting patient survival rates.
Article
Oncology
Francesca De Felice, Vincenzo Tombolini, Enrico Cortesi
Summary: Locally advanced rectal cancer requires a multidisciplinary management involving neoadjuvant radiotherapy, conservative surgery, and chemotherapy. Recent studies have examined the potential benefits of altering the sequencing or intensity of the standard trimodal therapy components, with a focus on the clinical significance of total neoadjuvant treatment. More long-term results and prospective studies are needed to accurately determine the clinical benefits and establish the role of total neoadjuvant therapy in locally advanced rectal cancer.
TRANSLATIONAL ONCOLOGY
(2021)
Review
Oncology
Yuedan Zhou, Elie Rassy, Alexandre Coutte, Samir Achkar, Sophie Espenel, Catherine Genestie, Patricia Pautier, Philippe Morice, Sebastien Gouy, Cyrus Chargari
Summary: Cervical cancer, caused by human papillomavirus infection, remains a leading cause of cancer death in women in low- and middle-income countries. The main treatments for early-stage cervical cancer are upfront surgery, while concurrent chemoradiotherapy is the standard care for locally advanced cervical cancer. Ongoing research is evaluating the use of immunotherapy in locally advanced tumors.