Article
Oncology
Zhen Li, Kehui Chen, Zhenyu Yang, Qingyuan Zhu, Xiaojing Yang, Zhaobin Li, Jie Fu
Summary: This study aimed to develop a reliable DVH prediction method for high-dose-rate brachytherapy plans using a workflow combining kernel density estimation (KDE), k-nearest neighbor (kNN), and principal component analysis (PCA). The combination of kNN, PCA, and KDE showed significantly better prediction performance than using KDE alone, improving by 30.3% for bladder and 33.3% for rectum in terms of model performance.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Rita Bentahila, Elie Rassy, Samir Achkar, Florence Sacino, Stefanos Bougas, Alexis Vallard, Vincent Vinh-Hung, Johan Encaoua, Pierre Gustin, Sylvie Mengue, Patricia Pautier, Philippe Morice, Sebastien Gouy, Sophie Espenel, Eric Deutsch, Cyrus Chargari
Summary: This retrospective study reports the experience of a referral network for women with locally advanced cervical cancer (LACC) who require image-guided adaptive brachytherapy (IGABT). The study demonstrates the feasibility of the referral process, but highlights the need for well-defined workflows and appropriate resource allocation to minimize overall treatment time for this advanced technique.
Review
Oncology
Nanda Horeweg, Prachi Mittal, Patrycja L. Gradowska, Ingrid Boere, Supriya Chopra, Remi A. Nout
Summary: The study summarized the impact of adjuvant chemotherapy in the treatment of locally advanced cervical cancer. The addition of platinum-pyrimidine antagonist or platinum-taxane did not significantly improve overall survival, but did increase toxicity. These adjuvant treatment strategies are not suitable for all patients.
Article
Oncology
Leila T. Tchelebi, Cathy Eng, Craig A. Messick, Theodore S. Hong, Ethan B. Ludmir, Lisa A. Kachnic, Nicholas G. Zaorsky
Summary: The treatment of squamous cell carcinoma of the anus has shifted from radical surgery to sphincter-preserving chemoradiation, with chemotherapy using mitomycin-C and 5-fluorouracil found to be essential for cure. Advanced radiation techniques are now considered standard of care, and further studies are exploring the addition of immune checkpoint inhibitors in locally advanced cancers.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Article
Nutrition & Dietetics
Zalina Abu Zaid, May Kay Neoh, Zulfitri Azuan Mat Daud, Nor Baizura Md Yusop, Zuriati Ibrahim, Zuwariah Abdul Rahman, Norshariza Jamhuri, Aishah Zafirah Abdul Azim
Summary: This study aimed to evaluate the weight loss during and post-treatment among head and neck cancer patients. The study found that the average weight loss during treatment was 7.4%, and post-treatment weight loss was 2.1%. One month after treatment completion, patients showed significant improvements in nutrition status and muscle mass, but there was a decrease in oral nutritional supplement intake.
Review
Oncology
Y. Jessica Huang, David Gaffney
Summary: Gynecologic radiation oncology is a complex and demanding field that requires both physicians and physicists to work together using various techniques to provide optimal treatment for patients. This study reviewed gynecological high dose rate brachytherapy treatment images and plans from the past decade, identified common problems, and presented strategies to prevent or address these issues. Recommendations for improving treatment safety and quality were also provided.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Oncology
K. A. Kanta, Adrien Laville, Elie Rassy, Radouane EL Ayachi, Patricia Pautier, Mouhamadou Bachir, Sophie Bockel, Samir Achkar, Sophie Espenel, Amandine Maulard, Philippe Morice, Christine Haie-Meder, Roger Sun, Cyrus Chargari
Summary: The study reports the experience of using IGABT in the treatment of locally advanced cervical cancer spreading to adjacent organs. The analysis of cases shows that IGABT has a good local control effect in treating these advanced tumors. The dose and patient performance are associated with survival rates and fistula formation.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Mame Daro Faye, Mariana Petruccelli Araujo, Michel D. Wissing, Khalid Alrabiah, Lucy Gilbert, Xing Zeng, Luis Souhami, Joanne Alfieri
Summary: This retrospective study compared the effects of two-dimensional-brachytherapy (2D-BT) and three-dimensional-image-guided adaptive BT (3D-IGABT) on locally advanced cervical cancer (LACC) patients. The results showed that 3D-IGABT significantly reduced the occurrence of late toxicities compared to 2D-BT. There were no significant differences in disease control or survival outcomes between the two groups.
Article
Oncology
Adam Eakin, Loise Wairiri, William Stadtlander, Amanda Bruegl, Jenna Emerson, Casey Williamson, Jenna Kahn
Summary: This study aims to characterize the utilization of brachytherapy in Oregon and identify where disparities in treatment may exist. The results showed that older patients, stage IV patients, and uninsured patients were less likely to receive brachytherapy. The combination of chemotherapy and brachytherapy can reduce the risk of cancer specific mortality.
Article
Oncology
Elizabeth B. Jeans, William G. Breen, Trey C. Mullikin, Brittany A. Looker, Andrea Mariani, Gary L. Keeney, Michael G. Haddock, Ivy A. Petersen
Summary: This study analyzed the outcomes of 182 patients with early-stage clear cell, serous, and mixed endometrial cancer who underwent adjuvant vaginal cuff brachytherapy. Results indicated that adjuvant vaginal cuff brachytherapy alone is suitable for patients with negative peritoneal cytology and small tumors, while larger tumors or positive/suspicious cytology may benefit from additional upfront treatments, such as platinum-based chemotherapy. Subgroup analysis showed improved outcomes with the use of adjuvant chemotherapy in these high-risk patients.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Review
Oncology
Katie Lichter, Chidinma Anakwenze Akinfenwa, Emily MacDuffie, Rohini Bhatia, Christina Small, Jennifer Croke, William Small, Junzo Chino, Daniel Petereit, Surbhi Grover
Summary: Brachytherapy is an essential component of cervical cancer treatment, but its global utilization is low and there are disparities in access. This review explores the current utilization practices and efforts to address barriers to implementation, emphasizing the need to expand access to brachytherapy for women in need worldwide.
EXPERT REVIEW OF ANTICANCER THERAPY
(2022)
Article
Medicine, General & Internal
Rong Zheng, Bi-Si Wang, Zhihua Li, Pan Chi, Benhua Xu
Summary: This study introduces a research on the treatment of locally advanced rectal cancer, indicating that short-course radiotherapy combined with systemic therapy can improve long-term efficacy. The aim of the study is to determine the optimal combination of chemotherapy, immunotherapy, and short-course radiotherapy for improved prognosis.
Article
Medicine, General & Internal
Wezile Chitha, Zukiswa Jafta, Onke R. Mnyaka, Danleen Hongoro, Lizo Godlimpi, Buyiswa Swartbooi, Natasha Williams, Christopher Zungu, Lazola Buthi, Sibulelo Kuseni, John Nasila, Siyabonga Sibulawa, Olona Giwu, Awam Mavimbela, Vivien Essel, Sikhumbuzo A. Mabunda
Summary: This study aims to describe the demographic, epidemiological, and clinical profile of various cancers at Nelson Mandela Academic Hospital and Rob Ferreira Hospital in South Africa, which have decentralized cancer care delivery since 2018 and 2019 respectively.
Article
Oncology
Alina Emiliana Sturdza, Richard Poetter, Michael Kossmeier, Kathrin Kirchheiner, Umesh Mahantshetty, Christine Haie-Meder, Jacob Christian Lindegaard, Ina Jurgenliemk-Schulz, Li Tee Tan, Peter Hoskin, Erik van Limbergen, Charles Gillham, Barbara Segedin, Ekkasit Tharavichitkul, Elena Villafranca Iturre, Lars Ulrik Fokdal, Stephan Polterauer, Christian Kirisits, Kari Tanderup
Summary: This study developed a nomogram for predicting overall survival in patients with locally advanced cervical cancer based on data from 720 patients. The nomogram included factors such as age, tumor characteristics, and treatment regimens, and showed promising calibration and discrimination in predicting 60-month survival.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Review
Oncology
Jyoti S. Mayadev, Guihao Ke, Umesh Mahantshetty, Marcos David Pereira, Rafal Tarnawski, Takafumi Toita
Summary: Cervical cancer is a significant burden for women worldwide, with low- and middle-income countries being most affected. Underserved populations in countries with sufficient resources may also have higher incidence and poorer outcomes. Current standard treatment for locally advanced cervical cancer is effective but faces barriers related to adherence, limited access to radiotherapy, and underutilization of brachytherapy. Efforts are being made to address these barriers and explore additional therapies to improve treatment efficacy.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Antoine Schernberg, Sylvain Reuze, Fanny Orlhac, Irene Buvat, Laurent Dercle, Roger Sun, Elaine Limkin, Alexandre Escande, Christine Haie-Meder, Eric Deutsch, Cyrus Chargari, Charlotte Robert
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2018)
Review
Cell Biology
Carole Helissey, Sophie Cavallero, Clement Brossard, Marie Dusaud, Cyrus Chargari, Sabine Francois
Summary: Radiation cystitis is a potential complication of pelvic cancer treatment, with unclear clinical management and underlying pathophysiology. The lack of prospective and randomized trials makes establishing therapeutic strategies difficult. The immunopathological processes and fibrotic process of radiation cystitis, as well as potential therapeutic approaches focusing on the interaction between mesenchymal stromal cells and macrophages, are key points of discussion.
Review
Oncology
Sophie Bockel, Sophie Espenel, Roger Sun, Isabelle Dumas, Sebastien Gouy, Philippe Morice, Cyrus Chargari
Summary: Reirradiation using three-dimensional image-guided brachytherapy (3D-IGBT) shows promise as an alternative to salvage surgery for inoperable patients with local recurrence in gynecological malignancies occurring in a previously irradiated field, although long-term toxicities may be high in some cases. Patients in this situation should be referred to highly experienced expert centers for treatment. Centralization of data and large-scale multicentric international prospective trials are needed to improve local control while minimizing toxicities.
Article
Oncology
Radouane El Ayachy, Roger Sun, Kanta Ka, Adrien Laville, Anne-Sophie Duhamel, Anne Tailleur, Isabelle Dumas, Sophie Bockel, Sophie Espenel, Pierre Blanchard, Yungan Tao, Stephane Temam, Antoine Moya-Plana, Christine Haie-Meder, Cyrus Chargari
Summary: The study confirms that excellent local control rate is achieved with PDR brachytherapy as treatment of lip carcinoma, with very limited late side effects and satisfactory functional outcomes.
Article
Oncology
Henrike Westerveld, Maximilian P. Schmid, Remi A. Nout, Cyrus Chargari, Bradley R. Pieters, Carien L. Creutzberg, Alina Sturdza, Jacob C. Lindegaard, Zdenko van Kesteren, Renaud Mazeron, Nicole Nesvacil, Lars U. Fokdal
Summary: This large retrospective multicenter study demonstrated that image-guided adaptive brachytherapy (IGABT) for primary vaginal cancer achieves high local control with acceptable morbidity. Results compare favorably with two-dimensional radiograph-based brachytherapy, highlighting the importance of IGABT in the treatment of vaginal cancer.
Review
Medicine, General & Internal
Francois Zaccarini, Claire Sanson, Amandine Maulard, Stephanie Scherier, Alexandra Leary, Patricia Pautier, Cyrus Chargari, Catherine Genestie, Sebastien Gouy, Philippe Morice
Summary: For early-stage cervical cancer patients, less radical surgeries such as conization or simple trachelectomy can be considered under specific conditions. However, for patients with larger tumors, treatment becomes more challenging and may require abdominal radical trachelectomy or neoadjuvant chemotherapy, which should be carried out in expert centers to preserve fertility.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Mickael Andraud, Manon Kissel, Roger Sun, Elie Rassy, Sophie Espenel, Samir Achkar, Philippe Morice, Christine Haie-Meder, Sebastien Gouy, Cyrus Chargari
Summary: Treatment of peri-urethral gynecological tumors presents challenges, and interstitial brachytherapy combined with external radiotherapy shows high local control probability as a conservative treatment option. This treatment strategy aims to spare patients from surgery-related morbidity while effectively managing the tumors.
Article
Oncology
Markus Glatzer, Kari Tanderup, Angeles Rovirosa, Lars Fokdal, Claudia Ordeanu, Luca Tagliaferri, Cyrus Chargari, Vratislav Strnad, Johannes Athanasios Dimopoulos, Barbara Segedin, Rachel Cooper, Esten Sondrol Nakken, Primoz Petric, Elzbieta van der Steen-banasik, Kristina Lossl, Ina M. Jurgenliemk-Schulz, Peter Niehoff, Ruth S. Hermansson, Remi A. Nout, Paul Martin Putora, Ludwig Plasswilm, Nikolaos Tselis
Summary: This study analysed decision criteria and techniques for adjuvant brachytherapy among European radiation oncology experts. The results showed that there was a clear trend towards adjuvant brachytherapy for certain stages and types of endometrial cancer. There were also variations in dose prescription and techniques used. Some experts already incorporated molecular markers into their decision-making process.
Article
Oncology
Rita Bentahila, Elie Rassy, Samir Achkar, Florence Sacino, Stefanos Bougas, Alexis Vallard, Vincent Vinh-Hung, Johan Encaoua, Pierre Gustin, Sylvie Mengue, Patricia Pautier, Philippe Morice, Sebastien Gouy, Sophie Espenel, Eric Deutsch, Cyrus Chargari
Summary: This retrospective study reports the experience of a referral network for women with locally advanced cervical cancer (LACC) who require image-guided adaptive brachytherapy (IGABT). The study demonstrates the feasibility of the referral process, but highlights the need for well-defined workflows and appropriate resource allocation to minimize overall treatment time for this advanced technique.
Article
Oncology
Mario Terlizzi, Veronique Minard, Christine Haie-Meder, Sophie Espenel, Helene Martelli, Florent Guerin, Cyrus Chargari
Summary: This study examines the experience of using pulsed dose rate brachytherapy for the treatment of pediatric vaginal tumors. The results show that this treatment method has good compliance, excellent local control, and low toxicity rates. Due to the rarity of the disease and the technical aspects of treatment in young patients, referral to specialized centers is recommended.
Review
Oncology
Stergios Boussios, Elie Rassy, Michele Moschetta, Aruni Ghose, Sola Adeleke, Elisabet Sanchez, Matin Sheriff, Cyrus Chargari, Nicholas Pavlidis
Summary: DNA damage is a hallmark of cancer. Epithelial ovarian cancer (EOC) and prostate cancer often have defects in DNA damage response (DDR) pathways. PARP inhibitors are a therapeutic strategy for EOC and prostate cancer, particularly in tumors with HR deficiency. Genetic testing plays an increasingly important role in the treatment of ovarian and prostate cancer patients.
Article
Biology
Carole Helissey, Nathalie Guitard, Helene Thery, Sylvie Goulinet, Philippe Mauduit, Maria Girleanu, Anne-Laure Favier, Michel Drouet, Charles Parnot, Cyrus Chargari, Sophie Cavallero, Sabine Francois
Summary: Pelvic radiotherapy is an important treatment for pelvic tumors, but it can cause symptoms that affect patients' quality of life. Despite improvements in radiation techniques, radiation cystitis remains stable and treatment options are limited. Mesenchymal stromal cells (MSC) have shown promise in promoting tissue repair through the release of extracellular vesicles (MSC-EVs) or conditioned medium (MSC-CM). In vitro experiments have demonstrated the potential of MSC-EVs and MSC-CM in preventing fibrosis in radiation cystitis models.
Article
Medicine, General & Internal
Carolin Marti, Elise Deluche, Floriane Jochum, Sofiane Bendifallah, Henri Azais, Jonas Deidier, Vincent Cockenpot, Ines Menoux, Vincent Balaya, Sarah Betrian, Cyrus Chargari, Sebastien Gouy, Catherine Genestie, Anis Feki, Catherine Uzan, Frederic Guyon, Mojgan Devouassoux-Shisheboran, Noemie Body, Cherif Akladios, Patrice Mathevet, Benedetta Guani
Summary: The study aimed to evaluate the opinion and achieve a consensus among a panel of experts on the management of endometrial cancer in France and French Switzerland. A Delphi survey was conducted, and the experts were asked to answer questionnaires to determine their views on various aspects of endometrial cancer management. The findings provide valuable recommendations for standardizing the management of endometrial cancer and improving clinical practices.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Oncology
Sheila Terwisscha van Scheltinga, Timothy Rogers, Naima Smeulders, Federica deCorti, Florent Guerin, Ross Craigie, Gabriela Guillen Burrieza, Ludi Smeele, Marinka Hol, Rick van Rijn, Joerg Fuchs, Guido Seitz, Andreas Schmidt, Beate Timmermann, Per-Ulf Tunn, Cyrus Chargari, Raquel Davila Fajardo, Olga Slater, Jenny Gains, Hans Merks
Summary: This review discusses the developments in staging and local treatment strategies for specific sites of rhabdomyosarcoma tumors, including head and neck, chest/trunk, bladder-prostate, female genito-urinary, perianal, and extremity sites. It also focuses on the treatment strategies for very young patients, as well as those with metastatic or relapsed disease. Specific surgical techniques such as whole limb perfusion, HIPEC, and fluorescence guided surgery are also addressed. The goal of these innovations is to improve loco-regional control of the disease while minimizing treatment morbidity.