The PB2 E627K mutation contributes to the high polymerase activity and enhanced replication of H7N9 influenza virus

Isolation and characterization of H7N9 viruses from live poultry markets — Implication of the source of current H7N9 infection in humans

(2013) JianZhong Shi et al.   CHINESE SCIENCE BULLETIN

Genomic signature and protein sequence analysis of a novel influenza A (H7N9) virus that causes an outbreak in humans in China

(2013) Qi Liu et al.   MICROBES AND INFECTION

Pathogenesis and transmission of avian influenza A (H7N9) virus in ferrets and mice

(2013) Jessica A. Belser et al.   NATURE

Clinical Findings in 111 Cases of Influenza A (H7N9) Virus Infection

(2013) Hai-Nv Gao et al.   NEW ENGLAND JOURNAL OF MEDICINE

H7N9 Influenza Viruses Are Transmissible in Ferrets by Respiratory Droplet

(2013) Q. Zhang et al.   SCIENCE

Environmental connections of novel avian-origin H7N9 influenza virus infection and virus adaptation to the human

(2013) Jun Li et al.   Science China-Life Sciences

Probable person to person transmission of novel avian influenza A (H7N9) virus in Eastern China, 2013: epidemiological investigation

(2013) X. Qi et al.   BMJ-British Medical Journal

Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cells

(2012) Benjamin Mänz et al.   Nature Communications

Amino acids 473V and 598P of PB1 from an avian-origin influenza A virus contribute to polymerase activity, especially in mammalian cells

(2011) C. Xu et al.   JOURNAL OF GENERAL VIROLOGY

Differential use of importin-α isoforms governs cell tropism and host adaptation of influenza virus

(2011) Gülsah Gabriel et al.   Nature Communications

Host Determinant Residue Lysine 627 Lies on the Surface of a Discrete, Folded Domain of Influenza Virus Polymerase PB2 Subunit

(2011) Franck Tarendeau et al.   PLoS Pathogens

Strand-specific real-time RT-PCR for distinguishing influenza vRNA, cRNA, and mRNA

(2010) Eiryo Kawakami et al.   JOURNAL OF VIROLOGICAL METHODS

Evidence for Avian and Human Host Cell Factors That Affect the Activity of Influenza Virus Polymerase

(2010) O. Moncorge et al.   JOURNAL OF VIROLOGY

Biological and Structural Characterization of a Host-Adapting Amino Acid in Influenza Virus

(2010) Shinya Yamada et al.   PLoS Pathogens

Structural Basis of the Influenza A Virus RNA Polymerase PB2 RNA-binding Domain Containing the Pathogenicity-determinant Lysine 627 Residue

(2009) Takashi Kuzuhara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adaptive strategies of the influenza virus polymerase for replication in humans

(2009) Andrew Mehle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transmission of Influenza Virus in a Mammalian Host Is Increased by PB2 Amino Acids 627K or 627E/701N

(2009) John Steel et al.   PLoS Pathogens

An Inhibitory Activity in Human Cells Restricts the Function of an Avian-like Influenza Virus Polymerase

(2008) Andrew Mehle et al.   Cell Host & Microbe

Avian Influenza A Virus Polymerase Association with Nucleoprotein, but Not Polymerase Assembly, Is Impaired in Human Cells during the Course of Infection

(2008) M.-A. Rameix-Welti et al.   JOURNAL OF VIROLOGY

Interaction of Polymerase Subunit PB2 and NP with Importin α1 Is a Determinant of Host Range of Influenza A Virus

(2008) Gülsah Gabriel et al.   PLoS Pathogens