Review
Chemistry, Multidisciplinary
Saurabh Shah, Mahavir Bhupal Chougule, Arun K. Kotha, Rama Kashikar, Chandraiah Godugu, Rajeev Singh Raghuvanshi, Shashi Bala Singh, Saurabh Srivastava
Summary: Millions of people die each year from viral infections, highlighting the urgent need to overcome current pitfalls in antiviral therapy. Nanomedicine offers a promising solution by using different types of nanoformulations to target the drawbacks in antiviral treatment.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Chemistry, Medicinal
Song Zhang, Zhujun Cheng, Yanan Wang, Tianyu Han
Summary: The progress of miRNA drugs in clinical trials is slow due to the characteristic of targeting multiple genes, leading to inevitable adverse effects.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Multidisciplinary Sciences
Danielle E. Anderson, Jin Cui, Qian Ye, Baoying Huang, Ya Tan, Chao Jiang, Wenhong Zu, Jing Gong, Weiqiang Liu, So Young Kim, Biao Guo Yan, Kristmundur Sigmundsson, Xiao Fang Lim, Fei Ye, Peihua Niu, Aaron T. Irving, Haoyu Zhang, Yefeng Tang, Xuming Zhou, Yu Wang, Wenjie Tan, Lin-Fa Wang, Xu Tan
Summary: Bats are found to play a crucial role in the zoonotic transmission of major viral diseases, and they exhibit unique innate immune characteristics that are essential for viral replication. The gene MTHFD1 is identified as a key player in the viral tolerance of both bat and human cells, presenting a potential target for developing broad-spectrum antiviral therapy. Research on bats provides valuable insights into understanding genetic factors influencing viral interactions and responses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Phillip Pymm, Stefan Tenzer, Edmund Wee, Mirjana Weimershaus, Anne Burgevin, Simon Kollnberger, Jan Gerstoft, Tracy M. Josephs, Kristin Ladell, James E. McLaren, Victor Appay, David A. Price, Lars Fugger, John I. Bell, Hansjoerg Schild, Peter van Endert, Maria Harkiolaki, Astrid K. N. Iversen
Summary: This study discovers that the cytotoxic T lymphocyte (CTL) and natural killer (NK) cell responses to a specific epitope in the human immunodeficiency virus are associated with enhanced immune control. The length and mutations of the epitope influence the CTL and NK cell responses, leading to viral escape.
Article
Biology
Atef Mohamed, Zhenhui Jin, Toba Osman, Nongnong Shi, Mahmut Tor, Stephen Jackson, Yiguo Hong
Summary: A hallmark of antiviral RNA interference (RNAi) is the production of viral small interfering RNA (vsiRNA). Profiling of vsiRNAs indicates that certain regions of viral RNA genome or transcribed viral RNA, dubbed vsiRNA hotspots, are more prone to RNAi-mediated cleavage for vsiRNA biogenesis. The biological relevance of hotspot vsiRNAs to the host innate defence against pathogens remains to be elucidated. This study demonstrates that direct targeting a hotspot by a synthetic vsiRNA confers host resistance to virus infection.
Article
Biochemistry & Molecular Biology
Dong-Eun Kim, Young Hyun Shin, Jung-Eun Cho, Subeen Myung, Hong Gi Kim, Kyung-Chang Kim, Chul Min Park, Cheol-Hee Yoon
Summary: This study synthesized a series of novel 3-oxindole-2-carboxylates and evaluated their antiviral activity against HIV-1 infection. One compound showed the most potent inhibitory effect without severe cytotoxicity. Mode-of-action studies indicated that these compounds specifically inhibited Tat-mediated viral transcription.
Review
Microbiology
Alexis Carpenter, Rollie J. Clem
Summary: Arboviral diseases transmitted by mosquitoes are a major global health concern. Current treatment and prevention methods are limited, so controlling the disease at the vector level is ideal. The midgut of the mosquito plays a crucial role in preventing the spread of arboviruses. Understanding the midgut escape barrier may aid in developing effective control strategies.
Review
Medicine, Research & Experimental
Shivam Chowdhary, Rahul Deka, Kingshuk Panda, Rohit Kumar, Abhishikt David Solomon, Jimli Das, Supriya Kanoujiya, Ashish Kumar Gupta, Somya Sinha, Janne Ruokolainen, Kavindra Kumar Kesari, Piyush Kumar Gupta
Summary: Human viral oncogenesis is a complex phenomenon that contributes significantly to the global cancer burden. Recent findings have uncovered cellular and molecular pathways involved in the development and initiation of malignancy during viral infections. Antiviral treatment has emerged as a strategy to eliminate viral infections and prevent oncogenesis. Exploring the molecular pathogenesis of various oncogenic viruses and developing potent antiviral therapies could enhance the eradication of infected malignant cells while sparing normal ones. This review discusses the advancements in natural and synthetic antivirals and highlights the challenges and future prospects of using antivirals in viral oncogenesis.
MOLECULAR PHARMACEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Eunjung Kim, Eun-Kyung Lim, Geunseon Park, Chaewon Park, Jong-Woo Lim, Hyo Lee, Woonsung Na, Minjoo Yeom, Jinyoung Kim, Daesub Song, Seungjoo Haam
Summary: While COVID-19 is currently causing a global pandemic, the emergence of unknown pathogens such as Disease X is a serious concern for the future. Utilizing advanced nanotechnology to address the challenges posed by emerging pathogens is crucial for global public health preparedness.
ADVANCED MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Huaibing Jin, Xinyun Han, Zhaohui Wang, Yilin Xie, Kunpu Zhang, Xiaoge Zhao, Lina Wang, Jin Yang, Huiyun Liu, Xiang Ji, Lingli Dong, Hongyuan Zheng, Weijuan Hu, Yan Liu, Xifeng Wang, Xueping Zhou, Yijing Zhang, Weiqiang Qian, Wenming Zheng, Qianhua Shen, Mingyue Gou, Daowen Wang
Summary: This study reveals that hosts can utilize phosphorylated viral proteins to regulate viral proliferation. Phosphorylated 17K protein enhances the abundance of virus-derived small interfering RNAs (vsiRNAs) and strengthens antiviral RNA interference. Additionally, phosphorylated 17K protein interacts with barley small RNA-degrading nuclease 1 (HvSDN1) and impedes its ability to degrade vsiRNAs.
Review
Virology
Yun Jin, Jian-Hua Zhao, Hui-Shan Guo
Summary: Molecular interactions between plants and viruses provide insights into host antiviral immunity and viral counter-defense mechanisms. Antiviral defense in plants is initiated by virus-derived small-interfering RNAs, while plant viruses have evolved viral suppressors of RNAi to counteract this defense. Recent research has shown that plant antiviral responses are regulated by endogenous small silencing RNAs, RNA decay, and autophagy, with some viral suppressors also targeting these defense responses to promote infection.
CURRENT OPINION IN VIROLOGY
(2021)
Review
Virology
Debashree Dass, Kishore Dhotre, Muskan Chakraborty, Anushka Nath, Anwesha Banerjee, Parikshit Bagchi, Anupam Mukherjee
Summary: microRNAs are small, single-stranded, noncoding RNAs that regulate gene expression. They can be dysregulated upon infection and serve as important biomarkers and therapeutic targets. Viral microRNAs, known as vmiRNAs, encoded by human DNA viruses and several herpesviruses, play a vital role in host-pathogen interactions and can manipulate host pathways.
Review
Microbiology
Phuong Thi Hoang, Quynh Xuan Thi Luong, Ramadhani Qurrota Ayun, Yongjun Lee, Thuy Thi Bich Vo, Taehyun Kim, Sukchan Lee
Summary: Outbreaks of viral diseases are increasing annually worldwide, demanding the development of rapid and broad-spectrum therapeutics. This article highlights the novel approach of degrading viral genomes for developing antiviral drugs and introduces a promising candidate, a single-chain variable fragment, for broad-spectrum antiviral therapeutics.
Article
Infectious Diseases
Nametso Kelentse, Sikhulile Moyo, Wonderful T. Choga, Kwana Lechiile, Tshepo B. Leeme, David S. Lawrence, Ishmael Kasvosve, Rosemary Musonda, Mosepele Mosepele, Thomas S. Harrison, Joseph N. Jarvis, Simani Gaseitsiwe
Summary: This study compared the patterns of HIV-1 drug resistance mutations between the cerebrospinal fluid (CSF) and plasma of individuals with HIV-associated cryptococcal meningitis. The results showed high concordance in HIV-1 drug resistance mutations between the CSF and plasma, suggesting intercompartmental mixing and possibly a lack of compartmentalization. Some individuals also harbored minority HIV-1 drug resistance mutations.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Review
Biotechnology & Applied Microbiology
Tolulope Joshua Ashaolu, Asad Nawaz, Noman Walayat, Ibrahim Khalifa
Summary: The use of biopeptides as antiviral molecules presents a promising alternative in treating viral diseases such as COVID-19. These peptides, sourced primarily from animal venoms, mammals, plants, and artificial origins, have the potential to become effective antiviral medications.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Abraham Goorhuis, Karin J. von Eije, Renee A. Douma, Noor Rijnberg, Michele van Vugt, Cornelis Stijnis, Martin P. Grobusch
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2016)
Review
Virology
Heli Harvala, Eeva Broberg, Kimberley Benschop, Natasa Berginc, Shamez Ladhani, Petri Susi, Claus Christiansen, James McKenna, David Allen, Phoebe Makiello, Georgina McAllister, Mirabelli Carmen, Katherina Zakikhany, Robert Dyrdak, Xiaohui Nielsen, Tina Madsen, Joel Paul, Catherine Moore, Karin von Eije, Antonio Piralla, Mieke Carlier, Laura Vanoverschelde, Randy Poelman, Andres Anton, F. Xavier Lopez-Labrador, Laura Pellegrinelli, Kathrin Keeren, Melanie Maier, Hayley Cassidy, Stavros Derdas, Carita Savolainen-Kopra, Sabine Diedrich, Svein Nordbo, Javier Buesa, Jean-Luc Bailly, Fausto Baldanti, Andrew MacAdam, Audrey Mirand, Susanne Dudman, Isabelle Schuffenecker, Seilesh Kadambari, Johan Neyts, Michael J. Griffiths, Jan Richter, Cristina Margaretto, Sheila Govind, Ursula Morley, Ortwin Adams, Sidsel Krokstad, Jonathan Dean, Margarita Pons-Salort, Birgit Prochazka, Maria Cabrerizo, Manasi Majumdar, Gaia Nebbia, Maryse Wiewel, Simon Cottrell, Peter Coyle, Javier Martin, Catrin Moore, Sofie Midgley, Peter Horby, Katja Wolthers, Peter Simmonds, Hubert Niesters, Thea K. Fischer
JOURNAL OF CLINICAL VIROLOGY
(2018)
Article
Immunology
Olivier ter Brake, Karin J. von Eije, Ben Berkhout
Article
Biochemistry & Molecular Biology
Qiuwei Pan, Petra E. de Ruiter, Karin J. von Eije, Ron Smits, Jaap Kwekkeboom, Hugo W. Tilanus, Ben Berkhout, Harry L. A. Janssen, Luc J. W. van der Laan
Article
Biochemistry & Molecular Biology
O. ter Brake, N. Legrand, K. J. von Eije, M. Centlivre, H. Spits, K. Weijer, B. Blom, B. Berkhout
Article
Biochemistry & Molecular Biology
L. Aagaard, J. Zhang, K. J. von Eije, H. Li, P. Saetrom, M. Amarzguioui, J. J. Rossi
Article
Biotechnology & Applied Microbiology
Olivier ter Brake, Karen 't Hooft, Ying Poi Liu, Mireille Centlivre, Karin Jasmijn von Eije, Ben Berkhout
Article
Biotechnology & Applied Microbiology
Ying Poi Liu, Karin Jasmijn von Eije, Nick C. T. Schopman, Jan-Tinus Westerink, Olivier ter Brake, Joost Haasnoot, Ben Berkhout
Article
Medicine, Research & Experimental
Mireille Centlivre, Nicolas Legrand, Sofieke Klamer, Ying Poi Liu, Karin Jasmijn von Eije, Martino Bohne, Esther Siteur-van Rijnstra, Kees Weijer, Bianca Blom, Carlijn Voermans, Hergen Spits, Ben Berkhout
MOLECULAR THERAPY-NUCLEIC ACIDS
(2013)
Article
Gastroenterology & Hepatology
Willem S. Lexmond, Vincent E. de Meijer, Rene Scheenstra, Sander T. H. Bontemps, Evelien W. Duiker, Elisabeth H. Scholvinck, Xuewei Zhou, Karin J. von Eije, Koen M. E. M. Reyntjens, Henkjan J. Verkade, Robert J. Porte, Ruben H. de Kleine
Summary: There is increasing global concern about the high incidence of severe acute hepatitis in young children. In the Netherlands, our liver transplantation center treated five children successively with indeterminate acute liver failure. This article presents the clinical course and comprehensive diagnostic workup of these patients.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Bernard Surial, Adria Ramirez Mena, Marie Roumet, Andreas Limacher, Colette Smit, Olivier Leleux, Amanda Mocroft, Marc van der Valk, Fabrice Bonnet, Lars Peters, Juergen K. Rockstroh, Huldrych F. Guenthard, Annalisa Berzigotti, Andri Rauch, Gilles Wandeler
Summary: HBV coinfection is the most important cause of hepatocellular carcinoma (HCC) among people living with HIV (PLWH). While risk prediction tools for HCC have been validated in patients with HBV monoinfection, they have not been evaluated in PLWH. This study performed an external validation of PAGE-B in PLWH with HBV coinfection, and found that PAGE-B is a valid tool to determine the need for HCC screening.
JOURNAL OF HEPATOLOGY
(2023)
Article
Virology
Karin Jasmijn von Eije, Olivier ter Brake, Ben Berkhout
JOURNAL OF VIROLOGY
(2008)
Article
Biochemistry & Molecular Biology
Samantha Barichievy, Sheena Saayman, Karin J. Von Eije, Kevin V. Morris, Patrick Arbuthnot, Marc S. Weinberg