Article
Immunology
Noemi Anna Nagy, Fernando Lozano Vigario, Rinske Sparrius, Toni M. M. van Capel, Ronald W. van Ree, Sander Tas, I. Jolanda M. de Vries, Teunis B. H. Geijtenbeek, Bram C. Slutter, Esther de Jong
Summary: Nanomedicine offers a promising platform for manipulating dendritic cells (DCs) and the adaptive immune response. Liposomal vitamin D3 can induce the development of regulatory CD4+ T cells and inhibit the proliferation of memory T cells. It can also suppress the development of Th1 and Th17 cells and stimulate the migration of CD14+ skin DCs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Khalid W. Kalim, Jun-Qi Yang, Mark Wunderlich, Vishnu Modur, Phuong Nguyen, Yuan Li, Ting Wen, Ashley Kuenzi Davis, Ravinder Verma, Qing Richard Lu, Anil G. Jegga, Yi Zheng, Fukun Guo
Summary: Targeting Cdc42 in Treg cells has shown promising therapeutic potential in cancer immunotherapy, by enhancing antitumor T-cell immunity without triggering autoimmune reactions. This approach involves inducing Treg cell instability through Cdc42 targeting, leading to improved immune responses against tumors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Rheumatology
Bingxia Ming, Yaowu Zhu, Jixin Zhong, Lingli Dong
Summary: Significant progress has been made in understanding the pathogenesis of SS, but effective treatments are still needed. Autoimmune lymphocytic infiltration is associated with glandular and extraglandular dysfunction in SS, affecting the epithelial structures of organs. Treg cells, a subset of CD4(+) T lymphocytes, play a role in inhibiting inflammation, immune response, and promoting tissue repair. The dysfunction of Treg cells in SS pathogenesis and potential therapeutic strategies targeting Treg cells are discussed in this review.
Review
Immunology
Aikaterini Hatzioannou, Athina Boumpas, Miranta Papadopoulou, Iosif Papafragkos, Athina Varveri, Themis Alissafi, Panayotis Verginis
Summary: Treg cell plasticity plays a significant role in autoimmunity and cancer, characterized by loss of Foxp3 expression. It has great therapeutic potential through destabilizing Treg cells to promote anti-tumor immunity or enhancing Treg cell stability to attenuate chronic inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Guirong Liu, Manman Liu, Junjuan Wang, Yao Mou, Huilian Che
Summary: The increasing prevalence of food allergies has spurred research on novel treatment strategies like EPIT, which has shown potential in inducing immune tolerance. Treg cells play a key role in immune tolerance induced by EPIT but further exploration is needed to understand its mechanism.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Rafael Nunez, Maria J. Rodriguez, Clara Lebron-Martin, Maria del Carmen Martin-Astorga, Javier Ramos-Soriano, Javier Rojo, Maria J. Torres, Jose A. Canas, Cristobalina Mayorga
Summary: This study investigates the epigenetic changes in splenic-Treg in mice treated with synthetic glycodendropeptide D1ManPrup3. The results show that different doses of treatment lead to different responses in mice, reflected by differential methylation changes in Tregs.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Ran Gao, Guo-Ping Shi, Jing Wang
Summary: Regulatory T cells (Tregs) are CD4(+) T cells that can suppress abnormal or excessive immune responses. Targeting Tregs selectively may alleviate their immunosuppressive activities and has shown promising results in preclinical and early-phase clinical trials. Combination therapy has been identified as a better choice than single immunotherapy, radiotherapy, or chemotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Marika Guercio, Simona Manni, Iolanda Boffa, Simona Caruso, Stefano Di Cecca, Matilde Sinibaldi, Zeinab Abbaszadeh, Antonio Camera, Roselia Ciccone, Vinicia Assunta Polito, Francesca Ferrandino, Sofia Reddel, Maria Luigia Catanoso, Emilia Bocceri, Francesca Del Bufalo, Mattia Algeri, Biagio De Angelis, Concetta Quintarelli, Franco Locatelli
Summary: This study investigates the inclusion of the inducible caspase 9 (iC9) suicide gene in CAR construct design as an effective safety switch to control malignant CAR+ B cells, potentially providing a safe CAR-T cell product even when starting from biological materials contaminated with leukemia blasts.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Audrey Moatti, Anais Debesset, Caroline Pilon, Asma Beldi-Ferchiou, Mathieu Leclerc, Rabah Redjoul, Frederic Charlotte, Nhu Hanh To, Adeline Bak, Yazid Belkacemi, Benoit Laurent Salomon, Fadi Issa, David Michonneau, Sebastien Maury, Jose Laurent Cohen, Allan Thiolat
Summary: This study reveals the potential of targeting TNFR2 to enhance anti-tumor responses and treat relapse of blood malignancies. The researchers also found that TNFR2 is over-expressed in Tregs from healthy donors and patients with leukemia relapse or GVHD. These findings provide new perspectives for the development of immunotherapies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Nicolas Krause, Joerg Mengwasser, Elpida Phithak, Francisca Beato, Marc Appis, Edgar Louis Milford, Johan Pratschke, Igor Sauer, Anja Kuehl, Arndt Vogel, Michael Goodyear, Linda Hammerich, Frank Tacke, Johanna Faith Haas, Tobias Mueller, Nalan Utku
Summary: IR1 cells are a subset of T regulatory cells that have immune suppressive functions and can inhibit proliferation in mixed lymphocyte reactions. They deliver regulatory signals by binding to their ligand, HLA-DR alpha 2, and have the potential to modulate immune dysregulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Mathematics, Applied
Peng Feng, Menaka Navaratna
Summary: Regulatory T cells play a crucial role in immunotherapy, with their ratio to effector T cells impacting the prognosis of many cancers. The tug of war between regulatory T cells and effector T cells for interleukin-2 influences the immune response against cancer. Mathematical modeling demonstrates that the initial ratio between regulatory T cells and effector T cells affects tumor recurrence time, and utilizing IL-2 effectively can potentially alter the outcome of immunotherapy.
COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION
(2021)
Review
Immunology
Bayley R. McRitchie, Billur Akkaya
Summary: The concept of cancer immunotherapy has made significant progress, but challenges related to the relationship between CD4(+) T cells and CD8(+) T cells and the immunosuppressive actions of Treg cells still require attention.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Prerana Muralidhara, Vanshika Sood, Vishnu Vinayak Ashok, Kushagra Bansal
Summary: Immunological tolerance is critical during pregnancy to protect the semi-allogeneic fetus from immune responses. Regulatory T cells (Tregs) accumulate at the placenta in the uterus during pregnancy and confer immunological tolerance at the maternal-fetal interface. Tregs play a role in supporting proper growth of the embryo during pregnancy and their dysfunction is associated with pregnancy-related complications. Tregs also have a similar role in tumor immunity by creating a tolerogenic system.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Can Lin, Jihua Guo, Rong Jia
Summary: Treg-EVs, derived from regulatory T cells, serve as a novel cell-contact independent inhibitory mechanism by delivering specific biological molecules to target cells and modulating immune responses. They are associated with various human diseases and possess potential applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Kota Itahashi, Takuma Irie, Junichiro Yuda, Shogo Kumagai, Tokiyoshi Tanegashima, Yi-Tzu Lin, Sho Watanabe, Yasushi Goto, Jun Suzuki, Keiju Aokage, Masahiro Tsuboi, Yosuke Minami, Genichiro Ishii, Yuichiro Ohe, Wataru Ise, Tomohiro Kurosaki, Yutaka Suzuki, Shohei Koyama, Hiroyoshi Nishikawa
Summary: Research has shown that Treg cells in the TME undergo a distinct open chromatin profile, with key transcription factors including BATF, IRF4, NF-κB, and NR4A, among which BATF serves as a crucial regulator influencing the differentiation and activation of Treg cells in the TME through epigenetic control of activation-associated gene expression. BATF deficiency may inhibit tumor growth, and high levels of BATF expression are associated with poor prognosis.
SCIENCE IMMUNOLOGY
(2022)
Review
Psychiatry
Dominique Endres, Thomas A. Pollak, Karl Bechter, Dominik Denzel, Karoline Pitsch, Kathrin Nickel, Kimon Runge, Benjamin Pankratz, David Klatzmann, Ryad Tamouza, Luc Mallet, Marion Leboyer, Harald Pruess, Ulrich Voderholzer, Janet L. Cunningham, Katharina Domschke, Ludger Tebartz van Elst, Miriam A. Schiele
Summary: This conceptual review paper summarizes the clinical manifestations, pathophysiological considerations, diagnostic investigations, and treatment approaches of immune-related secondary OCD. The novel concept of autoimmune OCD is proposed for a small subgroup of OCD patients, and clinical signs based on the PANDAS/PANS criteria and from recent experience with autoimmune encephalitis and autoimmune psychosis are suggested. Red flag signs for autoimmune OCD include (sub)acute onset, unusual age of onset, atypical presentation of OCS with neuropsychiatric features or accompanying neurological symptoms, autonomic dysfunction, treatment resistance, associations of symptom onset with infections such as group A streptococcus, comorbid autoimmune diseases or malignancies. Clinical investigations may also reveal alterations such as increased levels of anti-basal ganglia or dopamine receptor antibodies or inflammatory changes in the basal ganglia in neuroimaging. Based on these red flag signs, the criteria for a possible, probable, and definite autoimmune OCD subtype are proposed.
TRANSLATIONAL PSYCHIATRY
(2022)
Review
Rheumatology
Marie Binvignat, Valentina Pedoia, Atul J. Butte, Karine Louati, David Klatzmann, Francis Berenbaum, Encarnita Mariotti-Ferrandiz, Jeremie Sellam
Summary: This systematic literature review provides a comprehensive overview of the use of machine learning in the clinical care of osteoarthritis. The review identifies the characteristics and results of relevant studies. It reveals that machine learning has been applied in various aspects of osteoarthritis, such as diagnosis, prediction, phenotyping, severity, and progression. Deep learning and imaging analysis are commonly used methods. However, there are limitations in terms of external validation and data availability.
Article
Immunology
Valerie Pourcher, Lisa Belin, Cathia Soulie, Michelle Rosenzwajg, Stephane Marot, Karine Lacombe, Nadia Valin, Gilles Pialoux, Ruxandra Calin, Christia Palacios, Isabelle Malet, Karen Zafilaza, Roland Tubiana, Marc-Antoine Valantin, David Klatzmann, Vincent Calvez, Noemie Simon-Tillaux, Anne-Genevieve Marcelin
Summary: This study assessed the humoral responses to the SARS-CoV-2 Delta-variant in people with HIV after BNT162b2 vaccination. The results showed high seroconversion rates and comparable neutralization rates against the Delta variant as compared to the D61G strain.
Article
Rheumatology
Jens Y. Humrich, Patrice Cacoub, Michelle Rosenzwajg, Fabien Pitoiset, Hang Phuong Pham, Joel Guidoux, David Leroux, Thomas Vazquez, Gabriela Riemekasten, Josef S. Smolen, George Tsokos, David Klatzmann
Summary: Low-dose IL-2 therapy shows efficacy in patients with moderate-to-severe active systemic lupus erythematosus (SLE), but further research is needed.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Meeting Abstract
Rheumatology
M. Binvignat, V. Pedoia, A. Butte, K. Louati, D. Klatzmann, F. Berenbaum, E. Mariotti-Ferrandiz, J. Sellam
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Marie Binvignat, Gabriel Pires, Nicolas Tchitchek, Felicie Costantino, Alice Courties, David Klatzmann, Atul J. Butte, Bernard Combe, Maxime Dougados, Pascal Richette, Encarnita Mariotti-Ferrandiz, Francis Berenbaum, Jeremie Sellam
Summary: This study aimed to classify phenotypes in hand osteoarthritis (HOA) based on cardinal symptoms. Using the Australian/Canadian Osteoarthritis Hand Index (AUSCAN) subscores and visual analog scale, a hierarchical agglomerative clustering analysis was performed on data from the Digital Cohort Design (DIGICOD). Five clusters were identified, indicating different levels of symptoms and associations with joint destruction and physical/psychological burden.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Oncology
Matteo Ponzo, Anais Debesset, Melissande Cossutta, Mounira Chalabi-Dchar, Claire Houppe, Caroline Pilon, Alba Nicolas-Boluda, Sylvain Meunier, Fabio Raineri, Allan Thiolat, Remy Nicolle, Federica Maione, Serena Brundu, Carina Florina Cojocaru, Philippe Bouvet, Corinne Bousquet, Florence Gazeau, Christophe Tournigand, Jose Courty, Enrico Giraudo, Jose L. Cohen, Ilaria Cascone
Summary: This study explores the effects of a selective inhibitor of nucleolin (NCL) on the immune microenvironment of pancreatic ductal adenocarcinoma (PDAC), and highlights a new therapeutic strategy to restrain immunosuppressive cells, promote T-cell recruitment and activation, and re-program the tumor stroma of PDAC.
Article
Cardiac & Cardiovascular Systems
Murilo Delgobo, Emil Weiss, DiyaaElDin, Ashour Leon Richter, Lisa Popiolkowski, Panagiota Arampatzi, Verena Stangl, Paula Arias-Loza, Encarnita Mariotti-Ferrandiz, Peter P. Rainer, Antoine-Emmanuel Saliba, Burkhard Ludewig, Ulrich Hofmann, Stefan Frantz, Gustavo Campos Ramos
Summary: In this study, the researchers investigated how antigen-specific T-helper cells differentiate in the myocardial environment. They used a transgenic T cell receptor model and single-cell transcriptomics to study the cells in the murine infarcted myocardium. The results showed that these cells acquired a regulatory phenotype and influenced tissue repair.
CIRCULATION RESEARCH
(2023)
Article
Orthopedics
M. Binvignat, P. Emond, F. Mifsud, B. Miao, A. Courties, A. Lefevre, E. Maheu, M. D. Crema, D. Klatzmann, M. Kloppenburg, P. Richette, A. J. Butte, E. Mariotti-Ferrandiz, F. Berenbaum, H. Sokol, J. Sellam
Summary: The study investigates the relationship between Tryptophan metabolism and hand osteoarthritis (HOA), specifically focusing on the host and gut microbiota. Through the analysis of serum concentration of 20 Tryptophan metabolites, it was found that certain metabolites and metabolism pathways were associated with erosive HOA. Additionally, there were correlations between Tryptophan metabolite levels and HOA symptoms, particularly pain-related symptoms. The study highlights the role of low-grade inflammation and gut dysbiosis in HOA.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Biology
Valentin Quiniou, Pierre Barennes, Vanessa Mhanna, Paul Stys, Helene Vantomme, Zhicheng Zhou, Federica Martina, Nicolas Coatnoan, Michele Barbie, Hang-Phuong Pham, Beatrice Clemenceau, Henri Vie, Mikhail Shugay, Adrien Six, Barbara Brandao, Roberto Mallone, Encarnita Mariotti-Ferrandiz, David Klatzmann
Summary: T-cell receptors (TCRs) are generated through stochastic gene rearrangements, resulting in a wide range of sequences. The process of thymopoiesis selects a diverse repertoire of TCRs that can effectively recognize and respond to infectious agents. Human thymopoiesis releases a population of CD8(+) T cells harboring alpha/beta paired TCRs that have high generation probabilities, preferential usage of certain V and J genes, shared CDR3 sequences between individuals, and can bind and be activated by multiple unrelated viral peptides. These polyspecific T cells may serve as a first line of defense against infections before a more specific immune response is mounted.
Article
Rheumatology
Alexandre Le Joncour, Paul Regnier, Anna Maciejewski-Duval, Erwan Charles, Stephane Barete, Pierre Fouret, Michelle Rosenzwajg, David Klatzmann, Patrice Cacoub, David Saadoun
Summary: This study aimed to investigate the effect of phosphodiesterase 4 (PDE4) inhibition on neutrophil activation in Behcet's disease (BD). The results showed that surface markers, reactive oxygen species (ROS) production, and neutrophil extracellular traps (NETs) production were upregulated in BD patient neutrophils. Inhibition of PDE4 significantly reduced neutrophil surface activation markers, ROS production, NETosis, and genes and pathways related to innate immunity, intracellular signaling, and chemotaxis.
ARTHRITIS & RHEUMATOLOGY
(2023)
Meeting Abstract
Immunology
Aixin Yu, Alejandro Moro, Michelle Rosenzwajg, Nicolas Tchitchet, David Klatzmann, Thomas R. Malek
JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Orthopedics
M. Binvignat, G. Pires, N. Tchitchek, F. Costantino, A. Courties, D. Klatzmann, B. Combe, M. Dougados, P. Richette, E. Mariotti-Ferrandiz, F. Berenbaum, J. Sellam
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Critical Care Medicine
Antoine Monsel, Caroline Hauw-Berlemont, Miryam Mebarki, Nicholas Heming, Julien Mayaux, Otriv Nguekap Tchoumba, Jean-Luc Diehl, Alexandre Demoule, Djillali Annane, Clemence Marois, Sophie Demeret, Emmanuel Weiss, Guillaume Voiriot, Muriel Fartoukh, Jean-Michel Constantin, Bruno Megarbane, Gaetan Plantefeve, Stephanie Malard-Castagnet, Sonia Burrel, Michelle Rosenzwajg, Nicolas Tchitchek, Helene Boucher-Pillet, Guillaume Churlaud, Audrey Cras, Camille Maheux, Chloe Pezzana, Mamadou Hassimiou Diallo, Jacques Ropers, Philippe Menasche, Jerome Larghero
Summary: The efficacy of UC-MSCs in patients with SARS-CoV-2-induced ARDS was assessed in this study. The results showed no significant difference in respiratory indicators between the UC-MSCs and placebo groups. The repeated UC-MSCs infusions did not lead to any serious adverse events during treatment or thereafter.