Article
Medicine, General & Internal
Gonzalo Hijos-Mallada, Raul Velamazan, Raul Marti, Eduardo Chueca, Samantha Arechavaleta, Alberto Lue, Fernando Gomollon, Angel Lanas, Carlos Sostres
Summary: The study found that using a four-biomarker point-of-care test could effectively monitor the inflammatory activity in IBD patients, with fecal calprotectin showing the best sensitivity. Patients with negative results in all four biomarkers had a 100% negative predictive value, while those with all four biomarkers positive had a 100% positive predictive value of endoscopic inflammatory activity.
Article
Gastroenterology & Hepatology
Hirotaka Shimizu, Ryo Ebana, Takahiro Kudo, Takuro Sato, Tomoko Hara, Kenji Hosoi, Masaaki Usami, Masashi Yoshida, Ichiro Takeuchi, Hiroshi Nakase, Itaru Iwama, Katsuhiro Arai, Toshiaki Shimizu
Summary: Fecal calprotectin (FCP) and fecal immunochemical test (FIT) correlate well with endoscopic activity in pediatric patients with inflammatory bowel disease (IBD), and FCP is a superior marker for predicting mucosal healing (MH).
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lili He, Yinghua Sun, Xihong Hu, Qiong Yao
Summary: The meta-analysis indicates that MRE performs well in detecting IBD in pediatric patients. Only two studies used US, suggesting that additional research is needed to confirm the diagnostic performance of US for IBD in children.
EUROPEAN RADIOLOGY
(2022)
Article
Pediatrics
Manar Matar, Rachel Levi, Maya Zvuloni, Raanan Shamir, Amit Assa
Summary: This study aimed to assess the effect of anti-TNF alpha therapy on fecal calprotectin (FC) levels in children with inflammatory bowel disease (IBD). The results showed that the majority of patients achieved improvement in FC levels within a short period of time, but normalization of FC in responders required almost one year. The shorter the time from diagnosis to treatment, the faster the improvement in FC levels.
PEDIATRIC RESEARCH
(2023)
Review
Medicine, General & Internal
Jin-Tong Shi, Nuo Chen, Jia Xu, Hemant Goyal, Zhi-Qi Wu, Jie-Xin Zhang, Hua-Guo Xu
Summary: Fecal calprotectin (FC) levels are correlated with the disease activity of inflammatory bowel diseases (IBD), but its usefulness in predicting IBD relapse is yet to be determined. This study aimed to evaluate the efficacy of FC in predicting IBD relapse. A total of 24 prospective studies were included in the meta-analysis, and the optimal FC cut-off value was found to be 152 μg/g. The pooled sensitivity and specificity of FC were 0.720 (0.528 to 0.856) and 0.740 (0.618 to 0.834), respectively. FC is a valuable non-invasive and cost-effective biomarker for early prediction of IBD relapse, with an ideal threshold of 152 μg/g.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Benedicte Caron, Subrata Ghosh, Silvio Danese, Laurent Peyrin-Biroulet
Summary: Fecal urgency is a common and distressing symptom experienced by patients with inflammatory bowel disease, but there is a lack of standardized definition, pathophysiology, and therapeutic management. Medications such as loperamide, tricyclic antidepressants, and biofeedback therapy may be necessary when nonpharmacologic measures fail. However, medical management of fecal urgency is challenging due to limited data from randomized clinical trials.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Toer W. Stevens, Krisztina Gecse, Jerrold R. Turner, Gert de Hertogh, David T. Rubin, Geert R. D'Haens
Summary: A post hoc analysis of data from a phase 4 trial found that FC concentration can be used to discriminate patients with ongoing microscopic inflammation from patients with histologic remission even in patients with complete endoscopic healing of UC. The optimal cut-off concentration of FC is between 75 and 100 μg/g.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Medicine, General & Internal
Magdalena Stojek, Anna Jablonska, Krystian Adrych
Summary: The exact pathogenesis of inflammatory bowel disease is not fully understood, but it is believed to involve genetic predisposition, environmental triggers, and exaggerated immune responses. Current management strategies focus on correcting immune responses, with potential new treatments like FMT showing promising results.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Eleni Orfanoudaki, Ioannis Drygiannakis, Eirini Theodoraki, Kalliopi Foteinogiannopoulou, Aikaterini Mantaka, Ioannis E. Koutroubakis
Summary: The home-performed fecal calprotectin (FC) test has high compliance rates and performs better than other biomarkers in predicting endoscopic disease activity in IBD patients under maintenance treatment with adalimumab.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Medicine, General & Internal
Bahareh Sophia Khalilipour, Andrew S. Day, Kristin Kenrick, Michael Schultz, Kristina Aluzaite
Summary: This study found substantial diagnostic delays in pediatric patients with IBD and identified significant associations between longer total healthcare diagnostic delays and overall household income and higher self-reported barriers to accessing healthcare.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Xiaochen Zhang, Dai Ishikawa, Toshifumi Ohkusa, Shinji Fukuda, Akihito Nagahara
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the intestinal mucosa with a complex etiology. The altered gut microbiota in IBD patients is associated with dysbiosis, leading to disease. Fecal microbiota transplantation (FMT) has shown promising efficacy and safety in the treatment of IBD, but further optimization is needed for its implementation.
FRONTIERS IN MEDICINE
(2022)
Article
Gastroenterology & Hepatology
James P. Campbell, Claudia Zierold, Ashli M. Rode, Frank A. Blocki, Byron P. Vaughn
Summary: The automated LIAISON Calprotectin assay is an efficient method for distinguishing between inflammatory bowel disease and irritable bowel syndrome with high sensitivity.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Lidia Neamti, Tudor Drugan, Cristina Drugan, Ciprian Silaghi, Lidia Ciobanu, Alexandra Craciun
Summary: This study aimed to analyze the most commonly used biomarkers for patient monitoring and follow-up, both independently and as a group, in order to propose an improved activity score that accurately reflects the changes at the intestinal level, to reduce the number of colonoscopic interventions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Vickie Lacroix, Alexis Cassard, Emmanuel Mas, Frederick Barreau
Summary: Inflammatory bowel diseases (IBDs) such as Crohn's disease and ulcerative colitis are complex diseases involving gut microbiota dysbiosis. By incorporating the functional and integrative map of microbiota, researchers aim to develop personalized medicine and enhance the application of new diagnostic, prognostic, and therapeutic tools.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nutrition & Dietetics
Xue Guo, Chen Huang, Jing Xu, Haoming Xu, Le Liu, Hailan Zhao, Jiaqi Wang, Wenqi Huang, Wu Peng, Ye Chen, Yuqiang Nie, Yongjian Zhou, Youlian Zhou
Summary: Inflammatory bowel disease (IBD) is characterized by relapse and remission, making it challenging to diagnose and assess disease activity. Traditional biomarkers from plasma and stool lack specificity, while changes in gut microbiota are closely associated with IBD etiology and pathogenesis.
FRONTIERS IN NUTRITION
(2022)
Article
Gastroenterology & Hepatology
M. D. Coates, N. Seth, K. Clarke, H. Abdul-Baki, N. Mahoney, V Walter, M. D. Regueiro, C. Ramos-Rivers, I. E. Koutroubakis, K. Bielefeldt, D. G. Binion
DIGESTIVE DISEASES AND SCIENCES
(2020)
Review
Gastroenterology & Hepatology
Arie Levine, Jonathan M. Rhodes, James O. Lindsay, Maria T. Abreu, Michael A. Kamm, Peter R. Gibson, Christoph Gasche, Mark S. Silverberg, Uma Mahadevan, Rotem Sigall Boneh, Eyton Wine, Oriana M. Damas, Graeme Syme, Gina L. Trakman, Chu Kion Yao, Stefanie Stockhamer, Muhammad B. Hammami, Luis C. Garces, Gerhard Rogler, Ioannis E. Koutroubakis, Ashwin N. Ananthakrishnan, Liam McKeever, James D. Lewis
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Review
Medicine, Research & Experimental
Iain C. Macdougall, Josep Comin-Colet, Christian Breymann, Donat R. Spahn, Ioannis E. Koutroubakis
ADVANCES IN THERAPY
(2020)
Review
Peripheral Vascular Disease
Luca Zanoli, Dimitri P. Mikhailidis, Rosa Maria Bruno, Maria T. Abreu, Silvio Danese, Rami Eliakim, Paolo Gionchetti, Konstantinos H. Katsanos, Julien Kirchgesner, Ioannis E. Koutroubakis, Torsten Kucharzik, Peter L. Lakatos, Geoffrey C. Nguyen, Alfredo Papa, Stephan R. Vavricka, Ian B. Wilkinson, Pierre Boutouyrie
Article
Nutrition & Dietetics
Michael Kurin, Alyce Anderson, Claudia Ramos Rivers, Filippos Koutroumpakis, Patricia Centa, Juliette Bender-Heine, Gina Kozak, Elisabeth Kramer, Stephen J. O'Keefe, David C. Whitcomb, David J. Levinthal, Ioannis E. Koutroubakis, Michael A. Dunn, Jana G. Hashash, David G. Binion
Summary: This study investigated the characteristics of IBD patients requiring long-term home parenteral nutrition support. It found that these patients often had a history of smoking, narcotic use, and IBD-related surgeries, and their healthcare charges were significantly higher than control IBD patients.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Eirini Theodoraki, Eleni Orfanoudaki, Kalliopi Foteinogiannopoulou, Nikolaos-Panagiotis Andreou, Maria Gazouli, Ioannis E. Koutroubakis
Summary: This study investigated the association of serum antinuclear antibodies (ANA) with infliximab (IFX) and adalimumab (ADA) trough levels (TLs) and anti-drug antibodies in patients with inflammatory bowel disease (IBD) receiving IFX or ADA therapy. The results showed that ANA positivity was associated with lower TLs in IBD patients receiving anti-TNF therapy, but no significant association was found with the development of cutaneous or rheumatological manifestations.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)
Article
Gastroenterology & Hepatology
Eirini Theodoraki, Eleni Orfanoudaki, Kalliopi Foteinogiannopoulou, Evangelia Legaki, Maria Gazouli, Ioannis E. Koutroubakis
Summary: The study investigated the association of infliximab trough levels with adverse events in Greek IBD patients receiving maintenance treatment. The results showed that there was no significant correlation between IFX-TLs and the development of adverse events.
INTESTINAL RESEARCH
(2021)
Meeting Abstract
Gastroenterology & Hepatology
Eleni Orfanoudaki, Maria Gazouli, Kalliopi Foteinogiannopoulou, Eirini Theodoraki, Evangelia Legaki, Ioannis E. Koutroubakis
Meeting Abstract
Gastroenterology & Hepatology
Debbie F. Cheng, Claudia Ramos Rivers, Filippos Koutroumpakis, Ioannis E. Koutroubakis, Hashash Jana, Michael A. Dunn, Marc Schwartz, Arthur Barrie, Jeffrey Dueker, Siobhan Proksell, Elyse Johnston, David G. Binion
Meeting Abstract
Gastroenterology & Hepatology
Nicole A. Doria, Claudia Ramos Rivers, Maaz Ahsan, Filippos Koutroumpakis, Hashash Jana, Jeffrey Dueker, Siobhan Proksell, Elyse Johnston, Marc Schwartz, Arthur Barrie, Janet Harrison, Dmitriy Babichenko, Gong Tang, Michael A. Dunn, Ioannis Koutroubakis, David G. Binion
Meeting Abstract
Gastroenterology & Hepatology
Maaz Ahsan, Filippos Koutroumpakis, Claudia Ramos Rivers, Elyse Johnston, Siobhan Proksell, Jeffrey Dueker, Michael J. Kingsley, Marc Schwartz, Hashash Jana, Stephen J. O'Keefe, Ioannis E. Koutroubakis, Gong Tang, David G. Binion
Meeting Abstract
Gastroenterology & Hepatology
Maaz Ahsan, Filippos Koutroumpakis, Claudia Ramos Rivers, Gong Tang, Elyse Johnston, Siobhan Proksell, Jeffrey Dueker, Marc Schwartz, Stephen J. O'Keefe, Hashash Jana, Ioannis E. Koutroubakis, David G. Binion
Meeting Abstract
Gastroenterology & Hepatology
Maaz Ahsan, Filippos Koutroumpakis, Claudia Ramos Rivers, Eva Szigethy, David J. Levinthal, Siobhan Proksell, Jeffrey Dueker, Elyse Johnston, Hashash Jana, Marc Schwartz, Michael J. Kingsley, Stephen J. O'Keefe, Ioannis E. Koutroubakis, Arthur Barrie, David G. Binion
Meeting Abstract
Gastroenterology & Hepatology
Maaz Ahsan, Filippos Koutroumpakis, Claudia Ramos Rivers, Gong Tang, Elyse Johnston, Siobhan Proksell, Jeffrey Dueker, Marc Schwartz, Stephen J. O'Keefe, Hashash Jana, Ioannis E. Koutroubakis, David G. Binion
Meeting Abstract
Gastroenterology & Hepatology
K. Karmiris, K. Fotinogiannopoulou, M. Velegraki, E. Koureta, G. Axiaris, C. Kateri, G. Kokkotis, C. Kapizioni, P. Markopoulos, A. Katsoula, A. Gklavas, I. Papaconstantinou, O. Giouleme, E. Tsironi, G. Michalopoulos, G. Bamias, V. Papadopoulos, A. Kapsoritakis, E. Zampeli, S. Michopoulos, P. Karatzas, G. Papatheodoridis, A. Theodoropoulou, I. E. Koutroubakis
JOURNAL OF CROHNS & COLITIS
(2020)