Journal
JOURNAL OF CLINICAL MEDICINE
Volume 10, Issue 18, Pages -Publisher
MDPI
DOI: 10.3390/jcm10184055
Keywords
fecal microbiota transplantation; inflammatory bowel disease; ulcerative colitis; Crohn's disease
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The exact pathogenesis of inflammatory bowel disease is not fully understood, but it is believed to involve genetic predisposition, environmental triggers, and exaggerated immune responses. Current management strategies focus on correcting immune responses, with potential new treatments like FMT showing promising results.
The exact pathogenesis of inflammatory bowel disease (IBD) is still not completely understood. It is hypothesized that a genetic predisposition leads to an exaggerated immune response to an environmental trigger, leading to uncontrolled inflammation. As there is no known causative treatment, current management strategies for inflammatory bowel disease focus on correcting the excessive immune response to environmental (including microbial) triggers. In recent years, there has been growing interest in new avenues of treatment, including targeting the microbial environment itself. Fecal microbiota transplantation (FMT) is a novel treatment modality showing promising results in early studies. The article discusses the rationale for the use of FMT in inflammatory bowel disease and the yet-unresolved questions surrounding its optimal use in practice.
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