Article
Gastroenterology & Hepatology
M. C. Mommersteeg, I Simovic, B. Yu, S. A. van Nieuwenburg, I. M. J. Bruno, M. Doukas, E. J. Kuipers, M. C. W. Spaander, M. P. Peppelenbosch, N. Castano-Rodriguez, G. M. Fuhler
Summary: The SNP in the ATG16L1 gene is associated with increased intestinal endoplasmic reticulum stress and progression of gastric cancer induced by H. pylori. Individuals with the G-allele are more prone to developing gastric cancer.
Article
Gastroenterology & Hepatology
Lusheng Song, Minkyo Song, Charles S. Rabkin, Yunro Chung, Stacy Williams, Javier Torres, Alejandro H. Corvalan, Robinson Gonzalez, Enrique Bellolio, Mahasish Shome, Joshua LaBaer, Ji Qiu, M. Constanza Camargo
Summary: Our study provides a comprehensive assessment of anti-H. pylori antibody profiles in gastric intestinal metaplasia (IM). The identified novel antibodies against target antigens, in addition to CagA, may play a role in the progression of IM. Specific H. pylori antibodies, along with other biomarkers, can help identify IM patients for surveillance.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Yongqiang Liang, Yuanhai Yang, Ruiheng Nong, Hao Huang, Xiuyun Chen, Ying Deng, Zhicong Huang, Jingyao Huang, Chunsheng Cheng, Mingzhu Ji, Yinggang Chen, Fulan Hu
Summary: H. pylori eradication significantly improves atrophic gastritis (AG) and intestinal metaplasia (IM) at an early stage. Various factors such as study design, lesion sites, regions, and follow-up time are important in determining this association.
Article
Oncology
Ting Wang, Safwat Girgis, Hsiu-Ju Chang, Ali Assi, Katharine Fagan-Garcia, Taylor Cromarty, Rachel J. Munday, Karen Goodman, Sander Veldhuyzen van Zanten, (the CANHelp Working Group)
Summary: Community-driven projects in the Northwest Territories (NT) and Yukon (YT), Canada have explored the health impacts of Helicobacter pylori (Hp) infection in Indigenous communities. These projects aim to address community concerns about the frequent diagnosis of Hp infection and its link to gastric cancer deaths, which are perceived to be alarmingly common in the region. Previous results showed a high prevalence of stomach pathologies associated with increased cancer risk among Hp-positive participants. This follow-up study found that successful treatment to eliminate Hp infection has the potential to reduce the risk of stomach cancer in participating communities.
Article
Cell Biology
Xinhua Liang, Wenjun Du, Ling Huang, Li Xiang, Wenxu Pan, Fangying Yang, Fengfeng Zheng, Yongwu Xie, Lanlan Geng, Sitang Gong, Wanfu Xu
Summary: This study found that Helicobacter pylori promotes gastric intestinal metaplasia through the kynurenine pathway of tryptophan metabolism, which activates CDX2 gene expression in gastric epithelial cells. Inhibition of kynurenine aminotransferase II (KAT2) activity can reverse the effect of H. pylori on CDX2 expression.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Medicine, General & Internal
Hideki Mori, Hidekazu Suzuki, Juntaro Matsuzaki, Kaori Kameyama, Koji Igarashi, Tatsuhiro Masaoka, Takanori Kanai
Summary: The present study investigated the usefulness of plasma ghrelin levels as a marker for gastric mucosal atrophy and as a risk stratification marker for gastric cancer, even after H. pylori eradication.
ANNALS OF MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Massimo Rugge, Ludovica Bricca, Stefano Guzzinati, Diana Sacchi, Marco Pizzi, Edoardo Savarino, Fabio Farinati, Manuel Zorzi, Matteo Fassan, Angelo Paolo Dei Tos, Peter Malfertheiner, Robert M. Genta, David Y. Graham
Summary: The study found that autoimmune gastritis (AIG) patients exhibit oxyntic-predominant-mononuclear inflammation, PPM (more than IM), and ECL-cell hyperplasia/neoplasia as histological hallmarks. Over a cumulative follow-up time of 10,541 person years, there was no excess risk of gastric or other malignancies found, except for a (marginally significant) risk of thyroid cancer.
Article
Microbiology
Cheol Min Shin, Nayoung Kim, Ji Hyun Park, Dong Ho Lee
Summary: Helicobacter pylori infection alters gastric microbiota profiles, with changes observed in the relative abundance of different bacterial taxa. Eradication of H. pylori does not always lead to restoration of a healthy gastric microbiota. Aging also plays a role in shaping the gastric microbiota, with differences in microbial diversity and abundance observed in individuals over time.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biology
Catalina Danila, Ioana Alexandra Cardos, Andrea Pop-Crisan, Felicia Marc, Anica Hoza, Razvan Chirla, Andrei Pascalau, Calin Magheru, Simona Cavalu
Summary: This study aimed to investigate the concordance between endoscopic and histopathological findings, focusing on premalignant lesions. The study found statistical associations between endoscopic appearance and histopathological results for atrophic antral gastritis, intestinal metaplasia of the antrum, gastric polyps, and gastric corpus cancer. Female patients were more likely to be diagnosed with gastric atrophy or intestinal metaplasia through endoscopy, while chronic atrophic gastritis in the corpus was more prevalent in patients older than 65. The study also revealed a low concordance of 21% between Giemsa stain and RUT, emphasizing the importance of combining rapid testing with endoscopic and histopathological diagnostic methods for more accurate early diagnosis and prevention of gastric cancer.
Article
Medicine, General & Internal
Junichi Uematsu, Mitsushige Sugimoto, Mariko Hamada, Eri Iwata, Ryota Niikura, Naoyoshi Nagata, Masakatsu Fukuzawa, Takao Itoi, Takashi Kawai
Summary: This study compared the efficacy of a new third-generation ultrathin endoscope and an older second-generation endoscope in detecting gastric atrophy and intestinal metaplasia. The results showed that NBI using the third-generation endoscope produced greater color differences for detecting atrophy, while there was no significant difference in detecting intestinal metaplasia between the two endoscopes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Masaaki Kodama, Tadayoshi Okimoto, Kazuhiro Mizukami, Yuka Hirashita, Yasuhiro Wada, Masahide Fukuda, Osamu Matsunari, Kazuhisa Okamoto, Ryo Ogawa, Kensuke Fukuda, Yoko Kudo, Yoshinari Kawahara, Kazunari Murakami
Summary: The study found that atrophy significantly improved after H. pylori eradication therapy, but IM did not show significant changes. Male patients had more severe IM before eradication. Careful follow-up based on sex differences in gastric mucosal characteristics is important after HPE.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Medicine, General & Internal
Irena Mladenova
Summary: Helicobacter pylori is a pathogenic bacterium that infects approximately 50% of the world population, playing a role in chronic gastritis, ulcers, and gastric cancer. Treatment should be based on local antibiotic use and resistance, while diagnostic methods depend on clinical indications.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Samaneh Saberi, Maryam Esmaeili, Mohammad Tashakoripour, Mahmoud Eshagh Hosseini, Hossein Baharvand, Marjan Mohammadi
Summary: This study evaluated the expression patterns of candidate genes induced by H. pylori infection and found that it caused regulatory changes in genes related to gastric-to-intestinal transdifferentiation. These changes included upregulation of self-renewal and pluripotency factors and aberrant expression of intestine-specific transcription factors, further promoting the process of transdifferentiation. These findings may contribute to a better understanding of the mechanism of gastric-to-intestinal transdifferentiation.
MICROBIAL PATHOGENESIS
(2022)
Article
Medicine, General & Internal
Lina Feng, Mingyu Zhang, Jialun Guan, Yu Zhang, Yujie Huang, Ruonan Dong, Kai Zhao, Suhong Xia, Fang Xiao, Jiazhi Liao
Summary: A retrospective study found that esophageal/duodenal xanthelasma may not be associated with upper gastrointestinal diseases, but gastric xanthelasma (GX) is related to atrophic gastritis, intestinal metaplasia, gastric cancer, and H.pylori infection, especially multiple GXs which may serve as easily detectable warning signs for these diseases.
FRONTIERS IN MEDICINE
(2023)
Letter
Gastroenterology & Hepatology
Endrit Shahini, Marcello Maida
Summary: There is still controversy surrounding the best surveillance strategies for high-risk patients following H. pylori eradication, indicating the need for further research to establish optimal and cost-effective monitoring strategies. Additionally, studies are required to refine risk stratification for patients with a high likelihood of gastric cancer evolution, taking into account racial, ethnic, immigration factors, and the development of new biomarkers for early diagnosis of malignancy.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)