Review
Medicine, General & Internal
Hiroki Kurumi, Kouichi Nonaka, Yuichiro Ikebuchi, Akira Yoshida, Koichiro Kawaguchi, Kazuo Yashima, Hajime Isomoto
Summary: The development of image-enhanced endoscopy, particularly narrow band imaging (NBI), has greatly improved the qualitative and quantitative diagnosis of gastrointestinal tumors. Various diagnostic algorithms based on NBI, such as vessel plus surface (VS) classification and magnifying endoscopy simple diagnostic algorithm for early gastric cancer (MESDA-G), have been proposed to aid in the diagnosis of early gastric cancer. Additionally, the usefulness of NBI in differentiating gastric cancer from gastritis, determining lesion extent, inferring histopathological type, and diagnosing depth has been investigated.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Yusuke Horiuchi, Toshiaki Hirasawa, Naoki Ishizuka, Hiroyuki Hatamori, Yohei Ikenoyama, Junki Tokura, Mitsuaki Ishioka, Yoshitaka Tokai, Ken Namikawa, Shoichi Yoshimizu, Akiyoshi Ishiyama, Toshiyuki Yoshio, Tomohiro Tsuchida, Junko Fujisaki
Summary: The study demonstrated that the diagnostic performance of endocytoscopy with narrow-band imaging was superior to magnifying endoscopy with narrow-band imaging in diagnosing gastric cancer. These results may potentially impact the choice of diagnostic techniques for gastric cancer.
Article
Gastroenterology & Hepatology
Naohiro Yoshida, Hisashi Doyama, Tomonori Yano, Takahiro Horimatsu, Noriya Uedo, Yoshinobu Yamamoto, Naomi Kakushima, Hiromitsu Kanzaki, Shinichiro Hori, Kenshi Yao, Ichiro Oda, Chikatoshi Katada, Chizu Yokoi, Ken Ohata, Kenichi Yoshimura, Hideki Ishikawa, Manabu Muto
Summary: This study conducted an open-label, randomized controlled trial in high-risk gastric cancer patients, finding that 2G-NBI did not increase the detection rate of early gastric cancer. Although there were differences in the positive predictive value of suspicious lesions between the WLI group and 2G-NBI group, overall sensitivity still needs improvement.
Article
Medicine, General & Internal
Masashi Kawamura, Tomoyuki Koike, Yohei Ogata, Ryotaro Matsumoto, Kota Yano, Takashi Hiratsuka, Hideaki Ohyama, Isao Sato, Kimiko Kayada, Suguo Suzuki, Satsuki Hiratsuka, Yumiko Watanabe
Summary: Magnifying and nonmagnifying image-enhanced endoscopy (IEE) show comparable effectiveness in diagnosing gastric intestinal metaplasia (IM). Nonmagnifying IEE demonstrates similar performance as magnifying IEE in evaluating light-blue crest (LBC), white opaque substance (WOS), and endoscopic grading of gastric IM (EGGIM). The presence of high EGGIM score is correlated with gastric cancer (GC) in patients.
Article
Gastroenterology & Hepatology
Hiroya Ueyama, Yusuke Kato, Yoichi Akazawa, Noboru Yatagai, Hiroyuki Komori, Tsutomu Takeda, Kohei Matsumoto, Kumiko Ueda, Kenshi Matsumoto, Mariko Hojo, Takashi Yao, Akihito Nagahara, Tomohiro Tada
Summary: A study developed an AI-assisted CNN-CAD system based on ME-NBI images for diagnosing early gastric cancer, showing a high diagnostic accuracy. All misdiagnosed images of early gastric cancer were of low-quality or superficially depressed and intestinal-type intramucosal cancers.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Maarten R. Struyvenberg, Albert J. de Groof, Joost van der Putten, Fons van der Sommen, Francisco Baldaque-Silva, Masami Omae, Roos Pouw, Raf Bisschops, Michael Vieth, Erik J. Schoon, Wouter L. Curvers, Peter H. de With, Jacques J. Bergman
Summary: The research demonstrated the feasibility of a deep-learning CAD system for tissue characterization of NBI zoom imagery in Barrett's esophagus, achieving promising diagnostic accuracy in predicting the presence/absence of Barrett's neoplasia.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Gastroenterology & Hepatology
Melissa Gruner, Angelique Denis, Claude Masliah, Morgane Amil, Elodie Metivier-Cesbron, Dominique Luet, Medhi Kaasis, Emmanuel Coron, Marc Le Rhun, Stephane Lecleire, Michel Antonietti, Jean-Louis Legoux, Laurent Lefrou, Pascal Renkes, Anne-Laure Tarreirias, Philippe Balian, Philippe Rey, Benedicte Prost, Christophe Cellier, Gabriel Rahmi, Elia Samaha, Serge Fratte, Beatrice Guerrier, Verena Landel, Sandrine Touzet, Thierry Ponchon, Mathieu Pioche
Summary: This study demonstrated that in current gastroenterology practice, NBI was more specific than Lugol for the detection of early SCC, suggesting that combined approaches with both NBI and Lugol could improve the detection of squamous neoplasia.
Review
Radiology, Nuclear Medicine & Medical Imaging
Qingya Yang, Zhimei Liu, Hui Sun, Fangdong Jiao, Bing Zhang, Jun Chen
Summary: With the development of endoscopic techniques, narrow-band imaging (NBI) has been widely used in the diagnosis of various types of diseases. Different classifications have been established to assist clinicians in disease diagnosis, mainly focusing on distinguishing benign and malignant tumors and detecting early neoplastic lesions. This review summarizes the current NBI classifications and calls for continuous updates and advancements in optical techniques for better clinical decision-making.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Gastroenterology & Hepatology
Jun-Hyung Cho, Seong Ran Jeon, So-Young Jin, Suyeon Park
Summary: This study compared the diagnostic performance of standard and M-NBI endoscopy for H. pylori gastritis and precancerous conditions. In 254 patients, M-NBI endoscopy showed slightly higher accuracy for diagnosing H. pylori gastritis and benign conditions compared to standard endoscopy.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Ivor B. Asztalos, Caitlin A. Colling, Anna M. Buchner, Vinay Chandrasekhara
Summary: This study aimed to reduce the need for biopsies of low-risk gastric polyps by devising an NBI classification. The results successfully differentiated high-risk from low-risk polyps with high accuracy, and need to be validated in a separate test population.
GASTROENTEROLOGY REPORT
(2021)
Review
Medicine, General & Internal
Andrej Wagner, Stephan Zandanell, Tobias Kiesslich, Daniel Neureiter, Eckhard Klieser, Josef Holzinger, Frieder Berr
Summary: Endoscopic characterization of gastrointestinal neoplasias using image-enhanced and magnification endoscopy shows diagnostic accuracy over 90%, but further prospective clinical studies are needed for validation in various types of neoplasms.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Shunsuke Okumura, Misa Goudo, Satoru Hiwa, Takeshi Yasuda, Hiroaki Kitae, Yuriko Yasuda, Akira Tomie, Tatsushi Omatsu, Hiroshi Ichikawa, Nobuaki Yagi, Tomoyuki Hiroyasu
Summary: An accurate demarcation line between cancerous lesions and background mucosa is important in magnifying narrow-band imaging (M-NBI)-based diagnosis. This study aimed to automatically determine the accurate demarcation line using a machine learning method. The proposed system can support the training of inexperienced doctors and enrich the knowledge of experienced doctors in endoscopy.
Article
Medicine, General & Internal
Gwang Ha Kim, Kiyoun Yi, Dong Chan Joo, Moon Won Lee, Hye Kyung Jeon, Bong Eun Lee
Summary: This study aimed to evaluate the magnifying endoscopy with narrow-band imaging (ME-NBI) findings of duodenal neuroendocrine tumors (NETs) and analyze the endosonographic and histopathologic features of these tumors. The characteristic ME-NBI features of duodenal NETs were regular microsurface and microvascular patterns and the presence of thickened subepithelial vessels. These features can assist in differentiating duodenal NETs from other subepithelial lesions of the duodenum.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Nazila Esmaeili, Nikolaos Davaris, Axel Boese, Alfredo Illanes, Nassir Navab, Michael Friebe, Christoph Arens
Summary: This study introduces the CE-NBI data set, the first publicly accessible data set that features enhanced and magnified visualization of subepithelial blood vessels within the vocal fold. The data set has proven invaluable for numerous clinical assessments geared toward diagnosing laryngeal cancer using Optical Biopsy and can address critical clinical challenges through machine learning methods.
Review
Oncology
Mary Raina Angeli Fujiyoshi, Haruhiro Inoue, Yusuke Fujiyoshi, Yohei Nishikawa, Akiko Toshimori, Yuto Shimamura, Mayo Tanabe, Haruo Ikeda, Manabu Onimaru
Summary: With advancements in endoscopic technologies, various classifications for early gastric cancer based on different endoscopic diagnostic modalities have been developed. This review provides an overview of these classifications and introduces novel classifications specifically designed for assessing and diagnosing gastric lesions.
Article
Oncology
Yusuke Horiuchi, Satoshi Ida, Noriko Yamamoto, Souya Nunobe, Naoki Ishizuka, Shoichi Yoshimizu, Akiyoshi Ishiyama, Toshiyuki Yoshio, Toshiaki Hirasawa, Tomohiro Tsuchida, Koshi Kumagai, Manabu Ohashi, Takeshi Sano, Junko Fujisaki
Article
Gastroenterology & Hepatology
Kenshi Yao, Noriya Uedo, Tomoari Kamada, Toshiaki Hirasawa, Takashi Nagahama, Shigetaka Yoshinaga, Masashi Oka, Kazuhiko Inoue, Katsuhiro Mabe, Takashi Yao, Masahiro Yoshida, Isao Miyashiro, Kazuma Fujimoto, Hisao Tajiri
DIGESTIVE ENDOSCOPY
(2020)
Article
Gastroenterology & Hepatology
Yohei Ikenoyama, Toshiaki Hirasawa, Mitsuaki Ishioka, Ken Namikawa, Shoichi Yoshimizu, Yusuke Horiuchi, Akiyoshi Ishiyama, Toshiyuki Yoshio, Tomohiro Tsuchida, Yoshinori Takeuchi, Satoki Shichijo, Naoyuki Katayama, Junko Fujisaki, Tomohiro Tada
Summary: By utilizing a large dataset of endoscopic images, this study found that a CNN had higher sensitivity in detecting early gastric cancer compared to endoscopists, and did so in a shorter amount of time.
DIGESTIVE ENDOSCOPY
(2021)
Article
Gastroenterology & Hepatology
Yusuke Horiuchi, Toshiaki Hirasawa, Naoki Ishizuka, Yoshitaka Tokai, Ken Namikawa, Shoichi Yoshimizu, Akiyoshi Ishiyama, Toshiyuki Yoshio, Tomohiro Tsuchida, Junko Fujisaki, Tomohiro Tada
GASTROINTESTINAL ENDOSCOPY
(2020)
Article
Multidisciplinary Sciences
Yusuke Horiuchi, Junko Fujisaki, Noriko Yamamoto, Naoki Ishizuka, Akiyoshi Ishiyama, Toshiyuki Yoshio, Toshiaki Hirasawa, Yorimasa Yamamoto, Masatsugu Nagahama, Hiroshi Takahashi, Tomohiro Tsuchida
SCIENTIFIC REPORTS
(2020)
Article
Gastroenterology & Hepatology
Toshiaki Hirasawa, Noriko Yamamoto, Takeshi Sano
Summary: Gastrectomy with lymphadenectomy is recommended for type 3 G-NETs based on lymph node metastasis risk. However, endoscopic resection for type 3 G-NETs <= 10 mm, confined to the mucosa or submucosa, with a grade of G1 showed excellent survival outcomes as an alternative treatment option despite the risk of LNM.
DIGESTIVE ENDOSCOPY
(2021)
Article
Gastroenterology & Hepatology
Ken Namikawa, Toshiaki Hirasawa, Kaoru Nakano, Yohei Ikenoyama, Mitsuaki Ishioka, Sho Shiroma, Yoshitaka Tokai, Shoichi Yoshimizu, Yusuke Horiuchi, Akiyoshi Ishiyama, Toshiyuki Yoshio, Tomohiro Tsuchida, Junko Fujisaki, Tomohiro Tada
Article
Gastroenterology & Hepatology
Mitsuaki Ishioka, Toshiyuki Yoshio, Yuji Miyamoto, Ken Namikawa, Yoshitaka Tokai, Shoichi Yoshimizu, Yusuke Horiuchi, Akiyoshi Ishiyama, Toshiaki Hirasawa, Tomohiro Tsuchida, Junko Fujisaki
Summary: This study investigated the incidence and characteristics of metachronous cancer after endoscopic submucosal dissection for undifferentiated-type gastric cancer, finding a correlation between Helicobacter pylori infection and metachronous cancer development. The curative resection rate after ESD for undifferentiated-type cancer was significantly lower. Surveillance should be conducted more carefully after ESD for undifferentiated-type cancer, especially in H. pylori-infected patients.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Gastroenterology & Hepatology
Shoichi Yoshimizu, Hiroshi Kawachi, Yorimasa Yamamoto, Kaoru Nakano, Yusuke Horiuchi, Akiyoshi Ishiyama, Tomohiro Tsuchida, Toshiyuki Yoshio, Toshiaki Hirasawa, Hiromichi Ito, Junko Fujisaki
JOURNAL OF GASTROENTEROLOGY
(2020)
Review
Gastroenterology & Hepatology
Ken Namikawa, Toshiaki Hirasawa, Toshiyuki Yoshio, Junko Fujisaki, Tsuyoshi Ozawa, Soichiro Ishihara, Tomonori Aoki, Atsuo Yamada, Kazuhiko Koike, Hideo Suzuki, Tomohiro Tada
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2020)
Article
Oncology
Yusuke Horiuchi, Toshiaki Hirasawa, Naoki Ishizuka, Hiroyuki Hatamori, Yohei Ikenoyama, Junki Tokura, Mitsuaki Ishioka, Yoshitaka Tokai, Ken Namikawa, Shoichi Yoshimizu, Akiyoshi Ishiyama, Toshiyuki Yoshio, Tomohiro Tsuchida, Junko Fujisaki
Summary: The study demonstrated that the diagnostic performance of endocytoscopy with narrow-band imaging was superior to magnifying endoscopy with narrow-band imaging in diagnosing gastric cancer. These results may potentially impact the choice of diagnostic techniques for gastric cancer.
Article
Medicine, General & Internal
Chinatsu Yonekura, Takashi Sasaki, Takafumi Mie, Takeshi Okamoto, Tsuyoshi Takeda, Takaaki Furukawa, Yuto Yamada, Akiyoshi Kasuga, Masato Matsuyama, Masato Ozaka, Naoki Sasahira
Summary: Malignant afferent loop obstruction is a rare and challenging condition. Endoscopic transluminal treatment and self-expandable metal stent placement are both safe and effective options for patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Takafumi Mie, Takashi Sasaki, Tsuyoshi Takeda, Takeshi Okamoto, Tsuyoshi Hamada, Takahiro Ishitsuka, Manabu Yamada, Hiroki Nakagawa, Takaaki Furukawa, Akiyoshi Kasuga, Masato Matsuyama, Masato Ozaka, Naoki Sasahira
Summary: There is no established standard second-line chemotherapy for unresectable pancreatic cancer after modified FOLFIRINOX. The effectiveness and prognostic factors of gemcitabine plus nab-paclitaxel as second-line chemotherapy have been unclear. This study found that the median overall survival and progression-free survival of gemcitabine plus nab-paclitaxel as second-line treatment were 7.2 months and 3.6 months, respectively. Performance status, modified Glasgow prognostic score, and neutrophil-to-lymphocyte ratio were independent predictors of overall survival.
Article
Biochemistry & Molecular Biology
Haruki Inoue, Eriko Aimono, Akiyoshi Kasuga, Haruto Tanaka, Aika Iwasaki, Hideyuki Saya, Yoshimi Arima
Summary: Our mouse BTC models are suitable for studying BTC carcinogenesis and may contribute to the development of new therapeutic strategies. Analysis of images of mouse and human tumor tissues reveals similarities in tissue structure between the two, suggesting similarities in tumor characteristics independent of animal species. Additionally, our pixel-level clustering model can serve as a new diagnostic tool for BTC.
Article
Medicine, General & Internal
Manabu Yamada, Tsuyoshi Takeda, Takashi Sasaki, Takeshi Okamoto, Tsuyoshi Hamada, Takahiro Ishitsuka, Hiroki Nakagawa, Takafumi Mie, Takaaki Furukawa, Akiyoshi Kasuga, Masato Matsuyama, Masato Ozaka, Hideki Kobara, Tsutomu Masaki, Naoki Sasahira
Summary: This study evaluates the efficacy and safety of intraductal self-expandable metal stent (SEMS) placement in patients with unresectable distal malignant biliary obstruction. The results show that there is no significant difference in the recurrence rate, recurrence time, adverse events, and reintervention rates between SEMS placements above and across the papilla. Intraductal SEMS placement is not associated with a prolonged time to recurrence in this study.
JOURNAL OF CLINICAL MEDICINE
(2023)