Journal
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Volume 27, Issue 1, Pages 137-141Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1440-1746.2011.06835.x
Keywords
balloon-occluded transvenous obliteration; hepatic venous pressure gradient; liver function
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Funding
- Grants-in-Aid for Scientific Research [21591755] Funding Source: KAKEN
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Background and Aims: Balloon-occluded retrograde transvenous obliteration (B-RTO) is an effective treatment for gastric varices (GVx), as well as hepatic encephalopathy. The aim of this study was to examine the changes of the hepatic vein pressure gradient (HVPG) after B-RTO and determine the relation between the changes of HVPG and liver function. Patients and Methods: B-RTO was performed in 30 patients with GVx and hepatic encephalopathy. HVPG was measured in 19 of 30 patients both before and after B-RTO. Results: The B-RTO was successful in all patients. The GVx and hepatic encephalopathy were improved, and no recurrence or bleeding was observed within the follow-up period. The serum albumin and prothrombin activity were significantly Unproved 6 months after B-RTO in all patients. HVPG was elevated 44% above the baseline after B-RTO. Liver function significantly improved 6 months after B-RTO in patients whose HVPG increased >= 20% from baseline. Conclusion: An elevated HVPG after B-RTO is one aspect of the effect of liver function, and an HVPG increase of 20% from baseline is a predictive factor for obtaining an improvement of liver function.
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