Journal
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Volume 26, Issue 12, Pages 1740-1748Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1440-1746.2011.06805.x
Keywords
bile acid metabolism; biliary physiology; intestinal lipid and bile acid transport
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Funding
- National Institutes of Health [GM81363, GM54724, DK47987, CA68485, DK20593, DK58404, HD15052, DK59367, EY08126]
- Experimental Medicine (Department of Medicine, University of Western Ontario)
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Background and Aim: The major transporter responsible for bile acid uptake from the intestinal lumen is the apical sodium-dependent bile acid transporter (ASBT, SLC10A2). Analysis of the SLC10A2 gene has identified a variety of sequence variants including coding region single nucleotide polymorphisms (SNPs) that may influence bile acid homeostasis/intestinal function. In this study, we systematically characterized the effect of coding SNPs on SLC10A2 protein expression and bile acid transport activity.
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