Review
Biochemistry & Molecular Biology
Silvia Salvatori, Irene Marafini, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: H. pylori infection contributes to the onset and development of gastric cancer through the mechanisms of chronic inflammation and DNA damage to gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Han-Na Kim, Min-Jeong Kim, Jonathan. P. P. Jacobs, Hyo-Joon Yang
Summary: This study investigated the microbial changes and host inflammatory cytokine responses in H. pylori-negative gastric cancer patients. The results showed that the gastric mucosal microbiota in GC patients had reduced diversity and a different composition compared to controls. Lacticaseibacillus was enriched, while Haemophilus and Campylobacter were depleted in the cancer group. Furthermore, the combined abundance of these taxa correlated significantly with gastric mucosal IL1B expression.
Editorial Material
Microbiology
Agustina Taglialegna
Summary: In this study, Sharafutdinov et al. report the identification of a single nucleotide polymorphism in the gene encoding the HtrA protease of Helicobacter pylori that is linked to gastric cancer.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Oncology
Xiao-Yu Wang, Li-Li Wang, Shu-Zhen Liang, Chao Yang, Lin Xu, Meng-Chao Yu, Yi-Xuan Wang, Quan-Jiang Dong
Summary: This study evaluated the performance of a polygenic risk score (PRS) based on H. pylori SNPs in predicting the risk of gastric cancer. The PRS model showed good predictive power for gastric cancer risk. It also demonstrated good performance in predicting cancer risk for hpEurope strains.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Tomohiko Yasuda, Hyun Seok Lee, Su Youn Nam, Hiroto Katoh, Yuko Ishibashi, Somay Yamagata Murayama, Hidenori Matsui, Hiroki Masuda, Emiko Rimbara, Nobuyuki Sakurazawa, Hideyuki Suzuki, Hiroshi Yoshida, Yasuyuki Seto, Shumpei Ishikawa, Seong Woo Jeon, Masahiko Nakamura, Sachiyo Nomura
Summary: Genetic analysis and culturing techniques for gastric non-Helicobacter pylori Helicobacter (NHPH) are advancing, with NHPH reported to accompany certain gastric conditions. A study on Korean gastric cancer patients found a low percentage positive for NHPH, suggesting it may play a role in gastric cancer development, albeit with lower pathogenicity compared to H. pylori.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Yoshiaki Usui, Yukari Taniyama, Mikiko Endo, Yuriko N. Koyanagi, Yumiko Kasugai, Isao Oze, Hidemi Ito, Issei Imoto, Tsutomu Tanaka, Masahiro Tajika, Yasumasa Niwa, Yusuke Iwasaki, Tomomi Aoi, Nozomi Hakozaki, Sadaaki Takata, Kunihiko Suzuki, Chikashi Terao, Masanori Hatakeyama, Makoto Hirata, Kokichi Sugano, Teruhiko Yoshida, Yoichiro Kamatani, Hidewaki Nakagawa, Koichi Matsuda, Yoshinori Murakami, Amanda B. Spurdle, Keitaro Matsuo, Yukihide Momozawa
Summary: This study reveals that certain genetic variants associated with Helicobacter pylori infection can increase the risk of gastric cancer. Individuals carrying these genetic variants and infected with H. pylori have an even higher risk of developing gastric cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Biochemical Research Methods
Lusheng Song, Minkyo Song, Charles S. Rabkin, Stacy Williams, Yunro Chung, Jennifer Van Duine, Linda M. Liao, Kailash Karthikeyan, Weimin Gao, Jin G. Park, Yanyang Tang, Jolanta Lissowska, Ji Qiu, Joshua LaBaer, M. Constanza Camargo
Summary: This study evaluated humoral responses to a nearly complete H. pylori immunoproteome among GC cases and controls, finding higher prevalence of certain antibodies in controls and lower seroprevalence in GC cases, suggesting immune protection and potential changes in specific proteins.
JOURNAL OF PROTEOME RESEARCH
(2021)
Review
Microbiology
Victor E. Reyes
Summary: Helicobacter pylori infection is a major risk factor for gastric cancer and is associated with chronic inflammation and DNA damage. Understanding the mechanisms of H. pylori-induced carcinogenesis and immune evasion is crucial for preventing gastric cancer and reducing the burden of this disease.
Article
Gastroenterology & Hepatology
Suk Yee Lam, Michiel C. Mommersteeg, Bingting Yu, Linda Broer, Manon C. W. Spaander, Fabian Frost, Stefan Weiss, Henry Voelzke, Markus M. Lerch, Ben Schoettker, Yan Zhang, Hannah Stocker, Hermann Brenner, Daniel Levy, Shih-Jen Hwang, Alexis C. Wood, Stephen S. Rich, Jerome I. Rotter, Kent D. Taylor, Russell P. Tracy, Edmond K. Kabagambe, Marcis Leja, Janis Klovins, Raitis Peculis, Dace Rudzite, Liene Nikitina-Zake, Girts Skenders, Vita Rovite, Andre Uitterlinden, Ernst J. Kuipers, Gwenny M. Fuhler, Georg Homuth, Maikel P. Peppelenbosch
Summary: The association between anti-H pylori IgG titers and the TLR1/6/10 locus was not replicated across different populations, and the variation at this locus affected TLR1-mediated cytokine production and TLR1 surface expression on monocytes and neutrophils.
Review
Biotechnology & Applied Microbiology
Linqi Zhu, Yue Huang, Hong Li, Shihe Shao
Summary: Infection with Helicobacter pylori may promote the occurrence and progression of gastric cancer by influencing the tumor microenvironment (TME).
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Olga Sokolova, Michael Naumann
Summary: Gastric cancer is a major cause of cancer-related deaths globally, and its development is influenced by genetic predisposition, environmental factors, and Helicobacter pylori infection. Matrix metalloproteinases (MMPs) play an active role in the progression of gastric cancer, with bacterial dependence being less significant in later stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Surinder M. Soond, Andrey A. Zamyatnin
Summary: The relationship between pathogens and the increased risk of cancer has attracted significant attention, particularly the contribution of Helicobacter pylori infection to the risk of developing gastric cancer. Research is increasingly focusing on the mechanisms by which the microorganism affects host cells and the importance of the host immune system in disease progression.
Article
Oncology
Ken Namikawa, Norio Tanaka, Yuki Ota, Manabu Takamatsu, Mayuko Kosugi, Yoshitaka Tokai, Shoichi Yoshimizu, Yusuke Horiuchi, Akiyoshi Ishiyama, Toshiyuki Yoshio, Toshiaki Hirasawa, Sayuri Amino, Rie Furuya, Osamu Gotoh, Tomoko Kaneyasu, Izuma Nakayama, Yu Imamura, Tetsuo Noda, Junko Fujisaki, Seiichi Mori
Summary: This study compared the genomic differences between HP-exposed and HP-naive diffuse-type gastric cancer (DGC) and found that they develop along different molecular pathways. This finding provides a basis for early detection strategies in high incidence settings.
JOURNAL OF PATHOLOGY
(2022)
Article
Oncology
Qun Zhang, Ying Ni, Xiaofei Zhi, Jiwei Wang, Zheng Li, Jie Tang, Linjun Wang, Weizhi Wang, Zekuan Xu
Summary: In patients with gastric cancer infected with H. pylori, the expression of APRIL was upregulated and promoted the proliferation, migration, invasion, viability, and metastasis of GC cells through miR-145. Furthermore, APRIL induced gastric tumorigenicity by activating the NF-kappa B pathway. These findings lay the groundwork for a more in-depth analysis of APRIL in gastric cancer risk and prognosis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Chemistry, Analytical
Shan-Wen Hu, Xiao-Rong Zhang, Wan-Xin Li, Lan-Lan Chen, Wei Zhao, Jing-Juan Xu, Wei-Min Ye
Summary: This study designed an X-shaped DNA probe for specific hybridization with certain genotype DNA and developed a competitive reaction to amplify the thermodynamic difference between wild-type DNA and SNVs in H. pylori. Multiple SNVs were successfully identified and a paper strip for visual, fast screening of SNVs was fabricated. The approach was validated using clinical samples and demonstrated the potential for the prevention and cure of H. pylori infections through point-of-care testing diagnosis on saliva samples.
Article
Gastroenterology & Hepatology
Siew C. Ng, Gilaad G. Kaplan, Whitney Tang, Rupa Banerjee, Bhargavi Adigopula, Fox E. Underwood, Divine Tanyingoh, Shu-Chen Wei, Wei-Chen Lin, Hung-Hsin Lin, Jin Li, Sally Bell, Olga Niewiadomski, Michael A. Kamm, Zhirong Zeng, Minhu Chen, Pinjin Hu, David Ong, Choon Jin Ooi, Khoon-Lin Ling, Yinglei Miao, Jiarong Miao, H. Janaka de Silva, Madunil Niriella, Satimai Aniwan, Julajak Limsrivilai, Pises Pisespongsa, Kaichun Wu, Hong Yang, Ka Kei Ng, Hon Ho Yu, Yufang Wang, Qin Ouyang, Murdani Abdullah, Marcellus Simadibrata, Jeffri Gunawan, Ida Hilmi, Khean Lee Goh, Qian Cao, Hong Sheng, Arlinking Ong-Go, Vui Heng Chong, Jessica Y. L. Ching, Justin C. Y. Wu, Francis K. L. Chan, Joseph J. Y. Sung
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2019)
Article
Infectious Diseases
Ravishankar M. Ram, Xinsheng Teh, Tamayanthi Rajakumar, Khean Lee Goh, Alex Hwong Ruey Leow, Bee Hoon Poh, Vanitha Mariappan, Esaki M. Shankar, Mun Fai Loke, Jamuna Vadivelu
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2019)
Article
Gastroenterology & Hepatology
Wah-Kheong Chan, Sombat Treeprasertsuk, George Boon-Bee Goh, Jian-Gao Fan, Myeong Jun Song, Phunchai Charatcharoenwitthaya, Ajay Duseja, Yock-Young Dan, Kento Imajo, Atsushi Nakajima, Khek-Yu Ho, Khean-Lee Goh, Vincent Wai-Sun Wong
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2019)
Review
Gastroenterology & Hepatology
Choon Jin Ooi, Ida Hilmi, Rupa Banerjee, Sai Wei Chuah, Siew Chien Ng, Shu Chen Wei, Govind K. Makharia, Pises Pisespongsa, Min Hu Chen, Zhi Hua Ran, Byong Duk Ye, Dong Il Park, Khoon Lin Ling, David Ong, Vineet Ahuja, Khean Lee Goh, Jose Sollano, Wee Chian Lim, Wai Keung Leung, Raja Affendi Raja Ali, Deng Chyang Wu, Evan Ong, Nazri Mustaffa, Julajak Limsrivilai, Tadakazu Hisamatsu, Suk Kyun Yang, Qin Ouyang, Richard Geary, Janaka H. De Silva, Rungsun Rerknimitr, Marcellus Simadibrata, Murdani Abdullah, Rupert W. L. Leong
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2019)
Article
Gastroenterology & Hepatology
Yinglian Xiao, Shutian Zhang, Ning Dai, Guijun Fei, Khean-Lee Goh, Hoon Jai Chun, Bor-Shyang Sheu, Chui Fung Chong, Nobuo Funao, Wen Zhou, Minhu Chen
Article
Gastroenterology & Hepatology
Boon Pin Kee, Jin Guan Ng, Ching Ching Ng, Ida Hilmi, Khean Lee Goh, Kek Heng Chua
JOURNAL OF DIGESTIVE DISEASES
(2020)
Article
Immunology
Francesca Di Giallonardo, Angie N. Pinto, Phillip Keen, Ansari Shaik, Alex Carrera, Hanan Salem, Christine Selvey, Steven J. Nigro, Neil Fraser, Karen Price, Joanne Holden, Frederick J. Lee, Dominic E. Dwyer, Benjamin R. Bavinton, Jemma L. Geoghegan, Andrew E. Grulich, Anthony D. Kelleher
Summary: The study identified active and growing clusters of subtype B and CRF01_AE among men who have sex with men (MSM) as the driving force of the ongoing epidemic in New South Wales. The local transmission dynamics vary between the different subtypes, with CRF01_AE showing a more accelerated spread over time.
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2021)
Article
Infectious Diseases
P. G. Patel, P. Keen, H. McManus, T. Duck, D. Callander, C. Selvey, C. Power, R. T. Gray, V Knight, J. Asselin, P. Read, K. Johnson, B. R. Bavinton, V. J. Bowden, A. E. Grulich, R. Guy
Summary: In general, from 2010 to 2018, a total of 43,560 GBM attended participating clinics in New South Wales, Australia. There were increasing trends in testing uptake, testing frequency, and decreasing trend in HIV positivity among both Australian-born and overseas-born GBM. However, there were decreasing trends in the estimated undiagnosed HIV proportion overall and in Australian-born GBM, but an increasing trend in overseas-born GBM.
Article
Immunology
Robin Schaefer, Heather-Marie A. Schmidt, Giovanni Ravasi, Antons Mozalevskis, Bharat B. Rewari, Frank Lule, Kouadio Yeboue, Anne Brink, Nabeel Mangadan Konath, Mukta Sharma, Nicole Seguy, Joumana Hermez, Ahmed S. Alaama, Naoko Ishikawa, Boniface Dongmo Nguimfack, Daniel Low-Beer, Rachel Baggaley, Shona Dalal
Summary: The UN set a global target of 3 million PrEP users by 2020, but by the end of 2019, there were about 626,000 PrEP users globally. The forecast projects 0.9-1.1 million global PrEP users by the end of 2020 and 2.4-5.3 million by the end of 2023.
Editorial Material
Immunology
Heather-Marie Ann Schmidt, Michelle Rodolph, Robin Schaefer, Rachel Baggaley, Meg Doherty
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2022)
Review
Immunology
Lara Lorenzetti, Nhi Dinh, Ariane van der Straten, Virginia Fonner, Kathleen Ridgeway, Michelle Rodolph, Robin Schaefer, Heather-Marie A. Schmidt, Rachel Baggaley
Summary: This systematic review found that there is overall interest and preference for injectable PrEP as an HIV prevention option. However, preferences varied across different groups and regions, highlighting the importance of allowing individuals to choose the modality that suits their needs and preferences. Future research should focus on equitable implementation and support for individual decision-making.
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2023)
Editorial Material
Immunology
Mitchell Warren, Wawira Nyagah, Catherine Verde Hashim, Michelle Rodolph, Robin Schaefer, Heather-Marie A. Schmidt, Rachel Baggaley
Summary: Data from RCTs showed the efficacy of injectable cabotegravir (CAB) for HIV prevention, and it has been approved in several countries. However, implementation experience beyond RCTs is limited, and questions remain regarding delivery and inclusion of marginalized populations. A coordinated approach is needed to ensure timely and effective introduction of CAB in low- and middle-income countries.
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2023)
Meeting Abstract
Immunology
R. Schaefer, H-M A. Schmidt, G. Ravasi, A. Mozalevskis, B. B. Rewari, F. Lule, K. Yeboue, A. Brink, N. Mangadan Konath, M. Sharma, N. Seguy, J. Hermez, A. S. Alaama, N. Ishikawa, B. Dongmo Nguimfack, D. Low-Beer, R. Baggaley, S. Dalal
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2021)
Review
Medicine, Research & Experimental
Khean-Lee Goh
MALAYSIAN JOURNAL OF MEDICAL SCIENCES
(2019)
Review
Gastroenterology & Hepatology
Choon Jin Ooi, Ida Hilmi, Rupa Banerjee, Sai Wei Chuah, Siew Chien Ng, Shu Chen Wei, Govind K. Makharia, Pises Pisespongsa, Min Hu Chen, Zhi Hua Ran, Byong Duk Ye, Dong Il Park, Khoon Lin Ling, David Ong, Vineet Ahuja, Khean Lee Goh, Jose Sollano, Wee Chian Lim, Wai Keung Leung, Raja Affendi Raja Ali, Deng Chyang Wu, Evan Ong, Nazri Mustaffa, Julajak Limsrivilai, Tadakazu Hisamatsu, Suk Kyun Yang, Qin Ouyang, Richard Geary, Janaka H. De Silva, Rungsun Rerknimitr, Marcellus Simadibrata, Murdani Abdullah, Rupert W. L. Leong
INTESTINAL RESEARCH
(2019)
