Review
Medicine, General & Internal
Francisco Tustumi
Summary: This article discusses non-conventional treatments for achalasia, including cardiectomy, endoluminal substances injection, stents, and drugs. Currently available studies on non-conventional treatments lack high-quality evidence, and future randomized trials are still needed.
FRONTIERS IN MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Edoardo Vespa, Domenico A. Farina, Peter J. Kahrilas, Wenjun Kou, Eric E. Low, Rena Yadlapati, John E. Pandolfino, Dustin A. Carlson
Summary: This study found that patients with high PEP values on high-resolution manometry, high FLIP 60 mL pressures, and a spastic-reactive contractile response pattern on FLIP before treatment were more likely to experience post-treatment spasm. Evaluating these features may guide personalized patient management.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Afrin N. Kamal, Priya Kathpalia, Fouad Otaki, Albert J. Bredenoord, Donald O. Castell, John O. Clarke, Gary W. Falk, Ronnie Fass, C. Prakash Gyawali, Peter J. Kahrilas, Philip O. Katz, David A. Katzka, John E. Pandolfino, Roberto Penagini, Joel E. Richter, Sabine Roman, Edoardo Savarino, George Triadafilopoulos, Michael F. Vaezi, Marcelo F. Vela, David A. Leiman
Summary: By utilizing the RAND/UCLA Appropriateness Method, experts identified 12 quality indicators for achalasia patients, covering aspects such as patient education, diagnosis, and treatment options.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Dustin A. Carlson, Ikuo Hirano, Nirmala Gonsalves, Peter J. Kahrilas, Isis K. Araujo, Mira Yang, Marie-Pier Tetreault, John E. Pandolfino
Summary: Classifying the physiological and mechanical esophageal function in EoE based on FLIP panometry features may help define the severity of the disease and guide its management.
Article
Pediatrics
Daniel R. R. Duncan, Alexandra Cohen, Clare Golden, Margot Lurie, Paul D. D. Mitchell, Enju Liu, Tregony Simoneau, Rachel L. L. Rosen
Summary: This study evaluated gastrointestinal risk factors for bronchiectasis in children and found that enteral tubes and increased BAL neutrophil count were associated with increased risk, while neurologic comorbidities were associated with decreased risk.
PEDIATRIC PULMONOLOGY
(2023)
Article
Gastroenterology & Hepatology
Sourav Halder, John E. Pandolfino, Peter J. Kahrilas, Andree Koop, Jacob Schauer, Isis K. Araujo, Guy Elisha, Wenjun Kou, Neelesh A. Patankar, Dustin A. Carlson
Summary: This study aimed to evaluate novel FLIP metrics of contraction power and displaced volume in asymptomatic controls and a patient cohort. The results showed that these metrics effectively quantify peristaltic vigor and are correlated with the DCI metric on HRM.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Medicine, General & Internal
Amir Mari, Rami Sweis
Summary: Dysphagia can range from benign inconvenience to serious morbidity, requiring a detailed clinical assessment to identify underlying diseases. Treatment should be tailored according to the dysmotility phenotype and patient characteristics.
Article
Gastroenterology & Hepatology
Dustin A. Carlson, Wenjun Kou, Katharine P. Rooney, Alexandra J. Baumann, Erica Donnan, Joseph R. Triggs, Ezra N. Teitelbaum, Amy Holmstrom, Eric Hungness, Sajiv Sethi, Peter J. Kahrilas, John E. Pandolfino
Summary: Using FLIP panometry and machine learning, a model was developed to predict and classify achalasia subtypes on HRM. The model can differentiate type III achalasia from non-spastic achalasia, with potential for clinical application.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Alain J. Benitez, Stephen Budhu, Cassandra Burger, Rossella Turco, Lance Ballester, Amit Shah, Kristle Lynch, Kristin Fiorino, Calies Menard-Katcher, Amanda B. Muir, Petar Mamula
Summary: This study evaluated the use of FLIP in pediatric patients with achalasia undergoing dilations and compared to non-achalasia controls. It found that EGJ-DI in treatment-naive patients was significantly lower compared to controls, but increased significantly after balloon dilations, along with improvements in Eckardt scores. The results confirmed the therapeutic value of dilations in managing achalasia.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Medicine, General & Internal
Davide Bertoli, Esben Bolvig Mark, Donghua Liao, Tina Okdahl, Serena Nauser, Louise Hostrup Daugberg, Christina Brock, Birgitte Brock, Filip Krag Knop, Klaus Krogh, Jens Brondum Frokjaer, Asbjorn Mohr Drewes
Summary: In this study, we evaluated the structural and functional GI parameters in diabetic patients and healthy controls using multi-segmental magnetic resonance imaging (MRI). We observed differences in stomach, small bowel, and colon volumes, as well as an adynamic small bowel in patients with diabetes and GI symptoms. Associations between recorded parameters and perceived symptoms were also explored. The findings suggest that MRI can be a useful tool for studying diabetes-induced GI symptoms.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Jhony Willams Gusmao-Nascimento, Daniela Maione Nunes Cruz, Loyane Almeida Gama, Wellington David Luz Alves, Mariana Pirani Rocha Machado, Luciana Aparecida Cora, Madileine Francely Americo
Summary: The study found that Liraglutide can improve metabolic and gastrointestinal parameters in obese rats, reduce fat accumulation, and regulate inflammatory signaling in duodenal tissue. The therapeutic effects of Liraglutide are dose-dependent and are mainly driven by its action on slowing gastric motility in the gastrointestinal tract.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Surgery
Turyalai Hakimi, Ramazan Karimi
Summary: Esophageal achalasia is a rare motility disorder in children that can pose significant health challenges if left untreated. Misdiagnosis and mistreatment can delay proper treatment and lead to years of symptomatic management. Early evaluation and treatment can prevent malnutrition in undiagnosed patients.
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2022)
Article
Gastroenterology & Hepatology
Margaret J. Zhou, Afrin Kamal, Daniel E. Freedberg, David Markowitz, John O. Clarke, Daniela Jodorkovsky
Summary: An analysis of patients diagnosed with achalasia revealed a significant increase in the prevalence of type II achalasia and a decrease in type I cases. However, there were no apparent correlations between age or gender and these differences. The findings suggest that advancements in diagnostic techniques and increased awareness of the disease may be contributing factors to the changing epidemiology.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Emily Romanoff, Justin Zhuo, Annsa C. Huang, Deron Amador, Fouad Otaki, Afrin N. Kamal, Priya Kathpalia, David A. Leiman
Summary: This study aimed to determine adherence to established quality indicators for achalasia management. Through a retrospective multicenter evaluation, it was found that there is incomplete adherence to quality indicators in the diagnosis and treatment of achalasia, particularly in patient education.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Review
Nutrition & Dietetics
Julianna Martinez, K. Marco Rodriguez Hovnanian, Enid E. Martinez
Summary: Assessing biomarkers and functional assays for gastrointestinal dysfunction is crucial in providing optimal enteral nutrition therapy for critically ill patients.
Article
Gastroenterology & Hepatology
Youn Choi, Kyoung Oh Kim, Jun-Won Chung, Kwang An Kwon, Yoon Jae Kim, Jung Ho Kim, Dong Kyun Park
Summary: The study found that the Bamk-001 automatic abdominal massage device significantly improved symptom profiles and colon transit time in patients with chronic constipation. Patients' overall symptoms were alleviated with no serious adverse events reported. Using an automatic abdominal massage device as an adjunct treatment for slow-transit constipation patients may be a potentially beneficial intervention.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Otorhinolaryngology
Bo Gyeong Kim, Joo-Hyun Jung, Mi-Jung Kim, Eun Hyue Moon, Jae-Hwan Oh, Jung-Woo Park, Heung-Eog Cha, Ju-Hyun Kim, Yoon-Jae Kim, Jun-Won Chung, Ki-Baik Hahm, Hong-Ryul Jin, Yong-Ju Jang, Sung Wan Kim, Seung-Kyu Chung, Dae-Woo Kim, Young Jae Lee, Seon-Tae Kim
Summary: Hereditary hemorrhagic telangiectasia (HHT) is a vascular disorder caused by mutations in ACVRL1 and ENG genes, with pathogenic variants found in half of Korean HHT patients. Clinical diagnosis of definite HHT was only achieved in approximately half of patients, highlighting the importance of genetic screening for confirmation.
CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
(2021)
Article
Gastroenterology & Hepatology
Bong Eun Lee, Joon Sung Kim, Byung-Wook Kim, Jie-Hyun Kim, Jin Il Kim, Jun-Won Chung, Seong Woo Jeon, Jeong Hoon Lee, Ji Hyun Kim, Nayoung Kim, Ju Yup Lee, Seung Young Seo, Seon-Young Park, Sung Eun Kim, Moon Kyung Joo, Hyun Joo Song, Ki Bae Kim, Chang Seok Bang, Hyun Jin Kim
Summary: Concomitant therapy has consistently shown higher eradication rates for first-line H. pylori eradication, with an increasing trend over the past 10 years in Korea. Bismuth quadruple therapy should be considered for second-line therapy after initial eradication failure.
Review
Gastroenterology & Hepatology
Hong Jun Park, Byung-Wook Kim, Jun Kyu Lee, Yehyun Park, Jin Myung Park, Jun Yong Bae, Seung Young Seo, Jae Min Lee, Jee Hyun Lee, Hyung Ku Chon, Jun-Won Chung, Hyun Ho Choi, Myung Ha Kim, Dong Ah Park, Jae Hung Jung, Joo Young Cho
Summary: Sedation can alleviate anxiety and fear in patients undergoing endoscopy, but it is also associated with cardiopulmonary complications. The first Korean clinical practice guideline for endoscopic sedation has been developed to reduce complications.
CLINICAL ENDOSCOPY
(2022)
Review
Gastroenterology & Hepatology
Hong Jun Park, Byung-Wook Kim, Jun Kyu Lee, Yehyun Park, Jin Myung Park, Jun Yong Bae, Seung Young Seo, Jae Min Lee, Jee Hyun Lee, Hyung Ku Chon, Jun-Won Chung, Hyun Ho Choi, Myung Ha Kim, Dong Ah Park, Jae Hung Jung, Joo Young Cho
Summary: Sedation can help alleviate anxiety and fear in patients undergoing endoscopy, but it may also lead to cardiopulmonary complications. Screening high-risk patients before sedation and meticulous monitoring are crucial for reducing complications. The first Korean clinical practice guideline for endoscopic sedation provides healthcare professionals with guidance on how to perform endoscopy with minimal risk.
Review
Gastroenterology & Hepatology
Hong Jun Park, Byung-Wook Kim, Jun Kyu Lee, Yehyun Park, Jin Myung Park, Jun Yong Bae, Seung Young Seo, Jae Min Lee, Jee Hyun Lee, Hyung Ku Chon, Jun-Won Chung, Hyun Ho Choi, Myung Ha Kim, Dong Ah Park, Jae Hung Jung, Joo Young Cho
Summary: Sedation is effective in reducing anxiety and fear during endoscopy, but it carries the risk of cardiopulmonary complications. It is important to screen patients before sedation and closely monitor them to minimize complications.
KOREAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Chemistry, Analytical
Kicheol Yoon, Kwang Gi Kim, Jun-Won Chung, Won Suk Lee
Summary: Locating tumors during laparoscopic surgery is challenging. This study introduces a clip and detector system that can locate tumors in the stomach and colon. Animal experiments showed that the system had shorter detection times compared to previous studies, indicating potential increase in demand for laparoscopic surgery and endoscopes.
Article
Chemistry, Multidisciplinary
Kicheol Yoon, Jun-Won Chung, Kwang Gi Kim
Summary: This study designs a clip maker and detector for locating tumors during laparoscopic surgery. Through animal experiments, all clips were successfully detected. The demand for laparoscopic surgery and the endoscopic medical industry is predicted to increase due to the application of this clip-detector.
APPLIED SCIENCES-BASEL
(2022)
Review
Gastroenterology & Hepatology
Jae Min Lee, Yehyun Park, Jin Myung Park, Hong Jun Park, Jun Yong Bae, Seung Young Seo, Jee Hyun Lee, Hyung Ku Chon, Jun-Won Chung, Hyun Ho Choi, Jun Kyu Lee, Byung-Wook Kim
Summary: This article reviews the characteristics and clinical use of sedatives and analgesics in gastrointestinal endoscopy.
CLINICAL ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Joon Sung Kim, Weonjin Ko, Jun-Won Chung, Tae Ho Kim
Summary: This study compared the efficacy and safety profiles of tegoprazan-based quadruple therapy and lansoprazole-based quadruple therapy for Helicobacter pylori eradication. The results showed that tegoprazan-based quadruple therapy had higher eradication rates than lansoprazole-based quadruple therapy in intention-to-treat, modified intention-to-treat, and per-protocol analysis. There was no significant difference in the rate of adverse events between the two groups. Therefore, tegoprazan might be a substitute for proton pump inhibitors in H. pylori eradication regimens.
Article
Multidisciplinary Sciences
So Hyun Park, Young Jae Kim, Kwang Gi Kim, Jun-Won Chung, Hyun Cheol Kim, In Young Choi, Myung-Won You, Gi Pyo Lee, Jung Han Hwang
Summary: This study aimed to develop a CNN using the EfficientNet algorithm for automated classification of acute appendicitis, acute diverticulitis, and normal appendix on CT images, and evaluate its diagnostic performance. The results showed that the RGB serial image method had slightly higher sensitivity, accuracy, and specificity for classifying normal appendix and acute diverticulitis compared to the single image method. Additionally, the mean areas under the ROC curve were significantly higher with the RGB serial image method for all three conditions. Therefore, the model accurately distinguished these conditions on CT images, particularly when using the RGB serial image method.
Article
Gastroenterology & Hepatology
Hannah Lee, Hyo Sang Hwang, Jun-Won Chung, Kyeong Ah Kim, Seon Tae Kim
Summary: This study developed a liquid-type medium, Helicotest (R), to enable faster detection of Helicobacter pylori. Compared to other commercial kits, Helicotest (R) showed the fastest reaction time of 5 minutes for detecting H. pylori. Therefore, it is expected to facilitate faster diagnosis in clinical practice.
KOREAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Surgery
Younghee Choe, Byung-Wook Kim, Tae Ho Kim, Jun-Won Chung, Jongwon Kim, Soo-Young Na, Joon Sung Kim
Summary: This study aimed to determine the optimal interval for surveillance gastroscopy after endoscopic resection for gastric neoplasia and investigate the risk factors for metachronous gastric neoplasia. A retrospective review of medical records identified 677 patients who underwent endoscopic resection, and it was found that severe atrophic gastritis was an independent risk factor for metachronous gastric adenocarcinoma.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Oncology
JunHo Lee, Hanna Lee, Jun-won Chung
Summary: Stomach cancer has a high mortality rate worldwide, and AI technology is being developed to assist in early detection and accurate treatment. The deep learning algorithm can accurately detect gastric lesions and predict morphological characteristics, helping surgeons select the correct treatment method.
JOURNAL OF GASTRIC CANCER
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Byung-Wook Kim, Younghee Choe, Jongwon Kim, Joon Sung Kim, Tae Ho Kim, Jun-Won Chung
GASTROINTESTINAL ENDOSCOPY
(2022)
