Article
Neurosciences
Si-Ting Huang, Bin-Bin Chen, Zhi-Jing Song, Hui-Li Tang, Rong Hua, Yong-Mei Zhang
Summary: The Epac1-SOCS3 signaling pathway plays a significant role in visceral hypersensitivity. In this study, changes in the expression of Epac1 and SOCS3, as well as elevated levels of IL-6, were observed in a neonatal colorectal distension-induced visceral hypersensitivity model. Interventions targeting Epac1, SOCS3, or IL-6 were found to alleviate the symptoms of visceral hypersensitivity.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Ning-Ning Ji, Lei Du, Ying Wang, Ke Wu, Zi-Yang Chen, Rong Hua, Yong-Mei Zhang
Summary: Visceral hypersensitivity in irritable bowel syndrome is associated with the downregulation of membrane SK2 in the hypothalamic paraventricular nucleus. Activation of SK2 may alleviate visceral hypersensitivity, suggesting SK2 activators as a potential intervention for visceral pain.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
QiQi Zhou, Liuqing Yang, Meghan L. Verne, Benjamin B. Zhang, Jeremy Fields, George Nicholas Verne
Summary: This study found that decreased colonic COMT in PI-IBS-D patients contributes to the chronic abdominal pain phenotype via the COMT/miR-155/TNF-a axis. These findings could lead to new treatment options for gastrointestinal disorders after enteric infections.
Article
Biochemistry & Molecular Biology
M. Rocio Servin-Vences, Ruby M. Lam, Alize Koolen, Yu Wang, Dimah N. Saade, Meaghan Loud, Halil Kacmaz, Suzanne Frausto, Yunxiao Zhang, Arthur Beyder, Kara L. Marshall, Carsten G. Bonnemann, Alexander T. Chesler, Ardem Patapoutian
Summary: The gastrointestinal tract's movements are regulated by the presence of food and play a crucial role in digestion. The lack of PIEZO2 in humans leads to impaired bowel sensation and motility. In mice, Piezo2 in dorsal root neurons is required for sensing gut content and slows down food transit rates in various parts of the gut. This study uncovers the mechanosensory mechanisms that regulate gut transit and have important implications for digestion and waste removal.
Review
Gastroenterology & Hepatology
Brennan Spiegel
Summary: This article proposes a hypothesis, known as the gravity hypothesis, that seeks to explain the pathogenesis of irritable bowel syndrome (IBS) by relating it to the influence of gravity on human evolution. It suggests that ineffective gravity management systems may lead to the development of IBS. The article reviews the impact of gravity on human evolution, discusses the imperfect adaptation of Homo sapiens to gravity, and explores the consequences of gravity intolerance in relation to IBS. It also considers the diagnostic and therapeutic implications of this hypothesis and suggests further experiments to support or reject it.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Neurosciences
Ning-Ning Ji, Qing-Xiang Meng, Ying Wang, Zi-Ming Zhou, Yu Song, Rong Hua, Yong-Mei Zhang
Summary: The microglia-GABAergic neuron circuit in the limbic area, specifically BNST, plays a crucial role in the development of colorectal hypersensitivity and visceral pain. The decrease in GABAergic neuron activity and increase in proinflammatory microglia activity are associated with chronic visceral pain. Inhibition of microglial activity and neutralization of proinflammatory cytokines can alleviate visceral pain. This study provides new insights and potential targets for treating IBS-related visceral pain.
NEUROBIOLOGY OF STRESS
(2022)
Article
Neurosciences
QingQing Wang, Sonia Garcia Caraballo, Grigori Rychkov, Alice E. McGovern, Stuart B. Mazzone, Stuart M. Brierley, Andrea M. Harrington
Summary: This study compared the central circuits of vagal and spinal afferent pathways in the transmission of colorectal nociceptive information. The results showed differences in the projections and activation of neurons between the two pathways, as well as differences in their response to pressure intensity.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Article
Neurosciences
Hiromichi Tsushima, Yanli Zhang, Tomohiko Muratsubaki, Motoyori Kanazawa, Shin Fukudo
Summary: Visceral pain and anxiety may be related to the interaction of oxytocin and CRH in neurons in the brain.
NEUROSCIENCE RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Mohammad Sheibani, Yaser Azizi, Maryam Shayan, Sadaf Nezamoleslami, Faezeh Eslami, Mohammad Hadi Farjoo, Ahmad Reza Dehpour
Summary: Doxorubicin is an effective chemotherapeutic agent used to treat solid tumors, but it can cause cardiotoxicity, particularly congestive heart failure. The mechanisms underlying doxorubicin-induced cardiotoxicity are not fully understood, but inflammatory cytokines, oxidative stress pathways, mitochondrial damage, and other factors and pathways play critical roles. Currently, there are few medications available for the treatment of doxorubicin-induced cardiotoxicity, and further research is needed to explore preventive treatments.
CARDIOVASCULAR TOXICOLOGY
(2022)
Article
Neurosciences
Saina Saadat Boroujeni, Shahabaddin Solaimanian, Razieh Mohammad Jafari, Omid Sabzevari, Hamed Shafaroodi, Adeleh Maleki, Parsa Mohammadi, Elaheh Karimi, Ahmad Reza Dehpour
Summary: This study investigated the anticonvulsant effect of mefloquine and chloroquine in mice and found that both drugs reduced the occurrence of seizures and increased seizure latency. They also decreased mortality rate and seizure frequency, and increased seizure threshold. Co-administration of pharmacological intervention and nitrite levels measurement indicated the involvement of opioidergic/nitrergic systems in these anticonvulsant effects. Additionally, the potentiation of anticonvulsant effects by co-administration of morphine suggests the involvement of opioid receptors. Nitrite levels in mice hippocampi also increased after treatment with both drugs.
ACTA NEUROBIOLOGIAE EXPERIMENTALIS
(2022)
Article
Surgery
Armin Aryannejad, Faezeh Eslami, Maryam Shayan, Nafise Noroozi, Keshvad Hedayatyanfard, Seyed Mohammad Tavangar, Razieh Mohammad Jafari, Ahmad Reza Dehpour
Summary: This study aimed to evaluate the efficacy of CBD on random-pattern skin flap survival in rats and explore the involvement of CB2 receptors. The results showed that pretreatment with CBD significantly improved flap survival in rats and exerted desirable anti-inflammatory effects, possibly mediated by CB2 receptors.
JOURNAL OF RECONSTRUCTIVE MICROSURGERY
(2023)
Article
Pharmacology & Pharmacy
Sanaz Mokhtari, Neda Sistani Karampour, Mohammad-Hossein Shams, Ahmad Reza Dehpour, Amin Hasanvand
Summary: Progesterone has anti-inflammatory and antioxidative effects and protects against diabetic neuropathy. Treatment with progesterone reduces neuropathic sensitivity, inflammation, and edema, while improving nerve conduction velocity and reducing oxidative stress and inflammatory factors.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2023)
Article
Food Science & Technology
Ramin Goudarzi, Golnaz Zamanian, Zahra Seyyedian, Partow Mirzaee Saffari, Ahmad Reza Dehpour, Alireza Partoazar
Summary: This study evaluated the anti-inflammatory effect of arthrocen, avocado/soybean unsaponifiables (ASU), in improving poststroke complications like depression in a mice model. The results showed that arthrocen had significant antidepressant-like effects and reduced the production of proinflammatory cytokines in the ischemic brain hippocampus. Moreover, arthrocen increased the number of viable neurons in the stroke mice. These findings suggest that arthrocen has potential as a treatment for poststroke depression by reducing inflammation and protecting neural cells.
FOOD SCIENCE & NUTRITION
(2023)
Article
Behavioral Sciences
Mohammad Amin Sadeghi, Sara Hemmati, Hasan Yousefi-Manesh, Saba Fekrvand, Laleh Foroutani, Ehsan Nassireslami, Mojtaba Yousefi Zoshk, Yasaman Hosseini, Ahmad Reza Dehpour, Mohsen Chamanara
Summary: Combining subchronic fluoxetine with selective nNOS inhibitor 7-nitroindazole accelerated the efficacy of fluoxetine in treating post-traumatic stress disorder, and hippocampal activity showed biphasic correlation with anxiety-related behavior.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Sina Jourian, Mohammad Rahimi, Mohammad Amin Manavi, Mohammad-Taha Pahlevan-Fallahy, Razieh Mohammad Jafari, Ali Amini, Ahmad Reza Dehpour
Summary: This study found that ivermectin has an anticonvulsant effect on clonic seizure threshold. Furthermore, the anticonvulsant effect of ivermectin may be mediated through the interaction of the opioidergic system and the nitric oxide pathway.
NEUROCHEMICAL RESEARCH
(2023)
Article
Chemistry, Medicinal
Maryam Shayan, Faezeh Eslami, Ayda Khosravi, Amir Rashidian, Razie Mohammad Jafari, Seyed Farzad Maroufi, Hasti Tashak Golroudbari, Ahmad Reza Dehpour
Summary: This study found that cyclosporine, ondansetron, and tropisetron have neuroprotective effects against optic nerve crush injury in rats, possibly through the suppression of apoptosis and modulation of calcineurin activity directly and via 5-HT3 receptors.
Article
Pharmacology & Pharmacy
Aysa Ostovaneh, Faezeh Eslami, Nastaran Rahimi, Pegah Dejban, Hamed Shafaroodi, Ata Abbasi, Shirin Shahsavarhaghighi, Ahmad Reza Dehpour
Summary: This study investigated the beneficial effect of sumatriptan in rats with gastric ulcer by stimulating 5HT(1B/1D) receptors and suppressing pro-inflammatory cytokines. Sumatriptan significantly improved gastric injury induced by different ulcer models, suggesting its gastroprotective effects through the involvement of 5HT(1B/1D) receptors.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hasan Yousefi-Manesh, Samira Shirooie, Tayebeh Noori, Mohammad Sheibani, Seyed Mohammad Tavangar, Sara Hemmati, Mohammad Amin Sadeghi, Hassan Akbarniakhaky, Zohreh Mohammadi, Laleh Foroutani, Ahmad Reza Dehpour
Summary: English summary: The study investigates the effects of spermidine on oxidative stress markers and pain threshold in a rat model of chronic constriction injury. The findings suggest that spermidine treatment can alleviate neuropathic pain by reducing oxidative stress and improving pathological changes.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2023)
Article
Immunology
Arya Afrooghe, Mohammadreza Babaei, Maryam Shayan, Elham Ahmadi, Razieh Mohammad Jafari, Ahmad-Reza Dehpour
Summary: Itching is an unpleasant sensation on the skin that affects the quality of life. Bromhexine, derived from Adhatoda vasica, has been found to alleviate acute itch by inhibiting TMPRSS2 and reducing KP activation. Administering 1-Methyl Tryptophan, an IDO inhibitor, also reduces itching. The combined use of bromhexine and 1-MT results in synergistic antipruritic effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Moein Ala, Mohammad Reza Fallahpour Khoshdel, Razieh Mohammad Jafari, Mehrdokht Sadrkhanloo, Sepideh Goudarzi, Meisam Asl Soleimani, Ahmad Reza Dehpour
Summary: In this study, it was found that sumatriptan has protective effects against mesenteric ischemia and the inhibition of the kynurenine pathway may be involved in this process. Therefore, sumatriptan has the potential to be repurposed as a treatment for acute mesenteric ischemia.
PHARMACOLOGICAL REPORTS
(2023)
Review
Surgery
Arya Afrooghe, Amirmasoud Rayati Damavandi, Elham Ahmadi, Razieh Mohammad Jafari, Ahmad Reza Dehpour
Summary: The incorporation of skin flaps in wound closure management has shown promise in achieving desirable cosmetic outcomes. However, skin flaps are prone to complications, such as ischemia-reperfusion injury (IRI), due to various factors. Numerous approaches have been attempted to enhance skin flap survival, including pre/post-conditioning with surgical and pharmacological methods. These approaches utilize cellular and molecular mechanisms to reduce inflammation, promote angiogenesis, induce apoptosis and autophagy. The emerging role of stem cells in improving skin flap viability has led to the development of more translational methods. This review aims to provide current evidence on these approaches.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Review
Medicine, General & Internal
Arash Amanlou, Ehsan Nassireslami, Ahmad Reza Dehpour, Amir Rashidian, Mohsen Chamanara
Summary: Seizures and epilepsy have a severe impact on the quality of life for those affected. This review examines the effect of statins on the prevention and treatment of seizures and epilepsy using both animal models and human studies. It discusses the mechanisms of action, side effects, and comparison of different types of statins in relation to seizures. This review provides valuable insights for researchers to clarify the beneficial effects of statins on neurological disorders.
IRANIAN JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Mahla Masoumi, Mohammad Amin Manavi, Razieh Mohammad Jafari, Alireza Mirzaei, Keshvad Hedayatyanfard, Mohammad Taghi Beigmohammadi, Ahmad Reza Dehpour
Summary: This study investigated the anticonvulsant effects of CBD on lithium-pilocarpine-induced SE in rats and found a possible involvement of CB1 receptors and anti-inflammatory effects. The results suggest that CBD may have therapeutic potential for SE, independent of CB2 and GABA(A) receptors.
CANNABIS AND CANNABINOID RESEARCH
(2023)