Article
Oncology
Smita Sihag, Samuel C. Nussenzweig, Henry S. Walch, Meier Hsu, Kay See Tan, Sergio De La Torre, Yelena Y. Janjigian, Steven B. Maron, Geoffrey Y. Ku, Laura H. Tang, Pari M. Shah, Abraham Wu, David R. Jones, David B. Solit, Nikolaus Schultz, Karuna Ganesh, Michael F. Berger, Daniela Molena
Summary: MDM2 amplification and TP53 status are associated with response to therapy in patients with esophageal adenocarcinoma. Worsening TP53 dysfunction is directly correlated with worse treatment outcomes.
CLINICAL CANCER RESEARCH
(2022)
Review
Oncology
Ronald Chow, Kyle Murdy, Marcus Vaska, Sangjune Laurence Lee
Summary: Patients with esophageal carcinoma receiving neoadjuvant chemoradiotherapy and esophagectomy have better overall survival compared to those receiving definitive chemoradiotherapy. However, further studies are needed due to limited data and inconsistent reporting of endpoints.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Keting Li, Wentao Hao, Xianben Liu, Yin Li, Haibo Sun, Shilei Liu, Wenqun Xing, Yan Zheng
Summary: This study compared the efficacy of adjuvant chemotherapy and postoperative observation in patients with esophageal squamous cell carcinoma (ESCC) after neoadjuvant chemotherapy. The results showed that adjuvant chemotherapy did not improve overall survival (OS) in these patients, but it may benefit certain groups of patients.
Article
Immunology
Lei Xu, Xiu-feng Wei, Can-jun Li, Zhao-yang Yang, Yong-kui Yu, Hao-miao Li, Hou-nai Xie, Ya-fan Yang, Wei-wei Jing, Zhen Wang, Xiao-zheng Kang, Rui-xiang Zhang, Jian-jun Qin, Li-yan Xue, Nan Bi, Xian-kai Chen, Yin Li
Summary: This study compares the treatment response and postoperative complications of neoadjuvant immunochemotherapy (NICT) with conventional neoadjuvant chemoradiotherapy (NCRT) in patients with locally advanced esophageal squamous cell carcinoma (ESCC). The study finds that NICT has comparable R0 resection rate and pathological complete response (pCR) rate to NCRT, without increased incidence of postoperative complications and mortality. Notably, NICT may bring a better treatment response in metastatic lymph nodes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Tsuyoshi Harada, Tetsuya Tsuji, Junya Ueno, Yu Koishihara, Nobuko Konishi, Nanako Hijikata, Aiko Ishikawa, Daisuke Kotani, Takashi Kojima, Hisashi Fujiwara, Takeo Fujita
Summary: This study aimed to establish the prognostic impact of skeletal muscle mass loss during neoadjuvant chemotherapy on older patients with locally advanced esophageal cancer.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Tomo Ishida, Tomoki Makino, Makoto Yamasaki, Kotaro Yamashita, Koji Tanaka, Takuro Saito, Kazuyoshi Yamamoto, Tsuyoshi Takahashi, Yukinori Kurokawa, Masaaki Motoori, Yutaka Kimura, Kiyokazu Nakajima, Hidetoshi Eguchi, Yuichiro Doki
Summary: This study evaluated the clinical significance of assessing skeletal muscle quantity and quality in patients with esophageal cancer who underwent neoadjuvant chemotherapy followed by esophagectomy. The results showed that severe sarcopenia was associated with worse NAC response, postoperative complications, and long-term survival.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Chuan Li, Jing-Wei Lin, Hui-Ling Yeh, Cheng-Yen Chuang, Chien-Chih Chen
Summary: This study identified four independent predictors for pCR by combining inflammatory status and tumor glucose metabolic activity. Delta NLR had the highest accuracy and NPV, while the combination of Delta NLR <3 and Delta SUV ratio > 58% had the best PPV for pCR. Inflammatory status (Delta NLR) and tumor glucose metabolic activity (Delta SUV ratio) together constitute a promising low-invasive tool with high efficacy for predicting treatment response before surgery.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Lieven Depypere, Gert De Hertogh, Johnny Moons, An-Lies Provoost, Toni Lerut, Xavier Sagaert, Willy Coosemans, Hans Van Veer, Philippe Nafteux
Summary: In cN+ esophageal adenocarcinoma patients treated with nCRT, those with ypN0 and no signs of lymph node response (LNR) have a tripled median overall survival compared to those with LNR, and their survival is comparable to cN+/pN0 upfront esophagectomy patients.
ANNALS OF THORACIC SURGERY
(2021)
Article
Multidisciplinary Sciences
Guocan Yu, Wenfeng Yu, Xudong Xu, Bo Ye, Liwei Yao
Summary: This study aims to evaluate the efficacy and safety of immunotherapy for resectable esophageal cancer as neoadjuvant treatment, providing reliable evidence for clinicians and patients to formulate the best pre-surgical treatment plan.
Review
Oncology
M. Usman Ahmad, Christopher Javadi, George A. Poultsides
Summary: Neoadjuvant and/or perioperative therapy has emerged as a treatment tool to improve patient selection and locoregional control for resectable proximal gastric, gastroesophageal junction, and distal esophageal cancer. Treatment recommendations differ based on histologic type and tumor location. Neoadjuvant chemoradiation with concurrent taxane- or fluoropyrimidine-based chemotherapy has shown efficacy for both adenocarcinoma and squamous cell carcinoma of the distal esophagus and gastroesophageal junction.
Article
Oncology
Satoru Matsuda, Hirofumi Kawakubo, Akihiko Okamura, Keita Takahashi, Tasuku Toihata, Ryo Takemura, Shuhei Mayanagi, Hiroya Takeuchi, Masayuki Watanabe, Yuko Kitagawa
Summary: Histological response influenced long-term outcomes of patients post-NAC esophagectomy, even within same pathologic stage groups. Current risk stratification system aids in selecting appropriate candidates for adjuvant therapy.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Immunology
Zhi-Nuan Hong, Zhixin Huang, Kai Weng, Jihong Lin, Mingqiang Kang
Summary: This study aimed to investigate the impact of prolonged time to surgery (TTS) on the outcomes of patients with locally advanced esophageal squamous cell carcinoma (ESCC) undergoing neoadjuvant immunochemotherapy (nICT). The results showed that prolonged TTS did not significantly affect pathological complete response rate, disease-free survival, and short-term postoperative outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
H. Tang, H. Wang, Y. Fang, J. Y. Zhu, J. Yin, Y. X. Shen, Z. C. Zeng, D. X. Xiang, Y. Y. Hou, M. Du, C. H. Lian, Q. Zhao, H. J. Jiang, L. Gong, Z. G. Li, J. Liu, D. Y. Xie, W. F. Li, C. Chen, B. Zheng, K. N. Chen, L. Dai, Y. D. Liao, K. Li, H. C. Li, N. Q. Zhao, L. J. Tan
Summary: This study aimed to evaluate the safety and efficacy of neoadjuvant chemoradiotherapy (nCRT) versus neoadjuvant chemotherapy (nCT) followed by minimally invasive esophagectomy (MIE) for locally advanced esophageal squamous cell carcinoma (ESCC). The results showed that nCRT did not significantly improve overall survival compared to nCT.
ANNALS OF ONCOLOGY
(2023)
Article
Oncology
Jinmin Han, Zhongtang Wang, Chengxin Liu
Summary: This study compared the effectiveness of neoadjuvant chemotherapy (NCT) and chemoradiotherapy (NCRT) in terms of patient survival and complications, showing that NCRT provided better outcomes in terms of 3-year survival, R0 resection, and complete response rates, but no significant difference in 5-year survival. Personalized treatment should be considered as a priority.
Article
Immunology
Huilai Lv, Chao Huang, Jiachen Li, Fan Zhang, Chunyue Gai, Zhao Liu, Shi Xu, Mingbo Wang, Zhenhua Li, Ziqiang Tian
Summary: This study reports the survival follow-up outcomes of locally advanced esophageal squamous cell carcinoma patients treated with neoadjuvant sintilimab combined with chemotherapy. The 2-year disease-free survival rate was 78.3% and the 2-year overall survival rate was 88.0%. Postoperative pathological stage, pCR, MPR, and tumor down-staging were associated with favorable survival outcome. The number of neoadjuvant treatment cycles was identified as an independent predictor of disease-free survival.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Axel Wein, Robert Stoehr, Stephan Kersting, Juergen Siebler, Susanne Merkel, Dagmar Busse, Kerstin Wolff, Nicola Ostermeier, Clemens Neufert, Francesco Vitali, Markus Eckstein, Jan-Peter Roth, Peter Anhut, Waldemar Schreiner, Michael Uder, Arndt Hartmann, Markus F. Neurath, Robert Gruetzmann
Summary: This study aimed to evaluate the clinical outcomes of a new molecular biomarker panel for palliative first-line treatment of colorectal cancer. The results indicate that using FOLFIRI plus cetuximab for quintuple-wildtype patients led to higher response rates compared to RAS-mutations population, showing promise for this treatment approach.
Article
Gastroenterology & Hepatology
Naoyoshi Nagata, Suguru Nishijima, Yasushi Kojima, Yuya Hisada, Koh Imbe, Tohru Miyoshi-Akiyama, Wataru Suda, Moto Kimura, Ryo Aoki, Katsunori Sekine, Mitsuru Ohsugi, Kuniko Miki, Tsuyoshi Osawa, Kohjiro Ueki, Shinichi Oka, Masashi Mizokami, Ece Kartal, Thomas S. B. Schmidt, Esther Molina-Montes, Lidia Estudillo, Nuria Malats, Jonel Trebicka, Stephan Kersting, Melanie Langheinrich, Peer Bork, Naomi Uemura, Takao Itoi, Takashi Kawai
Summary: This study identified gut and oral metagenomic signatures that accurately predict pancreatic ductal carcinoma (PDAC) and validated their effectiveness in independent cohorts. Patients with certain microbial species in the gut and oral microbiomes were found to have higher risk of PDAC-related mortality. These findings provide valuable information for the diagnosis and prognosis of PDAC.
Article
Gastroenterology & Hepatology
Ece Kartal, Thomas S. B. Schmidt, Esther Molina-Montes, Sandra Rodriguez-Perales, Jakob Wirbel, Oleksandr M. Maistrenko, Wasiu A. Akanni, Bilal Alashkar Alhamwe, Renato J. Alves, Alfredo Carrato, Hans-Peter Erasmus, Lidia Estudillo, Fabian Finkelmeier, Anthony Fullam, Anna M. Glazek, Paulina Gomez-Rubio, Rajna Hercog, Ferris Jung, Stefanie Kandels, Stephan Kersting, Melanie Langheinrich, Mirari Marquez, Xavier Molero, Askarbek Orakov, Thea Van Rossum, Raul Torres-Ruiz, Anja Telzerow, Konrad Zych, Vladimir Benes, Georg Zeller, Jonel Trebicka, Francisco X. Real, Nuria Malats, Peer Bork
Summary: This study explored the potential of fecal and salivary microbiota as diagnostic biomarkers for pancreatic ductal adenocarcinoma (PDAC). Results showed that fecal metagenomic classifiers performed better than saliva-based classifiers, accurately identifying PDAC patients based on a set of 27 microbial species. The accuracy was further improved when combined with serum levels of carbohydrate antigen (CA) 19-9. The study also found that fecal PDAC marker species were detectable in pancreatic tumor and non-tumor tissue. These findings suggest that non-invasive fecal microbiota-based screening for early detection of PDAC is feasible.
Article
Multidisciplinary Sciences
Lea Miebach, Eric Freund, Ramona Clemen, Stephan Kersting, Lars-Ivo Partecke, Sander Bekeschus
Summary: Gas plasma technology can generate reactive oxygen and nitrogen species that cause lethal oxidative damage to tumor cells. The study suggests that gas plasma-oxidized liquids and concentration-matched control liquids have the same therapeutic efficacy in peritoneal carcinomatosis. Additionally, the treatment can increase tumor cell immunogenicity and enhance immune cell uptake and maturation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Emergency Medicine
Bruno Leonardo Bancke Laverde, Matthias Maak, Melanie Langheinrich, Stephan Kersting, Axel Denz, Christian Krautz, Georg Ferdinand Weber, Robert Gruetzmann, Maximilian Brunner
Summary: The purpose of this study was to identify risk factors associated with postoperative morbidity, major morbidity, prolonged length of hospital stay, and readmission in patients undergoing appendectomy for acute appendicitis. The study found that higher age, higher preoperative WBC-count and CRP, lower preoperative hemoglobin, longer time to surgery, and longer duration of surgery were independent risk factors for morbidity. Higher age, higher preoperative CRP, lower preoperative hemoglobin, and longer time to surgery were identified as independent risk factors for major morbidity. Higher age, higher preoperative WBC-count and CRP, lower preoperative hemoglobin, need for conversion, longer surgery duration, presence of intraoperative complicated appendicitis, and postoperative morbidity were independent risk factors for a prolonged length of hospital stay. Presence of malignancy and higher preoperative WBC-count were independent risk factors for readmission.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2023)
Article
Multidisciplinary Sciences
Julia van der Linde, Stephan Diedrich, Thorben Klee, Claus-Dieter Heidecke, Stephan Kersting, Wolfram Kessler
Summary: In this study, the suitability of a polymicrobial sepsis model in analyzing the complexity of DIC was investigated. The results showed that this model accurately replicated the characteristics of systemic DIC in murine abdominal sepsis, including thrombocytopenia, prolonged bleeding time, and loss of fibrinogen.
Article
Medicine, General & Internal
Melanie Langheinrich, Alexander Reinhard Siebenhuener, Justus Baecker, Maximilian Miragall, Felix Wiesmueller, Vera Schellerer, Susanne Merkel, Maximilian Brunner, Christian Krautz, Klaus Weber, Robert Gruetzmann, Stephan Kersting
Summary: This study aimed to evaluate the value of different blood-based markers and assess the significance of a newly developed inflammatory-nutrition-related biomarker (NCR = BMI x albumin/CRP) in colon cancer patients. Lower preoperative NCR levels were associated with worse prognosis, tumor sidedness, undifferentiated histology, nodal involvement, and advanced UICC stage. The NCR proved to be a reliable indicator of poor prognosis for colon cancer patients and could be used for risk stratification and treatment selection.
Letter
Gastroenterology & Hepatology
Maximilian Brunner, Klaus Weber, Axel Denz, Melanie Langheinrich, Stephan Kersting, Georg F. Weber, Robert Gruetzmann, Christian Krautz
COLORECTAL DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Barbara Kneis, Stefan Wirtz, Klaus Weber, Axel Denz, Matthias Gittler, Carol Geppert, Maximilian Brunner, Christian Krautz, Alexander Reinhard Siebenhuener, Robert Schierwagen, Olaf Tyc, Abbas Agaimy, Robert Gruetzmann, Jonel Trebicka, Stephan Kersting, Melanie Langheinrich
Summary: In the current era of precision oncology, it is recognized that colorectal cancer (CRC) is a heterogeneous disease. The tumor location is crucial in determining disease progression and prognosis. The microbiome has been identified as an important factor in CRC, but previous studies have shown inconsistent results due to the heterogeneous nature of microbiomes and the lack of separate analysis of colon cancer (CC) and rectal cancer (RC). Our prospective study aimed to map the colon cancer landscape using 16S rRNA amplicon sequencing, and we found distinct microbiomes in right- and left-sided colon cancers, as well as a significant increase in potentially pathogenic bacteria in stool samples after surgery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Aydar Khabipov, Dung Nguyen Trung, Julia van der Linde, Lea Miebach, Maik Lenz, Felix Erne, Wolfram von Bernstorff, Tobias Schulze, Stephan Kersting, Sander Bekeschus, Lars Ivo Partecke
Summary: Pancreatic cancer is characterized by a tumor microenvironment rich in stromal and immune cells that support cancer growth and resistance to therapy. Tumor-associated macrophages (TAMs), specifically, have properties that promote angiogenesis and metastasis, leading to the failure of conventional therapies. This study explores the effects of blocking the C-C chemokine receptor type 4 (CCR4) in pancreatic cancer-bearing mice through genetic or immunotherapeutic methods. The results show that CCR4 is critical for TAM generation and tumor progression in pancreatic cancer, and blockade of CCR4 may improve prognosis and extend the relapse-free period after curative surgery.
Article
Medicine, General & Internal
Bruno Leonardo Bancke Laverde, Matthias Maak, Melanie Langheinrich, Stephan Kersting, Axel Denz, Christian Krautz, Georg F. Weber, Robert Gruetzmann, Maximilian Brunner
Summary: The aim of this study was to identify risk factors for conversion from laparoscopic to open appendectomy in cases of acute appendicitis. The study found that a higher preoperative WBC count, presence of intraoperative perforation, necrosis or gangrene, perityphlitic abscess and peritonitis were all independent risk factors for conversion. Conversion was also associated with higher morbidity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Bruno Leonardo Bancke Laverde, Matthias Maak, Melanie Langheinrich, Stephan Kersting, Axel Denz, Christian Krautz, Georg F. Weber, Robert Grutzmann, Maximilian Brunner
Summary: This study investigated the impact of intraoperative swab during appendectomy on the postoperative outcome in patients with uncomplicated and complicated appendicitis. The results showed that a positive swab was significantly associated with worse postoperative outcomes and was an independent risk factor for postoperative morbidity and the need for adjustment of postoperative antibiotic therapy. However, the frequency of antibiotic regime changes based on the swab analysis was low.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Meeting Abstract
Oncology
Britta Buchhold, Stine Lutze, Jennis Freyer-Adam, Michael Juenger, Claudia Nordt, Sebastian Peters, Stephan Kersting
ONCOLOGY RESEARCH AND TREATMENT
(2022)
Meeting Abstract
Oncology
Melanie C. Langheinrich, Stefan Wirtz, Barbara Kneis, Klaus Weber, Maximilian Brunner, Christian Krautz, Jonel Trebicka, Abbas Agaimy, Robert Gruetzmann, Stephan Kersting
ONCOLOGY RESEARCH AND TREATMENT
(2022)
Article
Gastroenterology & Hepatology
Maximilian Brunner, Alaa Zu'bi, Klaus Weber, Axel Denz, Melanie Langheinrich, Stephan Kersting, Georg F. Weber, Robert Gruetzmann, Christian Krautz
Summary: This study compared the use of single-stapling technique (SST) and double-stapling technique (DST) in minimally invasive rectal anastomosis and found that using SST is associated with a lower rate of anastomotic complications, including leakage and stenosis. This suggests that SST may be an effective technique for reducing anastomotic complications.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)
