Article
Gastroenterology & Hepatology
Craig Haifer, Laurence Don Wai Luu, Sudarshan Paramsothy, Thomas J. Borody, Rupert W. Leong, Nadeem O. Kaakoush
Summary: This study characterized the differences in gut microbiota between two FMT donors and found that donor microbiota stability and species evenness were associated with therapeutic efficacy in UC. These findings have important implications for improving FMT donor selection.
Article
Gastroenterology & Hepatology
Andreas Blesl, Philipp Wurm, Silvio Waschina, Hans Peter Groechenig, Gottfried Novacek, Christian Primas, Walter Reinisch, Maximilian Kutschera, Constanze Illiasch, Barbara Hennlich, Pius Steiner, Robert Koch, Wolfgang Tillinger, Thomas Haas, Gerhard Reicht, Andreas Mayer, Othmar Ludwiczek, Wolfgang Miehsler, Karin Steidl, Lukas Binder, Simon Reider, Christina Watschinger, Stefan Fuerst, Patrizia Kump, Alexander Moschen, Konrad Aden, Gregor Gorkiewicz, Christoph Hoegenauer, Austrian IBD Study Grp ATISG
Summary: This study examined the association between fecal microbial composition and response to systemic corticosteroids in patients with active ulcerative colitis. It found that baseline microbial diversity and composition could not predict response to corticosteroids, but responders had significant changes in microbial diversity and composition after 4 weeks of treatment.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Computer Science, Artificial Intelligence
Mehmet Turan, Furkan Durmus
Summary: Ulcerative colitis (UC) is a type of inflammatory bowel disease caused by inflammation of colon and rectum tissue. The severity of the infection can significantly impact the overall well-being of patients. Diagnosis through colonoscopy imaging and personalized treatment can prevent the disease from progressing to more malignant stages.
MEDICAL IMAGE ANALYSIS
(2022)
Article
Nutrition & Dietetics
Chen Sarbagili-Shabat, Lindsey Albenberg, Johan Van Limbergen, Naomi Pressman, Anthony Otley, Michal Yaakov, Eytan Wine, Dror Weiner, Arie Levine
Summary: The pilot trial evaluated the efficacy and feasibility of a novel UC exclusion diet for inducing remission in children with mild to moderate UC. Around 37.5% of patients achieved clinical remission with UCED alone, while 50% of patients who failed on the diet entered remission after receiving antibiotic therapy. These findings suggest the potential of UCED and sequential antibiotics as a microbiome-targeted, steroid-sparing strategy for pediatric UC.
Article
Gastroenterology & Hepatology
Hiromu Morikubo, Taku Kobayashi, Ryo Ozaki, Shinji Okabayashi, Satoshi Kuronuma, Osamu Takeuchi, Tenyo Shiba, Hiroki Kiyohara, Mao Matsubayashi, Shintaro Sagami, Masaru Nakano, Osamu Ikezaki, Tadakazu Hisamatsu, Yoichi Tanaka, Toshifumi Hibi
Summary: This study found that time-dependent mesalazine has a stronger TPMT inhibitory effect compared to other formulations, and switching to MMX may lead to an increase in metabolite ratios and relapse rates.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Alex Adams, Vipin Gupta, Waled Mohsen, Thomas P. Chapman, Deloshaan Subhaharan, Pradeep Kakkadasam Ramaswamy, Sudheer Kumar, Saurabh Kedia, Colleen G. C. McGregor, Tim Ambrose, Bruce D. George, Rebecca Palmer, Oliver Brain, Alissa Walsh, Vineet Ahuja, Simon P. L. Travis, Jack Satsangi
Summary: The changes in acute severe colitis (ASC) management have resulted in improved outcomes. A simple predictive model can be used to identify patients who will not respond to steroids upon admission.
Article
Pharmacology & Pharmacy
Meng Wei, Dongdong Liu, Yingbao Sun, Hua Xie, Lina Du, Yiguang Jin
Summary: A hollow suppository for mesalazine treatment of ulcerative colitis was developed using 3D printing technology. The suppository, consisting of an inner supporting spring and an outer shell, showed faster drug release and improved therapeutic effects in experimental animals.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
F. Varum, H. Thorne, R. Bravo, D. Gilgen, C. Hartig, G. P. Nicolas, D. Wild, E. Liakoni, M. Haschke
Summary: This study demonstrates that a dual pH and enzymatic triggered release system in combination with an inner alkaline layer can promote mesalazine release at the target site with high accuracy. The three differently coated tablets showed comparable release characteristics in biorelevant dissolution media.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Nutrition & Dietetics
Rong Li, Xue Huang, Lu Yang, Xiao Liang, Wenjun Huang, Keng Po Lai, Liming Zhou
Summary: The study utilized a UC mouse model, network pharmacology, and omics bioinformatics to uncover the potential pharmaceutical targets and anti-inflammatory mechanism of mesalazine. Results identified the core targets of mesalazine and highlighted the correlation between gut microbiota and metabolite changes caused by mesalazine in the UC model. This research revealed the detailed molecular mechanisms of mesalazine in UC treatment and provided insights for targeting core targets for UC treatment.
FRONTIERS IN NUTRITION
(2022)
Article
Plant Sciences
Shuang Luo, Jinrong He, Shaowei Huang, Xiaojing Wang, Yulin Su, Yanyang Li, Yanping Chen, Guanghua Yang, Bin Huang, Shaoju Guo, Lian Zhou, Xia Luo
Summary: Emodin treats ulcerative colitis by regulating the PPAR gamma signal pathway, restoring intestinal homeostasis, and affecting colonic metabolism.
Article
Gastroenterology & Hepatology
Liron Marcovitch, Gili Focht, Natalie Carmon, Claudia Tersigni, Oren Ledder, Raffi Lev-Traion, Peter C. Chruch, Jeffrey S. Hyams, Robert N. Baldassano, Athos Bousvaros, David R. Mack, Seamus Hussey, Anthony Otley, Nicholas M. Croft, Michael D. Kapplemen, Anne M. Griffiths, Dan Turner
Summary: The TUMMY-UC, a patient-reported outcome measure for pediatric ulcerative colitis, has been validated and shown to be reliable, valid, and responsive. It can now be used in clinical practice and trials.
Article
Gastroenterology & Hepatology
Toshihiro Kita, Sinya Ashizuka, Naoki Ohmiya, Takayuki Yamamoto, Takanori Kanai, Satoshi Motoya, Fumihito Hirai, Hiroshi Nakase, Tomohiko Moriyama, Masanao Nakamura, Yasuo Suzuki, Shuji Kanmura, Taku Kobayashi, Hidehisa Ohi, Ryoichi Nozaki, Keiichi Mitsuyama, Shojiro Yamamoto, Haruhiko Inatsu, Koji Watanabe, Toshifumi Hibi, Kazuo Kitamura
Summary: This multicenter, double-blind, placebo-controlled phase-2a clinical trial aimed to evaluate the efficacy and safety of AM in patients with steroid-resistant UC. Results showed that the high-dose AM group achieved significant reductions in Mayo scores and higher rates of clinical remission at 8 weeks.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Biochemical Research Methods
Kun Liu, Bingjie Jia, Liping Zhou, Lei Xing, Lvying Wu, Yuanyuan Li, Jungang Lu, Lei Zhang, Su Guan
Summary: This study utilized metabolomics and lipidomics to identify biomarkers for evaluating the therapeutic efficacy of mesalazine on ulcerative colitis, revealing potential mechanisms of treatment. Through serum metabolomics analysis, metabolites associated with treatment outcomes were discovered, alongside identification of dysregulated metabolic pathways in colitis.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Health Care Sciences & Services
Jeong-Heon Kim, A. Reum Choe, Yehyun Park, Eun-Mi Song, Ju-Ran Byun, Min-Sun Cho, Youngeun Yoo, Rena Lee, Jin-Sung Kim, So-Hyun Ahn, Sung-Ae Jung
Summary: This study introduces a standardization method based on deep learning to address the issue of inconsistent diagnoses in the interpretation of endoscopic images for ulcerative colitis (UC) severity. By creating a consensus model that considers only the images and labels agreed upon by the majority of experts, the study achieves more reliable prediction results.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Microbiology
Lingyun Xu, Yingchao Li, Yingli He
Summary: Anxiety and depression still exist in UC patients even in the remission period. This study found that the composition of intestinal microbiota differs between UC patients with anxiety and depression and those without, with a decrease in probiotics and an increase in pathogens in the former group. These findings may provide new insights into the recurrence of UC caused by impaired psychological function and offer potential treatment strategies for UC patients with psychological issues.
FRONTIERS IN MICROBIOLOGY
(2023)