Review
Chemistry, Multidisciplinary
Mustafa Nakipoglu, Aysen Tezcaner, Christopher H. Contag, Nasim Annabi, Nureddin Ashammakhi
Summary: Bioadhesives with antimicrobial properties enable easier and safer treatment of wounds. However, designing these biomaterials with the required properties can be challenging. Developing bioadhesives with tunable physical, chemical, and biological properties is crucial for future advancements.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Medicinal
Hooman Mirzaee, Emily Ariens, Mark A. T. Blaskovich, Richard J. Clark, Peer M. Schenk
Summary: Our study showed that environmental microbiomes may contain bacteria producing uncharacterized antimicrobial compounds which can potentially be used for pathogen control. By isolating and characterizing these bacteria, we identified new potential antimicrobials and developed a method to rapidly discover such compounds.
Article
Ecology
Rachel H. Corney, Laura K. Weir
Summary: Reproductive isolation can occur due to differences in mate preference associated with body size, which can play a role in divergence between groups. The goal of the study was to examine differences in mate preference between two ecotypes of Threespine Stickleback males, with one ecotype providing parental care. Results showed that males investing in parental care preferred larger females, while those not providing care did not exhibit a preference for larger females.
ECOLOGY AND EVOLUTION
(2023)
Review
Chemistry, Analytical
Naseem Abbas, Sehyeon Song, Mi-Sook Chang, Myung-Suk Chun
Summary: Bacterial infections, specifically Escherichia coli (E. coli) O157:H7, pose a serious threat to public health and require rapid and accurate detection methods. Traditional approaches like PCR and ELISA have limitations in terms of time and cost. Microfluidic platforms based on SPR, electrochemical sensing, and RCA offer promising alternatives for the detection of pathogens, providing rapid and portable point-of-care diagnostic tools.
Article
Biology
Pramod K. Jangir, Lois Ogunlana, Petra Szili, Marton Czikkely, Liam P. Shaw, Emily J. Stevens, Yu Yang, Qiue Yang, Yang Wang, Csaba Pal, Timothy R. Walsh, Craig R. MacLean
Summary: Antimicrobial peptides (AMPs) have potential as a solution to antibiotic resistance crisis, but the evolution of resistance to therapeutic AMPs could lead to resistance to host AMPs, compromising the innate immune response. The study found that the globally disseminated mobile colistin resistance (MCR) in Escherichia coli increased resistance to human and animal AMPs and enhanced bacterial growth and virulence. These findings have significant implications for the use of AMPs and suggest that eradicating MCR may be challenging even with the withdrawal of colistin.
Article
Multidisciplinary Sciences
Huanxi Zheng, Jing Li, Yongsen Zhou, Chao Zhang, Wanghuai Xu, Yajun Deng, Jiaqian Li, Shile Feng, Zhiran Yi, Xiaofeng Zhou, Xianglin Ji, Peng Shi, Zuankai Wang
Summary: Researchers have reported an underwater capillary adhesive that can be strengthened by the combination of inner water bridge and outer air shell, and switched by a small direct current voltage. This study is important for the development of underwater adhesives with rapid and reversible adhesion in wet conditions.
NATURE COMMUNICATIONS
(2022)
Article
Plant Sciences
Byeong Jun Jeon, Nayeon Yoo, Jeong Do Kim, Jaeyoung Choi
Summary: This study identified highly conserved protein sequence profiles within the genus Streptomyces and discovered a highly conserved sequence with antimicrobial activity against bacterial and fungal plant pathogens. This sequence could be a potential antimicrobial agent for controlling plant diseases.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Reta D. Abdi, Barbara E. Gillespie, Susan Ivey, Gina M. Pighetti, Raul A. Almeida, Oudessa Kerro Dego
Summary: Mastitis is the most prevalent and economically significant disease caused by different pathogens in dairy cattle, leading to increased SCC and poor milk quality. Treatment with antimicrobials is crucial to reduce SCC and improve milk quality, but misuse of antimicrobials can contribute to the development of antimicrobial resistance. This study aimed to isolate and identify the etiological agents of mastitis and determine the antimicrobial resistance profiles of bacterial isolates.
Article
Microbiology
Raja Aadil Hussain Bhat, Victoria C. Khangembam, Dimpal Thakuria, Vinita Pant, Ritesh Shantilal Tandel, Gayatri Tripathi, Debajit Sarma
Summary: In this study, a peptide called KK16 was designed with potent antibacterial and antifungal activity and low toxicity to host cells. The peptide showed strong efficacy against various pathogenic bacteria and remained stable under different environmental conditions.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Chemistry, Physical
Yujie Gao, Yuanhao Dong, Shuting Yang, Anchun Mo, Xin Zeng, Qianming Chen, Qiang Peng
Summary: The size of MXene nanosheets affects their antibacterial photothermal therapy efficacy, with smaller-sized nanosheets displaying higher antibacterial activity under near-infrared irradiation. This study provides guidance for the development of MXene-based therapeutics and highlights the importance of drug-free antibacterial therapy in treating antibiotic-resistant bacterial infections.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Infectious Diseases
Alvaro Mourenza, Blanca Lorente-Torres, Elena Durante, Jesus Llano-Verdeja, Jesus F. Aparicio, Arsenio Fernandez-Lopez, Jose A. Gil, Luis M. Mateos, Michal Letek
Summary: The development of RNA-based anti-infectives, particularly after the successful application of mRNA vaccines, has attracted interest. MiRNAs have been extensively studied for their role in post-transcriptional gene regulation, and it has been discovered that some human miRNAs play important roles in antimicrobial defense. Recent research using exosomes as delivery vehicles for miRNAs has shown promising results, overcoming the challenges of cellular uptake and degradation. This review highlights the potential of exosomal delivery of miRNAs as a complementary treatment to combat multidrug-resistant bacteria.
Article
Pharmacology & Pharmacy
Ferdinand Anton Weinelt, Miriam Songa Stegemann, Anja Theloe, Frieder Pfaefflin, Stephan Achterberg, Lisa Schmitt, Wilhelm Huisinga, Robin Michelet, Stefanie Hennig, Charlotte Kloft
Summary: The study developed a tabular dosing decision tool for initial therapy of meropenem in ICU, integrating patient characteristics and hospital-specific pathogen susceptibility information. Personalized dosing adjustments have the potential to improve treatment outcomes in vulnerable ICU patients.
Article
Nanoscience & Nanotechnology
Susan Marqus, Heba Ahmed, Amgad R. Rezk, Tien Huynh, Ann Lawrie, Dao Nguyen, Yemima Ehrnst, Chaitali Dekiwadia, Leslie Y. Yeo
Summary: A unique copper-based quasi-two-dimensional metal-organic framework has been shown to exhibit enhanced antimicrobial properties against plant pathogens, with low phytotoxicity and significant reduction in viral load, making it a promising candidate for chemical control of plant diseases.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Immunology
Huili Li, Yuanyuan Sun, Li Sun
Summary: This study identified a CXC chemokine, PoCXCL10, from Japanese flounder and investigated its immune function. The results showed that PoCXCL10 promotes the migration, cytokine expression, and phagocytosis of flounder blood leukocytes. It also has bactericidal activity and inhibits the growth of common fish pathogens by causing bacterial membrane permeabilization and destruction.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Environmental
Lapo Mughini-Gras, Rozemarijn Q. J. van der Plaats, Paul W. J. J. van der Wielen, Patrick S. Bauerlein, Ana Maria de Roda Husman
Summary: This study highlights the presence of microplastic pollution in a major riverine environment, impacting microbial communities and potential pathogens. High concentrations of microplastics, primarily polyamide and polyvinylchloride, were found. Different microbial compositions were observed on microplastics of varying sizes, with seasonality and methodological effects also playing a role.
Article
Biotechnology & Applied Microbiology
Seanna J. McTaggart, Timothee Cezard, Jennie S. Garbutt, Phil J. Wilson, Tom J. Little
Article
Biology
Jennie S. Garbutt, Tom J. Little, Andy Hoyle
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2015)
Article
Biochemistry & Molecular Biology
Tom J. Little, Nick Colegrave
Article
Multidisciplinary Sciences
Luisa Orsini, Donald Gilbert, Ram Podicheti, Mieke Jansen, James B. Brown, Omid Shams Solari, Katina I. Spanier, John K. Colbourne, Douglas Rush, Ellen Decaestecker, Jana Asselman, Karel A. C. De Schamphelaere, Dieter Ebert, Christoph R. Haag, Jouni Kvist, Christian Laforsch, Adam Petrusek, Andrew P. Beckerman, Tom J. Little, Anurag Chaturvedi, Michael E. Pfrender, Luc De Meester, Mikko J. Frilander
Article
Ecology
C. M. Coakley, E. Nestoros, T. J. Little
JOURNAL OF EVOLUTIONARY BIOLOGY
(2018)
Article
Ecology
Jennie S. Garbutt, Tom J. Little
ECOLOGY AND EVOLUTION
(2017)
Correction
Multidisciplinary Sciences
Luisa Orsini, Donald Gilbert, Ram Podicheti, Mieke Jansen, James B. Brown, Omid Shams Solari, Katina I. Spanier, John K. Colbourne, Douglas B. Rusch, Ellen Decaestecker, Jana Asselman, Karel A. C. De Schamphelaere, Dieter Ebert, Christoph R. Haag, Jouni Kvist, Christian Laforsch, Adam Petrusek, Andrew P. Beckerman, Tom J. Little, Anurag Chaturvedi, Michael E. Pfrender, Luc De Meester, Mikko J. Frilander
Article
Biochemistry & Molecular Biology
Jack Hearn, Franklin Wang-Ngai Chow, Harriet Barton, Matthew Tung, Philip J. Wilson, Mark Blaxter, Amy Buck, Tom J. Little
Article
Biochemistry & Molecular Biology
Peter D. Fields, Darren J. Obbard, Seanna J. McTaggart, Yan Galimov, Tom J. Little, Dieter Ebert
MOLECULAR PHYLOGENETICS AND EVOLUTION
(2018)
Article
Biology
Jennie S. Garbutt, Anna J. P. O'Donoghue, Seanna J. McTaggart, Philip J. Wilson, Tom J. Little
JOURNAL OF EXPERIMENTAL BIOLOGY
(2014)
Article
Biotechnology & Applied Microbiology
Jack Hearn, Marianne Pearson, Mark Blaxter, Philip J. Wilson, Tom J. Little
Article
Biochemistry & Molecular Biology
Jack Hearn, Jessica Clark, Philip J. Wilson, Tom J. Little
Article
Ecology
Jessica Clark, Luke McNally, Tom J. Little
Summary: Reproduction, mortality, and immune function can change with age, but not necessarily deteriorate. There is extensive variation in age-specific performance and life-history traits across various species, ranging from classic senescence to juvenescence. Different patterns of aging can lead to significantly different transmission landscapes, where aging may reduce the probability of epidemics but also potentially promote severity.
AMERICAN NATURALIST
(2021)
Article
Genetics & Heredity
Jack Hearn, Fiona Plenderleith, Tom J. Little
Summary: The study found that methylated cytosines are most prevalent in exons two to five of gene bodies. One strain showed a significantly increased lifespan in response to caloric restriction, but no effect of food-level CpG methylation status was observed. Inter-strain differences dominated the methylation experiment, with over 15,000 differently methylated CpGs. Sixty-one CpGs were differentially methylated between young and old individuals, including multiple CpGs within the histone H3 gene, which were hypermethylated in old individuals. Across all age-related CpGs, a set highly correlated with chronological age was identified.
EPIGENETICS & CHROMATIN
(2021)
Article
Ecology
Jessica Clark, Jennie S. Garbutt, Luke McNally, Tom J. Little
