CHIP-mediated degradation of transglutaminase 2 negatively regulates tumor growth and angiogenesis in renal cancer

Tumor suppressive microRNA-1285 regulates novel molecular targets: Aberrant expression and functional significance in renal cell carcinoma

(2015) Hideo Hidaka et al.   Oncotarget

Extracellular Tissue Transglutaminase Activates Noncanonical NF-κB Signaling and Promotes Metastasis in Ovarian Cancer

(2015) Bakhtiyor Yakubov et al.   NEOPLASIA

Transglutaminase 2 inhibitor abrogates renal cell carcinoma in xenograft models

(2014) Bo Mi Ku et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

The increased transglutaminase 2 expression levels during initial tumorigenesis predict increased risk of metastasis and decreased disease-free and cancer-specific survivals in renal cell carcinoma

(2014) Selcuk Erdem et al.   WORLD JOURNAL OF UROLOGY

Transglutaminase 2 Accelerates Vascular Calcification in Chronic Kidney Disease

(2013) Neal X. Chen et al.   AMERICAN JOURNAL OF NEPHROLOGY

CHIP/Stub1 functions as a tumor suppressor and represses NF- B-mediated signaling in colorectal cancer

(2013) Y. Wang et al.   CARCINOGENESIS

Transglutaminase 2 inhibition found to induce p53 mediated apoptosis in renal cell carcinoma

(2013) Bo Mi Ku et al.   FASEB JOURNAL

CHIP functions as a novel suppressor of tumour angiogenesis with prognostic significance in human gastric cancer

(2012) Shouyu Wang et al.   GUT

The Chaperone-assisted E3 Ligase C Terminus of Hsc70-interacting Protein (CHIP) Targets PTEN for Proteasomal Degradation

(2012) Syed Feroj Ahmed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Androgen receptor degradation by the E3 ligase CHIP modulates mitotic arrest in prostate cancer cells

(2012) S Sarkar et al.   ONCOGENE

The ubiquitin ligase CHIP regulates c-Myc stability and transcriptional activity

(2012) I Paul et al.   ONCOGENE

Carboxyl terminus of Hsp70-interacting protein (CHIP) contributes to human glioma oncogenesis

(2011) Tao Xu et al.   CANCER SCIENCE

Akt phosphorylation at Thr308 and Ser473 is required for CHIP-mediated ubiquitination of the kinase

(2011) Chih-Hao Su et al.   CELLULAR SIGNALLING

A Unique Role for Heat Shock Protein 70 and Its Binding Partner Tissue Transglutaminase in Cancer Cell Migration

(2011) Lindsey K. Boroughs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin ligase CHIP induces TRAF2 proteasomal degradation and NF-κB inactivation to regulate breast cancer cell invasion

(2011) Kang Won Jang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

E3 ubiquitin ligase CHIP facilitates Toll-like receptor signaling by recruiting and polyubiquitinating Src and atypical PKCζ

(2011) Mingjin Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tid1, CHIP and ErbB2 interactions and their prognostic implications for breast cancer patients

(2011) Chia-Ing Jan et al.   JOURNAL OF PATHOLOGY

Cancer cells promote survival through depletion of the von Hippel–Lindau tumor suppressor by protein crosslinking

(2011) D-S Kim et al.   ONCOGENE

Transglutaminase 2: a multi-functional protein in multiple subcellular compartments

(2010) Donghyun Park et al.   AMINO ACIDS

Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90

(2010) Shan Yan et al.   EMBO JOURNAL

The transglutaminase 2 gene is aberrantly hypermethylated in glioma

(2010) Lisa M. Dyer et al.   JOURNAL OF NEURO-ONCOLOGY

The Chaperone-Dependent Ubiquitin Ligase CHIP Targets HIF-1α for Degradation in the Presence of Methylglyoxal

(2010) Carla Figueira Bento et al.   PLoS One

Arterial calcification in patients with chronic kidney disease

(2009) N. Koleganova et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Clinical and Biological Significance of Tissue Transglutaminase in Ovarian Carcinoma

(2008) J. Y. Hwang et al.   CANCER RESEARCH

The transglutaminase 2 gene ( TGM2 ), a potential molecular marker for chemotherapeutic drug sensitivity, is epigenetically silenced in breast cancer

(2008) Lingbao Ai et al.   CARCINOGENESIS

Tissue Transglutaminase Regulates Focal Adhesion Kinase/AKT Activation by Modulating PTEN Expression in Pancreatic Cancer Cells

(2008) A. Verma et al.   CLINICAL CANCER RESEARCH

Transglutaminase 2 protects against ischemic insult, interacts with HIF1β, and attenuates HIF1 signaling

(2008) Anthony J. Filiano et al.   FASEB JOURNAL

CHIP Deficiency Decreases Longevity, with Accelerated Aging Phenotypes Accompanied by Altered Protein Quality Control

(2008) J.-N. Min et al.   MOLECULAR AND CELLULAR BIOLOGY

Chaperone-dependent stabilization and degradation of p53 mutants

(2008) P Muller et al.   ONCOGENE