Loss of the E3 ubiquitin ligase HACE1 results in enhanced Rac1 signaling contributing to breast cancer progression

Primary breast tumor-derived cellular models: characterization of tumorigenic, metastatic, and cancer-associated fibroblasts in dissociated tumor (DT) cultures

(2014) Katherine Drews-Elger et al.   BREAST CANCER RESEARCH AND TREATMENT

Ubiquitylation and activation of a Rab GTPase is promoted by a  2AR-HACE1 complex

(2013) V. Lachance et al.   JOURNAL OF CELL SCIENCE

Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis

(2013) M. Laurin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transforming mutations of RAC guanosine triphosphatases in human cancers

(2013) M. Kawazu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mitochondrial transporter SLC25A43 is frequently deleted and may influence cell proliferation in HER2-positive breast tumors

(2012) Elisabet Tina et al.   BMC CANCER

Rac signaling in breast cancer: A tale of GEFs and GAPs

(2011) Eva Wertheimer et al.   CELLULAR SIGNALLING

The E3 Ubiquitin-Ligase HACE1 Catalyzes the Ubiquitylation of Active Rac1

(2011) Stéphanie Torrino et al.   DEVELOPMENTAL CELL

The ubiquitin ligase HACE1 regulates Golgi membrane dynamics during the cell cycle

(2011) Danming Tang et al.   Nature Communications

Direct modifications of Rho proteins: deconstructing GTPase regulation

(2010) Orane Visvikis et al.   BIOLOGY OF THE CELL

The role of ubiquitylation and degradation in RhoGTPase signalling

(2010) Micha Nethe et al.   JOURNAL OF CELL SCIENCE

Identification of the Rac-GEF P-Rex1 as an Essential Mediator of ErbB Signaling in Breast Cancer

(2010) Maria Soledad Sosa et al.   MOLECULAR CELL

HER-2/neu Overexpression as a Predictor for the Transition from In situ to Invasive Breast Cancer

(2009) R. E. Roses et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NF B

(2009) T. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of ErbB2 induces invasion of MCF10A human breast epithelial cells via MMP-9

(2008) In-Young Kim et al.   CANCER LETTERS

Itch: a HECT-type E3 ligase regulating immunity, skin and cancer

(2008) G Melino et al.   CELL DEATH AND DIFFERENTIATION

Signal Transduction in Transgenic Mouse Models of Human Breast Cancer—Implications for Human Breast Cancer

(2008) Richard Marcotte et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Mammalian Rho GTPases: new insights into their functions from in vivo studies

(2008) Sarah J. Heasman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY