Overexpression of GAB2 in ovarian cancer cells promotes tumor growth and angiogenesis by upregulating chemokine expression

Enhanced GAB2 Expression Is Associated with Improved Survival in High-Grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition

(2015) S. J. Davis et al.   MOLECULAR CANCER THERAPEUTICS

PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion

(2015) M. Cecilia Caino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-vascular therapies in ovarian cancer: moving beyond anti-VEGF approaches

(2014) Hyun-Jin Choi et al.   CANCER AND METASTASIS REVIEWS

In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene

(2014) G. P. Dunn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumour angiogenesis regulation by the miR-200 family

(2013) Chad V. Pecot et al.   Nature Communications

JAK2/STAT5 Inhibition Circumvents Resistance to PI3K/mTOR Blockade: A Rationale for Cotargeting These Pathways in Metastatic Breast Cancer

(2012) Adrian Britschgi et al.   CANCER CELL

Inhibition of PI3K/mTOR Leads to Adaptive Resistance in Matrix-Attached Cancer Cells

(2012) Taru Muranen et al.   CANCER CELL

A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis

(2012) Swarnali Acharyya et al.   CELL

Interleukin-8 secretion by ovarian cancer cells increases anchorage-independent growth, proliferation, angiogenic potential, adhesion and invasion

(2012) Yue Wang et al.   CYTOKINE

Current status of chemokine receptor inhibitors in development

(2012) Marcello Allegretti et al.   IMMUNOLOGY LETTERS

PI3K/AKT/mTOR Inhibitors in Patients With Breast and Gynecologic Malignancies HarboringPIK3CAMutations

(2012) Filip Janku et al.   JOURNAL OF CLINICAL ONCOLOGY

GAB2--a Scaffolding Protein in Cancer

(2012) S. J. Adams et al.   MOLECULAR CANCER RESEARCH

GAB2 induces tumor angiogenesis in NRAS-driven melanoma

(2012) Y Yang et al.   ONCOGENE

Targeting angiogenesis in ovarian cancer

(2011) Jordan Schmitt et al.   CANCER TREATMENT REVIEWS

Frequent genetic abnormalities of the PI3K/AKT pathway in primary ovarian cancer predict patient outcome

(2011) Jia Huang et al.   GENES CHROMOSOMES & CANCER

Phase II trial of the mTOR inhibitor, temsirolimus and evaluation of circulating tumor cells and tumor biomarkers in persistent and recurrent epithelial ovarian and primary peritoneal malignancies: A Gynecologic Oncology Group study

(2011) Kian Behbakht et al.   GYNECOLOGIC ONCOLOGY

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Gab2 regulates the migratory behaviors and E-cadherin expression via activation of the PI3K pathway in ovarian cancer cells

(2011) Y Wang et al.   ONCOGENE

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

(2011) H. W. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amplification of CRKL Induces Transformation and Epidermal Growth Factor Receptor Inhibitor Resistance in Human Non-Small Cell Lung Cancers

(2011) H. W. Cheung et al.   Cancer Discovery

Activation of NF- B Signaling by Inhibitor of NF- B Kinase   Increases Aggressiveness of Ovarian Cancer

(2010) L. Hernandez et al.   CANCER RESEARCH

CXCR2 Promotes Ovarian Cancer Growth through Dysregulated Cell Cycle, Diminished Apoptosis, and Enhanced Angiogenesis

(2010) G. Yang et al.   CLINICAL CANCER RESEARCH

The chemokine CXCL1 induces proliferation in epithelial ovarian cancer cells by transactivation of the epidermal growth factor receptor

(2010) Christine Bolitho et al.   ENDOCRINE-RELATED CANCER

CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts

(2010) Christophe Ginestier et al.   JOURNAL OF CLINICAL INVESTIGATION

Function, regulation and pathological roles of the Gab/DOS docking proteins

(2009) Franziska U Wöhrle et al.   Cell Communication and Signaling

The tumor-promoting actions of TNF-α involve TNFR1 and IL-17 in ovarian cancer in mice and humans

(2009) Kellie A. Charles et al.   JOURNAL OF CLINICAL INVESTIGATION

Ovarian Cancer

(2008) Kathleen R. Cho et al.   Annual Review of Pathology-Mechanisms of Disease

Effect of Interleukin-8 Gene Silencing With Liposome-Encapsulated Small Interfering RNA on Ovarian Cancer Cell Growth

(2008) William M. Merritt et al.   JNCI-Journal of the National Cancer Institute

Class 1A PI3K regulates vessel integrity during development and tumorigenesis

(2008) T. L. Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA