Article
Pharmacology & Pharmacy
Fatemeh Zahedipour, Parvin Zamani, Khadijeh Jamialahmadi, Mahmoud Reza Jaafari, Amirhossein Sahebkar
Summary: Angiogenesis plays a significant role in the metastasis and progression of melanoma. Vaccines targeting angiogenesis in melanoma, including specific immunotherapy, show promise in inducing strong anti-tumor immune responses by targeting genetically stable endothelial cells. Various types of vaccines, such as DNA, peptide, protein, dendritic cell-based, and endothelial cell vaccines, have been studied to target angiogenesis in melanoma for potential progress in developing effective treatments.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Xiaoya Ding, Yunru Yu, Wenzhao Li, Yuanjin Zhao
Summary: We developed an MoS2 accelerated gelling hydrogel scaffold for promoting chronic diabetic wound healing through in situ three-dimensional bioprinting. The hydrogel was formed rapidly by simple mixing of benzaldehyde and cyanoacetate group-functionalized dextran solutions with MoS2 nanosheets, which were used as a microfluidic 3D-bioprinting ink. The printed MoS2 hydrogel scaffold exhibited antioxidant and photothermal antibacterial properties, leading to accelerated wound healing, wound closure, alleviated oxidative stress, and eliminated bacterial infection in chronic diabetic wounds.
Article
Chemistry, Multidisciplinary
Jin Zhang, Dongmei Tong, Honghai Song, Renjie Ruan, Yifu Sun, Yandai Lin, Jun Wang, Linxi Hou, Jiayong Dai, Jianxun Ding, Huanghao Yang
Summary: Engineering a biomimetically hierarchical scaffold can improve bone tissue regeneration by facilitating the balance of the immune system and bone metabolism. The scaffold exhibits strong immunomodulatory, intensive angiogenic, weak osteoclastogenic, and superior osteogenic abilities, providing a valuable foundation and inspiration for large-scale bone defect repair.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Mingda Zhao, Ruiling Xu, Yuedi Yang, Lei Tong, Jie Liang, Qing Jiang, Yujiang Fan, Xingdong Zhang, Yong Sun
Summary: In this study, a hybridized cross-linked hydrogel scaffold (HG) was created using tissue-affinity mercapto gelatin (GelS) and dopamine-modified hyaluronic acid (HAD). The scaffold integrated reduction-responsive nano-micelles loaded with doxorubicin (DOX) via click reaction, resulting in a bioabsorbable nano-micelle hybridized hydrogel scaffold (HGMP). The HGMP slowly released DOX and targeted B16F10 cells, effectively inhibiting tumor formation in mouse models and reducing postoperative melanoma recurrence.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Materials Science, Biomaterials
Xiongcheng Xu, Long Xiao, Yanmei Xu, Jin Zhuo, Xue Yang, Li Li, Nianqi Xiao, Jing Tao, Quan Zhong, Yanfen Li, Yuling Chen, Zhibin Du, Kai Luo
Summary: The study developed a PCL/LAP scaffold with excellent bioactivity using 3D printing technology, promoting osteogenic differentiation and angiogenesis of bone marrow mesenchymal stem cells, resulting in significant enhancement of vascularized bone formation in a calvarial defect model.
REGENERATIVE BIOMATERIALS
(2021)
Article
Biotechnology & Applied Microbiology
Hao Pan, Li Deng, Lingwei Huang, Qi Zhang, Jing Yu, Yueyue Huang, Lei Chen, Jiang Chang
Summary: Biomaterial-based bone grafts have been shown to be effective in treating large bone defects, and this study highlights the importance of immunomodulation and immune-regulated bone regeneration in addition to the direct interaction between scaffolds and bone-related cells. The study presents a three-dimensional printed silicate bioceramic scaffold with well-defined pore structures, which has the potential to be an implantable biomaterial for bone repair.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ruoyu Mu, Yuhan Zhang, Lingli Yan, Zhencheng Liao, Yushun Yang, Huanxing Su, Lei Dong, Chunming Wang
Summary: This study introduces a glycan material mimicking fungal action to support endothelial cell adhesion, promote blood perfusion, and exhibit high safety potential for vascular therapy.
ADVANCED MATERIALS
(2021)
Article
Peripheral Vascular Disease
Cristina Mauri, Andreas van Impel, Eirinn William Mackay, Stefan Schulte-Merker
Summary: Recent studies have shown that the adaptor protein Grb2b plays a crucial role in lymphatic versus venous sprout cell behavior, with higher requirements for Grb2b and Vegfr3 downstream signaling levels in lymphatic structures compared to vein precursor-generating sprouts.
Review
Chemistry, Multidisciplinary
Jasna Nambiar, Sonali Jana, Samit Kumar Nandi
Summary: This review highlights the latest strategies to promote biomaterial-based scaffold vascularization, including the incorporation of cells, growth factors, inorganic ions, etc., as well as structural modifications, biophysical stimuli, and natural molecules.
Article
Biochemistry & Molecular Biology
Carly Boye, Kyle Christensen, Kamal Asadipour, Scott DeClemente, Michael Francis, Anna Bulysheva
Summary: This study optimized gene electrotransfer and bioprinting techniques to accelerate tendon healing, showing that the combination of collagen scaffolds and angiogenic GET therapy can improve angiogenesis and biocompatibility of implants, potentially enhancing graft biocompatibility in tendon repair.
BIOELECTROCHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Xueyang Zheng, Na Li, Yong Xu, Chuanxin Zhang, Yueping Ouyang, Depeng Meng
Summary: Stem cell-based tissue engineering combined with a bilayer scaffold loaded with bevacizumab shows promising results in promoting stable osteochondral regeneration and preventing vascular invasion. This study highlights a new avenue for osteochondral regeneration by leveraging anti-angiogenesis activity.
MATERIALS & DESIGN
(2022)
Review
Nanoscience & Nanotechnology
Inigo Perez-Estenaga, Merari Tumin Chevalier, Estefania Pena, Gloria Abizanda, Amir M. Alsharabasy, Eduardo Larequi, Myriam Cilla, Marta M. Perez, Jon Gurtubay, Manuel Garcia-Yebenes Castro, Felipe Prosper, Abhay Pandit, Beatriz Pelacho
Summary: Ischemic heart disease is a major cause of death worldwide. A collagen hydrogel loaded with pro-angiogenic SDF1 was combined with a compact collagen membrane to create a bilayer collagen-on-collagen scaffold (bCS), capable of efficiently delivering therapeutic growth factors after myocardial infarction (MI). In vitro and in vivo studies demonstrated that the bCS had suitable physicochemical properties, leading to sustained release of SDF1, integration into the heart tissue, anti-inflammatory and pro-angiogenic macrophage presence, revascularization, and improved cardiac function. This multimodal scaffold can serve as a promising matrix for drug delivery and functional recovery after MI.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Biomaterials
Jupei Zhang, Zhen Zeng, Yanxin Chen, Li Deng, Yanxin Zhang, Yumei Que, Yiren Jiao, Jiang Chang, Zhihong Dong, Chen Yang
Summary: The increasing number of mastectomies has led to the development of adipose tissue restoration techniques. However, current clinical strategies are not effective due to the need for personalized customization and timely vascularization in adipose regeneration. This study used 3D printing technology to create a composite hydrogel scaffold that promoted adipose tissue regeneration in vitro and in vivo, making it a potential candidate for adipose tissue engineering.
REGENERATIVE BIOMATERIALS
(2023)
Article
Engineering, Biomedical
Changru Zhang, Ya Ren, Weiqing Kong, Yihao Liu, Heyue Li, Han Yang, Bin Cai, Kerong Dai, Chengwei Wang, Liang Tang, Haoyi Niu, Jinwu Wang
Summary: In this study, a double-bond-functionalized photocurable mesoporous bioglass sol was developed for the fabrication of personalized and highly porous PMBG/TCP biphasic scaffolds. The scaffolds exhibited regulated mechanical properties and degradation behavior through the varying amount of TCP doping. In vitro and in vivo experiments confirmed the release of SiO2 and Ca2+ from the scaffolds, creating a bone regeneration microenvironment that promotes angiogenesis and accelerates bone tissue regeneration.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Article
Biochemistry & Molecular Biology
Weijia Zheng, Zhenzu Bai, Shan Huang, Kai Jiang, Long Liu, Xiaoyan Wang
Summary: Efficient biological scaffolds are needed to promote bone defect healing. This study reports on the preparation of a composite scaffold using coaxial electrospinning. The scaffold has a nano-scale morphology, high porosity, and sufficient mechanical strength to support tissue. Furthermore, the scaffold can sustain the release of nutrients, promoting bone and blood vessel growth, and accelerating bone defect repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jason K. Sa, Seung Won Choi, Junfei Zhao, Yeri Lee, Jing Zhang, Doo-Sik Kong, Jung Won Choi, Ho Jun Seol, Jung-Il Lee, Antonio Iavarone, Raul Rabadan, Do-Hyun Nam
INTERNATIONAL JOURNAL OF CANCER
(2019)
Article
Dermatology
Shuang Chen, Kaiwen Zhuang, Kaiyi Sun, Qin Yang, Xin Ran, Xiaoxi Xu, Chan Mu, Bin Zheng, Yanrong Lu, Jun Zeng, Yalin Dai, Pradhan Sushmita, Yuping Ran
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2019)
Article
Oncology
Maria Teresa Blasco, Carolina Navas, Guillermo Martin-Serrano, Osvaldo Grana-Castro, Carmen G. Lechuga, Laura Martin-Diaz, Magdolna Djurec, Jing Li, Lucia Morales-Cacho, Laura Esteban-Burgos, Javier Perales-Paton, Emilie Bousquet-Mur, Eva Castellano, Harrys K. C. Jacob, Lavinia Cabras, Monica Musteanu, Matthias Drosten, Sagrario Ortega, Francisca Mulero, Bruno Sainz Jr, Nelson Dusetti, Juan Iovanna, Francisco Sanchez-Bueno, Manuel Hidalgo, Hossein Khiabanian, Raul Rabadan, Fatima Al-Shahrour, Carmen Guerra, Mariano Barbacid
Letter
Hematology
Luciano Cascione, Andrea Rinaldi, Alessio Bruscaggin, Chiara Tarantelli, Alberto J. Arribas, Ivo Kwee, Lorenza Pecciarini, Afua A. Mensah, Valeria Spina, Elaine Y. L. Chung, Lodovico Terzi di Bergamo, Stephan Dirnhofer, Alexandar Tzankov, Roberto N. Miranda, Ken H. Young, Alexandra Traverse-Glehen, Gianluca Gaidano, Steven H. Swerdlow, Randy Gascoyne, Raul Rabadan, Maurilio Ponzoni, Govind Bhagat, Davide Rossi, Emanuele Zucca, Francesco Bertoni
Article
Biochemical Research Methods
Rose Orenbuch, Ioan Filip, Devon Comito, Jeffrey Shaman, Itsik Pe'er, Raul Rabadan
Article
Statistics & Probability
Lorin Crawford, Anthea Monod, Andrew X. Chen, Sayan Mukherjee, Raul Rabadan
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
(2020)
Article
Dermatology
Qian Zhou, Sun Hye Kim, Rolando Perez-Lorenzo, Chang Liu, Man Huang, Gian Paolo Dotto, Bin Zheng, Xunwei Wu
Summary: Phenformin not only exhibits antitumor activity, but also promotes keratinocyte differentiation, showing potential value in the treatment of cutaneous squamous cell carcinomas.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Editorial Material
Dermatology
Joanna Jackow, Avina Rami, Ryota Hayashi, Corey Hansen, Zongyou Guo, Dominick DeLorenzo, Alberto Pappalardo, David Alvarez Cespedes, Arianna L. Kim, Rolando Perez-Lorenzo, David M. Owens, Angela M. Christiano
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Zhaowei Chu, Lei Gu, Yeguang Hu, Xiaoyang Zhang, Man Li, Jiajia Chen, Da Teng, Man Huang, Che-Hung Shen, Li Cai, Toshimi Yoshida, Yifeng Qi, Zhixin Niu, Austin Feng, Songmei Geng, Dennie T. Frederick, Emma Specht, Adriano Piris, Ryan J. Sullivan, Keith T. Flaherty, Genevieve M. Boland, Katia Georgopoulos, David Liu, Yang Shi, Bin Zheng
Summary: STAG2 is involved in DNA looping and plays a role in controlling the expression of IRF9 and PD-L1, which are related to immune evasion in cancer cells. This study provides insights into the role of STAG2 in 3D genome organization and its functional link to interferon signaling in cancer.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Ping Yuan, Da Teng, Evelyn de Groot, Man Li, Sebastian Trousil, Che-Hung Shen, Jason Roszik, Michael A. Davies, Y. N. Vashisht Gopal, Bin Zheng
Summary: Through analysis of the TCGA melanoma dataset, it was discovered that the AMPK alpha 2 gene is mutated in approximately 9% of cutaneous melanomas, and these mutations often co-occur with NF1 mutations. Knockout of AMPK alpha 2 promotes the growth of NF1-mutant melanoma cells, while ectopic expression of AMPK alpha 2 inhibits their growth in soft agar assays. Additionally, loss of AMPK alpha 2 accelerates tumor growth and enhances brain metastasis in NF1-mutant melanoma.
Article
Medicine, Research & Experimental
Mahmudur Rahman, Atqiya Munawara Mahi, Rachel Melamed, Mohammad Arif Ul Alam
Summary: Through large-scale observational data and statistical analysis, this study found that antidepressants may increase the risk of COVID-19 complications and uncovered a correlation between certain antidepressants and a lower risk of hospitalization. These findings can guide preventive care and provide suggestions for drug repurposing in COVID-19 treatment.
INTERACTIVE JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Hongyun Zhao, Da Teng, Lifeng Yang, Xincheng Xu, Jiajia Chen, Tengjia Jiang, Austin Y. Feng, Yaqing Zhang, Dennie T. Frederick, Lei Gu, Li Cai, John M. Asara, Marina Pasca di Magliano, Genevieve M. Boland, Keith T. Flaherty, Kenneth D. Swanson, David Liu, Joshua D. Rabinowitz, Bin Zheng
Summary: This study reveals that itaconate, produced by myeloid-derived suppressor cells (MDSCs), acts as an immune checkpoint metabolite to suppress CD8(+) T cells. Inhibition of IRG1 may enhance anti-tumour immunity and improve the efficacy of immune checkpoint blockade. These findings have implications for understanding immune surveillance and developing new strategies for cancer treatment.
Review
Oncology
Hongyun Zhao, Kenneth D. Swanson, Bin Zheng
Summary: Biguanides demonstrate antitumor activities and have potential for cancer prevention and treatment, but further understanding of their mechanisms of action is needed to enhance their applications in cancer therapy.
Article
Health Care Sciences & Services
Rachel D. Melamed