Systematic integration of molecular profiles identifies miR-22 as a regulator of lipid and folate metabolism in breast cancer cells

High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion

(2015) Laura Lehtinen et al.   Oncotarget

A Regulatory Loop Involving miR-22, Sp1, and c-Myc Modulates CD147 Expression in Breast Cancer Invasion and Metastasis

(2014) L.-M. Kong et al.   CANCER RESEARCH

Fatty acid and phospholipid biosynthetic pathways are regulated throughout mammary epithelial cell differentiation and correlate to breast cancer survival

(2014) M. Luisa Dória et al.   FASEB JOURNAL

Mitochondrial MTHFD2L Is a Dual Redox Cofactor-specific Methylenetetrahydrofolate Dehydrogenase/Methenyltetrahydrofolate Cyclohydrolase Expressed in Both Adult and Embryonic Tissues

(2014) Minhye Shin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative flux analysis reveals folate-dependent NADPH production

(2014) Jing Fan et al.   NATURE

Proteomic and Lipidomic Signatures of Lipid Metabolism in NASH-Associated Hepatocellular Carcinoma

(2013) K. Muir et al.   CANCER RESEARCH

MicroRNA-Antagonism Regulates Breast Cancer Stemness and Metastasis via TET-Family-Dependent Chromatin Remodeling

(2013) Su Jung Song et al.   CELL

The Oncogenic MicroRNA miR-22 Targets the TET2 Tumor Suppressor to Promote Hematopoietic Stem Cell Self-Renewal and Transformation

(2013) Su Jung Song et al.   Cell Stem Cell

MicroRNA-22 Regulates Cardiac Hypertrophy and Remodeling in Response to Stress

(2013) Zhan-Peng Huang et al.   CIRCULATION RESEARCH

Inhibition of ATP citrate lyase induces triglyceride accumulation with altered fatty acid composition in cancer cells

(2013) Toshiro Migita et al.   INTERNATIONAL JOURNAL OF CANCER

A Myc–microRNA network promotes exit from quiescence by suppressing the interferon response and cell-cycle arrest genes

(2013) Damon Polioudakis et al.   NUCLEIC ACIDS RESEARCH

microRNA-22 Promotes Heart Failure through Coordinate Suppression of PPAR/ERR-Nuclear Hormone Receptor Transcription

(2013) Priyatansh Gurha et al.   PLoS One

Prognostic microRNA/mRNA signature from the integrated analysis of patients with invasive breast cancer

(2013) S. Volinia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A microRNA signature defines chemoresistance in ovarian cancer through modulation of angiogenesis

(2013) A. Vecchione et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

(2013) D. Rohle et al.   SCIENCE

Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells

(2013) P M Tedeschi et al.   Cell Death & Disease

Building Multivariate Systems Biology Models

(2012) Gemma M. Kirwan et al.   ANALYTICAL CHEMISTRY

IsoCor: correcting MS data in isotope labeling experiments

(2012) P. Millard et al.   BIOINFORMATICS

ATP-Citrate Lyase: A Key Player in Cancer Metabolism

(2012) N. Zaidi et al.   CANCER RESEARCH

Targeted Deletion of MicroRNA-22 Promotes Stress-Induced Cardiac Dilation and Contractile Dysfunction

(2012) Priyatansh Gurha et al.   CIRCULATION

A novel miR-155/miR-143 cascade controls glycolysis by regulatinghexokinase 2in breast cancer cells

(2012) Shuai Jiang et al.   EMBO JOURNAL

MicroRNA-22 is induced by vitamin D and contributes to its antiproliferative, antimigratory and gene regulatory effects in colon cancer cells

(2012) Silvia Alvarez-Díaz et al.   HUMAN MOLECULAR GENETICS

Differentiation-associated microRNAs antagonize the Rb–E2F pathway to restrict proliferation

(2012) Matteo J. Marzi et al.   JOURNAL OF CELL BIOLOGY

How cancer metabolism is tuned for proliferation and vulnerable to disruption

(2012) Almut Schulze et al.   NATURE

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

(2012) Dimitrios Anastasiou et al.   Nature Chemical Biology

miRSystem: An Integrated System for Characterizing Enriched Functions and Pathways of MicroRNA Targets

(2012) Tzu-Pin Lu et al.   PLoS One

Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC

(2012) W. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

(2012) M. Jain et al.   SCIENCE

A software complement to AMDIS for processing GC-MS metabolomic data

(2011) Volker Behrends et al.   ANALYTICAL BIOCHEMISTRY

Tumor Suppressor miR-22 Determines p53-Dependent Cellular Fate through Post-transcriptional Regulation of p21

(2011) N. Tsuchiya et al.   CANCER RESEARCH

MicroRNA Sequence and Expression Analysis in Breast Tumors by Deep Sequencing

(2011) T. A. Farazi et al.   CANCER RESEARCH

The Lin28/let-7 Axis Regulates Glucose Metabolism

(2011) Hao Zhu et al.   CELL

miR-22 represses cancer progression by inducing cellular senescence

(2011) Dan Xu et al.   JOURNAL OF CELL BIOLOGY

Attenuation of MicroRNA-22 derepressed PTEN to effectively protect rat cardiomyocytes from hypertrophy

(2011) Xu-Dong Xu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Global microRNA Analysis of the NCI-60 Cancer Cell Panel

(2011) R. Sokilde et al.   MOLECULAR CANCER THERAPEUTICS

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

(2011) Christian Frezza et al.   NATURE

microRNA-22, downregulated in hepatocellular carcinoma and correlated with prognosis, suppresses cell proliferation and tumourigenicity

(2010) J Zhang et al.   BRITISH JOURNAL OF CANCER

miR-378 ∗ Mediates Metabolic Shift in Breast Cancer Cells via the PGC-1β/ERRγ Transcriptional Pathway

(2010) Lillian J. Eichner et al.   Cell Metabolism

Regulation of MicroRNA Expression and Abundance during Lymphopoiesis

(2010) Stefan Kuchen et al.   IMMUNITY

A Link between mir-100 and FRAP1/mTOR in Clear Cell Ovarian Cancer

(2010) Ankur K. Nagaraja et al.   MOLECULAR ENDOCRINOLOGY

Ancient animal microRNAs and the evolution of tissue identity

(2010) Foteini Christodoulou et al.   NATURE

OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma

(2010) Pedro P. Medina et al.   NATURE

Discovery of microRNAs and other small RNAs in solid tumors

(2010) Eti Meiri et al.   NUCLEIC ACIDS RESEARCH

Tumor-suppressive microRNA-22 inhibits the transcription of E-box-containing c-Myc target genes by silencing c-Myc binding protein

(2010) J Xiong et al.   ONCOGENE

Control of EVI-1 oncogene expression in metastatic breast cancer cells through microRNA miR-22

(2010) J B Patel et al.   ONCOGENE

A scaling normalization method for differential expression analysis of RNA-seq data

(2010) Mark D Robinson et al.   GENOME BIOLOGY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

(2009) Balazs Györffy et al.   BREAST CANCER RESEARCH AND TREATMENT

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Downregulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells

(2009) Yohei Shimono et al.   CELL

Mitochondrial C1-Tetrahydrofolate Synthase (MTHFD1L) Supports the Flow of Mitochondrial One-carbon Units into the Methyl Cycle in Embryos

(2009) Schuyler T. Pike et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-22 Inhibits Estrogen Signaling by Directly Targeting the Estrogen Receptor   mRNA

(2009) D. P. Pandey et al.   MOLECULAR AND CELLULAR BIOLOGY

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice

(2009) Hervé Guillou et al.   PROGRESS IN LIPID RESEARCH

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH