Targeting hedgehog signaling reduces self-renewal in embryonal rhabdomyosarcoma

Glycogen synthase kinase 3 inhibitors induce the canonical WNT/ -catenin pathway to suppress growth and self-renewal in embryonal rhabdomyosarcoma

(2014) E. Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive Genomic Analysis of Rhabdomyosarcoma Reveals a Landscape of Alterations Affecting a Common Genetic Axis in Fusion-Positive and Fusion-Negative Tumors

(2014) J. F. Shern et al.   Cancer Discovery

Targeting Oxidative Stress in Embryonal Rhabdomyosarcoma

(2013) Xiang Chen et al.   CANCER CELL

Distinct Effects of Ligand-Induced PDGFR  and PDGFR  Signaling in the Human Rhabdomyosarcoma Tumor Cell and Stroma Cell Compartments

(2013) M. Ehnman et al.   CANCER RESEARCH

What is new in the biology and treatment of pediatric rhabdomyosarcoma?

(2013) Douglas S. Hawkins et al.   CURRENT OPINION IN PEDIATRICS

Characterization of Wnt/β-catenin signaling in rhabdomyosarcoma

(2013) Srinivas R Annavarapu et al.   LABORATORY INVESTIGATION

Unraveling the therapeutic potential of the Hedgehog pathway in cancer

(2013) Dereck Amakye et al.   NATURE MEDICINE

Targeting cancer stem cells to suppress acquired chemotherapy resistance

(2013) S J Vidal et al.   ONCOGENE

Distinct cellular origin and genetic requirement of Hedgehog-Gli in postnatal rhabdomyosarcoma genesis

(2013) M Rajurkar et al.   ONCOGENE

In Vivo Imaging of Tumor-Propagating Cells, Regional Tumor Heterogeneity, and Dynamic Cell Movements in Embryonal Rhabdomyosarcoma

(2012) Myron S. Ignatius et al.   CANCER CELL

Hedgehog Signaling Regulates MyoD Expression and Activity

(2012) Anastassia Voronova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The developing cancer stem-cell model: clinical challenges and opportunities

(2012) Louis Vermeulen et al.   LANCET ONCOLOGY

CD133 marks a myogenically primitive subpopulation in rhabdomyosarcoma cell lines that are relatively chemoresistant but sensitive to mutant HSV

(2012) Joseph G. Pressey et al.   PEDIATRIC BLOOD & CANCER

Wnt signaling in myogenesis

(2012) Julia von Maltzahn et al.   TRENDS IN CELL BIOLOGY

Gli Proteins in Development and Disease

(2011) Chi-chung Hui et al.   Annual Review of Cell and Developmental Biology

Inhibition of Notch3 signalling induces rhabdomyosarcoma cell differentiation promoting p38 phosphorylation and p21Cip1 expression and hampers tumour cell growth in vitro and in vivo

(2011) L Raimondi et al.   CELL DEATH AND DIFFERENTIATION

High-resolution array CGH identifies common mechanisms that drive embryonal rhabdomyosarcoma pathogenesis

(2011) Vera Paulson et al.   GENES CHROMOSOMES & CANCER

Uncommitted precursor cells might contribute to increased incidence of embryonal rhabdomyosarcoma in heterozygous Patched1-mutant mice

(2011) F Nitzki et al.   ONCOGENE

Hedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: A report from the Children's Oncology Group

(2011) Joseph G. Pressey et al.   PEDIATRIC BLOOD & CANCER

Switching on pluripotency: a perspective on the biological requirement of Nanog

(2011) T. W. Theunissen et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

CD133 Positive Embryonal Rhabdomyosarcoma Stem-Like Cell Population Is Enriched in Rhabdospheres

(2011) Dagmar Walter et al.   PLoS One

Targeting Hedgehog -- a Cancer Stem Cell Pathway

(2010) A. A. Merchant et al.   CLINICAL CANCER RESEARCH

Lmx1b is required for murine trabecular meshwork formation and for maintenance of corneal transparency

(2010) Pu Liu et al.   DEVELOPMENTAL DYNAMICS

Hedgehog controls neural stem cells through p53-independent regulation of Nanog

(2010) Agnese Po et al.   EMBO JOURNAL

NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53

(2010) Marie Zbinden et al.   EMBO JOURNAL

Activation of the hedgehog pathway confers a poor prognosis in embryonal and fusion gene-negative alveolar rhabdomyosarcoma

(2010) A Zibat et al.   ONCOGENE

Tumour formation by single fibroblast growth factor receptor 3-positive rhabdomyosarcoma-initiating cells

(2009) M Hirotsu et al.   BRITISH JOURNAL OF CANCER

A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers

(2009) Barbara Stecca et al.   EMBO JOURNAL

A Temporal Switch from Notch to Wnt Signaling in Muscle Stem Cells Is Necessary for Normal Adult Myogenesis

(2008) Andrew S. Brack et al.   Cell Stem Cell

Niche Regulation of Muscle Satellite Cell Self-Renewal and Differentiation

(2008) Shihuan Kuang et al.   Cell Stem Cell