LGR5, a novel functional glioma stem cell marker, promotes EMT by activating the Wnt/β-catenin pathway and predicts poor survival of glioma patients

An advanced glioma cell invasion assay based on organotypic brain slice cultures

(2018) Tanja Eisemann et al.   BMC CANCER

LGR5 overexpression confers poor relapse-free survival in breast cancer patients

(2018) Ming-Feng Hou et al.   BMC CANCER

β-catenin-mediated YAP signaling promotes human glioma growth

(2017) Yan Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Sulfasalazine attenuates evading anticancer response of CD133-positive hepatocellular carcinoma cells

(2017) Yeonhwa Song et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Notch signaling plays a crucial role in cancer stem-like cells maintaining stemness and mediating chemotaxis in renal cell carcinoma

(2017) Wei Xiao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

LGR5 Is a Gastric Cancer Stem Cell Marker Associated with Stemness and the EMT Signature Genes NANOG, NANOGP8, PRRX1, TWIST1, and BMI1

(2017) Bei Wang et al.   PLoS One

Epithelial-mesenchymal transition in glioblastoma progression

(2016) YASUO IWADATE   Oncology Letters

Glioma Stem Cells: Signaling, Microenvironment, and Therapy

(2016) Brandon D. Liebelt et al.   Stem Cells International

The role of LGR5 and ALDH1A1 in non-small cell lung cancer: Cancer progression and prognosis

(2015) Fei Gao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mechanisms regulating glioma invasion

(2015) Ivy Paw et al.   CANCER LETTERS

Stem cell signature in glioblastoma: therapeutic development for a moving target

(2015) Ichiro Nakano   JOURNAL OF NEUROSURGERY

The methylation status of the platelet-derived growth factor-B gene promoter and its regulation of cellular proliferation following folate treatment in human glioma cells

(2014) Yiqiang Zhou et al.   BRAIN RESEARCH

Leucine-rich repeat-containing G-protein-coupled receptor 5 is associated with invasion, metastasis and could be a potential therapeutic target in human gastric cancer

(2014) H Q Xi et al.   BRITISH JOURNAL OF CANCER

Transforming growth factor-β1-induced epithelial–mesenchymal transition generates ALDH-positive cells with stem cell properties in cholangiocarcinoma

(2014) Ze-Yu Shuang et al.   CANCER LETTERS

Detection of Brain Tumor Cells in the Peripheral Blood by a Telomerase Promoter-Based Assay

(2014) Kelly M. MacArthur et al.   CANCER RESEARCH

LGR5 is required for the maintenance of spheroid-derived colon cancer stem cells

(2014) XIANG CHEN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Targeting adaptive glioblastoma: an overview of proliferation and invasion

(2014) Q. Xie et al.   NEURO-ONCOLOGY

Knockdown of LGR5 Suppresses the Proliferation of Glioma Cells in Vitro and in Vivo

(2014) Phillip V. Parry et al.   NEUROSURGERY

Targeting Role of Glioma Stem Cells for Gliobastoma Multiforme

(2013) X. Zhang et al.   CURRENT MEDICINAL CHEMISTRY

Helicobacter pylori generates cells with cancer stem cell properties via epithelial–mesenchymal transition-like changes

(2013) E Bessède et al.   ONCOGENE

Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3

(2013) P. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LGR5 is a Marker of Poor Prognosis in Glioblastoma and is Required for Survival of Brain Cancer Stem-Like Cells

(2012) Susumu Nakata et al.   BRAIN PATHOLOGY

EMT and Dissemination Precede Pancreatic Tumor Formation

(2012) Andrew D. Rhim et al.   CELL

LGR5-Positive Colon Cancer Stem Cells Interconvert with Drug-Resistant LGR5-Negative cells and are Capable of Tumor Reconstitution

(2012) Shinta Kobayashi et al.   STEM CELLS

Current Strategies for Identification of Glioma Stem Cells: Adequate or Unsatisfactory?

(2012) Paola Brescia et al.   Journal of Oncology

MAP3K4/CBP-Regulated H2B Acetylation Controls Epithelial-Mesenchymal Transition in Trophoblast Stem Cells

(2011) Amy N. Abell et al.   Cell Stem Cell

Significance of Lgr5+ve Cancer Stem Cells in the Colon and Rectum

(2010) Hidekazu Takahashi et al.   ANNALS OF SURGICAL ONCOLOGY

Transcriptional Profiles of CD133+ and CD133- Glioblastoma-Derived Cancer Stem Cell Lines Suggest Different Cells of Origin

(2010) C. Lottaz et al.   CANCER RESEARCH

Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

(2010) Nick Barker et al.   Cell Stem Cell

Glioma stem cells are more aggressive in recurrent tumors with malignant progression than in the primary tumor, and both can be maintained long-term in vitro

(2008) Qiang Huang et al.   BMC CANCER

Hypoxia-Inducible Factor-1  Obstructs a Wnt Signaling Pathway by Inhibiting the hARD1-Mediated Activation of  -Catenin

(2008) J.-H. Lim et al.   CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Epithelial-Mesenchymal Transition and the Stem Cell Phenotype

(2008) Derek C. Radisky et al.   Cell Stem Cell

Malignant Gliomas in Adults

(2008) Patrick Y. Wen et al.   NEW ENGLAND JOURNAL OF MEDICINE