Article
Oncology
Giorgio Bogani, Francesco Sopracordevole, Violante Di Donato, Andrea Ciavattini, Alessandro Ghelardi, Salvatore Lopez, Tommaso Simoncini, Francesco Plotti, Jvan Casarin, Maurizio Serati, Ciro Pinelli, Gaetano Valenti, Alice Bergamini, Barbara Gardella, Andrea Dell'acqua, Ermelinda Monti, Paolo Vercellini, Margherita Fischetti, Giovanni D'ippolito, Lorenzo Aguzzoli, Vincenzo D. Mandato, Paola Carunchio, Gabriele Carlinfante, Luca Giannella, Cono Scaffa, Francesca Falcone, Chiara Borghi, Antonino Ditto, Mario Malzoni, Andrea Giannini, Maria Giovanna Salerno, Viola Liberale, Biagio Contino, Cristina Donfrancesco, Michele Desiato, Anna Myriam Perrone, Giulia Dondi, Pierandrea De Iaco, Valentina Chiappa, Simone Ferrero, Giuseppe Sarpietro, Maria G. Matarazzo, Antonio Cianci, Sara Bosio, Simona Ruisi, Rocco Guerrisi, Claudia Brusadelli, Lavinia Mosca, Antonio Simone Lagana, Raffaele Tinelli, Mauro Signorelli, Rosa De Vincenzo, Gian Franco Zannoni, Gabriella Ferrandina, Sara Lovati, Marco Petrillo, Salvatore Dessole, Annunziata Carlea, Fulvio Zullo, Roberto Angioli, Stefano Greggi, Arsenio Spinillo, Fabio Ghezzi, Nicola Colacurci, Ludovico Muzii, Pierluigi Benedetti Panici, Giovanni Scambia, Francesco Raspagliesi
Summary: This study evaluated the outcomes of high-risk (HR) HPV-positive and -negative women with high-grade cervical dysplasia. It found that HR-HPV-positive patients had a higher risk of recurrence at 5 years compared to HR-HPV-negative patients. Further prospective studies are needed to corroborate these findings.
GYNECOLOGIC ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Pui-Wah Choi, Tin Lun Liu, Chun Wai Wong, Sze Kei Liu, Yick-Liang Lum, Wai-Kit Ming
Summary: This review focuses on the dysregulation of miRNAs in the pre-stage of cervical cancer. Several dysregulated miRNAs have been identified and found to be associated with the DNA damage response and cell growth response induced by human papillomavirus (HPV) infection. However, discrepancies in sample types, HPV status, expression measurement, and analysis methods have led to non-aligned results across studies. This review provides insight into identifying miRNAs involved in early pathogenic processes and highlights their potential as biomarkers for cervical pre-cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Natasja Hendriks, Margot M. Koeneman, Anna J. M. van de Sande, Charlotte G. J. Penders, Jurgen M. J. Piek, Loes F. S. Kooreman, Sander M. J. van Kuijk, Linde Hoosemans, Simone J. S. Sep, Peggy J. de Vos Van Steenwijk, Heleen J. van Beekhuizen, Brigitte F. M. Slangen, Hans W. Nijman, Roy F. P. M. Kruitwagen, Arnold-Jan Kruse
Summary: Topical imiquimod cream may be an alternative treatment for high-grade cervical intraepithelial neoplasia, although its effectiveness is considerably lower compared to standard treatment options.
JOURNAL OF IMMUNOTHERAPY
(2022)
Article
Pathology
Antonio Raffone, Antonio Travaglino, Antonio Angelino, Rosanna Esposito, Giuliana Orlandi, Paolo Toscano, Antonio Mollo, Luigi Insabato, Matilde Sansone, Fulvio Zullo
Summary: This study investigated the prognostic impact of GV and TV infections on CIN1/L-SIL in HIV-positive women, finding that GV infection is a risk factor for persistence of CIN1/L-SIL while TV infection is a risk factor for progression. Women with these infections may require closer and more careful follow-up of CIN1/L-SIL.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Maria Kyrgiou, Anna-Barbara Moscicki
Summary: The microbiome in the female reproductive tract plays a crucial role in maintaining health and homeostasis. Imbalances in the genital tract microbiome and specific bacteria and cytokines may contribute to the development of HPV infection and cervical intra-epithelial neoplasia, leading to cervical cancer.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Medicine, General & Internal
Gaetano Riemma, Maria Teresa Schettino, Gaetano Maria Munno, Diego Domenico Fasulo, Lucia Sandullo, Emanuele Amabile, Marco La Verde, Marco Torella
Summary: This study found that supplementation with Echinacea extracts in women with L-SIL/CIN-1 significantly enhances HPV lesion clearance and improves colposcopic, histological, and vaginal parameters. However, the limited sample size reduces the quality of the evaluated evidence, highlighting the need for further studies to validate these findings.
MEDICINA-LITHUANIA
(2022)
Article
Oncology
Smita Joshi, Richard Muwonge, Vinay Kulkarni, Mahesh Mandolkar, Eric Lucas, Sanjay Pujari, Rengaswamy Sankaranarayanan, Partha Basu
Summary: This study provides updated incidence rates of cervical intraepithelial neoplasia (CIN) among women living with HIV (WHIV), and examines disease outcomes and HPV status among women treated for CIN. The study found that women who cleared HPV infection had a significantly increased risk of incident CIN 2 or worse lesions, while those with persistent HPV infection had an even higher risk of such lesions. The study also highlights the importance of long-term surveillance and the possibility of extending screening intervals among HPV negative women.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Biology
Georgios Panagakis, Ioannis K. Papapanagiotou, Charalampos Theofanakis, Paraskevi Tsetsa, Adamantia Kontogeorgi, Nikolaos Thomakos, Alexandros Rodolakis, Dimitrios Haidopoulos
Summary: The study evaluates the effectiveness of combining electrical impedance spectroscopy (EIS) with colposcopy in detecting high-grade cervical lesions. The results demonstrate that EIS exhibits high sensitivity and specificity in detecting high-grade lesions.
Article
Immunology
Barbara Gardella, Mattia Dominoni, Marianna Francesca Pasquali, Chiara Melito, Giacomo Fiandrino, Stefania Cesari, Marco La Verde, Arsenio Spinillo
Summary: This study aimed to evaluate the effect of anti-HPV preventive vaccination on patients with low-grade cervical lesions. The results showed that the rate of persistence and progression of CIN was higher in the unvaccinated group compared to the vaccinated group. The study also found that vaccination, age, and HPV genotypes were associated with the development of CIN2+.
Article
Virology
Ian N. Hampson
Summary: Vaccination programs with HPV vaccines have been proven effective in preventing HPV infection and related diseases. Reductions in vaccine-covered HPV types have also been observed in unvaccinated women, but the effects of vaccine-associated HPV type-replacement are still unclear.
Review
Biochemistry & Molecular Biology
Barbara Gardella, Marianna Francesca Pasquali, Marco La Verde, Stefano Cianci, Marco Torella, Mattia Dominoni
Summary: This study reviewed the interaction between vaginal microbiota, cervical intraepithelial neoplasia (CIN), and the immune response. While some studies struggle to demonstrate the correlation between vaginal microbiota and HPV-related lesions, there is significant evidence suggesting changes in vaginal microbiota in HPV-positive women. The presence of new bacteria, pathway deregulation, and cytokine overexpression are strongly associated with the progression of cervical dysplasia and chronic inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Xiaoyun Wang, Lifang You, Weijiang Zhang, Yaxi Ma, Yixin Tang, Wenxuan Xu
Summary: This retrospective study evaluated the clinical efficacy and safety of 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) for the treatment of low-grade squamous intraepithelial neoplasia (LSIL) of the cervix with high-risk HPV infection. The results showed a significant pathological regression ratio and clearance of HPV-DNA in the majority of patients, as well as shrinkage of cervical ectropion and reduction of vaginal secretions after PDT treatment.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Oncology
Qiaoli Zheng, Xianzhen Chen, Rui Han, Jiang Zhu, Hui Wang, Lingjing Chen, Yinjing Song, Luxia Chen, Hao Cheng, Na Jin
Summary: The HPV58 E7 protein is highly expressed in both cervical cancer and CIN tissues. Combined with p16 and Ki-67 immunohistochemistry, the HPV58 E7 IHC may be sensitive and specific for evaluating HPV-driven cervical cancer and pre-cancerous lesions.
Article
Medicine, General & Internal
Sarah J. Bowden, Triada Doulgeraki, Emmanouil Bouras, Georgios Markozannes, Antonios Athanasiou, Harriet Grout-Smith, Konstantinos S. Kechagias, Laura Burney Ellis, Verena Zuber, Marc Chadeau-Hyam, James M. Flanagan, Konstantinos K. Tsilidis, Ilkka Kalliala, Maria Kyrgiou
Summary: Persistent HPV infection is necessary but not sufficient for cervical cancer. Behavioral, environmental, or comorbid exposures may affect the development of cervical cancer. However, the validity of the observational studies describing these associations is still unclear.
Article
Obstetrics & Gynecology
Agustina Guacimara Gomez de la Rosa, Alfonso Quesada Lopez-Fe, Monica Vilar Chesa, Alejandro Ferrer Machin, Antonio Gimeno Gil, Armando Molina Bethancourt, Miguel Angel Garcia Bello, Lina Inmaculada Perez-Mendez
Summary: The study demonstrated the efficacy of HPV vaccination in reducing recurrence risk after conization for high-grade cervical neoplasia. It recommended closer and longer follow-up for nonvaccinated women and provided a 4-year prognosis for patients undergoing conization for high-grade cervical lesions.
JOURNAL OF LOWER GENITAL TRACT DISEASE
(2021)
Article
Oncology
Giacomo Corrado, Francesca Ciccarone, Francesco Cosentino, Francesco Legge, Andrea Rosati, Martina Arcieri, Luigi Carlo Turco, Camilla Certelli, Alex Federico, Enrico Vizza, Francesco Fanfani, Giovanni Scambia, Gabriella Ferrandina
Summary: This retrospective study compared surgical and survival outcomes in early-stage UCS patients undergoing laparotomic surgery (LPT) versus minimally invasive surgery (MIS). The results showed that MIS group had shorter operative time, less blood loss, shorter hospital stay, and lower complication rate compared to the LPT group, while there were no significant differences in disease-free survival and overall survival between the two groups.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Nicolo Bizzarri, Andreas du Bois, Robert Fruscio, Francesca De Felice, Pierandrea De Iaco, Jvan Casarin, Enrico Vizza, Vito Chiantera, Giacomo Corrado, Stefano Cianci, Sonia Magni, Debora Ferrari, Daniela Giuliani, Philipp Harter, Beyhan Ataseven, Mareike Bommert, Anna Myriam Perrone, Giovanni Scambia, Anna Fagotti
Summary: The study evaluated the therapeutic role of systematic lymphadenectomy in patients with early-stage epithelial ovarian cancer, showing that comprehensive lymphadenectomy improved disease-free survival but was associated with higher post-operative complications and delayed chemotherapy initiation. Lymphadenectomy did not significantly impact overall survival.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Medicine, General & Internal
Giovanni Cristalli, Aldo Venuti, Fabiola Giudici, Francesca Paolini, Fabio Ferreli, Giuseppe Mercante, Giuseppe Spriano, Francesca Boscolo Nata
Summary: Beta HPV is more common than alpha HPV in MESCC. The presence or genotype of HPV is not statistically related to disease-specific survival or cumulative incidence of recurrence in MESCC. p16 expression is not predictive for HPV infection in MESCC.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Eriseld Krasniqi, Maddalena Barba, Aldo Venuti, Laura Pizzuti, Federico Cappuzzo, Lorenza Landi, Silvia Carpano, Paolo Marchetti, Alice Villa, Enrico Vizza, Greta Giuliano, Marco Mazzotta, Daniele Marinelli, Sandra Gnignera, Cristina Vincenzoni, Vincenzo Stranges, Domenico Sergi, Antonio Giordano, Federica Tomao, Marcello Maugeri-Sacca, Giuseppe Sanguineti, Francesca Sofia Di Lisa, Silverio Tomao, Gennaro Ciliberto, Patrizia Vici
Summary: HPVs are linked to cervical and oropharyngeal cancers, and circulating HPV DNA serves as a potential biomarker for clinical management. Specific and minimally invasive tests can enable early detection and treatment monitoring, with innovative techniques enhancing the detection rate of serum HPV DNA.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Andrea Giannini, Ottavia D'Oria, Benito Chiofalo, Valentina Bruno, Ermelinda Baiocco, Emanuela Mancini, Rosanna Mancari, Cristina Vincenzoni, Giuseppe Cutillo, Enrico Vizza
Summary: The development of surgical treatment for vulvar cancer includes both radical and personalized conservative approaches, aiming to reduce complications and improve treatment outcomes.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Oncology
Enrico Vizza, Valentina Bruno, Giuseppe Cutillo, Emanuela Mancini, Isabella Sperduti, Lodovico Patrizi, Camilla Certelli, Ashanti Zampa, Andrea Giannini, Giacomo Corrado
Summary: This study aimed to investigate the role of the excised vaginal cuff length as a prognostic factor in terms of DFS and recurrence rate/site in low-risk endometrial cancer (EC) patients, and to correlate the recurrence with the expression of L1CAM. The results suggest that in low-risk EC patients, increasing the length of the excised vaginal cuff does not decrease the recurrence rate, and the size of the removed vaginal cuff does not affect the site of recurrence or survival likelihood.
Article
Medicine, General & Internal
Silvia Massa, Riccardo Pagliarello, Francesca Paolini, Aldo Venuti
Summary: Human papillomavirus (HPV) remains a significant health threat globally, and natural substances, particularly phytochemicals, are being investigated as potential sources for antiviral and anticancer drugs. Some natural bioactives and dietary phytochemicals have shown promise in interfering with HPV and improving the efficacy of chemotherapy. Although there have been clinical trials, further assessment and research are needed to explore the clinical application of these natural substances.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Immunology
Angela Sousa, Christiane P. Soares, Aldo Venuti
Review
Dermatology
Nicoleta Neagu, Caterina Dianzani, Aldo Venuti, Serena Bonin, Septimiu Voidazan, Iris Zalaudek, Claudio Conforti
Summary: Keratinocyte skin cancers are the most frequent malignancy, and the distribution of different HPV subtypes in these cancers may provide new possibilities for future treatments.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Oncology
Alessia Farneti, Marta Bottero, Adriana Faiella, Diana Giannarelli, Luca Bertini, Valeria Landoni, Patrizia Vici, Pasqualina D'Urso, Giuseppe Sanguineti
Summary: The study investigated the predictive value of dynamic contrast-enhanced-magnetic resonance imaging (DCE-MRI) findings in restaging before salvage radiotherapy (sRT) for prostate cancer. The results showed that DCE-MRI provides both predictive and therapeutic information, especially in patients with biochemical failure after radical prostatectomy. Patients with small lesions in the vesico-urethral anastomosis have an excellent prognosis after sRT.
Review
Otorhinolaryngology
Francesca Paolini, Flaminia Campo, Oreste Iocca, Valentina Manciocco, Armando De Virgilio, Valentina De Pascale, Silvia Moretto, Giuanluca Dalfino, Antonello Vidiri, Giovanni Blandino, Fulvia Pimpinelli, Aldo Venuti, Raul Pellini
Summary: By evaluating 998 patients, this study found that ddPCR has good accuracy, sensitivity, and specificity for the diagnosis of HPV + OPSCC, suggesting it as an effective method for diagnosing HPV-positive oropharyngeal cancer.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Oncology
Lauro Bucchi, Alessandra Ravaioli, Luigino Dal Maso, Fabio Falcini, Lucia Mangone, Samuele Massarut, Laura Schirosi, Anna Crispo, Patrizia Vici, Silvia Franceschi
Summary: A study in Italy found that sentinel lymph node biopsy and post-lumpectomy radiotherapy were rarely performed in low-risk breast cancer patients aged >= 70. These findings can serve as a baseline to monitor the impact of future guidelines, but improvements in the recording and storage of hospital-based information are needed.
Review
Biochemistry & Molecular Biology
Eriseld Krasniqi, Frauke Goeman, Claudio Pulito, Alina Catalina Palcau, Ludovica Ciuffreda, Francesca Sofia Di Lisa, Lorena Filomeno, Maddalena Barba, Laura Pizzuti, Federico Cappuzzo, Giuseppe Sanguineti, Marcello Maugeri-Sacca, Gennaro Ciliberto, Maurizio Fanciulli, Giovanni Blandino, Patrizia Vici
Summary: This review summarizes the mechanisms of resistance to CDK4/6 inhibitors in breast cancer cells and focuses on potential biomarkers that could predict patients' response/resistance to treatment. Recent advances in biomarker identification, including the use of liquid biopsy and multiple microRNAs, are also discussed in the context of breast cancer management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Giuseppe Caruso, Innocenza Palaia, Giorgio Bogani, Federica Tomao, Giorgia Perniola, Pierluigi Benedetti Panici, Ludovico Muzii, Violante Di Donato
Summary: For advanced epithelial ovarian cancer patients, systematic lymph node dissection (SyLND) after neoadjuvant chemotherapy (NACT) did not significantly improve progression-free survival (PFS) and overall survival (OS), and resulted in a higher risk of severe postoperative complications.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2022)