Article
Pharmacology & Pharmacy
Xiao-Li He, Yong-Hong Hu, Jia-Mei Chen, Ding-Qi Zhang, Hai-Lin Yang, Lin-Zhang Zhang, Yong-Ping Mu, Hua Zhang, Gao-Feng Chen, Wei Liu, Ping Liu
Summary: SNS-032 alleviates liver fibrosis by inhibiting the activation and inducing the apoptosis of active HSCs. CDK9 could be a potential target for the treatment of liver fibrosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Qi Jia, Zhiqiang Hu, Nannan Song, Weike Mao
Summary: The role of CDK9 and the therapeutic potential of a CDK9 inhibitor in monocrotaline-induced PH were investigated. CDK9 was upregulated in pulmonary arterial tissues from PH rats and hypoxic cultured HPASMCs, leading to increased expression of prosurvival and antiapoptotic proteins. Flavopiridol treatment alleviated pulmonary artery remodeling and partially reversed the progression of PH by targeting CDK9.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Ilona Faustova, Kaidi Moll, Ervin Valk, Mart Loog, Mihkel Ord
Summary: Cyclins not only activate CDK complexes, but also serve as docking scaffolds for CDK substrates and inhibitors. G1-cyclins in yeast play a specific role in promoting bud growth and polarization, essential for cell survival. The discovery of a specific docking motif in G1-cyclins expands our understanding of cyclin specificity mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Satu Pallasaho, Aishwarya Gondane, Anni Kuivalainen, Samuel Girmay, Siver Moestue, Massimo Loda, Harri M. Itkonen
Summary: The study reveals that CDK7 and CDK9 are highly active in castration-resistant prostate cancer (CRPC) cells, and inhibiting these kinases can effectively suppress the proliferation of CRPC cells.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Aftab Nadeem, Kyaw Min Aung, Tanusree Ray, Athar Alam, Karina Persson, Amit Pal, Bernt Eric Uhlin, Sun Nyunt Wai
Summary: Colorectal cancer is a major cause of cancer-related deaths worldwide, with APC gene mutations playing a key role in tumor development. The novel cytotoxin MakA induces apoptosis in cancer cells, with potent cytotoxic activity against cancer cell lines while sparing nontransformed cells. MakA inhibits beta-catenin-mediated tumor cell proliferation, making it a promising candidate for therapeutic development against colon cancer.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Environmental Sciences
Cheng-Hsun Lin, Kuang-Hsuan Lin, Hsiang-Ju Ku, Kun-Ching Lee, Song-Shei Lin, Fei-Ting Hsu
Summary: Amentoflavone has been found to inhibit the progression of colorectal cancer through mechanisms such as triggering G1 arrest, DNA damage, and apoptosis, making it a potential treatment option.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biology
Mohamed A. Elkady, Ahmed S. Doghish, Ahmed Elshafei, Mostafa M. Elshafey
Summary: miR-567 is downregulated in A549 NSCLC cells, but its upregulation can inhibit cell proliferation, promote apoptosis, induce cell cycle arrest, and act as a tumor suppressor by regulating CDK8 gene expression.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell & Tissue Engineering
Mingming Zhang, Jing Huang, Shiyang Wei, Jia Lei, Hua Bai
Summary: The decreased level of microRNA-101 in Uterine cervical cancer affects the migration, invasion, and proliferation of UCC cells by targeting CDK8. Potential applications in the treatment of UCC have been identified for miR-101 through its interaction with CDK8.
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Jiahui Yuan, Xiaomei Li, Gongye Zhang, Weipeng Cheng, Weiwei Wang, Yongbin Lei, Qiujuan Ma, Gang Song
Summary: USP39 is frequently overexpressed in colon cancer, and its knockdown inhibits the growth of colon cancer cells by stabilizing p21. It regulates the proliferation of colon cancer cells through the p53/p21/CDC2/cyclin B1 axis in a p21-dependent manner, suggesting it as a novel potential target for colon cancer therapy.
MOLECULAR CARCINOGENESIS
(2021)
Article
Plant Sciences
Rui-Yi Yang, Jia-Yi Tan, Zhe Liu, Xiao-Ling Shen, Ying-Jie Hu
Summary: The natural lignan LAF from Arctium lappa Linne has been found to inhibit tumor cell growth in vitro and in vivo. However, its role in cell cycle regulation remains unknown.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Yung-Hsuan Wu, Shu-Ting Mo, I. -Ting Chen, Fu-Yi Hsieh, Shie-Liang Hsieh, Jinake Zhang, Ming-Zong Lai
Summary: Inhibition of Caspase-8 leads to inflammasome assembly and production of IL-10 and IL-18 in Toll-like receptor (TLR)-primed myeloid cells. Autophagy and cathepsin-B play important roles in the activation of inflammasomes when apoptosis and necroptosis are blocked and Caspase-8 is inhibited.
Retraction
Chemistry, Multidisciplinary
Laura Fisher
Summary: The article by Liang Chang et al., titled 'Overexpression of PCDH8 inhibits proliferation and invasion, and induces apoptosis in papillary thyroid cancer cells', published in RSC Adv. in 2018, has been retracted.
Article
Cell Biology
Si Wu, Zixin Cheng, Ye Peng, Ying Cao, Zuping He
Summary: This study explores the expression, function, and mechanism of GPx3 in controlling the proliferation and apoptosis of human SSCs. The results show that GPx3 is expressed in human SSCs and its knockdown leads to reduced proliferation, DNA synthesis, and enhanced early apoptosis. The study also identifies CXCL10 as a target of GPx3 in human SSCs, highlighting its role in regulating cell proliferation, DNA synthesis, and apoptosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Anatomy & Morphology
Ayse Cakir Gundogdu, Rumeysa Ozyurt
Summary: Epithelial sodium channels (ENaCs) play important roles in cancer progression, including proliferation, migration, invasion, and apoptosis. Inhibition of ENaCs may have therapeutic potential in cancer treatment. Resveratrol, a natural polyphenol, activates AMP-activated protein kinase (AMPK) and reduces ENaC abundance in cell membrane. However, the effects of resveratrol on ENaCs in cancer cells are unknown. This study investigated the effects of resveratrol on ENaCs in human colon cancer cells and found that resveratrol activates AMPK, inhibits ENaCs, decreases cell viability, and increases apoptosis. These findings suggest that ENaC inhibition through AMPK activation may contribute to the anti-cancer effects of resveratrol.
Article
Endocrinology & Metabolism
Jinpeng Wu, Zengqi Tan, Hongjiao Li, Meixuan Lin, Yazhuo Jiang, Liang Liang, Qilong Ma, Junjie Gou, Lulu Ning, Xiang Li, Feng Guan
Summary: Melatonin inhibits the elevated O-GlcNAc levels in bladder cancer cells, leading to reduced proliferation and increased apoptosis. This effect is achieved by decreasing glucose uptake, metabolic flux, and CDK5 expression, ultimately suppressing tumor growth.
JOURNAL OF PINEAL RESEARCH
(2021)