Article
Fisheries
Chohelee Choudhury, Ritwik Mazumder, Rajib Biswas, Mahuya Sengupta
Summary: The study investigated the effects of cadmium exposure on the immune response and molecular changes in monocytes/macrophages of Channa punctatus. Results showed alterations in hematological profile, tissue damage, impaired innate immune parameters, ROS generation, and induced inflammation, highlighting the role of NF-kappa B pathway and proinflammatory cytokines such as TNF-alpha, IL-1 beta, IL-6, and IL-12.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Ranyah Shaker M. Labban, Hanan A. Alfawaz, Ahmed T. Almnaizel, May N. Al-Muammar, Ramesa Shafi Bhat, Afaf El-Ansary
Summary: This study showed that Garcinia mangostana extract and curcumin have significant effects in modulating oxidative stress, dyslipidemia, and hyperglycemia in high-fat diet-induced obesity in rodent models.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Alexander Th Wu, Yuan-Chieh Yeh, Yan-Jiun Huang, Ntlotlang Mokgautsi, Bashir Lawal, Tse-Hung Huang
Summary: This study evaluated the therapeutic potential of gamma-mangostin (gMG) isolated from Garcinia mangostana in colorectal cancer (CRC). The results showed that gMG suppressed CRC carcinogenesis and stemness by downregulating GSK3 beta-catenin/CDK6 signaling and upregulating the miR-26b-5p tumor suppressor. In an animal model, gMG reduced tumor growth and overcame chemotherapy resistance induced by cancer-associated fibroblasts (CAFs).
Article
Environmental Sciences
Nargis Jamila, Naeem Khan, Nousheen Bibi, Muhammad Waqas, Sadiq Noor Khan, Amir Atlas, Farhat Amin, Faryal Khan, Malka Saba
Summary: The study successfully synthesized silver nanoparticles (AgNPs) using Garcinia mangostana fruit pericarp extracts and alpha-mangostin. These AgNPs showed excellent performance in Hg(II) detection, as well as demonstrated potential applications in dye degradation and anticancer research.
Review
Multidisciplinary Sciences
Luthfi Utami Setyawati, Wiwit Nurhidayah, Nur Kusaira Khairul Ikram, Wan Ezumi Mohd Fuad, Muchtaridi Muchtaridi
Summary: A systematic review was conducted to summarize the research on the safety profile of mangosteen pericarp (GM) containing alpha mangostin (AM). The LD50 and NOAEL values of AM were determined through general toxicity tests. The results provide valuable information for the development of GM-or-AM-based products.
Article
Integrative & Complementary Medicine
Wenkan Zhang, Guangyao Jiang, Xiaozhong Zhou, Leyi Huang, Jiahong Meng, Bin He, Yiying Qi
Summary: The study found that alpha-mangostin can inhibit the formation and function of osteoclasts and prevent inflammatory osteolysis by inhibiting the activation of the NF-kappa B/mitogen-activated protein kinase signaling pathways. This has potential clinical applications for treating osteoclast-related diseases.
Article
Immunology
Keyvan Amirshahrokhi, Mahsa Imani
Summary: This study aimed to investigate the potential protective effect of the antiepileptic drug levetiracetam against ulcerative colitis (UC) in mice. The results showed that levetiracetam can alleviate colonic mucosal injury in UC mice, promote antioxidant responses, reduce lipid peroxidation and myeloperoxidase activity, decrease inflammatory mediator expression, and increase anti-inflammatory cytokine levels.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jennifer Kusumah, Erick Damian Castaneda-Reyes, Neal A. Bringe, Elvira Gonzalez de Mejia
Summary: Soybean compounds have anti-inflammatory effects, and different soybean varieties can inhibit inflammation through the inhibition of key enzymes and cytokines. The glycinin: beta-conglycinin ratio in soybeans is also associated with inflammatory responses. Soybean colonic digests (SCD) reduce the production of pro-inflammatory cytokines and enzymes, and this effect is mediated by the NF-kappa B pathway. These findings highlight the potential of soybeans as a natural anti-inflammatory agent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Li Yang, Lan Cao, Chunlong Li, Xiaobin Li, Jiashui Wang, Hongping Chen, Junwei He
Summary: Hostaflavone A (HA), a new flavonoid component isolated from Hosta plantaginea (Lam.) Asch. flower, shows anti-inflammatory effects by inhibiting NF-kappa B, iNOS, COX-2, MAPKs, and Akt pathways in RAW 264.7 cells activated by LPS.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Monica Zuzarte, Catia Sousa, Carlos Cavaleiro, Maria Teresa Cruz, Ligia Salgueiro
Summary: Portuguese lavenders remain undervalued in global markets due to the lack of high-quality end-products and scarcity of scientific-based studies validating their bioactive potential. This study assessed the anti-inflammatory potential of L. luisieri and L. pedunculata, two prevalent species in Portugal, and correlated it with their chemical variability. The results demonstrated that L. luisieri essential oil with low quantities of necrodane derivatives was the most effective at inhibiting inflammation.
Article
Medicine, Research & Experimental
Yiwei Fang, Li Yang, Junwei He
Summary: Plantanone C from Hosta plantaginea flowers shows anti-inflammatory effects in RAW 264.7 macrophages by inhibiting NF-kappa B, iNOS, COX-2, MAPKs, and Akt signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Geovana F. Guedes Silvestre, Renally Pereira de Lucena, Harley da Silva Alves
Summary: Cucurbitacins are natural products with anti-inflammatory, antioxidant, and immunomodulatory potential. Cucurbitacin B and cucurbitacin E are the most investigated compounds, playing important roles in both innate and adaptive immunity. Their mechanisms of action include inhibition of COX-2 and NOS, reduction of oxidative stress, suppression of proinflammatory cytokines, and modulation of acquired immunity proteins.
CURRENT MEDICINAL CHEMISTRY
(2022)
Review
Infectious Diseases
Omer Sheriff Sultan, Haresh Kumar Kantilal, Suan Phaik Khoo, Amalraj Fabian Davamani, Sumaiya Zabin Eusufzai, Farah Rashid, Nafij Bin Jamayet, Jue Ann Soh, Yen Yee Tan, Mohammad Khursheed Alam
Summary: This systematic review evaluates the antimicrobial activity of alpha-mangostin derived from Garcinia mangostana against various microbes. The results demonstrate that alpha-mangostin has effective disinfection and inhibitory effects on multiple microbes, including those with antibiotic resistance.
Article
Biochemistry & Molecular Biology
Ji Yun Baek, Kiwon Jung, Young-Mi Kim, Hyun-Young Kim, Ki Sung Kang, Young-Won Chin
Summary: The study demonstrated that gamma-mangostin has a protective effect against glutamate-induced cell damage by reducing reactive oxygen species production, stimulating heme oxygenase-1 expression, and inhibiting the intrinsic mitochondrial apoptotic pathway in HT22 cells.
Article
Biochemistry & Molecular Biology
Bingyu Shen, Haoqing Zhang, Zhengjin Zhu, Zixi Ling, Fangyuan Zeng, Yazhou Wang, Jianguo Wang
Summary: Baicalin, extracted from Scutellaria, has anti-inflammatory effects and can reduce pulmonary edema caused by ALI. It inhibits the expression of TLR4 and MyD88, leading to a decrease in inflammatory molecules. Baicalin also promotes an increase in white blood cells and improves lung pathology, indicating its potential as a treatment for ALI.
Article
Cell Biology
Yee Teng Chan, Yi Ying Cheok, Heng Choon Cheong, Grace Min Yi Tan, Shi Rui Seow, Ting Fang Tang, Sofiah Sulaiman, Chung Yeng Looi, Rishein Gupta, Bernard Arulanandam, Won Fen Wong
Summary: This study explored the expression and function of podoplanin in a C. trachomatis infection model. It found that podoplanin expression increased in inflammatory macrophages and that macrophages lacking podoplanin had impaired migration towards the infection site.
IMMUNOLOGY AND CELL BIOLOGY
(2023)
Article
Microbiology
Heng Choon Cheong, Yi Ying Cheok, Yee Teng Chan, Ting Fang Tang, Sofiah Sulaiman, Chung Yeng Looi, Rishein Gupta, Bernard Arulanandam, Li-Yen Chang, Won Fen Wong
Summary: In this study, the Pgp3 protein was synthesized and used to stimulate Hela cervical carcinoma cells in vitro. The results showed that Pgp3 induced significant expression of host inflammatory cytokine genes, suggesting a potential role of Pgp3 in modulating the host's inflammatory reaction.
Article
Biochemistry & Molecular Biology
Nor Hisam Zamakshshari, Idris Adewale Ahmed, Muhammad Nazil Afiq Nasharuddin, Nurul Syahira Zaharudin, Najihah Mohd Hashim, Rozana Othman
Summary: The study compared the secondary metabolites and biological activities of mushroom extracts (Pleurotus pulmonarius) cultured on durian peel and rubberwood sawdust substrates using GCMS, LCMS, and various biological assays. The results showed that mushroom extracts from durian peel substrate exhibited remarkable biological activities, with the organic extracts being more effective against cancer cells and the aqueous extracts showing stronger antioxidant activities. Further research is needed to understand the molecular mechanism of action of P. pulmonarius extracts against cancer cell proliferation and the effects of different substrates on the nutritional composition and other biological activities of the extracts.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Pharmacology & Pharmacy
Rahamat Unissa Syed, Sivakumar S. Moni, Muhammad Nawaz, Mohammed Khaled Bin Break, Nasrin E. Khalifa, Siddig Ibrahim Abdelwahab, Reham Meshal Alharbi, Raghad Huraid Alfaisal, Bayan Naif Al Basher, Entsar Mohammed Alhaidan
Summary: Amikacin sulfate-loaded dextran sulfate sodium nanoparticles (LADNP) were prepared and analyzed. LADNP had a zeta potential of -20.9 +/- 8.35 mV, PDI of 0.256, and % PDI of 67.7. The size of LADNP was 317.9 d. nm, with individual particles measuring 259.3 +/- 73.52 nm. The release kinetics of amikacin from LADNP demonstrated zero order kinetics, with 37% of the drug released in 7 hours.
Review
Biochemistry & Molecular Biology
Moong Yan Leong, Yeo Lee Kong, Kevin Burgess, Won Fen Wong, Gautam Sethi, Chung Yeng Looi
Summary: Nano-engineered medical products have emerged in the past decade. Current research focuses on developing safe drugs with minimal adverse effects. Transdermal drug delivery offers convenience, local targeting, and reduced toxicity. Nanomaterials provide alternatives to conventional methods and this article reviews the recent research and emphasizes the mechanisms and nano-formulations in use.
Review
Biochemistry & Molecular Biology
Vaisnevee Sugumar, Maan Hayyan, Priya Madhavan, Won Fen Wong, Chung Yeng Looi
Summary: The use of transdermal delivery system as an alternative to conventional oral or injectable routes has gained recognition due to its non-invasive and easily adaptable nature. However, the stratum corneum of the skin poses a barrier for large molecules like insulin. Various chemical enhancers have been proposed to increase the permeability of the stratum corneum or the full epidermis. This review discusses the recent progress in the development of chemical enhancers for transdermal insulin delivery and compares them to other therapeutical drugs.
Review
Biochemistry & Molecular Biology
Yee Teng Chan, Yi Ying Cheok, Heng Choon Cheong, Ting Fang Tang, Sofiah Sulaiman, Jamiyah Hassan, Chung Yeng Looi, Kim-Kee Tan, Sazaly AbuBakar, Won Fen Wong
Summary: The resurgence of Zika virus infection has become a serious global health threat. Although most infected individuals do not show symptoms or only experience mild symptoms, Zika virus infection can lead to severe complications in adults and birth defects in newborns. The host immune system recognizes Zika virus primarily through certain receptors and triggers an immune response to limit viral survival. However, Zika virus is able to evade the host immune system through various strategies such as suppressing immune receptors and pathways, viral protein mutation, RNA modulation, and altering cellular pathways. Understanding the interaction between the host immune system and Zika virus provides valuable insights for developing new preventive and therapeutic strategies against Zika virus infection.
Article
Health Care Sciences & Services
Yasir Osman Hassan Babiker, Muhannad Hussain Shawkan Najmi, Ibrahim Mohammed A. Muslihi, Ali Fathuldeen Mohammed Amri, Tariq Yahya Mohammed Magafi, Wail Mohammad Hadi Alughbi, Mohammad Refah A. Bashir, Ali Nasser Ahmed Alsharif, Anas Elyas Ahmedand, Siddig Ibrahim Abdelwahab
Summary: This study investigated the knowledge and attitudes towards epidural analgesia (EA) among women in Jazan, Saudi Arabia. The findings showed that a large proportion of participants had limited knowledge about EA. Attitudes played a significant role in determining the knowledge level, while demographics did not. Cognitive intervention is needed to change attitudes and disseminate EA-related knowledge.
Article
Health Care Sciences & Services
Anas Elyas Ahmed, Suhaila Abdelkarim, Maria Zenida, Maisa Ali Hussein Baiti, Atyaf Abbas Yahya Alhazmi, Bushra Ahmed Hussain Alfaifi, Rania Qarmoush Mohammed Majrabi, Nidaa Qasem M. Khormi, Alyaj Alla Ali Hakami, Rafa Abdu Mohammed Alqaari, Raffan Ahmed Alhasani, Ramzi Abdu Alajam, Mohammed M. Alshehri, Aqeel M. Alenazi, Bader Alqahtani, Meshal Alshamrani, Ahmed Alhowimel, Siddig Ibrahim Abdelwahab
Summary: This research aims to evaluate the risk factors and prevalence of urinary tract infections (UTIs) among people with diabetes mellitus (DM) in Saudi Arabia (KSA). The study found that UTIs are common in individuals with DM and are associated with gender. The findings of this study can provide important guidance for the health management of DM patients.
Review
Microbiology
Heng Choon Cheong, Sofiah Sulaiman, Chung Yeng Looi, Li-Yen Chang, Won Fen Wong
Summary: Chlamydia infection is a global public health concern with various complications in females. As a obligate intracellular bacterium, Chlamydia relies on host cell metabolism and apoptotic pathway molecules for survival and propagation. This review explores the strategies employed by Chlamydia in manipulating host cell metabolism for its own benefit.
Review
Medicine, General & Internal
Won Fen Wong, Kuan Ping Ang, Gautam Sethi, Chung Yeng Looi
Summary: Transdermal patches are a non-invasive method of drug administration that deliver medication through the skin into the bloodstream. They offer advantages such as being less invasive and bypassing issues with oral ingestion. Recent advances have led to the development of smart, dissolvable/biodegradable, high-loading/release, and 3D-printed patches. This review discusses the design and usage of medical patches in transdermal drug delivery.
MEDICINA-LITHUANIA
(2023)
Article
Health Care Sciences & Services
Amani Osman Abdelmola, Ahmed Bahari, Ibrahim Gosadi, Khdeeja Shami Aburasain, Njoud Ali Osaisi, Nidaa Sameer Jilan, Sarah Rashad Alsanosy, Haneen Ali Mahnashi, Hadeel Fuad Gadri, Amnah Ahmad Khobrani, Alaa Ahmad Darraj, Mohamed Salih Mahfouz, Hadi Dhafer Hassan Kariri, Siddig Ibrahim Abdelwahab
Summary: This study aimed to investigate the prevalence of postpartum depression (PPD) in the Jazan region, as well as the significant risk factors and likelihood of seeking help among depressed women. The results revealed a high prevalence of PPD (75.7%) in Jazan and identified a lack of family support as a significant association with PPD. Pregnant women need to be aware of PPD and learn how to prevent or manage it.
Article
Health Care Sciences & Services
Yahia Ali Kaabi, Nahla A. Alshaikh, Ahmed A. Jerah, Mustafa A. Halawi, Mahmoud M. Habibullah, Siddig Ibrahim Abdelwahab
Summary: This study validated the Arabic version of the Diabetes Self-Management Scale (DSMS) using Rasch and confirmatory factor analyses. The results showed good fit, reliability, and content validity for the scale, with minor issues in one item. The DSMS was found to be beneficial as a screening tool for patient-reported diabetes self-management, though further improvements are needed.
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)