Article
Chemistry, Applied
Anderson Camargo, Ana Paula Dalmagro, Andrey Martinez Rebelo, Cassia Katrin Reinke, Ana Lucia Bertarello Zeni
Summary: The study found that Maclura tinctoria leaf aqueous extract (MtAE) has antidepressant-like and neuroprotective effects, which may be associated with the presence of phenolic compounds identified in the extract.
NATURAL PRODUCT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Mersedeh Shayan, Soghra Mehri, Bibi Marjan Razavi, Hossein Hosseinzadeh
Summary: Arsenic is a naturally occurring metalloid that can cause acute and chronic toxicity in humans. Neurotoxicity is a serious manifestation of arsenic toxicity. This study found that minocycline, an antimicrobial agent with antioxidant properties and the ability to cross the blood-brain barrier, can significantly attenuate arsenic-induced neurotoxicity by reducing oxidative stress and apoptosis. These findings suggest that minocycline could be a promising treatment for arsenic toxicity.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Neurosciences
Chen Song, Yishu Yin, Yue Qin, Tianzhu Li, Deyong Zeng, Ting Ju, Fangyuan Duan, Yingchun Zhang, Weihong Lu
Summary: This study found that Acanthopanax senticosus extract has a protective effect on radiation-induced learning and memory impairment. In the experiment with mice, the extract improved learning and memory ability, changed neurotransmitter levels in the hippocampus and colon, and caused changes in the gut microbiota. The extract also increased expression of tight junction proteins in the colon, inhibited inflammation, and influenced protein expression in the hippocampus.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Oncology
Yutaka Kawano, Maki Tanaka, Masaki Fujishima, Eri Okumura, Hideo Takekoshi, Kohichi Takada, Osamu Uehara, Yoshihiro Abiko, Hidekatsu Takeda
Summary: The root extract of Acanthopanax senticosus exhibits inhibitory effects on liver cancer cells by inducing cell cycle arrest, apoptosis, and enhancing autophagy, potentially serving as a therapeutic agent for liver cancer and autophagy-related diseases.
Article
Biochemistry & Molecular Biology
Khoa Nguyen Tran, Nhi Phuc Khanh Nguyen, Ly Thi Huong Nguyen, Heung-Mook Shin, In-Jun Yang
Summary: This study sought to identify essential oils with potential for rapid-acting antidepressant development. Nineteen essential oils significantly reduced cell death and leakage of lactate dehydrogenase induced by corticosterone, while 13 oils decreased tumor necrosis factor alpha and interleukin 6 induced by lipopolysaccharide. Six essential oils reduced immobility time in mice and two oils increased time and entries into the open arms of the elevated plus maze. Atractylodes lancea (Thunb.) DC and Chrysanthemum morifolium Ramat. essential oils showed promise as fast-acting antidepressants through interactions with glutamate receptors, with specific compounds potentially responsible for the effect.
Article
Nutrition & Dietetics
Jingbin Li, Yang He, Jia Fu, Yimin Wang, Xing Fan, Tian Zhong, Hui Zhou
Summary: In this study, the protective effects of Acanthopanax senticosus extract (ASE) on MPTP-induced Parkinson's disease (PD) were investigated. ASE significantly improved motor coordination in mice with MPTP-induced PD. Proteomic analysis revealed that ASE modulated the expression of multiple proteins involved in Fc gamma receptor-mediated phagocytosis, PI3K/AKT signaling, and insulin receptor signaling pathways. Network analysis further showed that ASE regulated protein networks related to cellular assembly, lipid metabolism, and morphogenesis, suggesting its potential for treating PD.
FRONTIERS IN NUTRITION
(2023)
Article
Pharmacology & Pharmacy
Pei-Rong Chang, Je-Wen Liou, Pei-Yi Chen, Wan-Yun Gao, Chia-Ling Wu, Ming-Jiuan Wu, Jui-Hung Yen
Summary: This study investigates the potential neuroprotective properties of fisetin against corticosterone-induced cell death and explores the underlying molecular mechanism. The results demonstrate that fisetin effectively protects PC12 cells against corticosterone-induced neurotoxicity by reducing reactive oxygen species generation and inhibiting apoptosis. Fisetin exerts its neuroprotective effect through the modulation of MAPK/ERK, p38, and the PI3K/Akt/FOXO3a-dependent pathways.
Article
Toxicology
Xinrong Pei, Fangyan Hu, Feiya Luo, Xianglu Huang, Xiaoling Li, Shuxia Xing, Dingxin Long
Summary: With the aging population increasing, the prevalence of Alzheimer's disease (AD) has risen and caused a heavy burden on society and patients' families. In this study, it was found that alpha-lipoic acid (LA) could alleviate amyloid beta fragment (Aβ(25-35))-induced PC12 cell toxicity through the Wnt-beta-catenin pathway, rescuing Aβ(25-35)-induced neurocytotoxicity.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Bokai Liao, Zhigang Luo, Shan Wan, Lijuan Chen
Summary: In this study, the extract of acanthopanax senticosus leaf (ASLE) prepared using a one-step pure water extraction method is used as a sustainable eco-friendly corrosion inhibitor for carbon steel in acidic solutions. The corrosion inhibition efficiency is evaluated by weight loss method and electrochemical tests, and the compositions and microstructures of ASLE and corrosion products are analyzed. The results show that ASLE is an efficient mixed-type corrosion inhibitor for carbon steel in 1 mol/L HCl, with a maximum corrosion inhibition efficiency of 98.79% after 144 h immersion with the addition of 150 mg/L. It also displays superior long-term corrosion inhibition performance.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2023)
Article
Agriculture, Dairy & Animal Science
L. N. Long, H. H. Zhang, F. Wang, Y. X. Yin, L. Y. Yang, J. S. Chen
Summary: Acanthopanax senticosus (AS) is a traditional Chinese herbal medicine with potential benefits as a feed additive for broiler chickens. Polysaccharides extracted from AS (ASPS) improved growth performance, immune status, antioxidant capacity, and beneficial gut bacteria in broiler chickens. A dosage of 1 g/kg ASPS was found to be optimal for these effects.
Article
Biochemistry & Molecular Biology
Jianqing Su, Xinyu Zhang, Qibin Kan, Xiuling Chu
Summary: The process of redox reaction in biological metabolism leads to the production of free radicals, which can cause oxidative stress and inflammation under certain conditions. Acanthopanax senticosus (A. senticosus) flavonoids have shown significant antioxidant properties, reducing oxidative damage and protecting cells or tissues both in vivo and in vitro through activation of the Nrf2 pathway.
Article
Environmental Sciences
Malwina Lisek, Tomasz Boczek, Joanna Stragierowicz, Julia Wawrzyniak, Feng Guo, Michal Klimczak, Anna Kilanowicz, Ludmila Zylinska
Summary: PCN67 is considered the most toxic congener among polychlorinated naphthalenes, affecting human health by causing hepatotoxicity and disrupting reproductive, endocrine, and hematological systems. Studies have shown that PCN67 disturbs dopaminergic transmission by reducing dopamine synthesis, affecting the expression of antioxidant enzymes, and altering vesicular monoamine transporter 1 expression.
Article
Pharmacology & Pharmacy
Aijing Bi, Zhen Guo, Guocui Yang, Youfang Huang, Zhimin Yin, Lan Luo
Summary: The highly toxic environmental pollutant cadmium (Cd) can lead to the occurrence and development of multiple neurological diseases. Gamma-glutamylcysteine (gamma-GC) has been found to inhibit Cd-induced apoptosis in PC12 cells by reducing oxidative stress and inhibiting the activation of MAPK and PI3K/Akt signaling pathways. This suggests that gamma-GC could potentially be used as a protective agent against Cd neurotoxicity.
Article
Pharmacology & Pharmacy
Ruohong Lin, Linlin Liu, Marta Silva, Jiankang Fang, Zhiwei Zhou, Haitao Wang, Jiangping Xu, Tiejun Li, Wenhua Zheng
Summary: Hederagenin, a triterpenoid saponin extracted from Fructus Akebiae, has been proposed to have potential therapeutic effects in depression. This study found that Hederagenin protected PC12 cells against corticosterone-induced damage through activation of the PI3K/AKT pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dong Wook Lim, Daeseok Han, Changho Lee
Summary: The antidepressant-like effects of Pedicularis resupinata extract (PRE) were evaluated in mice with CORT-induced depression. The study found that high dose PRE significantly alleviated the depressive-like behaviors induced by CORT and improved the effects on brain-derived neurotrophic factor.
Article
Fisheries
Le Xu, Yongping Xu, Liangyu He, Meixia Zhang, Lili Wang, Zhen Li, Xiaoyu Li
FISH & SHELLFISH IMMUNOLOGY
(2019)
Article
Fisheries
Hongyu Ren, Zhen Li, Yongping Xu, Lili Wang, Xiaoyu Li
Article
Immunology
Yuyu Yuan, Kunli Qu, Demeng Tan, Xiaoyu Li, Lili Wan, Cong Cong, Zhilong Xiu, Yongping Xu
MICROBIAL PATHOGENESIS
(2019)
Article
Food Science & Technology
Dongye He, Ning Wang, Xuan Sai, Xiaoyu Li, Yongping Xu
FOOD AND CHEMICAL TOXICOLOGY
(2019)
Article
Virology
Yuyu Yuan, Feiyang Zhao, Lili Wang, Demeng Tan, Cong Cong, Xiaoyu Li, Yongping Xu
ARCHIVES OF VIROLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Huijun Geng, Wei Zou, Meixia Zhang, Le Xu, Fanming Liu, Xiaoyu Li, Lili Wang, Yongping Xu
FOLIA MICROBIOLOGICA
(2020)
Article
Biotechnology & Applied Microbiology
Juntao Shen, Jinjie Zhou, Yongping Xu, Zhilong Xiu
Article
Virology
Hongyu Ren, Zhen Li, Le Xu, Xiaoyu Li, Lili Wang, Yongping Xu
ARCHIVES OF VIROLOGY
(2019)
Article
Oncology
Mengya Tong, Mingzhao Gao, Yongping Xu, Li Fu, Yun Li, Xubin Bao, Haoyu Fu, Haitian Quan, Liguang Lou
Article
Biochemistry & Molecular Biology
Yuge Guan, Wenzhong Hu, Aili Jiang, Yongping Xu, Rengaowa Sa, Ke Feng, Manru Zhao, Jiaoxue Yu, Yaru Ji, Mengyang Hou, Xiaozhe Yang
Article
Virology
Yuyu Yuan, Lili Wang, Xiaoyu Li, Demeng Tan, Cong Cong, Yongping Xu
Article
Fisheries
Zhen Li, Hongyu Ren, Qiang Li, Bilal Murtaza, Xiaoyu Li, Jiancheng Zhang, Yongping Xu
Article
Biotechnology & Applied Microbiology
Dongye He, Shu Jia, Yongping Xu
BIOMED RESEARCH INTERNATIONAL
(2019)
Article
Biotechnology & Applied Microbiology
Yan Chen, Yongping Xu, Tong Zhou, Mahinur S. Akkaya, Lili Wang, Shuying Li, Xiaoyu Li
Article
Agricultural Engineering
Leibing Wan, Xitao Wang, Cong Cong, Jingbo Li, Yongping Xu, Xiaoyu Li, Fuqin Hou, Yanyan Wu, Lili Wang
BIORESOURCE TECHNOLOGY
(2020)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)