Article
Medicine, Research & Experimental
Siqi Xu, Hongsheng Li, Xiaoyan Wu, Jianwei Guo, Jiaoli Zhang, Xuqi Hu
Summary: This study aimed to evaluate the necessity of Western blotting (WB) in samples with inconsistent results in detecting anti-TP antibodies by ELISA and TPPA. The results showed that WB confirmation is necessary when ELISA and TPPA results are inconsistent.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Jian Li, Mingyi Zhao, Xinying Xiang, Qingnan He, Rong Gui
Summary: Pm-GCH is a promising treatment strategy for SRNS with good biocompatibility and targeting effects.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Khulud M. Alshehri, Ehab M. Abdella
Summary: This study aimed to construct a ternary nanoformulation (BPE-TOE-CSNPs NF) by immobilizing the ethanolic extract of bee pollen (BPE) with thymol oil extract (TOE) into chitosan nanoparticles (CSNPs) for its anti-proliferative and anti-inflammatory effects. The BPE-TOE-CSNPs exhibited significant inhibitory activity against HepG2 and MCF-7 cells. Moreover, the nanoformulation induced cell cycle arrest and apoptotic mechanisms.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Environmental Sciences
Fahui Gong, Yafeng Zhang, Wei Xie, Xiuqin Wu, Han Zhang, Suixuan Huang, Jun Gong, Kedong Yin
Summary: In oligotrophic seas like the South China Sea, the deep chlorophyll maximum (DCM) is always present. The surface planktonic community lacks nutrients, while the DCM layer is under light limitation but receives frequent nutrient supply. Vertical mixing plays a critical role in determining their community composition and changes by responding to light and nutrients. This study found significant differences in bacterial and eukaryotic community structure and cell abundance between the surface and DCM, indicating that phytoplankton at the DCM layer responds to enhanced light and frequent nutrient supply due to vertical mixing, maintaining primary productivity in oligotrophic oceans.
FRONTIERS IN MARINE SCIENCE
(2023)
Review
Chemistry, Medicinal
Dominik Langer, Dariusz T. Mlynarczyk, Jolanta Dlugaszewska, Ewa Tykarska
Summary: Despite the advancement of medicine, influenza remains a significant global epidemiological problem. With the increasing resistance of influenza viruses to antiviral drugs, there is a need to search for new compounds or drug forms with high efficacy against human influenza A and B viruses. This study focuses on chemically modifying natural compounds and using modern drug carriers to enhance antiviral activity against influenza viruses. The findings provide directions for further development in this field.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Myoungjee Choi, Le Thi Thuy, Youngki Lee, Chunxian Piao, Joon Sig Choi, Minhyung Lee
Summary: The dendrimer micelles with glycyrrhizic acid (GA) successfully integrated the anti-inflammatory drug GA and improved gene delivery efficiency. By enhancing cellular uptake, increasing gene delivery efficiency to the lungs, and interacting with the GA receptor, the micelles showed enhanced transfection efficiency.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Materials Science, Multidisciplinary
Jeong Chan Lee, Laskar Hulu Seksama, Chan Hee Park, Cheol Sang Kim
Summary: Licorice contains glycyrrhizic acid, which has been widely used as an ingredient for disinfection and trauma treatment due to its antibacterial and anti-inflammatory properties. This study prepared antibacterial capsules by conjugating glycyrrhizic acid with beta-cyclodextrin and successfully manufactured fibers using electrospinning technology. The antibacterial test confirmed the effectiveness of the glycyrrhizic acid encapsulated with beta-cyclodextrin. The electrospun fiber containing the antibacterial capsule can be applied in trauma treatment and has potential applications in infection prevention and disease treatment due to the anti-inflammatory and antiviral effects of glycyrrhizic acid.
Article
Nanoscience & Nanotechnology
Zhaoyan Zhao, Yuchen Xiao, Lingqing Xu, Ye Liu, Guanmin Jiang, Wei Wang, Bin Li, Tianchuan Zhu, Qingqin Tan, Lantian Tang, Haibo Zhou, Xi Huang, Hong Shan
Summary: COVID-19 is a worldwide pandemic characterized by massive morbidity and mortality, with uncontrolled inflammatory processes playing a significant role in fatalities. Glycyrrhizic acid nanoparticles show potential for inhibiting viral growth and reducing inflammation, with possible applications in treating COVID-19.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Veterinary Sciences
Pavla Hamouzova, Zuzana Drabkova, Sarka Stehlikova, Kristina Rehakova, Petr Cizek, Olga Dobesova, Petr Jahn, Jaroslav Doubek
Summary: This study examined Tregs and inflammatory cytokines in BALF and peripheral blood of horses with mild and severe asthma. The results suggest that evaluating selected parameters in peripheral blood may be less invasive and of potential importance in assessing asthma severity and inflammation.
RESEARCH IN VETERINARY SCIENCE
(2023)
Article
Immunology
Shahriar Sepahvand, Mahboobeh Madani, Hassan Sepahvand, Mohammad Ali Davarpanah
Summary: The study found that mice receiving colistin-resistant A. baumannii isolates showed a stronger immune response and higher tissue inflammation compared to mice receiving colistin-sensitive isolates. The lung had the highest bacterial load and tissue damage among all the studied organs.
MICROBIAL PATHOGENESIS
(2022)
Article
Biochemical Research Methods
Chan Zhang, Qiang Li, Ling Zhan, Xiao-Lou Wang, Jia-Jia Zhang, Chao-Jin Xu
Summary: The study found that using 20% crotonic acid as an alternative for stripping in immunoblotting experiments can effectively inhibit the activity of horseradish peroxidase without damaging the transferred proteins and membrane structure. This method eliminates the need to rerun gels, saving time and valuable samples.
ANALYTICAL BIOCHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Nan Jin, Jingwen He, Chenyuan Wu, Zejun Chen, Yuling Li, Jianmin Chen, Jianhu Lin
Summary: This study explored the function of glycyrrhizic acid in an anti-psoriatic dermal delivery and found that a high proportion of glycyrrhizic acid significantly improved the efficacy of curcumin in inhibiting psoriatic lesions and reducing histological changes.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Sai Wang, Xin-Yu Li, Hong-Fang Ji, Liang Shen
Summary: This study found that glycyrrhizic acid, licorice flavonoids, and licorice extract can significantly reduce the level of triglycerides in the liver of NAFLD model rats. They also caused significant changes in the structural composition of the gut microbiota.
Article
Chemistry, Analytical
Chengxin Wu, Xue Men, Meijun Liu, Yujia Wei, Xing Wei, Yong-Liang Yu, Zhang-Run Xu, Ming-Li Chen, Jian-Hua Wang
Summary: A 2D flow cytometry platform called CytoLM Plus was developed for multi-parameter single-cell analysis. This platform combines fluorescence and side scattering optical detection with ICP-MS detection for a comprehensive analysis of single cells. The performance of CytoLM Plus was evaluated using fluorescent microspheres and cells, and it showed comparable results to a commercial flow cytometer.
ANALYTICAL CHEMISTRY
(2023)
Article
Agriculture, Dairy & Animal Science
Eleonora Gori, Alessio Pierini, Martina Nesci, Elena Benvenuti, Silvia Tasca, George Lubas, Veronica Marchetti
Summary: This study aimed to investigate the presence of anti-RBC antibodies and potential red blood cell abnormalities in dogs with chronic intestinal inflammation (IBD). Results showed that a high percentage of dogs with IBD had anti-RBC antibodies present, suggesting possible subclinical chronic immune-mediated hemolysis. Additional findings of red blood cell regeneration were also observed in some dogs, indicating potential hemolytic processes at play in canine IBD.
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)