Article
Plant Sciences
Gayathri Nataraj, Gayathri Jagadeesan, Ashwini Lydia Manoharan, Kasipandi Muniyandi, Saikumar Sathyanarayanan, Parimelazhagan Thangaraj
Summary: This study investigated the polyphenolic content, antioxidant activity, and wound healing properties of Ipomoea pes-tigridis. The results showed that I. pes-tigridis has antioxidant and anti-inflammatory effects, promotes wound healing, and enhances collagen synthesis and antioxidant enzyme activity.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Engineering, Biomedical
Yuxuan Yang, Xiaodan Zhao, Jing Yu, Xingxing Chen, Ruyue Wang, Mengyuan Zhang, Qiang Zhang, Yanfeng Zhang, Shuang Wang, Yilong Cheng
Summary: In this study, a bioactive skin-mimicking hydrogel band-aid was developed to promote the recovery of skin incision and defects on diabetic mice. The hydrogel showed promising anti-inflammation, antibacterial, and antioxidant properties, as well as moisture-resistant adhesiveness.
BIOACTIVE MATERIALS
(2021)
Article
Polymer Science
Harshad S. Kapare, Prabhanjan S. Giram, Sadhana S. Raut, Hemant K. Gaikwad, Ana Claudia Paiva-Santos
Summary: Flavonoids and polyphenolic compounds found in propolis, a natural bee product, play a crucial role in wound healing. This study aimed to develop and characterize a propolis-based hydrogel composition with wound healing potential. The formulation was analyzed for its phytochemical content, pH, viscosity, and in vitro release. Results from burn and excision wound healing models demonstrated the efficacy of the propolis hydrogel in promoting wound contraction and re-epithelialization, comparable to the standard povidone iodine ointment. This formulation shows promise for further clinical research on wound healing.
Article
Plant Sciences
Aaliya Ali, Prakrati Garg, Rohit Goyal, Gurjot Kaur, Xiangkai Li, Poonam Negi, Martin Valis, Kamil Kuca, Saurabh Kulshrestha
Summary: The study evaluated the wound healing efficacy of n-hexane extract and hydrogels of Moringa oleifera seeds, demonstrating their significant effectiveness in wound healing.
Article
Biochemistry & Molecular Biology
Ta-Wei Liu, Sui-Wen Hsiao, Chi-Ting Lin, George Hsiao, Ching-Kuo Lee
Summary: This study extracted 20 compounds from the ethyl acetate fraction of Pinus morrisonicola Hayata's pine needles and investigated their anti-aging effects using HT-1080 cells. Compounds 3, 4, and 5 showed remarkable inhibitory effects against MMP-2 and exhibited no significant cell toxicity at a concentration of 25 μM.
Article
Biochemistry & Molecular Biology
Ping-Chung Kuo, Yue-Chiun Li, Anjar M. Kusuma, Jason T. C. Tzen, Tsong-Long Hwang, Guan-Hong Ye, Mei-Lin Yang, Sheng-Yang Wang
Summary: This study isolated and characterized five undescribed compounds and seventy-two known compounds from P. taiwanensis needles, with six compounds showing significant anti-inflammatory bioactivity. Among them, compounds 49, 50, and 51 were found to form stable complexes with the ghrelin receptor through hydrogen bonds and different types of interactions, indicating flavonoids may be responsible for the potential anti-aging effects of pine needle tea.
Review
Medicine, Research & Experimental
Qing Sun, Le Tang, Dan Zhang
Summary: Wound healing is a complex process involving the regulation of cytokines and molecules. Recent studies have shown that proper regulation of these factors can improve wound healing and achieve scar-free wound closure.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Shilpa Das, Tanmoy Kumar Dey, Arnab De, Anurag Banerjee, Samrat Chakraborty, Bhaskar Das, Asish Kumar Mukhopadhyay, Biswajit Mukherjee, Amalesh Samanta
Summary: The gum odina and gelatin based biomimetic scaffold showed excellent biocompatibility and the ability to promote cutaneous healing in vitro studies. Results demonstrated significant deposition of collagen and formation of intact epidermis, indicating strong potential for wound treatment applications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Multidisciplinary Sciences
Naira Nayeem, Syed Mohammed Basheeruddin Asdaq, Abdulhakeem S. Alamri, Walaa F. Alsanie, Majid Alhomrani, Yahya Mohzari, Ahmed A. Alrashed, Norah Alotaibi, Aseel S. Aalhathal, Mansour A. Alharbi, Norah N. Aldhawyan, Mohammed Asad, Faisal Mohammad Ali Abdalla, Saeed Y. Najmi
Summary: The study demonstrated the potential of methanolic and chloroform extracts of Dodonaea viscosa as effective wound healing agents in animal models, indicating the healing potency of the extracts.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2021)
Article
Plant Sciences
Barbhara Mota Marinho, Victor Hugo Dantas Guimara, Daniel Silva Moraes, Guilherme Henrique Mendes Ribeiro, Rodrigo Moreira da Silva, Norberto Peporine Lopes, Andre Luiz Sena Guimara, Alfredo Mauricio Batista de Paula, Sergio Henrique Sousa Santos
Summary: The present study investigated the effects of Lychnophora ericoides ethanolic extract (EELE) on cutaneous wound healing and the underlying mechanisms. The results revealed that EELE significantly reduced the wound area, improved anatomical skin features, promoted collagen production and angiogenesis, and decreased the number of mast cells at the injury site. Real-time PCR data showed that EELE increased important factors for wound healing, such as FGF, VEGF, collagen formation, and the expression of the proliferative axis of the renin-angiotensin system.
Article
Chemistry, Medicinal
Nancy S. Younis, Maged E. Mohamed, Nermin A. El Semary
Summary: This study demonstrates that the cyanobacterium Synechocystis sp. can produce silver nanoparticles with antibacterial, antioxidant, anti-inflammatory, and angiogenesis promoting effects in diabetic wounded animals.
Article
Biochemistry & Molecular Biology
Yapeng Lu, Xiaopeng Zhu, Chao Hu, Peng Li, Meihui Zhao, Jinfeng Lu, Guanghua Xia
Summary: A tilapia fish skin gelatin-fucose gum-tannic acid hydrogel wound dressing was designed to promote wound healing. The hydrogel showed excellent properties and could effectively accelerate wound healing while reducing inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Medicinal
Chanchal Kumar Mishra, Ashok Kumar Pattnaik, Pankaj Dagur, Dhiraj Kumar, Manik Ghosh
Summary: The study found that the ethanolic fruit extract of Carissa carandas has a significant effect on wound healing, with better results compared to the untreated and simple ointment groups. Through mechanical and pathological studies, it was also found that the extract promotes the production of collagen, mononuclear cells, and fibroblasts.
PHARMACOGNOSY MAGAZINE
(2022)
Article
Biochemistry & Molecular Biology
Xiaolong Lin, Tao Fu, Yuqing Lei, Jiajia Xu, Sa Wang, Fuming He, Zhijian Xie, Ling Zhang
Summary: This study developed a new antibacterial hydrogel with excellent antimicrobial activity, histocompatibility, and wound healing potential. The hydrogel released antibacterial peptides to inhibit bacterial biofilm formation and regulate inflammatory responses, as well as promote angiogenesis, thereby aiding in the rapid healing of infected wounds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Dermatology
Nathnael Teshome, Abel Degu, Ephrem Ashenafi, Esayas Ayele, Abiy Abebe
Summary: This study assessed the anti-inflammatory and wound healing properties of Clematis simensis leaf extract. The results showed that the extract promoted wound healing by increasing wound contraction rate and epithelium formation, and had anti-inflammatory and antioxidant effects.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Necla Benlier, Nilay Ucar, Eda Ogut, Havva Yesil Cinkir, Mustafa Yildirim, Pinar Gunel Karadeniz, Esra Kupeli Akkol, Haroon Khan, Eyup Ilker Saygili
Summary: The present study found that beta-glucan can significantly reduce DNA damage in colorectal cancer patients and exhibit antimutagenic effects. These results suggest that dietary intake of beta-glucan may play an important role in the genesis of colorectal cancer tumors.
CURRENT MOLECULAR PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sajad Fakhri, Zeinab Nouri, Seyed Zachariah Moradi, Esra Kupeli Akkol, Sana Piri, Eduardo Sobarzo-Sanchez, Mohammad Hosein Farzaei, Javier Echeverria
Summary: The complex pathogenic pathways of COVID-19 require urgent development of new therapies to address future epidemics. Research shows that the destructive pathways of COVID-19 share similar clinical symptoms with severe acute coronary syndrome. Revealing the exact pathogenic pathways and host factors can pave the way for combating COVID-19.
Review
Chemistry, Medicinal
Kevser Taban Akca, Murside Ayse Demirel, Ipek Suntar
Summary: Medicinal plants have been widely used as food and medicine in traditional and modern societies. They provide a rich source of chemical compounds, many of which cannot be synthesized by current methods. Natural products with aromatase inhibitory activity may be effective in treating diseases associated with excessive aromatase secretion, including various cancers and infertility. Recent studies have also shown their potential as chemopreventive agents for breast cancer recurrence. Therefore, screening for new plant-based aromatase inhibitors could lead to novel drug discoveries with improved clinical efficacy and reduced side effects.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Review
Cell Biology
Esra Kuepeli Akkol, Hilal Bardakci, Cigdem Yuecel, Goekce Seker Karatoprak, Buesra Karpuz, Haroon Khan
Summary: Sleep disturbances and sleep-wake rhythm disorders are characteristic symptoms of Alzheimer's disease, and sleep quality is closely related to learning and memory functions. Curcumin has significant improvements in the treatment of AD and sleep deprivation-related consequences, but its low solubility is one of the therapeutic limitations.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Review
Cell Biology
Gokce Seker Karatoprak, Esra Kupeli Akkol, Cigdem Yucel, Ozlem Bahadir Acikara, Eduardo Sobarzo-Sanchez
Summary: Cancer is a major cause of death worldwide, and drug resistance remains a challenge for cancer treatment. Natural sources, particularly anthraquinones, offer potential as drug candidates due to their diverse structures, notable biological activity, and low toxicity. Aloe emodin, an anthraquinone derivative found in the roots and rhizomes of many plants, has demonstrated antineoplastic, anti-inflammatory, antiangiogenic, and antiproliferative properties, as well as the ability to reverse multidrug resistance in cancer cells. This review summarizes the antiproliferative and anticarcinogenic properties of aloe emodin, the enhanced activity of its derivatives, and the advantages of drug delivery systems in improving its bioavailability.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Pharmacology & Pharmacy
Esra Kupeli Akkol, Esma Kozan, Hilal Bardakci, Timur Hakan Barak, Sara Khalilpour
Summary: This study found that extracts of Jasminum fruticans have strong anthelmintic and antioxidant activities, with the methanol extract showing significant effects and rich in phenolic metabolites.
PHARMACEUTICAL SCIENCES
(2022)
Review
Integrative & Complementary Medicine
Arif Ali, Tiago Lima Sampaio, Haroon Khan, Philippe Jeandet, Esra Kuepeli Akkol, Humaira Bahadar, Alice Maria Costa Martins
Summary: Acute kidney injury (AKI) is a complex condition caused mainly by renal ischemic reperfusion injury (RIRI), which involves hemodynamic, inflammatory, and cellular toxic effects. The use of plant-derived extracts and compounds has shown nephroprotective properties against AKI by increasing endogenous antioxidants and reducing anti-inflammatory cytokines. However, there is a lack of defined biomarkers or targets for complete treatment of AKI.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Review
Integrative & Complementary Medicine
Atif Ali Khan Khalil, Falak Zeb, Raees Khan, Sayed Afzal Shah, Esra Kupeli Akkol, Ishaq N. Khan, Jawad Khan, Syed Babar Jamal, Fazli Khuda, Adnan Haider, Saeed Ahmed, Naveed Ur Rehman
Summary: Rumex dentatus, also known as toothed dock or Aegean dock, is a medicinal plant with high culinary value, and has been scientifically evaluated to confirm its traditional uses and demonstrate a wide range of biological and pharmacological potentials. Future research may focus on the identification of pharmacologically active chemical constituents and development prospects.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Review
Cell Biology
Esra Kuepeli Akkol, Hilal Bardakci, Timur Hakan Barak, Michael Aschner, Goekce Seker Karatoprak, Haroon Khan, Yaseen Hussain
Summary: Breast cancer is the most prevalent cancer type in women worldwide. The complex etiology of the disease poses challenges in its treatment. This review summarizes the molecular mechanisms of breast cancer and identifies the mechanisms by which natural compounds can be effective in its treatment.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Biochemistry & Molecular Biology
Cigdem Kahraman, Suat Sari, Esra Kupeli Akkol, Irem Tatli Cankaya
Summary: The present study assessed the ethnopharmacological use of Primula vulgaris Huds. in treating skin damage and inflammation. The butanol fraction of the roots of P. vulgaris exhibited the highest wound-healing activity, and primulasaponin I and primulasaponin I methyl ester were identified as the major active compounds. These compounds exerted their activities through the inhibition of collagenase and elastase enzymes, suggesting their potential therapeutic use in wound healing.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Biochemistry & Molecular Biology
Selen Ilgun, Gokce Seker Karatoprak, Derya Cicek Polat, Esra Kongul Safak, Gulsum Yildiz, Esra Kupeli Akkol, Eduardo Sobarzo-Sanchez
Summary: This study investigated the phytochemical composition and biological activities of Arctium minus, a medicinally important plant in Turkey. The results showed that the ethyl acetate sub-fractions of the leaves and flowers exhibited the highest antioxidant activity. The extracts also demonstrated significant cytotoxic effects on breast cancer cell lines. These findings provide promising results for future research on this plant.
Article
Biochemistry & Molecular Biology
Derya Cicek Polat, Selen Ilgun, Gokce Seker Karatoprak, Esra Kupeli Akkol, Raffaele Capasso
Summary: This study investigated the pharmacological properties and phytochemical composition of traditionally used plants in Turkey. The methanol extracts from these plants showed antioxidant activity and cytotoxic effects on cancer cells. The extract from C. pichleri subsp. pichleri was found to be the most effective in terms of phenolic compounds and had the highest antioxidant activity. It also showed the strongest inhibitory effects on cell viability and anti-inflammatory activity. These findings highlight the potential of C. pichleri subsp. pichleri as a valuable source of bioactive compounds for various industrial uses.
Article
Biochemistry & Molecular Biology
Esra Kupeli Akkol, Busra Karpuz, Gizem Turkcanoglu, Fatma Gul Cosguncelebi, Hakki Tastan, Michael Aschner, Anurag Khatkar, Eduardo Sobarzo-Sanchez
Summary: This study investigated the effects of Malva neglecta leaves in a rat endometriosis model. The results showed that the methanol extract significantly reduced endometrial volume, adhesion score, and levels of TNF-alpha, VEGF, and IL-6. The phytochemical content analysis revealed that polyphenols were responsible for the activity. These findings suggest that Malva neglecta may be a promising alternative for the treatment of endometriosis.
Article
Biology
Esra Kupeli Akkol, Tugba Gunbatan, Ilhan Gurbuz, Hayri Duman, Ceyda Sibel Kilic, Mert Ilhan
Summary: This study investigated the inhibitory potential of ethanol extracts from the roots of ten Ferulago species on hyaluronidase, collagenase, and elastase, which are relevant to wound healing activities. The ethanol extracts of F. mascrosciadia and F. syriaca exhibited the strongest inhibitory effects on collagenase and elastase, respectively. In addition, the in vitro wound healing activity of ten Ferulago species was reported for the first time in this study.
BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Cigdem Kahraman, Suat Sari, Esra Kupeli Akkol, Zeliha S. Akdemir, Iffet Irem Tatli Cankaya
Summary: Verbascum L. species are commonly used in traditional medicine for treating inflammatory diseases and malaria. This study investigated the in vivo anti-inflammatory and antinociceptive effects, as well as the in vitro antimalarial activity of Verbascum latisepalum Hub.-Mor. Various active compounds were isolated from the plant, but no antimalarial activity was found in the methanolic extract.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2022)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
