Renoprotective potential of Macrothelypteris torresiana via ameliorating oxidative stress and proinflammatory cytokines

Ethnopharmacological relevance: Macrothelypteris torresiana is traditionally used in Chinese folk medicine for the treatment of edema for patients suffering from kidney/bladder problems due to its satisfactory therapeutic effectiveness. Aim of the study:The aim of this study was to investigate the renoprotective nature of the total polyphenols fraction from Macrothelypteris torresiana (PMT). Materials and methods: The biochemical criterions of plasma and kidney tissues were evaluated to study the effects of PMT on puromycin aminonucleoside-induced chronic nephrotic syndrome (NS) in hyperlipidemic mice. Results: In this study, the NS and hyperlipidemia were ameliorated after 9 weeks administration of PMT. Besides, PMT was able to modulate the level of renal oxidative stress and vascular endothelial growth factor-nitric oxide (VEGF-NO) pathway. Conclusions: It represented a potential resource of PMT for the treatment of NS involved in metabolic syndrome. (C) 2011 Elsevier Ireland Ltd. All rights reserved.