Article
Food Science & Technology
Jingjing Dong, Shen Wang, Xiaoyao Yin, Min Fang, Zhiyong Gong, Yongning Wu
Summary: This study investigated the antihypertensive effect of rice peptide (RP) and revealed its mechanism of action. The results demonstrated that RP could effectively reduce systolic blood pressure in hypertensive rats, potentially through regulating the renin-angiotensin system and nitric oxide release.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Clinical Neurology
Malik Nassan, Iyas Daghlas, Ignazio S. Piras, Emily Rogalski, Lianne M. Reus, Yolande Pijnenburg, Leah K. Cuddy, Richa Saxena, M-Marsel Mesulam, Matt Huentelman
Summary: This study used genetic approaches to find that angiotensin-converting enzyme (ACE) inhibition is associated with Alzheimer's disease and frontotemporal dementia, but not with Lewy body dementia or vascular dementia. These results provide evidence for further research on the neurocognitive effects of ACE inhibition.
ALZHEIMERS & DEMENTIA
(2023)
Review
Food Science & Technology
Nishithkumar Jogi, Undiganalu Gangadharappa Yathisha, Ishani Bhat, Bangera Sheshappa Mamatha
Summary: Food proteins are sources for ACE-I inhibitory peptides that can be extracted by enzymatic hydrolysis and exhibit anti-hypertensive activity. However, these peptides are susceptible to degradation by gastrointestinal enzymes during oral consumption. The bio-activity of ACE-I inhibitory peptides is dependent on their intact absorption after gastrointestinal digestion.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Chemistry, Multidisciplinary
Moaz M. Abdou, Dewen Dong, Paul M. O'Neill, Eric Amigues, Magdalini Matziari
Summary: In drug discovery, molecular modification of lead molecules is crucial for drug development. This study reports the synthesis of a novel RXPA380-proline hybrid, which showed lower inhibition of ACE compared to the parent compound RXPA380.
Article
Nutrition & Dietetics
Hui Chen, Yu Chen, Huizhen Zheng, Xingwei Xiang, Lu Xu
Summary: In this study, a novel peptide AEYLCEAC with high ACE inhibitory activity was identified from oyster hydrolysates. It exhibited stronger binding to ACE compared to the positive drug phosphoinic tripeptide. In vitro experiments showed that AEYLCEAC had the highest ACE inhibition rate with a competitive inhibitory type. Molecular docking analysis revealed that the ACEI activity of AEYLCEAC was mainly attributed to its hydrogen bonding interactions with the active pockets of ACE. In addition, AEYLCEAC effectively reduced blood pressure in hypertensive rats.
FRONTIERS IN NUTRITION
(2022)
Article
Food Science & Technology
Estefania Bueno-Gavila, Adela Abellan, Francisco Giron-Rodriguez, Jose Maria Cayuela, Luis Tejada
Summary: This study aimed to obtain chicken egg ovalbumin hydrolysates using aspartic proteinases present in extracts from the artichoke flower and evaluate their antioxidant, antimicrobial, and ACE inhibitory activity in vitro. The hydrolysis time and molecular weight significantly influenced the activity of the hydrolysates, with specific peptides showing antioxidant and ACE inhibitory activity.
Review
Oncology
Jianhui Du, Jianhua Lan, Hai Yang, Qiao Ying, Guohua Huang, Jian Mou, Jia Long, Zhenghua Qiao, Qiyi Hu
Summary: This meta-analysis reveals that the ACE I/D locus polymorphism is associated with the risk of prostate cancer. The D allele, DD+DI genotype, and DD at the ACE I/D locus are found to increase susceptibility to prostate cancer, suggesting their potential as diagnostic and screening molecular markers for prostate cancer patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Filippo Confalonieri, Xhevat Lumi, Goran Petrovski
Summary: Epiretinal membrane (ERM) is a common condition affecting the macula. The current treatment approach is surgery, but this case report suggests that angiotensin receptor blockers (ARBs) may have antifibrotic activity on ERM formation and resolution. Further clinical studies are needed to explore this phenomenon.
Article
Pharmacology & Pharmacy
Taikang Yao, Zhenchao Wu, Zilu Wang, Liting Chen, Beibei Liu, Ming Lu, Ning Shen
Summary: Observational studies and meta-analyses have shown a positive correlation between the use of angiotensin-converting enzyme inhibitors (ACEIs) and lung cancer. The study used Mendelian randomization to verify the associations between ACE inhibition, ACEI-induced cough, and the risk of lung cancer. The results indicate a significant relationship between ACE inhibition and the development of lung cancer, as well as a higher risk of lung cancer for Europeans with ACEI-induced cough.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Genetics & Heredity
Mitra Rezaei, Hadiseh Mohammadpour, Mahya Eftekhari, Mihan Pourabdollah, Farinaz Nasr Azadani, Payam Tabarsi, Majid Marjani, Seyed Ali Ziai
Summary: This study aimed to investigate the correlation between angiotensin I converting enzyme (ACE) insertion/deletion polymorphism and the severity of symptoms in COVID-19 patients. The study found that the ACE D allele was associated with an increased risk of disease severity.
FRONTIERS IN GENETICS
(2022)
Article
Pharmacology & Pharmacy
Kung-Ming Laio, Chuan-Wei Shen, Yun-Hui Huang, Chun-Hui Lu, Hsuan-Lin Lai, Chung-Yu Chen
Summary: The prescription pattern and effectiveness of antihypertensive drugs in surgical patients with aortic dissection were investigated. The study found that no specific type of antihypertensive drug was associated with a better outcome in patients with type A aortic dissection, while the use of beta-blockers and calcium channel blockers (CCBs) was related to a significantly lower risk of the composite outcome in patients with type B aortic dissection.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fatih Aydin, Vedat Turkoglu, Zehra Bas
Summary: The study successfully purified ACE enzyme from sheep lungs in one step and determined that captopril, a specific ACE inhibitor, has a significant inhibitory effect with a very low IC50 value of 0.51 nM.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Pharmacology & Pharmacy
Steven D. Brooks, Rachel L. Smith, Aline S. Moreira, Hans C. Ackerman
Summary: Lisinopril increases ACE2 expression in tissues relevant to COVID-19, while adding losartan prevents the lisinopril-induced increase. A sex difference was observed with higher ACE2 levels in the kidneys of male mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Ayse Esra Karadag, Sevde Nur Biltekin, Betul Demirci, Fatih Demirci, Usman Ghani
Summary: This study evaluates the inhibitory activities of Rosa x damascena and Pelargonium graveolens essential oils, as well as their major constituent geraniol, against various enzymes. Geraniol shows the strongest inhibitory effect on ACE2 enzyme. R. damascena essential oil moderately inhibits cancer cell lines, and P. graveolens essential oil inhibits several cancer cell lines for the first time. Molecular docking reveals that geraniol binds to the active sites of target enzymes similar to known drugs. The findings suggest the potential of geraniol for drug development. The similar biological activities of these essential oils are attributed to their similar phytochemistry.
Article
Biochemistry & Molecular Biology
Se Yeong Park, Eun Woo Jeong, Yun Sun Yang, Hyun-Joo Kim, Gwang-woong Go, Hyeon Gyu Lee
Summary: Finger millet ethanol extracts (FEs) exhibit lipid-lowering, antioxidant, renin-angiotensin system-controlling, and vascular remodeling-improving effects in spontaneously hypertensive rats (SHRs), significantly reducing systolic blood pressure.
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)