Article
Plant Sciences
Samina Rubnawaz, Mohammad K. Okla, Nosheen Akhtar, Imdad Ullah Khan, Muhammad Zeeshan Bhatti, Hong-Quan Duong, Mohamed A. El-Tayeb, Yahaya B. Elbadawi, Khalid S. Almaary, Ihab M. Moussa, Zahid Khurshid Abbas, Bushra Mirza
Summary: The study confirmed that transgenic Ajuga bracteosa plants have higher metabolic content and stronger biological activities. Among them, ABRL3 showed the highest antibacterial, anticancer, and antiparasitic activities, as well as high toxicity against human cancer cell lines.
Article
Biochemistry & Molecular Biology
Samina Rubnawaz, Waqas Khan Kayani, Nosheen Akhtar, Rashid Mahmood, Asif Khan, Mohammad K. Okla, Saud A. Alamri, Ibrahim A. Alaraidh, Yasmeen A. Alwasel, Bushra Mirza
Summary: In transgenic regenerants of Ajuga bracteosa, kaempferol was the most abundant polyphenol among 18 standards, and transgenic line ABRL3 exhibited the highest phenolics and flavonoids content. Furthermore, transformed plant extracts showed significant analgesic, anti-inflammatory, anticoagulant, and antidepressant activities in BALB/c mice models.
Article
Biochemistry & Molecular Biology
Muhammad Shakeeb Sharif, Hajra Hameed, Abdul Waheed, Muhammad Tariq, Afshan Afreen, Asif Kamal, Eman A. Mahmoud, Hosam O. Elansary, Saddam Saqib, Wajid Zaman
Summary: This study synthesized iron oxide nanoparticles from algae and plant extracts using a simple, environmentally friendly, and cost-effective method, and characterized their properties. Plant-based Fe3O4 NPs exhibited stronger antioxidant and antibacterial activities compared to algal-based NPs, possibly due to the higher content of phytochemicals in plants, which can encapsulate the nanoparticles during the fabrication process.
Review
Immunology
Wen Yu, Shu Wang, Yangyang Wang, Hui Chen, Hao Nie, Lian Liu, Xiaoting Zou, Quan Gong, Bing Zheng
Summary: Macrophages play important roles in liver fibrosis by triggering inflammation and activating hepatic stellate cells. MicroRNAs have unique regulatory roles in macrophage activation, polarization, tissue infiltration, and inflammation regression. Understanding the heterogeneity of hepatic macrophages and the role of miRNAs in macrophage polarization provides valuable insights for further research and the development of new therapies for liver fibrosis targeting miRNAs and macrophage subsets.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Sadaf Azad Raja, Saiqa Andleeb, Aneela Javed, Sana Sabahat, Fahed Parvaiz, Hafsah Mureed, Sohaib Ahmad, Falak Naz
Summary: This study synthesized gold nanoparticles using extract from Ajuga bracteosa, a medicinal herb found in the northern Himalayas. The synthesized nanoparticles were characterized and their antibacterial efficacy was tested against pathogenic bacteria. The study also assessed the anticancer activity of the nanoparticles and the toxicity of the supernatant. In addition, in-silico analysis was conducted to evaluate the binding efficacy of small molecular weight ligands from Ajuga bracteosa. The findings revealed that the Aj-AuNps have good antibacterial and anticancer properties, while the Nps-free supernatant is highly effective against resistant pathogens and cancer cell lines.
Article
Chemistry, Applied
Ab Majeed Ahanger, Suresh Kumar
Summary: This article introduces a novel drug delivery system based on ZIF-8 nanoparticles, which shows biocompatibility, precise drug release ability, and high stability. The system encapsulates drugs extracted from Ajuga bracteosa and demonstrates effective inhibition of cancer growth.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Ab Majeed Ahanger, Suresh Kumar, Dolly Kain, Atul Arya, Vandana
Summary: Researchers encapsulated Ajuga bracteosa extract into the ZIF-8 framework to form a nanoconjugate, which showed superior antibacterial efficiency through a specific mechanism of inhibiting bacterial growth.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Rongrong Zhao, Huajun Zhao, Quanjuan Guo, Yongliang Mu, Jian Zhang, Yuhang Su, Qiuju Han
Summary: Edaravone (EDA), a novel free radical scavenger, has been shown to have neurovascular protective effects. This study found that EDA can also inhibit liver injury and fibrosis by suppressing monocyte/macrophage recruitment and IL-1 beta production, thereby reducing liver fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Medicine, Research & Experimental
Suhong Xia, Yujie Huang, Yu Zhang, Mingyu Zhang, Kai Zhao, Ping Han, Dean Tian, Jiazhi Liao, Jingmei Liu
Summary: The study found that macrophages can undergo macrophage-to-myofibroblasts transition (MMT) in liver fibrosis tissues and various animal models of chronic liver injury. MMT cells were identified in liver fibrosis patients based on the co-expression of macrophage (CD68) and myofibroblast (a-SMA) markers. Additionally, macrophages were found to transform into myofibroblasts in CCL4-induced liver fibrosis model, high-fat diet (HFD) and methionine-choline-deficient diet (MCD)-induced nonalcoholic fatty liver diseases (NAFLD) model, and ethanol-induced alcoholic fatty liver diseases (AFLD) model. Furthermore, it was highlighted that MMT cells mainly exhibited a predominant M2 phenotype in both human and experimental chronic liver injury.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Shuang Ge, Wei Yang, Haiqiang Chen, Qi Yuan, Shi Liu, Yongxiang Zhao, Jinhua Zhang
Summary: Deficiency of MyD88 in myeloid cells attenuates liver fibrosis and reduces inflammatory cell infiltration, possibly through inhibiting the secretion of CXCL2. Targeting CXCL2 using CXCR2 inhibitors can also reduce liver fibrosis. MyD88 may be a potential target for the prevention and treatment of liver fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Muhammad Imran, Hasnain Jan, Shah Faisal, Sajjad Ali Shah, Sumaira Shah, Muhammad Naeem Khan, Muhammad Taj Akbar, Muhammad Rizwan, Faheem Jan, Suliman Syed
Summary: This study evaluated the anti-parasitic, insecticidal, cytotoxic, and anti-Alzheimer potential of various leaf extracts of Ajuga bracteosa. The n-hexane extract showed significant activity against Leishmania Tropica and promising anti-Alzheimer activity. The insecticidal potential of the extracts varied, with n-hexane showing the highest mortality rate.urther research is warranted to explore the potential of Ajuga bracteosa as a botanical insecticide and source of anti-tumor compounds.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Gastroenterology & Hepatology
Da Cheng, Jin Chai, Huiwen Wang, Lei Fu, Shifang Peng, Xin Ni
Summary: Hepatic fibrosis is a common pathological process involving persistent liver injury and inflammatory responses, which can lead to serious liver diseases if left untreated. Hepatic macrophages play a crucial role in this process, contributing to liver inflammation, fibrosis progression, and fibrosis resolution.
LIVER INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Sadia Nazer, Saiqa Andleeb, Shaukat Ali, Nazia Gulzar, Abida Raza, Habib Khan, Kalsoom Akhtar, Muhammad Naeem Ahmed
Summary: The study investigated the anti-diabetic and hepato-protective effects of green synthesized silver nanoparticles using Ajuga bracteosa. Results showed valuable potential in reducing blood glucose levels, improving liver function, and protecting the liver in diabetic and CCl4-induced mice. These findings suggest that ABaqu and ABAgNPs possess strong anti-diabetic and hepatoprotective properties.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2022)
Article
Cell Biology
Lisha Chen, Yan Huang, Zhixi Duan, Peiqi Huang, Hongbing Yao, Yu Zhou, Qin Ji, Xiangfeng Liu
Summary: Liver fibrosis is a consequence of chronic hepatic injury, where the activation of hepatic stellate cell (HSC) plays a key role. Recent studies have shown that crosstalk between HSCs and immune cells is crucial for the initiation and progression of liver fibrosis, with exosomes serving as important mediators of intercellular communication. Exosomal miR-500 derived from LPS-activated macrophages promotes HSC proliferation and activation by targeting MFN2 in liver fibrosis, suggesting it could potentially serve as a biomarker for liver fibrosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Microbiology
Xujun Zhang, Yan Liang, Jingjing Jiang, Chong Lu, Fan Shi, Qingyi Cao, Yanhui Zhang, Hongyan Diao
Summary: This study confirms that Enterococcus induces liver fibrosis in mice. An HSD exacerbates liver fibrosis by altering the gut microbiota composition and impairing intestinal barrier function. This highlights a new target for liver fibrosis therapy and gut microbiota management.
MICROBIOLOGY SPECTRUM
(2023)
Article
Mathematical & Computational Biology
Wen-Tsong Hsieh, Ke-Rung Tzeng, Jin-Shuei Ciou, Jeffrey J. P. Tsai, Nilubon Kurubanjerdjit, Chien-Hung Huang, Ka-Lok Ng
BMC SYSTEMS BIOLOGY
(2015)
Article
Environmental Sciences
Jai-Sing Yang, Chia-Chun Wu, Hong-Zin Lee, Wen-Tsong Hsieh, Feng-Yao Tang, Da-Tian Bau, Kuang-Chi Lai, Jin-Cherng Lien, Jing-Gung Chung
ENVIRONMENTAL TOXICOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Kun-Cheng Li, Yu-Ling Ho, Wen-Tsong Hsieh, Shyh-Shyun Huang, Yuan-Shiun Chang, Guan-Jhong Huang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2015)
Article
Urology & Nephrology
Yung-Hsiang Chen, Chao-Jung Chen, Yu-Ning Lin, Yang-Chang Wu, Wen-Tsong Hsieh, Bor-Tsang Wu, Wen-Lung Ma, Wen-Chi Chen, Kao-Sung Tsai, San-Yuan Wu, Chawnshang Chang, Huey-Yi Chen, Shuyuan Yeh
WORLD JOURNAL OF UROLOGY
(2015)
Article
Mathematical & Computational Biology
Praveen Kumar Korla, Jack Cheng, Chien-Hung Huang, Jeffrey J. P. Tsai, Yu-Hsuan Liu, Nilubon Kurubanjerdjit, Wen-Tsong Hsieh, Huey-Yi Chen, Ka-Lok Ng
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
(2015)
Article
Physiology
Kun-Cheng Li, Yu-Ling Ho, Cing-Yu Chen, Wen-Tsong Hsieh, Yuan-Shiun Chang, Guan-Jhong Huang
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2016)
Article
Nutrition & Dietetics
Ya-Yuan Chang, Hui-Min Su, Szu-Han Chen, Wen-Tsong Hsieh, Jong-Ho Chyuan, Pei-Min Chao
Article
Engineering, Biomedical
Ting-Ying Wei, Chung-Ping Young, Yu-Ting Liu, Jia-Hao Xu, Sheng-Fu Liang, Fu-Zen Shaw, Chin-En Kuo
BIOMEDICAL ENGINEERING ONLINE
(2019)
Article
Environmental Sciences
Yu-Hsien Lin, Yu-Jung Lin, Ting-Hsuan Chang, Yun-Hsuan Chang, Yun-Ping Lim, Jing-Gung Chung, Wen-Tsong Hsieh
ENVIRONMENTAL TOXICOLOGY
(2020)
Article
Pharmacology & Pharmacy
Yu-Hsien Lin, Ya-Hsin Hsiao, Ka-Lok Ng, Yueh-Hsiung Kuo, Yun-Ping Lim, Wen-Tsong Hsieh
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Wen-Tsong Hsieh, Min-Hsien Hsu, Wen-Jen Lin, Yi-Cheng Xiao, Ping-Chiang Lyu, Yi-Chung Liu, Wei-Yong Lin, Yueh-Hsiung Kuo, Jing-Gung Chung
Summary: EK100 derived from Cordyceps militaris exhibits anti-inflammatory properties by modulating multiple signaling pathways to suppress cytokine release and pro-inflammatory mediator expression, while interfering with LPS binding to receptors. Compared with other drugs, EK100 shows superior efficacy in inhibiting the inflammatory pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Chemical
Geng-Ruei Chang, Wen-Tsong Hsieh, Lan-Szu Chou, Chen-Si Lin, Ching-Fen Wu, Jen-Wei Lin, Wei-Li Lin, Tzu-Chun Lin, Huei-Jyuan Liao, Chen-Yung Kao, Chuen-Fu Lin
Summary: The study showed that curcumin can reduce high-fat diet-induced hyperglycemia and hyperlipidemia, improve fatty liver scores and renal injury in obese mice, and promote a positive chromium balance to mitigate glucose intolerance and metabolic disorders.
Review
Environmental Sciences
Wen-Hsiu Yeh, Ya-Ju Ju, Yu-Ting Liu, Ting-Yi Wang
Summary: This study investigated the effects of neurofeedback training on working memory and episodic memory in healthy participants through a systematic review and meta-analysis. The results showed that neurofeedback training is effective in improving memory outcomes, and it can be used as a nonpharmacological adjunct training to improve working memory and episodic memory in healthy participants.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Chuan-Hsiu Liu, Mei-Ying Chen, Yueh-Hsiung Kuo, Jack Cheng, Li-Zhong Chang, Meng-Shiun Chang, Tsai-Ni Chuang, Wen-Tsong Hsieh, Yan-Ru Xiao, Bor-Tsang Wu, Wei-Yong Lin, Hsin-Ping Liu
Summary: OST has the ability to antagonize microglial activation induced by LPS and NRF2 is necessary for OST's antagonism.
Article
Integrative & Complementary Medicine
Hsin-Shun Tseng, Yu-Fen Wang, Yew-Min Tzeng, Dar-Ren Chen, Ya-Fan Liao, Hui-Yu Chiu, Wen-Tsong Hsieh
AMERICAN JOURNAL OF CHINESE MEDICINE
(2017)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)