Review
Endocrinology & Metabolism
Michael R. Laurent, Jean De Schepper, Dominique Trouet, Nathalie Godefroid, Emese Boros, Claudine Heinrichs, Bert Bravenboer, Brigitte Velkeniers, Johan Lammens, Pol Harvengt, Etienne Cavalier, Jean-Francois Kaux, Jacques Lombet, Kathleen De Waele, Charlotte Verroken, Koenraad van Hoeck, Geert R. Mortier, Elena Levtchenko, Johan Vande Walle
Summary: X-linked hypophosphatemia (XLH) is the most common genetic form of hypophosphatemic rickets and osteomalacia, caused by mutations in the PHEX gene leading to elevated levels of FGF23 hormone. Belgian experts convened to discuss translating international best evidence into locally feasible recommendations to improve diagnostic and therapeutic landscape for XLH patients in Belgium.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Physics, Multidisciplinary
Tiago P. Peixoto
Summary: Community detection methods aim to divide a network into groups with similar properties, but often face challenges in yielding consistent answers. Instead of relying on single partition point estimates, this study presents a comprehensive set of methods to characterize and summarize complex populations of partitions, capturing both consensus and dissensus within the population. The approach can model mixed populations of partitions, compare pairs of partitions, generalize to hierarchical divisions, and perform statistical model selection between competing hypotheses for network structure.
Article
Physics, Fluids & Plasmas
P. L. Krapivsky, S. Redner
Summary: In a population composed of two classes of people, if the interaction rate between people in different classes is below a certain critical value, the population may become polarized, with the time to escape this polarized state and reach consensus scaling exponentially with population size; however, if the interaction rate is above that critical value, consensus can be achieved in a time scaling logarithmically with population size.
Article
Multidisciplinary Sciences
Zhijie Liu, Wei Su, Jianpeng Ao, Min Wang, Qiuli Jiang, Jie He, Hua Gao, Shu Lei, Jinshan Nie, Xuefeng Yan, Xiaojing Guo, Pinghong Zhou, Hao Hu, Minbiao Ji
Summary: This study demonstrates a new imaging method, integrating femto-SRS technique with U-Net, for rapid and accurate diagnosis of gastric cancer. The method can diagnose gastric cancer without the need for pathologist-based diagnosis and holds potential for synchronizing with gastroscopic examination.
NATURE COMMUNICATIONS
(2022)
Article
Computer Science, Artificial Intelligence
Neta Shoham, Haim Avron
Summary: The impressive performance of modern machine learning models relies on training them with a large amount of labeled data. However, obtaining such data is often limited or expensive, so curating the training set becomes desirable. Classical experimental design methods are not applicable to overparameterized machine learning models. This paper proposes a design strategy suitable for overparameterized models and demonstrates its applicability in the context of deep learning.
IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE
(2023)
Article
Physics, Fluids & Plasmas
Antonio F. Peralta, Matteo Neri, Janos Kertesz, Gerardo Iniguez
Summary: Individuals in modern societies share ideas and participate in collective processes within a hidden ecosystem of content filtering technologies. Little is known about the impact of algorithms on information transfer and opinion formation, and how algorithmic bias can influence collective decision-making by polarizing debates. A general theoretical framework has been introduced to systematically link models of opinion dynamics, social network structure, and content filtering to explore the effects of bias-enhanced opinion polarization and develop heuristics to tackle harmful effects of online bias.
Article
Engineering, Civil
Zhenliang Zhou, Zhongsheng Tan, Jinpeng Zhao, Zikai Dong, Dekun Kong, Zonglin Li
Summary: The voids between primary support and secondary lining in existing tunnels pose a significant safety risk and have become a major challenge in tunnel engineering. Utilizing slight-expanding concrete slurry for vault grouting has been effective in addressing this issue. The compatibility of the slight-expanding slurry and lining concrete was analyzed, and a reasonable set of operational parameters was proposed based on laboratory tests and field studies conducted in a expressway tunnel in south China. The results can serve as a reference for future tunnel construction.
KSCE JOURNAL OF CIVIL ENGINEERING
(2022)
Article
Thermodynamics
Lumin Shi, Sayed M. Eldin, Zuhair R. Abdulghani, Elimam Ali, Wei Guo, Ali E. Anqi, Nawaf Alkhamis
Summary: Portable picnic food thermoelectric fridge (COOLMAN Esky) is a commercialized product that utilizes Peltier module. The latest thermoelectric modules have improved efficiency, allowing a single 50 x 50 mm Peltier module to generate 100-250W cooling capacity. Researchers are focusing on performance improvement and new applications of thermoelectric modules. However, economic cost evaluation is a main concern when using Peltier module for heating/cooling purposes. This research evaluates the economic cost of instant cooling of drinkable water using thermoelectric module.
CASE STUDIES IN THERMAL ENGINEERING
(2023)
Article
Chemistry, Analytical
Xiaojia Liu, Shikun Yang, Xianglong Lyu, Sanhu Liu, Yong Wang, Yang Li, Bo Wang, Wenjun Chen, Wei Wang, Jinhong Guo, Xing Ma
Summary: Researchers have developed a convenient SERS kit that can rapidly produce ultra-clean gold nanothorn-based SERS chips, allowing for the specific detection of molecules like H2O2, NO2-, and ClO- through modification of Raman reporter molecules. This on-site preparation method addresses longstanding challenges in SERS substrate practicality, enabling convenient and quick SERS analysis for point-of-care testing while integrating remote data terminals and medical resources for potential environmental and healthcare applications.
ANALYTICAL CHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Andrea Giustina, Nienke Biermasz, Felipe F. Casanueva, Maria Fleseriu, Pietro Mortini, Christian Strasburger, A. J. van der Lely, John Wass, Shlomo Melmed, Acromegaly Consensus Grp
Summary: The 14th Acromegaly Consensus Conference discussed and reviewed biochemical criteria for acromegaly diagnosis and therapeutic evaluation. The conference emphasized the importance of expert management for this rare disease.
Editorial Material
Geriatrics & Gerontology
Avan Aihie Sayer, Alfonso Cruz-Jentoft
Summary: Sarcopenia is a skeletal muscle disorder that commonly occurs with advancing age and long-term conditions. It is associated with adverse health effects and its recognition in clinical practice is relatively recent. Progress in the future may include the use of routine health data, prescription of resistance exercise, and the translation of biology and epidemiology into new treatment research.
Article
Gastroenterology & Hepatology
C. Prakash Gyawali, Rena Yadlapati, Ronnie Fass, David Katzka, John Pandolfino, Edoardo Savarino, Daniel Sifrim, Stuart Spechler, Frank Zerbib, Mark R. Fox, Shobna Bhatia, Nicola de Bortoli, Yu Kyung Cho, Daniel Cisternas, Chien-Lin Chen, Charles Cock, Albis Hani, Jose Maria Remes Troche, Yinglian Xiao, Michael F. Vaezi, Sabine Roman
Summary: The Lyon Consensus 2.0 provides conclusive criteria for diagnosing gastro-oesophageal reflux disease (GERD) and offers additional metrics to support or refute the diagnosis when primary criteria are inconclusive. A global team evaluated research since the original Lyon Consensus and collaborated on developing statements to update criteria. The updated consensus includes a modern definition of actionable GERD, describes the likelihood of symptoms being related to reflux episodes, and provides diagnostic strategies and testing options based on proven or unproven GERD.
Article
Psychiatry
Mary E. McNamara, Jason Shumake, Rochelle A. Stewart, Jocelyn Labrada, Alexandra Alario, John J. B. Allen, Rohan Palmer, David M. Schnyer, John E. McGeary, Christopher G. Beevers
Summary: The study applied a data-driven approach to predict and classify depression groups from various aspects, highlighting the important role of self-referent processing, anhedonia, and psychosocial functioning in differentiating between MDE and PC groups.
PSYCHIATRY RESEARCH
(2021)
Article
Endocrinology & Metabolism
Chen-Yi Wang, Yang Li, Meng-Meng Zhang, Zhi-Long Yu, Zi-Zhen Wu, Chen Li, Dong-Chen Zhang, Ying-Jiang Ye, Shan Wang, Ke-Wei Jiang
Summary: This study aimed to determine the ultrasound characteristics associated with malignant or benign partially cystic thyroid nodules (PCTNs). The results showed that TI-RADS classification can detect malignant PCTNs, and the shape, margin, and structure of the nodules are related to their nature. The calcification and free margin of the solid part were identified as important factors for predicting malignancy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biology
Balazs Aczel, Barnabas Szaszi, Gustav Nilsonne, Olmo R. van den Akker, Casper J. Albers, Marcel Alm van Assen, Jojanneke A. Bastiaansen, Daniel Benjamin, Udo Boehm, Rotem Botvinik-Nezer, Laura F. Bringmann, Niko A. Busch, Emmanuel Caruyer, Andrea M. Cataldo, Nelson Cowan, Andrew Delios, Noah N. N. van Dongen, Chris Donkin, Johnny B. van Doorn, Anna Dreber, Gilles Dutilh, Gary F. Egan, Morton Ann Gernsbacher, Rink Hoekstra, Sabine Hoffmann, Felix Holzmeister, Juergen Huber, Magnus Johannesson, Kai J. Jonas, Alexander T. Kindel, Michael Kirchler, Yoram K. Kunkels, D. Stephen Lindsay, Jean-Francois Mangin, Dora Matzke, Marcus R. Munafo, Ben R. Newell, Brian A. Nosek, Russell A. Poldrack, Don van Ravenzwaaij, Jorg Rieskamp, Matthew J. Salganik, Alexandra Sarafoglou, Tom Schonberg, Martin Schweinsberg, David Shanks, Raphael Silberzahn, Daniel J. Simons, Barbara A. Spellman, Samuel St-Jean, Jeffrey J. Starns, Eric Luis Uhlmann, Jelte Wicherts, Eric-Jan Wagenmakers
Summary: This article discusses how employing multiple analysts can improve the robustness of data analysis results and conclusions, and presents consensus-based guidance for conducting such studies.
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)