Article
Biochemistry & Molecular Biology
Sung-Ju Lee, Hyun Yang, Seong Cheol Kim, Dong Ryun Gu, Jin Ah Ryuk, Seon-A Jang, Hyunil Ha
Summary: Radix Asteris, a traditional Chinese medicine, has been historically used to treat respiratory conditions. This research reveals its potential in managing osteoporosis by inhibiting osteoclast differentiation and protecting against bone degradation. The study also identifies specific constituents in Radix Asteris that regulate bone and fat metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
P. L. Salmon, S. Monzem, B. Javaheri, L. Oste, G. Kerckhofs, A. A. Pitsillides
Summary: Histomorphometry of rodent metaphyseal trabecular bone is often limited to the secondary spongiosa and excludes the primary spongiosa. This study explores the value of spatially resolved trabecular morphometry based on the distance from the growth plate and the inclusion of mixed primary-secondary spongiosal bone. The findings suggest that spatial resolution and the inclusion of primary spongiosal bone enhance the sensitivity of trabecular analysis and reveal significant differences in bone changes at different distances from the growth plate.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Luis Gracia-Marco, Sheila Gonzalez-Salvatierra, Antonia Garcia-Martin, Esther Ubago-Guisado, Beatriz Garcia-Fontana, Jose Juan Gil-Cosano, Manuel Munoz-Torres
Summary: This study analyzed differences in 3D DXA parameters at the hip site among patients with acromegaly or AGHD and healthy controls. The study found cortical bone impairment in AGHD patients and highlighted the trochanter as the site with greater cortical bone differences between acromegaly patients and controls. 3D-DXA provided useful information about bone involvement in GH-related disorders, with AGHD patients showing distinct involvement of the cortical structure.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Zhiyuan Guan, Zheng Xuanqi, Junxiong Zhu, Wanqiong Yuan, Jialin Jia, Chenggui Zhang, Tiantong Sun, Huijie Leng, Changtao Jiang, Yingsheng Xu, Chunli Song
Summary: Postmenopausal osteoporosis is a common bone metabolic disease, and gut microbiota (GM) imbalance plays an important role in its development. This study found that ovariectomized mice had gut microbiota dysbiosis, and reducing gut microbiota through antibiotic treatment improved bone health. G-protein coupled bile acid receptor and systemic inflammatory factors were identified as key players in bone metabolism.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Sung-Ju Lee, Seon-A Jang, Seong Cheol Kim, Jin Ah Ryuk, Hyunil Ha
Summary: The water extract of Lophatherum gracile leaves inhibits osteoclast differentiation and bone loss, making it a potential candidate for therapy and prevention of postmenopausal osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Francesca Salamanna, Deyanira Contartese, Francesca Veronesi, Lucia Martini, Milena Fini
Summary: Sheep ovariectomy plays a crucial role in osteoporosis research, and the impact of variables such as breed, age, diet, and time after surgery should be monitored. Comparative studies are necessary to minimize the impact of these variables and to better understand bone remodeling. Results showed a significant decline in bone mineral density and structural parameters after 12 months of ovariectomy, with site-specific bone alterations in the lumbar vertebra, femoral neck, and ribs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Hangsha Wu, Yue Lv, Feiyang Wei, Changyu Li, Weihong Ge, Weifeng Du
Summary: This study investigated the effect of salt processing on the antiosteoporosis efficacy of Radix Dipsaci and found that salt-processed Radix Dipsaci had better antiosteoporosis efficacy. The fingerprint analysis identified the active ingredients that influenced the antiosteoporosis efficacy.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Medicine, General & Internal
Hui-Yuan Shih, Jun-Hua Lu, Ai-Hua Xiong, Juliana Man-Wai Tse, Ben Siu-Tak Wong
Summary: This study investigated the effects of the natural plant extract, SDTL-E, in ovariectomized-induced osteoporosis rats. The results showed that 20 days of SDTL-E topical treatment improved bone strength and trabecular bone structure. These findings suggest that topical application of plant extract is a potential new approach for treating osteoporosis.
FRONTIERS IN MEDICINE
(2022)
Article
Plant Sciences
Kenneth Kin Leung Kwan, Tina Ting Xia Dong, Karl Wah Keung Tsim
Summary: The study revealed that Danggui Buxue Tang (DBT) enhanced mitochondrial function and energy kinetics in osteoblasts, increasing maximal respiration, spare capacity, glycolysis capacity, and glycolysis reserve. DBT also modulated bioenergetic metabolism through cellular signaling pathways and affected mitochondrial morphology and dynamics. Overall, DBT can be considered a beneficial herbal extract for improving osteoblastic metabolism and bone disorders through central energy metabolism and mitochondrial bioenergetics.
Article
Nutrition & Dietetics
Sung-Ju Lee, Seon-A Jang, Seong Cheol Kim, Dong Ryun Gu, Hyun Yang, Jin Ah Ryuk, Hyunil Ha
Summary: This study found that Euonymus alatus (Thunb.) Siebold has inhibitory effects on osteoclast differentiation and osteoporosis. Through downregulating the expression of RANKL and interfering with RANKL-mediated signaling pathways, it can inhibit the generation and function of osteoclasts. Additionally, oral administration of the ethanolic extract significantly alleviated bone loss in a mouse model. These findings suggest that E. alatus holds potential as a biotherapeutic candidate for anti-postmenopausal osteoporosis.
Article
Microbiology
Yuan-Wei Zhang, Mu-Min Cao, Ying-Juan Li, Ren-Wang Sheng, Ruo-Lan Zhang, Meng-Ting Wu, Jia-Yu Chi, Rui-Xin Zhou, Yun-Feng Rui
Summary: This study aimed to investigate whether supplementation of Prevotella histicola (Ph) could prevent bone loss in mice with ovariectomy (OVX)-mediated osteoporosis (OP), and explore related mechanisms. The results showed that regular and quantitative perfusion of Ph mitigated the bone loss in mice with OVX-mediated OP and improved gut microbiota disturbance.
Article
Medicine, Research & Experimental
Ra-Yeong Choi, In-Woo Kim, Moongi Ji, Man-Jeong Paik, Eu-Jin Ban, Joon Ha Lee, Jae Sam Hwang, HaeYong Kweon, Minchul Seo
Summary: The ethanol extract of P. brevitarsis larvae (PBE) can inhibit RANKL-induced osteoclast formation and prevent bone loss. PBE decreases tartrate-resistant acid phosphatase activity and the expression of osteoclastogenesis-associated genes and proteins. It also inhibits the phosphorylation of p38 and NF-κB.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Geochemistry & Geophysics
Ewerton Vieira, Marcos Silva, Antonio Maia-Filho, Daniel Ferreira, Jose Figueredo-Silva, Karla Rovaris, Ana Cristina Fialho, Ana Leite-Oliveira, Andre L. Menezes de Oliveira, Maria Gardennia da Fonseca, Josy A. Osajima, Edson C. Da Silva-Filho
Summary: This study introduced a cerium-containing HA material, which exhibited good antimicrobial properties and demonstrated a strong osteogenic effect in bone repair.
Article
Biotechnology & Applied Microbiology
Zhiqi Zhao, Haibiao Sun, Yongliang Fu, Xingyu Liang, Tao Fan, Xiaoqiong Li, Liying Zhu, Liubei Xu, Xin Wang, Jinjun Li, Xiaoqiang Han
Summary: This study explored the effects of fucoidan on the gut-bone axis in ovariectomized mice with osteoporosis and demonstrated its efficacy in treating osteoporosis. Fucoidan improves bone health by regulating gut microbiota, protecting the intestinal barrier, and altering lipid metabolism.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2023)
Article
Endocrinology & Metabolism
Robert Brommage, Sabrina Jeter-Jones, Wendy Xiong, Jeff Liu
Summary: Analysis of mouse femoral neck structure provides valuable information for studying osteoporosis therapies, with variations observed among different mouse strains. Age, genetic factors, and treatments influence BV/TV in the femoral neck of mice.
Article
Endocrinology & Metabolism
R. Zhang, Z. G. Liu, C. Li, S. J. Hu, L. Liu, J. P. Wang, Q. B. Mei
Article
Endocrinology & Metabolism
X. Ma, H. Hui, Z. Liu, G. He, J. Hu, J. Meng, L. Guan, X. Luo
DIABETES OBESITY & METABOLISM
(2009)
Article
Immunology
Li Liu, Zhenjun Guo, Zhengguang Lv, Yang Sun, Wei Cao, Rong Zhang, Zhenguo Liu, Chen Li, Shousong Cao, Qibing Mei
INTERNATIONAL IMMUNOPHARMACOLOGY
(2008)
Article
Neurosciences
Xiao-Ling Zhu, Li-Ze Xiong, Qiang Wang, Zhen-Guo Liu, Xue Ma, Zheng-Hua Zhu, Sheng Hu, Gu Gong, Shao-Yang Chen
NEUROSCIENCE LETTERS
(2009)
Article
Medicine, Research & Experimental
Xinshang Wang, Yongli Jiang, Ban Feng, Xue Ma, Kun Zhang, Fan Yang, Zhenguo Liu, Le Yang, Jiao Yue, Liang Lu, Dake Song, Qingjuan Guo, Jingyu Qi, Xubo Li, Min Wang, Huinan Zhang, Jing Huang, Minggao Zhao, Shuibing Liu
Summary: This study reveals the crucial role of astrocytic GPR30 in learning and memory abilities of female mice and identifies GPR30/PJA1/Serpina3n as potential therapeutic targets for learning and memory loss in peri- and postmenopausal women.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Chemistry, Multidisciplinary
ZH Lu, XY Xiong, BL Zhang, GC Lin, YX Shi, ZG Liu, JR Meng, YM Zhou, QB Mei
ACTA PHARMACOLOGICA SINICA
(2005)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)