Article
Multidisciplinary Sciences
Ahmed Sameh, Amr A. Gouda, Esraa Elmligy, Hossam Hatem, Salma S. Sadek, Osama Ahmed, Azza El Amir
Summary: The misuse of antibiotics has caused the emergence of antibiotic-resistant bacterial strains, posing greater challenges in treating infections. This study compared the cytotoxic and antibacterial effects of bee venom-loaded chitosan nanoparticles (BV-loaded CS-NPs) with gamma-irradiated BV and native BV. Physiochemical characterizations and in-vitro/in-vivo experiments demonstrated that BV-loaded CS-NPs exhibited superior antibacterial activity and lower cytotoxicity than the alternative treatments.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Chun-Hao Chang, Yun-Li Lin, Yeu-Sheng Tyan, Yun-Hsuan Chiu, Ya-Han Liang, Chie-Pein Chen, Jiahn-Chun Wu, Hwai-Shi Wang
Summary: Human umbilical cord Wharton's jelly derived mesenchymal stem cells (hUCMSCs) have the ability to migrate to damaged sites in response to signals. IL-1 beta induces the expression of MMP-3 in hUCMSCs, which is related to cell migration. Additionally, ERK1/2, JNK, p38 MAPK and Akt signaling pathways are involved in IL-1 beta-induced hUCMSCs migration through MMP-3 expression.
Article
Medicine, Research & Experimental
Faten Zahran, Alaa Mohamad, Nabila Zein
Summary: Bee venom has hypoglycemic, hypolipidemic, anti-inflammatory, and antioxidant effects, improving cardiac dysfunction in diabetic hyperlipidemic rats. Administration of bee venom and combined therapy with metformin and atorvastatin significantly reduced concentrations of various markers in blood.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Entomology
Hyun Seok Yun, Jisun Oh, Ji Sun Lim, Hyo Jung Kim, Jong-Sang Kim
Summary: This study compared the anti-inflammatory effects of wasp venom from the yellow-legged hornet (Vespa velutina) with bee venom on BV-2 murine microglial cells. The results showed that wasp venom effectively suppressed LPS-induced inflammation in microglial cells by inhibiting the NF-kappa B-mediated signaling pathway.
Article
Plant Sciences
Monica Zuzarte, Catia Sousa, Carlos Cavaleiro, Maria Teresa Cruz, Ligia Salgueiro
Summary: Portuguese lavenders remain undervalued in global markets due to the lack of high-quality end-products and scarcity of scientific-based studies validating their bioactive potential. This study assessed the anti-inflammatory potential of L. luisieri and L. pedunculata, two prevalent species in Portugal, and correlated it with their chemical variability. The results demonstrated that L. luisieri essential oil with low quantities of necrodane derivatives was the most effective at inhibiting inflammation.
Article
Pharmacology & Pharmacy
Xue-Fei Wu, Chun Li, Guang Yang, Ying-Zi Wang, Yan Peng, Dan-Dan Zhu, Ao-Ran Sui, Qiong Wu, Qi-Fa Li, Bin Wang, Na Li, Yue Zhang, Bi-Ying Ge, Jie Zhao, Shao Li
Summary: The study demonstrates that SVHRP can inhibit neuroinflammation and microglia activation, potentially explaining the therapeutic effects of BmK-derived materials and suggesting that BmK venom could be a potential source for CNS drug development.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell & Tissue Engineering
Jing Cao, Haiyan Zhou, Fan Yang, Duojiao Fan, Hengzhou Li, Tao Fan, Peng Sun
Summary: The study revealed that ZEB1 is upregulated in glioma tumor tissues, and downregulating ZEB1 through siRNA interference can inhibit cell proliferation, promote apoptosis, and alter the process of epithelial-mesenchymal transition in glioma cells.
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
(2021)
Article
Oncology
Xin Liu, Shenglin Zhang, Yi Dong, Yunpeng Xie, Qingshan Li
Summary: Gliomas, the most common primary brain tumors in adults, present clinical challenges due to their infiltrative growth patterns and high relapse tendencies. This study identified SENP1 as an upregulated SUMOylation regulator in gliomas and demonstrated its association with poor prognoses. Mechanistically, SENP1 inhibited SIRT1 expression through de-SUMOylation, leading to the activation of NF-kappa B and promotion of glioma cell malignant phenotype. This suggests that SENP1-mediated de-SUMOylation of SIRT1 could have therapeutic implications for gliomas.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Andrea A. Lebel, Michee Kisembo, Marie-France N. Soucy, Mathieu P. A. Hebert, Pier Morin, Luc H. Boudreau
Summary: Glioblastoma multiforme (GBM) is a common form of malignant glioma with limited treatment options, highlighting the importance of developing new therapeutic approaches. This study found that bee venom and its components exhibit anti-cancer activities in human glioma cells by impacting apoptosis, necrosis, and the expression levels of certain genes, suggesting potential value in the treatment of GBM.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Neurosciences
Yu-Hua Hu, Bao-Hua Jiao, Cheng-Ye Wang, Jian-Liang Wu
Summary: RIP2 is involved in TMZ resistance through the regulation of the NF-κB/MGMT signaling pathway. Interference with NF-κB or MGMT activity may be a novel strategy for treating RIP2-positive TMZ-resistant glioma.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Medicine, General & Internal
Galinos Fanourakis, Efthymios Kyrodimos, Vasileios Papanikolaou, Aristeidis Chrysovergis, Georgia Kafiri, Nikolaos Papanikolaou, Mihalis Verykokakis, Konstantinos Tosios, Heleni Vastardis
Summary: The enzymatic activity of APOBEC3B has been implicated as a main cause of mutagenesis in head and neck squamous cell carcinoma. The expression of PKC alpha and NF-kappa B p65 has been linked to the upregulation of A3B. The study evaluated the expression of PKC alpha, NF-kappa B p65, and A3B in non-HPV related oral and oropharyngeal squamous cell carcinomas and found that A3B expression is associated with PKC alpha/NF-kappa B p65 expression, suggesting a potential role for the PKC/NF-kappa B signaling pathway in the development of oral and oropharyngeal cancer.
Article
Fisheries
Chohelee Choudhury, Ritwik Mazumder, Rajib Biswas, Mahuya Sengupta
Summary: The study investigated the effects of cadmium exposure on the immune response and molecular changes in monocytes/macrophages of Channa punctatus. Results showed alterations in hematological profile, tissue damage, impaired innate immune parameters, ROS generation, and induced inflammation, highlighting the role of NF-kappa B pathway and proinflammatory cytokines such as TNF-alpha, IL-1 beta, IL-6, and IL-12.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Immunology
Zhukai Cong, Cui Yang, Zhaojin Zeng, Changyi Wu, Feng Zhao, Ziyuan Shen, Han Xiao, Xi Zhu
Summary: In this study, it was found that alpha 1-AR activation could alleviate lung injuries and inflammation and improve alveolar capillary barrier integrity in the lipopolysaccharide-induced ARDS mouse model without influencing cardiovascular hemodynamics.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xin Yang, Maodi Liang, Yihan Tang, Dingling Ma, Menghuan Li, Chenggang Yuan, Yanting Hou, Chaoyue Sun, Jie Liu, Qianqian Wei, Yongsheng Chang, Cuizhe Wang, Jun Zhang
Summary: In the context of obesity, inflammatory cytokines secreted by adipocytes contribute to insulin resistance and play a key role in the development of metabolic syndrome. Our previous study found that the transcription factor KLF7 promotes the expression of p-p65 and IL-6 in adipocytes, but the specific molecular mechanism remains unclear. In this study, we found that the expression of KLF7, PKC?, p-I?B, p-p65, and IL-6 was significantly increased in epididymal white adipose tissue (Epi WAT) of mice fed a high-fat diet (HFD). However, in KLF7 fat conditional knockout mice, the expression of PKC?, p-I?B, p-p65, and IL-6 was significantly decreased in Epi WAT. In 3T3-L1 adipocytes, KLF7 promotes the expression of IL-6 through the PKC?/NF-?B pathway. Furthermore, luciferase reporter and chromatin immunoprecipitation assays confirmed that KLF7 upregulates the expression of PKC? transcripts in HEK-293T cells. Together, our results demonstrate that KLF7 promotes the expression of IL-6 by upregulating PKC? expression and activating the NF-?B signaling pathway in adipocytes.
Article
Agriculture, Multidisciplinary
Fang Wang, Yuanrong Chen, Kiyoshi Itagaki, Bin Zhu, Yajuan Lin, Haizhao Song, Luanfeng Wang, Ling Xiong, Zebin Weng, Xinchun Shen
Summary: Wheat-germ-derived peptide APEPEPAF (APE) has protective properties against ulcerative colitis by regulating the PKC zeta/NF-kappa B signaling pathway, preserving colon barrier function, and improving intestinal flora imbalance.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Seung-Hak Cho, Jun-young Park, Cheorl-Ho Kim
Summary: Microorganisms and host cells have carbohydrate chains and lectins that can recognize each other, playing a critical role in defense mechanisms and pathogen infection. This review aims to identify the role of host glycans in the immune response against pathogenic intestinal bacteria through studies on the lectin-glycan interaction, providing a new perspective for the prevention and treatment of infectious diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mi-Jin Choi, Yeo Reum Kim, Nam Gyu Park, Cheorl-Ho Kim, Young Dae Oh, Han Kyu Lim, Jong-Myoung Kim
Summary: This study identified a gene that influences the growth of Pacific abalone and found that it plays an important role in the host defense mechanism. The protein encoded by this gene was also found to exhibit antimicrobial activity against various bacteria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fukushi Abekura, Junyoung Park, Hakseong Lim, Hee-Do Kim, Hyunju Choi, Moon-Jo Lee, Cheorl-Ho Kim
Summary: The study demonstrates that LprG can suppress lipopolysaccharide-induced inflammation by downregulating the expression of related proteins and cytokines. These findings are of great significance for the development of anti-inflammatory medications and the utilization of Mycobacterium tuberculosis as a medical resource.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Integrative & Complementary Medicine
Jennifer K. Lee, Inyong Kim, Eun-Kyeong Jeon, Jung-Heun Ha, Cher-Won Hwang, Jin-Chul Kim, Woong-Suk Yang, Hyunju Choi, Hee-Do Kim, Cheorl-Ho Kim
Summary: Oat is a widely consumed cereal grain with high nutritional value and potential health benefits. Microbial fermentation enhances the quality and content of functional ingredients in oats, providing natural dietary supplements, antioxidants, and antiaging agents.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Kyong-Oh Shin, Yoshikazu Uchida, Kyungho Park
Summary: Both intrinsic and extrinsic factors, such as an individual's body clock and air pollutants, accelerate premature aging. This study demonstrates that diesel particulate extract (DPE) increases cell senescence and activates matrix metalloprotease (MMP)-1 and MMP-3, leading to collagen degradation in human dermal fibroblasts. DPE activates NADPH oxidase and increases ceramide production, which in turn activates the arachidonate cascade and promotes MMP activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Biochemistry & Molecular Biology
Yu-Chan Chang, Cheorl-Ho Kim
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Kyong-Oh Shin, Hisashi Mihara, Kenya Ishida, Yoshikazu Uchida, Kyungho Park
Summary: This study investigates the biological effects of exogenous NP and NDS, widely used as topical ceramide agents, on cultured human keratinocytes. NDS serves as a precursor for diverse ceramide species required for the permeability barrier and enhances differentiation and innate immunity, while NP does not have the same effects.
Article
Chemistry, Medicinal
Kyong-Oh Shin, Sungeun Kim, Bokyung Kim, Hye-Yoon Park, Eunhee Jung, Garyun Kim, Donghee Kim, Hwang Eui Cho, Yoshikazu Uchida, Kyungho Park
Summary: Air pollutants, such as diesel particulate matter (DPM), contribute to the development of diseases. However, extracts from the Korean weed Euphorbia supina Rafin (ESR) have been found to protect keratinocytes from DPM-induced apoptosis by inhibiting NOX activation.
Review
Biochemistry & Molecular Biology
Abekura Fukushi, Hee-Do Kim, Yu-Chan Chang, Cheorl-Ho Kim
Summary: Aerobic glycolysis is a characteristic of many human cancers, playing a crucial role in the growth, invasion, immune escape, and drug resistance of cancer cells. The glycolysis pathway consists of multiple enzymatic reactions, with increased levels of glycolytic proteins and enzymatic activities observed in cancer cells. In the Warburg effect, cancer cells rely on glycolysis to generate energy instead of oxidative phosphorylation. The understanding of the Warburg effect can lead to the development of targeted therapies for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jun-Young Park, Cheorl-Ho Kim, Seung-Hak Cho
Summary: In this study, we developed a FimH inhibitor to prevent adhesion of enterohemorrhagic Escherichia coli on human intestinal epithelium during the early stage of infection. By investigating the ligand binding domain of FimH and analyzing its evolutionary characteristics, we identified a potential drug target and found that glycan-like peptides can serve as initial infection inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Yi-Fang Yang, Chien-Hsiu Li, Huei-Yu Cai, Bo-Syuan Lin, Cheorl-Ho Kim, Yu-Chan Chang
Summary: Cellular metabolism regulates physiological mechanisms and homeostasis in an individual. Abnormal metabolic reprogramming, caused by various factors such as gene mutations and epigenetic modifications, is associated with the development of diseases, including cancer. Metabolism-related molecules can serve as markers or prevention targets for cancer progression. Translational medicines using metabolic substrates and precursors have been developed for imaging and therapeutic purposes. Isotopically labeled compounds can be used to localize and visualize tumor cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Hee-Do Kim, Hyunju Choi, Fukushi Abekura, Jun-Young Park, Woong-Suk Yang, Seung-Hoon Yang, Cheorl-Ho Kim
Summary: There are three major assaying methods used to validate in vitro whitening activity from natural products: methods using mushroom tyrosinase, human tyrosinase, and dopachrome tautomerase (or tyrosinase-related protein-2, TRP-2). Whitening agent development consists of two ways, melanin synthesis inhibition in melanocytes and downregulation of melanocyte stimulation. Many researchers have recently presented the bioactivity-guided fractionation, discovery, purification, and identification of whitening agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hyunju Choi, Hee-Do Kim, Yeon-Woo Choi, Hakseong Lim, Kyung-Woon Kim, Kyoung-Sook Kim, Young-Choon Lee, Cheorl-Ho Kim
Summary: This study isolated the GM3-interacting protein NOLC1 using the T7 phage display method, further elucidating the functional roles of GM3 and providing evidence for the association between GM3 and NOLC1.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Biochemistry & Molecular Biology
So-Young An, Ji-Won Lee, Hee-Do Kim, Kyoung-Sook Kim, Jong-Hyun Cho, Cheorl-Ho Kim, Young-Choon Lee
Summary: In this study, it was observed that human glioblastoma cells particularly expressed the hST8Sia V gene. The study found that the JNK/AP-1 signaling pathway controls the specific expression of the hST8Sia V gene in U87MG cells.
GLYCOCONJUGATE JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Hee-Do Kim, Hyunju Choi, Fukushi Abekura, Junyoung Park, Seung-Hak Cho, Young-Choon Lee, Cheorl-Ho Kim
Summary: This study investigates the immunomodulatory effect of MPT32 in murine macrophage cells, demonstrating the possibility of using it as a TB vaccine and drug candidate for TB prevention.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)