Article
Biochemistry & Molecular Biology
Juan Luo, Muhammad Abid, Yi Zhang, Xinxia Cai, Jing Tu, Puxin Gao, Zupeng Wang, Hongwen Huang
Summary: This study identified and functionally analyzed SGR family members in kiwifruit, and found their expression characteristics related to light and plant developmental stages. The results provide valuable insights for kiwifruit cultivar development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Beibei Xiong, Xiangfeng Chen, Jue Tu, Ziyi Han, Xiang Meng, Hongxiang Sun
Summary: This study demonstrates for the first time the role of lncRNAs in regulating the adjuvant activity of polysaccharides and its mechanisms. These findings expand our current understanding of the mechanism of action of adjuvants and provide a new target for the design and development of vaccine adjuvants.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Horticulture
Guanglian Liao, Xiaobiao Xu, Chunhui Huang, Min Zhong, Dongfeng Jia
Summary: Actinidia eriantha, known for its high nutrient content and vitamin C levels, has abundant wild germplasm resources in China with rich genetic diversity. The use of SSR techniques allows for effective genotype differentiation. Through genetic transformation and breeding efforts, A. eriantha shows potential for functional genomics research in the Actinidia genus.
SCIENTIA HORTICULTURAE
(2021)
Article
Immunology
Fangmei Zhou, Yan Lu, Tong Sun, Ling Sun, Bixu Wang, Jingjing Lu, Zhimin Li, Bingqi Zhu, Shigao Huang, Zhishan Ding
Summary: The study demonstrates that Tetrastigma hemsleyanum polysaccharides (THP) can enhance antitumor effects, regulate gut microbiota, and improve immunosuppression induced by antitumor drugs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rui-Fang Zhong, Jing-Juan Yang, Jia-Huan Geng, Jian Chen
Summary: In this study, a polysaccharide named LVF-I was successfully isolated from Lactarius volemus, containing various monosaccharides and showing inhibitory effects on the proliferation of lung and breast cancer cells, as well as enhancing splenocyte proliferative response and macrophage phagocytic ability. LVF-I also induced the secretion of nitric oxide, interleukin-6, and tumor necrosis factor-alpha by macrophages.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Pharmacology & Pharmacy
Shiyu Wang, Xiaoqi Gao, Qingmei Sun, Yichun Zhu, Luping Qin, Bo Zhu
Summary: Actinidia eriantha, known as Maohuamihoutao in China, has been used by the She ethnic minority as a heat-clearing drug for a long time. Pharmacological research has shown that it possesses various activities including anti-cancer, immunoregulatory, and anti-angiogenic effects. The polysaccharides in A. eriantha appear to contribute significantly to its therapeutic effects. However, further investigation is needed to understand the mechanisms of action, chemical interactions, and long-term toxicity and efficacy in vivo.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Guanglian Liao, Min Zhong, Zhiqiang Jiang, Junjie Tao, Dongfeng Jia, Xueyan Qu, Chunhui Huang, Qing Liu, Xiaobiao Xu
Summary: The study revealed the complex biological characteristics of kiwifruit flowers and leaves through GWAS, identifying key genes associated with these traits. An analysis of 946,337 SNP markers also uncovered the genetic structure of A. eriantha and drew conclusions from it.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
Dongfeng Jia, Zhiqiang Jiang, Haihui Fu, Lu Chen, Guanglian Liao, Yanqun He, Chunhui Huang, Xiaobiao Xu
Summary: This study identified and analyzed 142 NAC transcription factor genes in kiwifruit fruit, and investigated their phylogeny, genomic structure, and expression patterns. The findings provide valuable insights for the future functional identification of NAC genes involved in kiwifruit fruit development.
Article
Biochemistry & Molecular Biology
Liuming Xie, Zhibing Huang, Hui Meng, Zhibing Fan, Xiaoyi Shi, Jianhua Xie
Summary: The addition of genistein during fermentation increased the yield of EPS produced by M. purpureus and improved its physicochemical properties, as well as enhanced its immunomodulatory activity. The genistein-treated M. purpureus EPS stimulated higher levels of nitric oxide and cytokine secretion in RAW264.7 macrophages, indicating its potential for improving the EPS yield of M. purpureus.
Article
Plant Sciences
Guanglian Liao, Qing Liu, Xiaobiao Xu, Yanqun He, Yiqi Li, Hailing Wang, Bin Ye, Chunhui Huang, Min Zhong, Dongfeng Jia
Summary: The study identified an early mature germplasm of Kiwifruit with higher carbohydrate content and lower levels of endogenous hormones, mainly due to a reduced sucrose decomposition rate leading to early harvest.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Multidisciplinary Sciences
Shaza M. Elhusseiny, Taghrid S. El-Mahdy, Nooran S. Elleboudy, Mohamed M. S. Farag, Khaled M. Aboshanab, Mahmoud A. Yassien
Summary: This study investigated the immunomodulatory activity of five common edible mushrooms in rats. The results showed that the mushroom extracts significantly enhanced the immune system with increased white blood cells, lymphocytes, lysozyme activity, NO concentration, and cytokines.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Huimin Jia, Junjie Tao, Wenqi Zhong, Xudong Jiao, Shuangshuang Chen, Mengting Wu, Zhongshan Gao, Chunhui Huang
Summary: In this study, the metabolites of A. eriantha fruit were analyzed using a metabolomics approach and transcriptome analysis. The biosynthesis and metabolism of phenolic acid, flavonoids, sugars, organic acid and AsA were investigated. The results showed that polyphenols were correlated with specific genes, sugars mainly consisted of sucrose, glucose, arabinose and melibiose, organic acids were mainly citric acid, quinic acid, succinic acid and D-xylonic acid, and the metabolism of AsA acid primarily occurred through the L-galactose pathway. These findings provide valuable insights for kiwifruit molecular breeding.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Quan Jiang, Zhi Wang, Guangming Hu, Xiaohong Yao
Summary: In this study, the AP2/ERF gene family in kiwifruit was identified and characterized, specifically focusing on their gene structures, conserved motifs, and phylogeny relationships. The study also revealed the potential role of AP2/ERF genes in flower development in kiwifruit.
Article
Horticulture
Qing Liu, Yiqi Li, Guanglian Liao, Xiaobiao Xu, Dongfeng Jia, Min Zhong, Hailing Wang, Bin Ye
Summary: Fruit bagging is an effective method for producing pollution-free fruit, but it may affect the internal quality of the fruit. This study investigated the effects of fruit shading by bagging on kiwifruit quality and identified the molecular mechanisms behind the decrease in ascorbic acid content.
SCIENTIA HORTICULTURAE
(2022)
Article
Food Science & Technology
Siyuan Su, Xiang Ding, Yiling Hou, Binbin Liu, Zhouhe Du, Junfeng Liu
Summary: A new water-soluble heteropolysaccharide (BRS-X) with a molecular weight of 15 kDa was isolated from the fruiting bodies of Boletus reticulatus Schaeff. BRS-X exhibited strong proliferative activity in T cells and B cells, and promoted the secretion of immunoglobulins. It also facilitated cell proliferation and phagocytosis, and significantly inhibited tumor growth. Transcriptome sequencing analysis revealed the involvement of MAPK and PI3K/Akt signaling pathways, and a reduction in VEGF and VEGFR expression under the treatment of BRS-X.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Cell Biology
Xiangfeng Chen, Yanfei He, Yongliang Zhu, Jing Du, Hongxiang Sun
Summary: The study identifies linc-AAM as a long intergenic noncoding RNA associated with activated macrophages, which functions as a transcription enhancer to activate macrophages and promote adaptive immunity by modulating hnRNPL. This reveals a new mechanism of lncRNA in immune responses.
Article
Immunology
Yuhua Shi, Qian Lv, Mengjie Zheng, Hongxiang Sun, Fushan Shi
Summary: INF39 is a specific inhibitor for NLRP3 inflammasome activation, without affecting other inflammasomes. It exerts its anti-inflammatory effect by inhibiting the interaction of NEK7-NLRP3 and other downstream events.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yanfei He, Haoxuan Peng, Huifang Zhang, Yaqin Liu, Hongxiang Sun
Summary: The two homogeneous polysaccharides PCSPA and PCSPB extracted from Crocus sativus petals exhibited different sugar compositions, containing sulfonic and acetyl groups, and were able to activate cells and enhance immune activity through the MAPK and NF-kappa B pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Immunology
Jing Du, Hongxiang Sun
Summary: AJSAF induces early innate immune responses at the injection site, characterized by cytokine production and neutrophil recruitment. It mainly elicits the expression of Th1 immune response and Neutrophils genes, expanding the current knowledge on the mechanisms of action of saponin-based adjuvants.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Environmental Sciences
Yu Han, Weishang Zhou, Yu Tang, Wei Shi, Yanqing Shao, Peng Ren, Jiongming Zhang, Guoqiang Xiao, Hongxiang Sun, Guangxu Liu
Summary: The study revealed that exposure of mussels to antibiotics and microplastics led to synergistic immunotoxic effects, including significant reductions in phagocytic rate and total hemocyte count, increases in intracellular reactive oxygen species and decreases in F-actin cytoskeleton, cell viability, and immune-related gene expression. Coexposure to antibiotic-MP also resulted in higher accumulation of antibiotics, possibly explaining the observed synergistic immunotoxic effect. Additionally, exposure to pollutants suppressed glutathione-S-transferase activity, downregulated detoxification-related genes, and induced lipid peroxidation in gills, potentially facilitating the entry of antibiotics and increasing their accumulation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Cell Biology
Liyan Zhu, Ziyi Han, Yanfei He, Hongxiang Sun
Summary: This study identified the potential signaling pathways involved in the adjuvant activity of Platycodin D (PD) using in vitro and in vivo models. The results showed that PD induced cytotoxicity and inflammatory response via the caspase-1-dependent NLRP3 inflammasome signaling pathway in C2C12 cells. In vivo analysis further demonstrated that blocking NLRP3 and caspase-1 inhibited PD-induced cytokine production and immune cell recruitment, and impaired the adjuvant activity of PD in mice. These findings expand our understanding of the mechanisms of action of saponin-based adjuvants.
Article
Biochemistry & Molecular Biology
Yanfei He, Xiaoying Hu, Huifang Zhang, Xiangfeng Chen, Hongxiang Sun
Summary: Two polysaccharides from Crocus sativus petals demonstrated immunopotentiatory activity by activating macrophages via the MAPK and NF-KB pathway. This study investigated their adjuvant effects and underlying mechanisms using ovalbumin in mice. The results showed that these polysaccharides enhanced immune responses, triggered the production of cytokines, and facilitated antigen transport, making them promising vaccine adjuvant candidates.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Environmental Sciences
Yu Han, Wei Shi, Yu Tang, Weishang Zhou, Hongxiang Sun, Jiongming Zhang, Maocang Yan, Lihua Hu, Guangxu Liu
Summary: The study investigated the effects of microplastics and bisphenol A on gonadal development in whiteleg shrimp, revealing significant inhibition of gonadal development probably through interfering with metabolism and disrupting endocrine regulation. Co-exposure to both pollutants was more toxic and led to increased accumulation of BPA in shrimp gonads, potentially due to the Trojan horse effect and cumulative toxic impacts.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biotechnology & Applied Microbiology
Li-Wei Wang, Jie Li, Le-Xin Gao, Feng-Yang Chen
Summary: Through this study, a novel immunosuppressant dibenzofuran named iME was obtained from the endophytic fungus Mycosphaerella nawae. iME demonstrated selective inhibition on the activation and proliferation of CD4(+) T cells.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Food Science & Technology
Zhe-Han Zhao, Xian-Yan Ju, Kui-Wu Wang, Xin-Juan Chen, Hong-Xiang Sun, Ke-Jun Cheng
Summary: In this study, a novel polysaccharide (PAP-3) was isolated and identified from P. aquilinum for the first time. PAP-3 showed strong free-radical scavenging activity and significant immunomodulatory activity. These findings are of great significance for further research on the polysaccharides of P. aquilinum and their applications in the food and medical industries.
Article
Medicine, Research & Experimental
Zuoting Yu, Dinggang Li, Hongxiang Sun
Summary: This study investigated the protective effect of Herba Origani on dextran sodium sulfate (DSS)-induced ulcerative colitis in mice. The results showed that Herba Origani alleviated colitis symptoms, inflammation, and pathological injury, and repaired intestinal barrier function. It also restored gut microbiota dysbiosis, regulated bile acids metabolism, and adjusted short-chain fatty acids (SCFAs). These findings suggest that Herba Origani has the potential to be used for the treatment of inflammatory intestinal diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Ziyi Han, Junjie Jin, Xiangfeng Chen, Yanfei He, Hongxiang Sun
Summary: In this study, the adjuvant activities of tubeimoside I, II, and III (TBMs) were investigated. The TBMs significantly boosted the immune responses and influenced the expression of immune, chemotaxis, and inflammation-related genes. The interaction between TBM I and SYK and LYN was found to be involved in its adjuvant activity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Plant Sciences
Chang-An Geng, Feng-Yang Chen, Jing-Bin Zheng, Ping Liao, Tian-Ze Li, Xue-Mei Zhang, Xin Chen, Ji-Jun Chen
Summary: The compound RGB from Rhododendron brachypodum inhibits the differentiation of regulatory T cells and enhances anti-tumor immune responses through the calcineurin-NFAT signaling pathway. It suppresses Foxp3 expression and inhibits tumor growth in mouse models. RGB or its analogs may have potential as adjuvant agents for tumor therapy.
Article
Immunology
Jing Du, Xiang Meng, Tiantian Ni, Beibei Xiong, Ziyi Han, Yongliang Zhu, Jue Tu, Hongxiang Sun
Summary: This study explored the intracellular molecular mechanisms of the innate immune response induced by Albizia julibrissin saponin active fraction (AJSAF) in mouse C2C12 myoblasts. The results showed that AJSAF activated the Ca2+-MAPK-CREB pathway and upregulated cell death- and inflammatory response-related genes.
Article
Immunology
Yinuo Zou, Haiting Wang, Juan Fang, Hongxiang Sun, Xuming Deng, Jianfeng Wang, Yanhong Deng, Gefu Chi
Summary: This study identified the natural flavonoid isorhamnetin as an inhibitor of PLY, which reduces the pathogenicity of S. pneumoniae. Isorhamnetin also decreases the formation of bacterial biofilms and attenuates PLY-mediated injury. In vivo experiments confirmed the efficacy of isorhamnetin in ameliorating lung tissue injury caused by S. pneumoniae.
MICROBIAL PATHOGENESIS
(2023)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)