Article
Agricultural Engineering
Naiara C. Zotti-Sperotto, Mariane Br de Avila, Raiane A. de Souza, Evandro de C. Melo, Julia L. Governici, Diego A. Gonzaga, Maira C. M. Fonseca, Antonio P. de S. Carneiro, Antonio Jacinto Demuner, Patricia Fontes Pinheiro, Cristiane Fernandes Lisboa
Summary: Drying with a 10:20 intermittence ratio at 70 degrees Celsius yielded the highest and best quality essential oil for Lippia origanoides leaves, preserving Thymol and color attributes. Similarly, drying with a 10:20 intermittence ratio at 50 degrees Celsius maximized essential oil yield and alpha-Phellandrene concentration for Schinus terebinthifolius fruits.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Plant Sciences
Maria Milene Costa da Silva, Jose Bezerra de Araujo Neto, Antonia Thassya Lucas dos Santos, Cicera Datiane de Morais Oliveira-Tintino, Ana Carolina Justino de Araujo, Priscilla Ramos Freitas, Luiz Everson da Silva, Wanderlei do Amaral, Cicero Deschamps, Francisco Roberto de Azevedo, Clara Mariana Goncalves Lima, Nadezhda Golubkina, Joao Tavares Calixto-Junior, Jaime Ribeiro-Filho, Henrique Douglas Melo Coutinho, Gianluca Caruso, Saulo Relison Tintino
Summary: This study evaluated the chemical composition and antibiotic-enhancing effects of Schinus terebinthifolius Raddi essential oil (STEO) against standard and multidrug-resistant strains of Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The results showed that STEO enhanced the antibacterial activity of norfloxacin and gentamicin against all strains and increased the action of penicillin against Gram-negative strains.
Review
Food Science & Technology
Adilson Roberto Locali-Pereira, Nathalie Almeida Lopes, Vania Regina Nicoletti
Summary: Bioactive compounds obtained from Schinus terebinthifolius Raddi extracts have antimicrobial and antioxidant activities and can be used as natural preservatives and flavorings. Pink pepper extracts show great market potential.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Odara Araujo Oliveira, Sarah Rodrigues Ferreira, Elane Da Silva Ribeiro, Andre T. S. Ferreira, Jonas Perales, Katia V. S. Fernandes, Antonia E. A. Oliveira
Summary: This study explored the toxicity of Schinus terebinthifolius seed flour against the insect C. maculatus. The seed flour decreased larval survival, mass, and length. Proteins with different molecular masses isolated using chromatography were toxic to the insect. Changes in protein levels, glucose, and enzyme activity were detected in the larvae.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Chemistry, Applied
Mysrayn Yargo de Freitas Araujo Reis, Ana Luisa de Melo Xavier, Ramon Ramos Marques de Souza, Izola Morais de Meideiros Ramalho, Yuri Mangueira do Nascimento, Maria Denise Leite Ferreira, Bolivar Ponciano Goulart de Lima Damasceno, Marianna Vieira Sobral, Fabio Correira Sampaio
Summary: The study revealed that EOpp extracted from pink pepper fruits contains various chemical components and exhibits cytotoxic activity, suggesting its potential as an important source of active natural compounds in traditional Brazilian medicine.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Carla Fernanda Targueta Barreira, Vanessa Sales de Oliveira, Davy William Hidalgo Chavez, Ormindo Domingues Gamallo, Rosane Nora Castro, Pedro Correa Damasceno Junior, Alexandra Christine Helena Frankland Sawaya, Micheli da Silva Ferreira, Geni Rodrigues Sampaio, Elizabeth Aparecida Ferraz da Silva Torres, Tatiana Saldanha
Summary: The effect of adding pink pepper during sardines canning to minimize cholesterol oxidation was investigated. The results showed that pink pepper could reduce the levels of cholesterol oxides, thus minimizing the loss of nutritional quality in canned fish.
Article
Chemistry, Applied
Juliana Huei Zago Wang, Patricia Kozuchovski Dare, Aline Armiliato Emer
Summary: The study described the perceptions and psychological associations of UNISUL's Naturology students when inhaling pink pepper essential oil. Most participants' expressed emotions were more directly related to physical sensations and memories triggered by inhalation, rather than the oil itself.
FLAVOUR AND FRAGRANCE JOURNAL
(2021)
Article
Environmental Sciences
Francisco Napoleao Tulio Varela-Barca, Maria Beatriz Mesquita Cansancao Felipe, Silvia Regina Batistuzzo de Medeiros
Summary: Flavonoids from Brazilian pepper tree stem bark show mutagenic potential, possibly inducing mutations due to oxidative damage. Some medicinal plant flavonoids may have oxidative and toxic effects, requiring further investigation.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2021)
Article
Biochemistry & Molecular Biology
Milene Dias Ferreira, Lourdes Cardoso de Souza Neta, Geovani Cardoso Brandao, Walter Nei Lopes dos Santos
Summary: This study evaluated the antimicrobial activity of silver nanoparticles synthesized from the aqueous extract of Schinus terebinthifolius Raddi leaves. The results showed that the silver nanoparticles had greater antimicrobial efficacy compared to the extract, inhibiting the growth of both bacteria and fungi.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Jorge Makhlouta Alonso, Renato Nunes Pereira, Elton Luis da Silva Abel, Marjorie Ochoski, Gilsonley Lopes dos Santos, Alan Henrique Marques de Abreu
Summary: This study evaluated the effects of different substrates and fertilizer rates on the production of Schinus terebinthifolia seedlings. The results showed that producing Schinus terebinthifolia in Ilha's sewage sludge substrate is recommended and can save nursery costs. Multivariate analysis proved to be an effective method for assessing seedling quality.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Priscilla Guimaraes Silva Vasconcelos, Erika Ponchet Alves, Carolina Medeiros de Almeida Maia, Arella Cristina Muniz Brito, Diego Romario Silva, Irlan Almeida Freires, Yuri Wanderley Cavalcanti, Vera Lucia Garcia Rehder, Ana Lucia Tasca Gois Ruiz, Marta Cristina Teixeira Duarte, Pedro Luiz Rosalen, Gustavo Pina Godoy, Edja Maria Melo de Brito Costa
Summary: The essential oil of Schinus terebinthifolia Raddi green fruits has low antimicrobial and antibiofilm activities, with constituents mainly composed of alpha-phellandrene and beta-phellandrene. It exhibits cytotoxic activity against tumor cells but no toxicity to human tumor and non-tumor cells.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Plant Sciences
Jessica Patricia Oliveira De Mattos, Marcos Vinicius Miranda Aguilar, Jover da Silva Alves, Thalia Preussler Birck, Caroline Castro Kuinchtner, Camila Peligrinotti Tarouco, Thomas Wink Peixoto, Luciane Almeri Tabaldi
Summary: Aluminum (Al) toxicity affects the yield of many crops worldwide. The use of selenium (Se) as a beneficial element to mitigate the toxic effects of metals on crops has been studied. This study evaluated the tolerance/sensitivity to Al and the mitigating effects of Se on Schinus terebinthifolius seedlings. The results showed that Al reduced leaf area, shoot and root dry mass, root increment, as well as root length, surface area, volume, and diameter. Se was unable to mitigate the toxic effects of Al on the seedlings' photosynthetic and antioxidant systems.
JOURNAL OF PLANT NUTRITION
(2023)
Article
Food Science & Technology
Milena Ramos Vaz Fontes, Camila Ramao Contessa, Caroline Costa Moraes, Elessandra da Rosa Zavareze, Alvaro Renato Guerra Dias
Summary: This study produced ultrafine fiber membranes of polylactic acid loaded with pink pepper essential oil and evaluated their antimicrobial potential. The addition of pink pepper essential oil enhanced the thermal and antimicrobial properties of the membranes, showing inhibitory effects on Staphylococcus aureus and Listeria monocytogenes. The membranes applied in cream cheese packaging also exhibited inhibitory effects on bacterial growth.
Article
Food Science & Technology
Raquel Clasen Pich, Eva Larissa de Andrade Batista, Lorrane Santos de Oliveira, Rafaella Camila da Silva, Leticia Rocha Guidi, Marta Fernanda Zotarelli, Ricardo Correa de Santana
Summary: The maturation degree of pink pepper fruits and their powder production by cast-tape drying were studied. The process variables of circulating water temperature and thickness of paste spreading layer were analyzed for their influence on the physicochemical properties of the produced powders. Six ripening stages were observed for pink pepper fruits. A short drying time (60 min) with the lowest spreading thickness (2 mm) and the highest temperature (95 degrees C) achieved a suitable moisture content of the powders. The powders obtained had a low water activity and moisture content in all drying conditions. The color variation was minimal at a temperature of 65°C and a thickness of 3 mm. Higher levels of phenolic compounds were obtained at a slightly lower temperature and a thicker pink pepper paste layer (4 mm).
FOOD AND BIOPROCESS TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yun-Fang Chen, Chun-Chieh Hsu, Ching-Hu Chung
Summary: This study evaluated the acute and subacute toxicity of fluorescent gold nanoclusters conjugated with alpha-lipoic acid (FANC) in mice. The results showed that FANC had no significant toxicity in the tested dose range, with no adverse effects on physiological parameters, organ histopathology, or liver and renal function. The only observed change was a slight effect on body weight, but it was below the threshold of concern and not dose-dependent.
Article
Polymer Science
Isabel Sousa Alcantara, Anita Oliveira Brito Pereira Bezerra Martins, Maria Rayane Correia de Oliveira, Cathia Coronel, Maria Celeste Vega Gomez, Miriam Rolon, Almir Goncalves Wanderley, Lucindo Jose Quintans Junior, Adriano Antunes de Souza Araujo, Ana Carolina Justino de Araujo, Priscilla Ramos Freitas, Henrique Douglas Melo Coutinho, Irwin Rose Alencar de Menezes
Summary: Croton rhamnifolioides essential oil shows potential antiparasitic activity against T. cruzi, Leishmania braziliensis, and Leishmania infantum, with the inclusion complex with beta-cyclodextrin presenting lower cytotoxicity. This suggests that C. rhamnifolioides essential oil could be a promising natural source for antiparasitic product development.
Article
Green & Sustainable Science & Technology
Marcelanio Laurentino, Elcida de Lima Araujo, Marcelo Alves Ramos, Maria Clara Bezerra Tenorio Cavalcanti, Paulo Henrique Santos Goncalves, Ulysses Paulino Albuquerque
Summary: The study found that socioeconomic variables have limited impact on willingness to accept (WTA) compensation; women are willing to accept lower compensation to not use certain plant species; individuals from larger families also accept lower compensation to not use a specific plant species.
ENVIRONMENT DEVELOPMENT AND SUSTAINABILITY
(2022)
Article
Cardiac & Cardiovascular Systems
Debora S. Alves-de-Oliveira, Aline M. N. L. G. Bloise, Laura M. L. Silva, Reginaldo L. Rocha-Junior, Nelson C. Lima-Junior, Luiza G. S. Menezes, Elionay G. S. Silva, Yohanna De Oliveira, Almir G. Wanderley, Jose L. De-Brito-Alves, Viviane O. N. Souza, Joao H. Costa-Silva
Summary: The study found that maternal consumption of a high-fat diet enriched with omega-3 can prevent metabolic disruptions caused by HFD in offspring until early adulthood, but the long-term effects are limited.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Environmental Sciences
Henrique Fernandes Magalhaes, Ivanilda Soares Feitosa, Elcida de Lima Araujo, Ulysses Paulino Albuquerque
Summary: This study investigated the perception of diseases and adaptive strategies among farmers living in the semiarid region of Northeastern Brazil. The findings indicated that farmers had limited knowledge about climate change-related diseases, with low incidence rates. Direct transmission diseases were the most frequently mentioned, while adaptive strategies related to prophylactic behavior were less mentioned.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2022)
Review
Physiology
Aiany Cibelle Simoes-Alves, Ana Paula Fonseca Cabral Arcoverde-Mello, Jessica de Oliveira Campos, Almir Goncalves Wanderley, Carol Virginia Gois Leandro, Joao Henrique da Costa-Silva, Viviane de Oliveira Nogueira Souza
Summary: In recent years, the worldwide phenomenon of a nutritional transition, characterized by a shift in diet from undernutrition to the excessive consumption of hypercaloric and ultra-processed foods, has caused concerns due to the replacement of infectious and parasitic diseases with chronic and degenerative diseases. This transition has also led to the coexistence of malnutrition and obesity in the same population, posing significant health risks.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Samira Leila Baldin, Karolyne de Pieri Pickler, Ana Caroline Salvador de Farias, Henrique Teza Bernardo, Rahisa Scussel, Barbara da Costa Pereira, Suzielen Damin Pacheco, Eduardo Ronconi Dondossola, Ricardo Andrez Machado-de-Avila, Almir Goncalves Wanderley, Eduardo Pacheco Rico
Summary: This study demonstrates that pretreatment with gallic acid can prevent the inhibitory effects of ethanol on the purinergic signaling pathway in the zebrafish brain. This is achieved through the degradation of extracellular nucleotides and the reduction of oxidative stress, resulting in the modulation of nucleotide levels.
PURINERGIC SIGNALLING
(2022)
Editorial Material
Pharmacology & Pharmacy
Almir Goncalves Wanderley, Lucindo Jose Quintans Junior, Henrique Douglas Melo Coutinho, Jackson Roberto Guedes da Silva Almeida, Irwin Rose Alencar De Menezes
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Amanda Damasceno Leao, Juliano Ribeiro da Silva, Jotele Fontana Agostini, Glaucia Dal Santo, Leucio Duarte Vieira, Jacinto da Costa Silva Neto, Katharina Rodrigues de Lima Porto Ramos, Teresinha Goncalves da Silva, Carmen Alvarez-Lorenzo, Almir Goncalves Wanderley, Jose Lamartine Soares-Sobrinho
Summary: Glibenclamide nanoparticles combined with organophilized Layered Double Hydroxide were developed to improve the oral bioavailability of glibenclamide and showed potential as a controlled release system for the treatment of type II diabetes mellitus. The combination effectively normalized blood glucose levels without causing toxicity, and also improved the oxidative balance of vascular tissue.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biology
Priscila Silva dos Santos, Kleber Andrade da Silva, Elcida de Lima Araujo, Danielle Melo dos Santos, Josiene Maria Falcao Fraga dos Santos, Gicelia Lira dos Prazeres, Elba Maria Nogueira Ferraz
Summary: The type of land use surrounding forest remnants can affect plant populations and communities, leading to changes in pollination and seed dispersion processes. This study compared the seed density, species richness, floristic composition, habit, dispersal syndrome, and successional category of seed rain between urban and rural fragments of Atlantic Forest. The results showed differences in these characteristics between the fragments, which may be influenced by external pressures and temporal variation in precipitation.
REVISTA DE BIOLOGIA TROPICAL
(2023)
Article
Chemistry, Medicinal
Fernando Sabia Tallo, Patricia Oliveira de Santana, Sandra Augusta Gordinho Pinto, Rildo Yamaguti Lima, Erisvaldo Amarante de Araujo, Jose Gustavo Padrao Tavares, Marcelo Pires-Oliveira, Lucas Antonio Duarte Nicolau, Jand Venes Rolim Medeiros, Murched Omar Taha, Andre Ibrahim David, Braulio Luna-Filho, Carlos Eduardo Braga Filho, Adriano Henrique Pereira Barbosa, Celia Maria Camelo Silva, Almir Goncalves Wanderley, Adriano Caixeta, Afonso Caricati-Neto, Francisco Sandro Menezes-Rodrigues
Summary: Acute myocardial infarction is a major cause of morbidity and mortality worldwide, characterized by severe arrhythmias induced by cardiac ischemia/reperfusion. This study reveals that pharmacological modulation of the cardiac Ca2+/cAMP/adenosine signaling pathway could be a promising therapeutic strategy to reduce the incidence of severe and fatal arrhythmias caused by AMI.
Article
Biochemistry & Molecular Biology
Rafael Carneiro Bastos, Carlos Franciney Moreira Vasconcelos, Marcela Bezerra Paiva, Thomas Dominik de Sousa dos Reis, Ricardo Basto Souza, Helcio Silva dos Santos, Paulo Nogueira Bandeira, Lissiana Magna Vasconcelos Aguiar, Rodrigo Maranguape Silva da Cunha
Summary: This study aimed to analyze the antioxidant and neuroprotective potential of a new diterpene isolated from C. argyrophylloides (MP-1). The results showed that MP-1 has a high antioxidant capacity and can reduce the effects of Parkinson's disease, such as behavioral changes, motor alterations, and body weight loss. MP-1 was also able to control the upregulated levels of nitrosative stress and lipid peroxidation, suggesting it as a potential treatment for Parkinson's disease.
FREE RADICAL RESEARCH
(2022)
Article
Immunology
Momtchilo Russo, Maria Cassia Mendes-Correa, Bruna B. Lins, Victor Kersten, Paulo C. A. Pernambuco, Toni Ricardo Martins, Tania Regina Tozetto-Mendoza, Lucy Santos Vilas Boas, Brisa Moreira Gomes, Livia Mendonca Munhoz Dati, Amaro Nunes Duarte-Neto, Gustavo Roncoli Reigado, Ana Beatriz T. Frederico, Danielle R. de A. Cunha, Anderson Vicente de Paula, Jose Igor G. da Silva, Carlos F. Moreira Vasconcelos, Felipe S. Chambergo, Viviane Abreu Nunes, Ana Paula Dinis Ano Bom, Leda R. Castilho, Rodrigo A. P. Martins, Mario Hiroyuki Hirata, Luciana Mirotti, Ralph A. Tripp
Summary: Mucosal vaccination is effective in protecting against SARS-CoV-2 infection. Intranasal administration of a liposomal vaccine containing SARS-CoV-2 spike protein and an adjuvant showed no toxicity and provided efficient protection in mice. Intranasal vaccination induced higher levels of neutralizing antibodies and IgA titers, and demonstrated efficacy against different variants of concern. Compared to intramuscular vaccination, intranasal administration resulted in better lung clearance of the virus and higher antibody production. The intranasal liposomal formulation also enhanced heterologous immunity induced by previous vaccination.
Article
Surgery
Patricia Brassolatti, Cynthia Aparecida de Castro, Hugo Leonardo dos Santos, Isabelle Taira Simoes, Luciana Almeida-Lopes, Juliana Virginio da Silva, Fernanda Oliveira Duarte, Genoveva Lourdes Flores Luna, Wladimir Rafael Beck, Paulo Sergio Bossini, Fernanda de Freitas Anibal
Summary: The study found that HA/PLGA/BLEED biomaterial implantation had a significant effect on the morphological structure of bone and accelerated osteoblast activation within three days without causing exacerbated systemic inflammation. In addition, it was found that the biomaterial modulated the expression of important genes involved in bone repair.
ACTA CIRURGICA BRASILEIRA
(2023)
Article
Surgery
Gleide Gatti Fontes, Rodrigo de Barros Freitas, Palloma Porto Almeida, Luciana Moreira Lima, Silvia Almeida Cardoso, Virginia Ramos Pizziolo, Ricardo Tabach, Almir Goncalves Wanderley, Ricardo Mario Arida, Afonso Caricati-Neto, Murched Omar Taha, Camilo Amaro de Carvalho, Fernando Sabia Tallo, Francisco Sandro Menezes-Rodrigues
Summary: The study found that Calendula officinalis extract can reduce lipid infiltration in the liver, modulate oxidative stress and lipid metabolism markers, and therefore has a modulatory effect on dyslipidemia.
ACTA CIRURGICA BRASILEIRA
(2023)
Article
Biochemistry & Molecular Biology
Natalie Emanuelle Ribeiro Rodrigues, Alisson Rodrigo da Silva Oliveira, Sandrine Maria de Arruda Lima, Daniel Medeiros Nunes, Priscilla Barbosa Sales de Albuquerque, Maria das Gracas Carneiro da Cunha, Almir Goncalves Wanderley, Flavio Manoel Rodrigues da Silva Jr, Jose Bruno Nunes Ferreira Silva, alvaro Aguiar Coelho Teixeira, Teresinha Goncalves da Silva
Summary: Toxicological studies on medicinal plants are crucial for ensuring their safety and effectiveness in treating diseases. This study aimed to assess the potential embryotoxic and teratogenic effects of the AECi on Wistar rats. The results showed that the AECi at doses of 100, 200, and 400 mg/kg did not induce reproductive toxicity but caused some skeletal changes.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)