Article
Agronomy
Henry Leonel Bueso Castro, Jhennifer Cristina de Souza Alves, Joanina Gladenucci, Rosangela Cristina Marucci, Filippe Elias de Freitas Soares
Summary: This study evaluated the activity of proteases from papaya latex, pineapple peel, and crown extracts on agricultural pests. The results showed that papaya latex and papain reduced Panagrellus sp's population, and the extracts were toxic to Tenebrio molitor larvae. Furthermore, papaya latex had significant effects on the development and feeding behavior of T. molitor.
Review
Genetics & Heredity
Ziwei Zhou, Rebecca Ford, Ido Bar, Chutchamas Kanchana-udomkan
Summary: The papaya industry faces challenges in fruit quality consistency and flavor, necessitating a better understanding of genetic and biochemical mechanisms for breeding new varieties with improved taste. Research methods such as studying sugar components, volatile compounds, and genomics are used to identify the flavor profile of papaya.
Article
Engineering, Biomedical
Que Bai, Caiyun Zheng, Na Sun, Wenting Chen, Qian Gao, Jinxi Liu, Fangfang Hu, Tong Zhou, Yanni Zhang, Tingli Lu
Summary: This study presents an oxygen-releasing hydrogel that promotes cell survival, migration, and tube formation under hypoxic conditions, and facilitates tissue repair by reducing inflammation, increasing angiogenesis, and collagen deposition.
ACTA BIOMATERIALIA
(2022)
Review
Food Science & Technology
Rebecca A. Haber, Reicelle D. Garcia, Jamie N. Hernandez, Sarah Jamieson, Arijit Mondal, Anupam Bishayee
Summary: This paper provides a comprehensive analysis of the cancer-preventive potential of Carica papaya extracts, fractions, and isolated phytochemicals. It discusses the cellular and molecular mechanisms of action, bioavailability, pharmacokinetics, and safety profiles of these phytochemicals, as well as the limitations, challenges, and future directions of research.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Horticulture
Carlos Lopez Encina, Manuel Lopez Granero, Jose Javier Regalado
Summary: In this article, the authors present a reliable method for the long-term micropropagation of papaya, using microshoots developed from the axillary buds of papaya shoots as primary explants. The proliferation medium (PPRM) was found to maintain papaya shoots under continuous proliferation for 20 years, while the elongation medium (PELM) and rooting medium (PROM) were designed to recover shoots with poor growth and induce high-quality roots from nonrooted shoots, respectively. The main objective of this work was to provide a micropropagation method that can maintain healthy elite genotypes of papaya for long periods of time and produce a high number of good quality plants.
Article
Agronomy
Juan Alberto Cabrera, Axel Ritter, Vanesa Raya, Eudaldo Perez, Maria Gloria Lobo
Summary: To optimize papaya yield and quality, crop phenology studies are necessary, involving measurement of meteorological variables and morphological characteristics, as well as calculation of source-sink ratios and study of fruit quality. Results indicated that better environmental control inside greenhouses and screenhouses is needed to maintain good fruit quality.
Review
Pharmacology & Pharmacy
Md Moklesur Rahman Sarker, Farzana Khan, Isa Naina Mohamed
Summary: Dengue fever, caused by the Aedes aegypti virus, has seen a drastic increase in prevalence and mortality rates in recent years in countries like Bangladesh, Philippines, Thailand, Brazil, and India. While traditional medicine using papaya leaves has shown some effectiveness in treating the disease, physicians in Bangladesh do not recommend its use.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Junyao Li, Chunru Wang, Xiangsheng Han, Shuai Liu, Xintao Gao, Chuanlong Guo, Xiaochen Wu
Summary: A fibrous hydrogel containing nanofibers and an antibacterial drug was developed for the treatment of Staphylococcus aureus-infected burn wounds. The hydrogel exhibited favorable physicochemical properties and biocompatibility, and continuously released antibacterial drugs to promote wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Nutrition & Dietetics
Bee Ping Teh, Norzahirah Binti Ahmad, Saharuddin Bin Mohamad, Terence Yew Chin Tan, Mohd Ridzuan Bin Mohd Abd Razak, Adlin Binti Afzan, Ami Fazlin Binti Syed Mohamed
Summary: This scoping review critically appraised the scientific evidence related to the efficacy of Carica papaya leaf juice in relieving dengue related manifestations. The review revealed that besides its larvicidal activity, Carica papaya leaf juice also exhibited anti-thrombocytopenic and immunomodulatory effects on dengue infection. This study suggests that Carica papaya leaf juice has the potential to be a new safe and effective drug against dengue disease.
Article
Multidisciplinary Sciences
Juan Liu, Jennifer Han, Anupma Sharma, Ching Man Wai, Ray Ming, Qingyi Yu
Summary: The study found that dosage compensation in papaya is regulated on a gene-by-gene level rather than whole sex-linked region, with seven genes on the papaya X chromosome showing dosage compensation. Expression ratios in different evolutionary strata suggest different mechanisms of gene regulation and maintenance of transcriptional balance between females and males.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Pallavi S. Patil, Umesh B. Deshannavar, M. Ramasamy, Sampath Emani
Summary: The study investigated the use of sugarcane juice blended with different fruit juices as substrate for wine production, identifying a promising blend of sugarcane-papaya juice based on total alcohol content and overall acceptability. Optimum fermentation conditions were determined for the sugarcane-papaya wine, resulting in high overall acceptability and physicochemical parameters within standard range. GC-HRMS analysis identified 12 volatile compounds in the wine, while inductively coupled plasma atomic emission spectroscopy revealed the presence of minerals such as Ca, Cu, K, Mg, Mn, Na, Zn, and P.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2021)
Article
Plant Sciences
Sumit K. Soni, Manoj Kumar Mishra, Maneesh Mishra, Swati Kumari, Sangeeta Saxena, Virendra Shukla, Sudeep Tiwari, Pramod Shirke
Summary: The present investigation revealed that the infection of papaya leaves by PaLCuV resulted in significant changes in the anatomy, physiology, and pharmacological properties of the leaves. The infected leaves showed reduced stomatal density, photosynthesis rate, and enzymatic activity, while the size of guard cells, transpiration rate, and anthocyanin content increased. Moreover, the pharmacological potential of the infected leaves was significantly decreased.
Article
Engineering, Biomedical
Yan Hu, Bangrui Yu, Yuanbo Jia, Meng Lei, Zhijie Li, Hao Liu, Haishui Huang, Feng Xu, Jing Li, Zhao Wei
Summary: A bioadhesive and injectable ECM-mimicking hydrogel dressing with antibacterial capacity has been developed for burn injury therapy. The HG/Doxy hydrogel dressing exhibits biocompatibility and antibacterial activity against both Gram-positive and Gram-negative bacteria. In a rat model of burn wound, the HG/Doxy hydrogel dressing significantly accelerates wound closure and promotes skin structure regeneration, demonstrating its potential for clinical applications.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Chuanjin Yin, Xiangsheng Han, Qingyang Lu, Xueju Qi, Chuanlong Guo, Xiaochen Wu
Summary: A high-performance dressing with both antibacterial and anti-inflammatory properties was developed by incorporating an anti-inflammatory and antibacterial drug, rhein, into a silk fibroin matrix. The resulting hydrogel dressing exhibited a fibrous network nanostructure, high water content, and water adsorption ability, making it suitable for treating bacterial infected wounds and accelerating wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Food Science & Technology
Sherif Shaheen, Charis M. Galanakis, Mohamed A. Farag
Summary: Papaya is a tropical fruit known for its nutritional value and health benefits. The seeds and peels of papaya, which account for 20% of the fruit weight, contain valuable chemical constituents such as glucosinolates, lipids, proteins, and dietary fibers. This review outlines the composition of papaya fruit biowastes, their biological functions, and their applications in functional food, bioenergy, and other industries.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Nanoscience & Nanotechnology
Zeljka Vanic, Zora Rukavina, Suvi Manner, Adyary Fallarero, Lidija Uzelac, Marijeta Kralj, Daniela Amidzic Klaric, Anita Bogdanov, Timea Raffai, Dezso Peter Virok, Jelena Filipovic-Grcic, Natasa Skalko-Basnet
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2019)
Article
Pharmacology & Pharmacy
Julia F. Alopaeus, Marie Hellfritzsch, Tobias Gutowski, Regina Scherliess, Andreia Almeida, Bruno Sarmento, Natasa Skalko-Basnet, Ingunn Tho
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Article
Chemistry, Medicinal
May Wenche Joraholmen, Abhilasha Bhargava, Kjersti Julin, Mona Johannessen, Natasa Skalko-Basnet
Article
Pharmacology & Pharmacy
Barbara Giordani, Purusotam Basnet, Ekaterina Mishchenko, Barbara Luppi, Natasa Skalko-Basnet
Article
Pharmacology & Pharmacy
Selenia Ternullo, Laura Victoria Schulte Werning, Ann Mari Holster, Natasa Skalko-Basnet
Article
Biochemistry & Molecular Biology
Jennifer Cauzzo, Mona Nystad, Ann Mari Holsaeter, Purusotam Basnet, Natasa Skalko-Basnet
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Chemistry, Multidisciplinary
Sybil Obuobi, Kjersti Julin, Elizabeth G. A. Fredheim, Mona Johannessen, Natasa Skalko-Basnet
JOURNAL OF CONTROLLED RELEASE
(2020)
Article
Pharmacology & Pharmacy
Margherita Falavigna, Martina Pattacini, Richard Wibel, Fabio Sonvico, Natasa Skalko-Basnet, Goril Eide Flaten
Review
Pharmacology & Pharmacy
Sybil Obuobi, Natasa Skalko-Basnet
Article
Pharmacology & Pharmacy
May Wenche Joraholmen, Mona Johannessen, Kirsten Gravningen, Mirja Puolakkainen, Ganesh Acharya, Purusotam Basnet, Natasa Skalko-Basnet
Article
Chemistry, Medicinal
Lisa Myrseth Hemmingsen, Kjersti Julin, Luqman Ahsan, Purusotam Basnet, Mona Johannessen, Natasa Skalko-Basnet
Summary: In an era of antimicrobial resistance, novel treatment options are urgently needed to improve the prevention and eradication of infectious skin biofilm-producing pathogens, while enhancing wound healing. Tailoring formulations for acute skin injuries is crucial for proper skin retention and release of antimicrobials.
Article
Pharmacology & Pharmacy
Jennifer Cauzzo, Nikhil Jayakumar, Balpreet Singh Ahluwalia, Azeem Ahmad, Natasa Skalko-Basnet
Summary: The study identifies limitations of traditional methods, introduces QPM as a promising complementary technique, and successfully locates and tracks liposomes.
Article
Chemistry, Applied
Lisa Myrseth Hemmingsen, Barbara Giordani, Ann Kristin Pettersen, Beatrice Vitali, Purusotam Basnet, Natasa Skalko-Basnet
Summary: The incorporation of chlorhexidine (CHX) liposomes into chitosan hydrogel significantly enhances its antimicrobial activity, leading to effective eradication of bacteria and biofilms, with potential therapeutic applications for skin infections.
CARBOHYDRATE POLYMERS
(2021)
Article
Pharmacology & Pharmacy
Laura Victoria Schulte-Werning, Anjanah Murugaiah, Bhupender Singh, Mona Johannessen, Rolf Einar Engstad, Natasa Skalko-Basnet, Ann Mari Holsaeter
Summary: The development of multifunctional nanofibrous wound dressings containing chloramphenicol, beta-glucan, and chitosan shows promising anti-inflammatory and antimicrobial properties for the treatment of infected and exuding wounds.
Article
Pharmacology & Pharmacy
Ivo Laidmae, Andres Meos, Irja Alainezhad Kjaervik, Sveinung G. Ingebrigtsen, Natasa Skalko-Basnet, Kalle Kirsimae, Tavo Romann, Urmas Joost, Vambola Kisand, Karin Kogermann
Summary: The study compared the preparation of drug-loaded liposomes using two methods and found that liposomes prepared by electrospinning were smaller and more homogeneous but contained less drug. Additionally, the electrospinning method was faster for in-situ liposome preparation.
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
