Article
Nutrition & Dietetics
Bo-Ying Zang, Li-Xia He, Ling Xue
Summary: Obesity and diabetes are significant health issues, and moderate weight loss is important for reducing the risk of metabolic diseases. Intermittent fasting (IF) is a popular weight loss strategy, but more research is needed, especially regarding its application in obese and type 2 diabetic patients.
Article
Endocrinology & Metabolism
Daniel Schembri Wismayer, Marcello C. Laurenti, Yilin Song, Aoife M. Egan, Andrew A. Welch, Kent R. Bailey, Claudio Cobelli, Chiara Dalla Man, Michael D. Jensen, Adrian Vella
Summary: Changes in overnight concentrations of free fatty acids (FFAs) and glucose do not affect islet function or glucose metabolism. Elevated FFAs and glucose levels impair the dynamic component of the beta-cell response to glucose.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Endocrinology & Metabolism
Fernando Bril, Michael J. McPhaul, Srilaxmi Kalavalapalli, Romina Lomonaco, Diana Barb, Meagan E. Gray, Dov Shiffman, Charles M. Rowland, Kenneth Cusi
Summary: Measuring intact fasting insulin levels by mass spectrometry is an accurate and noninvasive method to predict the presence of NAFLD in patients without diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Katsiaryna Prystupa, Rebecka Renklint, Youssef Chninou, Julia Otten, Louise Fritsche, Sebastian Hoerber, Andreas Peter, Andreas L. Birkenfeld, Andreas Fritsche, Martin Heni, Robert Wagner
Summary: This study aims to validate various surrogate indices based on OGTT and fasting measurements by comparing them with gold standard methods. The results showed that certain indices have strong correlation with the gold standard measures and could be potentially used in future research and clinical practice.
BMJ OPEN DIABETES RESEARCH & CARE
(2022)
Article
Endocrinology & Metabolism
Sine W. Jorgensen, Line Hjort, Linn Gillberg, Louise Justesen, Sten Madsbad, Charlotte Brons, Allan A. Vaag
Summary: This study found that 36-hour prolonged fasting compared to 12-hour overnight fasting led to a slight decrease in first-phase insulin secretion in healthy young males, but with opposite changes in hepatic versus whole body insulin action. Reduced insulin secretion during prolonged fasting may represent a healthy response to improved hepatic insulin action, challenging the physiological understanding of insulin secretion disposition indices not considering organ-specific insulin action.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Nutrition & Dietetics
Farshad Teymoori, Hossein Farhadnejad, Nazanin Moslehi, Parvin Mirmiran, Ebrahim Mokhtari, Fereidoun Azizi
Summary: The study revealed that a diet high in GL, GI, II, and IL can increase the incidence of diabetes. Glycemic and insulin load are stronger predictors of diabetes risk compared to glycemic index and insulin index.
CLINICAL NUTRITION
(2021)
Article
Endocrinology & Metabolism
Lixia Shen, Dongyu Wang, Yihong Huang, Lisha Ye, Caixia Zhu, Shaofeng Zhang, Shiqin Cai, Zilian Wang, Haitian Chen
Summary: This study investigated the correlation between lipid profiles and insulin indices as well as the development of gestational diabetes mellitus (GDM) in pregnant women. The results showed that triglycerides (TG) were consistently correlated with insulin indices and glucose metabolism indices. Persistently high TG levels were independent risk factors for persistent insulin resistance (IR) and second-trimester IR alone. Lowering TG levels in early and middle pregnancy could help reduce the risk of developing IR.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Schafer C. Boeder, Justin M. Gregory, Erin R. Giovannetti, Jeremy H. Pettus
Summary: This study evaluated the effect of SGLT2 inhibitors on the glucagon response to hypoglycemia in individuals with type 1 diabetes. The results showed that although SGLT2 inhibitors increased basal glucagon concentrations, they did not restore the impaired glucagon response to hypoglycemia. Therefore, the reduction in hypoglycemia associated with SGLT2 inhibitors may be a result of changes in diabetes care rather than a direct physiological effect on alpha-cell function.
Article
Medicine, General & Internal
Stefan Zoltan Lutz, Joerg Hennenlotter, Andras Franko, Corinna Dannecker, Louise Fritsche, Konstantinos Kantartzis, Robert Wagner, Andreas Peter, Norbert Stefan, Andreas Fritsche, Tilman Todenhoefer, Arnulf Stenzl, Hans-Ulrich Haering, Martin Heni
Summary: The study found that patients with prostate cancer have higher fasting blood glucose levels and insulin resistance, with no significant changes in insulin secretion. Meanwhile, the serum triglyceride levels of cancer patients are lower, but there is an increase in adrenal steroid biosynthesis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Xingyun Zhu, Chu Lin, Li Li, Suiyuan Hu, Xiaoling Cai, Linong Ji
Summary: SGLT2 inhibitors treatment increases plasma fasting glucagon levels in patients with diabetes, potentially leading to reduced insulin levels and elevated ketone body levels.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Gary J. Farkas, Phillip S. Gordon, Nareka Trewick, Ashraf S. Gorgey, David R. Dolbow, Eduard Tiozzo, Arthur S. Berg, David R. Gater
Summary: This study shows that QUICKI has the highest agreement with insulin sensitivity in individuals with chronic motor complete SCI. HbA1C and FPG have poor agreement with Si.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Spela Volcansek, Urska Rahne Perc, Mojca Lunder, Drazenka Pongrac Barlovic
Summary: Reactive postprandial hypoglycemia (RPH) is an understudied condition that lacks clinical definition and knowledge of future health implications. This study aimed to assess the glycemic response after glucose ingestion in individuals with RPH and compare it with healthy volunteers. The results showed that RPH subjects did not exhibit deteriorated insulin sensitivity or insulin resistance, and there were no significant differences in glucose-insulin curves during oral glucose tolerance tests compared to healthy controls.
Article
Nutrition & Dietetics
Allison M. Hodge, Md Nazmul Karim, James R. Hebert, Nitin Shivappa, Barbora de Courten
Summary: The study found that dietary inflammatory index and Alternative Healthy Eating Index-2010 were positively associated with diabetes incidence, while Mediterranean Diet Score was not. Mediation analysis indicated that body size played a moderate to large mediating role in the association between AHEI and DII and incident diabetes.
Review
Biochemistry & Molecular Biology
Amrita Balram, Spriha Thapa, Subroto Chatterjee
Summary: This review discusses three major concepts regarding sphingolipids and diabetes: the potential involvement of GM3 in insulin-insulin receptor interactions, the potential roles of Cer and LacCer in apoptosis and mitochondrial dysfunction, and the larger role of LacCer in antioxidant status and inflammation. In addition, the review discusses the efficacy of glycosphingolipid synthesis inhibitors in ameliorating diabetes in experimental animal models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Lisandra Joaquim, Ana Faria, Helena Loureiro, Paulo Matafome
Summary: Intermittent fasting is an emergent nutritional strategy that can improve multiple features of cardiometabolic diseases by regulating evolution-conserved cellular responses and modulating the circadian rhythms of hormones like insulin or leptin. However, more studies are needed to determine the duration of interventions and the participants' anterior metabolic status.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Infectious Diseases
Adedayo O. Oduola, Abiodun Obembe, Olukayode J. Adelaja, Adeniyi K. Adeneye, Joel Akilah, Taiwo S. Awolola
Article
Integrative & Complementary Medicine
Adejuwon Adewale Adeneye, Adekunle Ibrahim Oreagba, Ismail Ogunbayode Ishola, Hassanat Adeola Kalejaiye
AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES
(2014)
Article
Toxicology
A. J. Akindele, A. A. Adeneye, F. Olatoye, A. S. Benebo
HUMAN & EXPERIMENTAL TOXICOLOGY
(2014)
Article
Integrative & Complementary Medicine
I. O. Ishola, I. A. Oreagba, A. A. Adeneye, C. Adirije, K. A. Oshikoya, O. O. Ogunleye
JOURNAL OF HERBAL MEDICINE
(2014)
Article
Pharmacology & Pharmacy
Abidemi J. Akindele, Adejuwon A. Adeneye, Oluwole S. Salau, Margaret O. Sofidiya, Adokiye S. Benebo
FRONTIERS IN PHARMACOLOGY
(2014)
Article
Public, Environmental & Occupational Health
Adeniyi K. Adeneye, Ayodele S. Jegede, Ezebunwa E. Nwokocha, Margaret A. Mafe
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2014)
Article
Integrative & Complementary Medicine
Adejuwon Adewale Adeneye, Joseph Abayomi Olagunju, Babatunde Adekunle Murtala
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2019)
Article
Cell Biology
Olufunke Olorundare, Adejuwon Adeneye, Akinyele Akinsola, Phillip Kolo, Olalekan Agede, Sunday Soyemi, Alban Mgbehoma, Ikechukwu Okoye, Ralph Albrecht, Hasan Mukhtar
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Toxicology
Olufunke Esan Olorundare, Adejuwon Adewale Adeneye, Akinyele Olubiyi Akinsola, Daniel Ayodele Sanni, Mamoru Koketsu, Hasan Mukhtar
JOURNAL OF TOXICOLOGY
(2020)
Meeting Abstract
Public, Environmental & Occupational Health
Adeola Y. Olukosi, Chimere Agomo, Oluwagbemiga Aina, Samuel Akindele, Hilary Okoh, Bartholomew Brai, Olusola Ajibaye, Bassey Orok, Bamidele Iwalokun, Adeniyi Adeneye, Adedapo Adeogun, Olajumoke Akinyele, Nkechi Oparaugo, Grace Akintunde, Veronica Enya, Maureen Aniedobe, Olatoun Fesobi, Abiodun Olakiigbe, Samson Awolola
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2015)
Meeting Abstract
Biochemistry & Molecular Biology
Grace Umoren, Simiat Elias, Adejuwon Adeneye
Meeting Abstract
Pharmacology & Pharmacy
A. Adeneye, S. Adenekan, O. Adeyemi, E. Agbaje
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2014)
Article
Infectious Diseases
O. P. Akinwale, J. O. Oyefara, P. E. Adejoh, A. A. Adeneye, A. K. Adeneye, Z. A. Musa, K. S. Oyedeji, M. A. Sulyman
SOUTHERN AFRICAN JOURNAL OF INFECTIOUS DISEASES
(2014)
Article
Public, Environmental & Occupational Health
Olaoluwa Pheabian Akinwale, Lekan John Oyefara, Pius Adejoh, Adejuwon Adewale Adeneye, Adeniyi Kazeem Adeneye, Zaidat Adesola Musa, Kolawole Solomon Oyedeji, Medinat Ayobami Sulyman
IRANIAN JOURNAL OF PUBLIC HEALTH
(2013)
Article
Environmental Sciences
Kolawole S. Oyedeji, Mary-Theresa Niemogha, Francisca O. Nwaokorie, Tajudeen A. Bamidele, Michael Ochoga, Kehinde A. Akinsinde, Bartholomew I. Brai, David Oladele, Emmanuel A. Omonigbehin, Moses Bamidele, Toun W. Fesobi, Adesola Z. Musa, Adeniyi K. Adeneye, Stella I. Smith, Innocent A. Ujah
JOURNAL OF HEALTH POPULATION AND NUTRITION
(2013)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)